JPH0817785B2 - Bone marrow fluid distributor for promoting ossification of bioactive bone cement - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a bone marrow fluid distributor for promoting ossification of bioactive bone cement used for bone treatment in orthopedics, dentistry and veterinary surgery. It is a device for achieving reliable and rapid ossification of the entire bone cement layer by inducing bone marrow fluid rich in osteoblasts to every corner of the bone cement.

[0002]

2. Description of the Related Art
In the first issue, a method of treating animal bone by artificial bone marrow cavity formation was disclosed for the first time. That is, when filling a paste-like bioactive bone cement into a bone defect or void resulting from crushed bone fracture or surgical resection, a bone marrow cavity and a bone marrow cavity opening on both sides of the bone defect, As shown in FIG. 4, they are connected by a single-tube type artificial bone marrow tube 9 made of a porous living body transplant material such as polypropylene mesh formed into a cylindrical shape. The bone marrow cavity cut at a bone defect or the like is repaired with an artificial bone marrow tube 9, and the periphery thereof is covered with a paste-like bioactive bone cement 8 so that bone marrow fluid rich in osteoblasts can be artificial bone marrow tube. Filled inside. As a result, the bone marrow fluid exudes from the artificial bone marrow tube 9 and permeates the fine voids of the hardened bone cement layer. Along with this, the osteoblasts contained in the bone marrow fluid spread to every corner of the bone cement. As a result, the entire bioactive bone cement 8 filled in the bone defect portion or the like can be reliably and quickly ossified at once.

[0003]

However, the distance that the bone marrow can penetrate into the bone cement layer by the capillary phenomenon is only about 5 mm. Therefore, the conventional single-tube type artificial bone marrow tube can be used only for the treatment of a diaphyseal portion having a small compact quality such as small animals and long bones of limbs of infants.

The present invention eliminates the above-mentioned drawbacks of the prior art, and enables paste-like bioactive bone cement filled or molded in any shape and size to be ossified reliably and quickly in every corner. The present invention provides a bone marrow fluid dispenser.

[0005]

A bone marrow fluid distributor according to claim 1 is a tuft-like deployable device in which both ends of a plurality of elongated artificial bone marrow tubules 1 are bundled in place of the single-tube artificial bone marrow tubule. The bone marrow fluid distribution part 2 is formed, and the marrow fluid introduction parts 3 are provided at both ends of the bundled artificial bone marrow tubules 1. The bone marrow fluid distributor according to claim 2 is the one according to claim 1, wherein each of the bone marrow fluid introducing parts 3, 3 is provided with a bone marrow fluid guide tube 4, 4 for guiding the bone marrow fluid out of the bone. Is.

[0006]

When this bone marrow fluid distributor is used, both the bone marrow fluid introducing parts 3 and 3 are inserted into the bone marrow cavities 5 and 5 which are open on both sides of the bone defect part or the like. Are connected to the bone marrow fluid guide tubes 4 and 4 for leading out of the bone. Then, the bone marrow fluid distribution unit 2 is developed into an arbitrary shape, and the surroundings of the developed artificial bone marrow tubules 1 and the gaps between the tubules and the tubules are filled with paste bioactive bone cement without any gaps. Then, the bone marrow fluid is induced in each of the artificial bone marrow tubules, and the osteoblasts uniformly penetrate with the bone marrow fluid into the bone cement layer within 5 mm around each artificial bone marrow tubule.

Therefore, the interval between the artificial bone marrow tubules 1 is 1
By expanding the bone marrow fluid distribution part 2 into an arbitrary shape while keeping it within 0 mm, the bioactive bone cement molded into a desired shape, size and thickness can be swiftly and surely meticulously prepared in every detail. Can be transformed. In other words, if we compare the conventional thick single-tube type artificial bone marrow canal to a tree "trunk," a bone marrow fluid distribution device that bundles several thin artificial marrow tubules is a "branch".
Functions equivalent to.

[0008]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS An embodiment of the present invention will be described with reference to FIGS. That is, this bone marrow fluid distributor is a bundle of both ends of a plurality of elongated artificial bone marrow tubules 1, and has a tuft-like bone marrow fluid distributor 2 that can be freely deployed, and bone marrow cavities 5, 5 or. It has the bone marrow fluid introduction parts 3 and 3 having a thickness that can be inserted into the bone marrow fluid guide tubes 4 and 4.

