JPH08165227A - Hair dye composition - Google Patents

Abstract

PURPOSE: To obtain a safe hair dye composition effective for preventing or ameliorating contact dermatitis and suppressing inflammatory dermatic diseases and capable of keeping the hair-dyeing property by compounding an extract of comfrey leaf to a p-phenylenediamine derivative or its salt. CONSTITUTION: This hair dye composition is produced by compounding an extract of comfrey leaf as a natural vegetable component with one or more kinds of solvents selected from water, hot water, a lower alcohol and a polyol- based organic solvent to prevent or ameliorate contact dermatitis caused by a p-phenylenediamine derivative or its salt used as an intermediate for hair dye. The p-phenylenediamine derivative or its salt is e.g. p-phenylenediamine or N-phenylene-p-phenylenediamine acetate. Comfrey is a perennial plant native to Europe and belonging to the genus Symphytum, family Boraginaceae. The composition can suppress various inflammatory diseases of scalp and skin and is usable as a hair dye, hair-dyeing shampoo, hair-dyeing rinse, hair-dyeing treatment agent, etc.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a safe hair dye composition capable of preventing and improving contact dermatitis, suppressing skin inflammatory diseases, and maintaining hair dyeing power. Specifically, it can be applied to hair dyes, shampoos for hair dyes, rinses for hair dyes, treatment agents for hair dyes, and hair treatment agents for simultaneously performing permanent and hair dyes.

[0002]

2. Description of the Related Art Conventionally, for dyeing and dyeing hair, oxidative hair dyes containing an oxidative dye as a main component have been mainly used. These oxidative hair dyes are generally dye intermediates in the presence of an alkaline agent. The body and hydrogen peroxide are mixed and used just before the hair dyeing process, and the dye intermediate whose permeation / adsorption to the hair is enhanced by the alkaline agent is oxidatively polymerized by the enzyme generated by the decomposition of hydrogen peroxide by the alkaline agent However, an insoluble coloring pigment is produced inside the hair.

At this time, at the same time, an enzyme generated by the decomposition of hydrogen peroxide by an alkaline agent has the function of destroying the melanin pigment in the hair to decolorize it, and depending on the balance between the degree of decolorization and the color density of the coloring pigment. , Not only for dyeing gray hair,
It is said that it is possible to dye a wide range of colors from fashionable dyes to bright gray hair dyes. These hair dyes contain, for example, a first agent containing an oxidizing intermediate such as paraphenylenediamine