The artificial bone marrow tubule 1 has a micropore or a mesh-like space through which osteoblasts having a size of about 30 μ can pass, and is made of a non-absorbable bioimplant material having a high elasticity. desirable. The material of the artificial bone marrow tubule 1 is not limited as long as it satisfies the above conditions, but polypropylene mesh is particularly preferable. When molding a medical polypropylene mesh into a thin tube, the thinner the better, the better. It is easier to make and use the outer diameter of about 1 to 2 mm. However, there is a risk that blood will be mixed with the bone marrow fluid during operation and coagulated, resulting in clogging of the tubules. Therefore, prior heparin treatment is essential.

In this respect, a heparin sustained-release collagen membrane for artificial skin which has been subjected to a porosity treatment is advantageous. Further, as another means for saving the labor of preparatory treatment for heparin, a thin tube or a thin rod of collagen or gelatin which is decomposed and absorbed in a living body and has plasticity may be used. If these are heated and bowed, they are bundled into tufts, or they are crossed vertically and horizontally to form a net and then embedded in bioactive bone cement. However, the thin cavity formed in the bone cement layer plays the same role as the non-resorbable artificial bone marrow tubule.

When the tuft-shaped bone marrow fluid distribution part 2 is developed, the space between the artificial bone marrow tubules 1 is kept within 10 mm. Although the ossification rate is accelerated as the distance is made narrower, if it is too narrow, the strength of the bone cement decreases due to insufficient bone cement. Therefore, 6m
The spacing around m is optimal. The outer diameter of the bone marrow fluid introducing parts 3 and 3 is formed to a thickness that can be inserted into the bone marrow cavity 5 or the bone marrow fluid guide tube 4, but the number of artificial bone marrow tubules is too large for the bone marrow cavity or the bone marrow fluid guide tube. If it does not fit, connect it using a connecting pipe of an appropriate shape.

Since the bone marrow fluid guide tube 4 is for guiding the bone marrow fluid from the bone marrow cavity, it is made of a material such as a Teflon tube or an artificial blood vessel that does not allow the bone marrow fluid to leak out of the tube. The joint tube may be integrally formed with one end of the bone marrow fluid guide tube.

When this bone marrow fluid distributor is used for the diaphysis of a long bone, the outer diameter of the tufted bone marrow fluid distributor 2 can be adjusted so that it can be used regardless of the thickness of the bone or the thickness of the compact. The bone cement paste can be filled even in a bone defect portion having such a shape.

In addition, in a portion where strength against load is particularly required, such as in the vicinity of the head of the femur, as shown in FIG. 2, several important points of the compact 6 are previously arranged along the outer edge of the bone stump. The small hole 7 is drilled. Then, after inserting the bone marrow fluid introducing portions 3 and 3 into the bone marrow cavities 5 and 5 opening at the bone stump, respectively, a part of the artificial bone marrow tubule 1 is cut at the center,
Alternatively, one of the ends is released without being bundled, and these are folded back so that the tip reaches the bone marrow cavity 5, and the small hole 7
To insert. Thereafter, the artificial bone marrow tubules 1 are filled with the bioactive bone cement 8 kneaded into a paste without any gaps, and the bone cement is thickly piled up at the connection site of the bone stumps.
By forming the connection portion thick in this way, the connection strength between the bone stump and the bone cement layer is significantly increased.

Furthermore, by using this bone marrow fluid distributor, bridging ossification between bones separated via joints and cartilage becomes possible. For example, when it is desired to replace the second cervical vertebra with artificial bone, a bioactive bone cement molded into a vertebral shape is transplanted with the bone marrow fluid distributor as a "core". Then, the bone marrow fluid introducing parts 3, 3 are directly inserted into the anterior and posterior first cervical vertebrae and the third cervical vertebrae respectively, or both the marrow fluid introducing parts are fitted with the marrow fluid guide tubes 4, 4, respectively. The guide tubes may be connected to the anterior and posterior cervical vertebrae. The spine, lumbar spine, pelvis, phalanges, etc. can be similarly treated.

Furthermore, by applying this bone marrow fluid distributor, it becomes possible to make full use of a new technique which should be called "subcutaneous ossification" outside the bone. That is, a balloon type skin expander is used to form a cavity in the skin such as the thigh, where the bioactive bone cement is ossified and the artificial bone can be self-made. For example, when it is desired to replace the femoral head, as shown in FIG. 3, a paste-like bioactive bone cement is applied with the artificial bone marrow tubule 1 that has been freely deployed as a core, and the shape is almost the same as the head to be replaced. Mold. At that time, molding can be easily performed by using a mold made of metal or synthetic resin. Next, the bone marrow fluid introduction parts 3 and 3 in which the ends of the artificial bone marrow tubules 1 are bundled are connected to the bone marrow fluid guide tubes 4 and 4, respectively, and after waiting for the bone cement to harden, the artificial bone head is subcutaneously attached. Store in the cavity. Thereafter, both bone ends of a healthy femur are perforated to allow the bone marrow fluid to flow out, and the bone marrow fluid guide tubes 4 and 4 are inserted into these holes, respectively. For about a month,
By circulating and supplying the bone marrow fluid in this state, the bone cement is completely ossified and a femoral head similar to an autogenous bone can be obtained.
Therefore, this is collected subcutaneously and replaced with the femoral head on the affected side. When exchanging, measure both accurately and scrape the homemade artificial head to adjust it to have the same shape. Also,
The bone marrow guide tube is cut to an appropriate length and left in the artificial bone, which is then inserted into the bone marrow cavity of the transplant destination.

[0017]

According to the bone marrow fluid distributor of the first aspect, the bone shape can be adjusted by adjusting the outer diameter of the entire tuft-shaped marrow fluid distributing portion or by expanding the bone marrow into any shape. , Size, thickness of compact, inner diameter of bone marrow cavity, etc.
A paste-like bioactive bone cement filled or molded in an arbitrary shape or size can be surely and quickly ossified to every corner.

Further, the bone marrow fluid distributor comprising a large number of elastic fine strips exerts an effect as if it were a reinforcing bar of concrete. That is, bioactive bone cement is extremely fragile until it is completely ossified, but the strength of the bone cement layer centered on artificial bone marrow tubules is the same as that of reinforced concrete in buildings that enhances strength and durability. Is significantly improved. Therefore, the bone marrow fluid distributor can be used to treat not only adult bones but also elephant foot bones.

According to the bone marrow fluid distributor of the second aspect, the bone marrow fluid can be supplied from another adjacent bone by attaching the bone marrow fluid guide tubes to both ends of the bundled artificial bone marrow tubules. Therefore, when replacing the cervical spine, thoracic spine, lumbar spine, pelvis, phalanges of limbs, etc. that have suffered from deformation / damage or osteoporosis or chronic rheumatism with artificial bone, bioactive bone cement molded into any shape and size. Can be transplanted, resulting in faster ossification and shorter treatment period.

In addition, by utilizing the technique of "subcutaneous ossification", for example, when performing leg extension in a patient with brachydactyly, a pair of left and right homemade long bones formed into a cylindrical shape are transplanted. You can Since the artificial bone that has been completely ossified subcutaneously in advance is transplanted, the stump of the long bone cut for transplant surgery and the homemade long bone are easily fused. For this reason,
Since the immobility rest period of the patient is significantly shortened, it becomes possible to perform leg extension surgery simultaneously on the right and left sides. At that time, since the artificial bone marrow tubules embedded in the columnar artificial bone continue to function as the bone marrow cavity, there is no risk of necrosis of the transplanted artificial bone due to nutritional deficiency or the like.

In the same manner, the range of application is expanded to the dental field. For example, in the treatment of rubber jaws whose teeth fall out due to bone resorption of the lower jaw, the artificial lower jaw bone and the denture are integrally formed with a bioactive bone cement with a bone marrow fluid distributor as the core,
It may be subcutaneously ossified and then replaced with the affected bone.

[Brief description of drawings]

FIG. 1 is a perspective view showing an embodiment of the present invention.

FIG. 2 is a perspective view showing an example of a usage state of the present invention.

FIG. 3 is a perspective view showing another usage state of the present invention.

FIG. 4 is a perspective view of a conventional example.

[Explanation of symbols]

 1 is an artificial bone marrow tubule 2 is a bone marrow fluid distribution part 3 is a bone marrow fluid introduction part 4 is a bone marrow fluid guide tube 5 is a bone marrow cavity 6 is a compact body 7 is a small hole 8 is a bone cement 9 is an artificial bone marrow tube

Claims (2)

[Claims] 1. A plurality of elongated artificial bone marrow tubules 1 are bundled at both ends to form a deployable tufted bone marrow fluid distribution part 2, and both ends of the bundled artificial bone marrow tubules 1 are made into bone marrow fluid introduction parts 3, 3. The bone marrow fluid dispenser for promoting ossification of bioactive bone cement, characterized in that 2. The bone marrow fluid distributor according to claim 1, wherein said bone marrow fluid introducing parts 3 and 3 are respectively connected with bone marrow fluid guide tubes 4 and 4 for leading out bone marrow fluid from the bone marrow cavity.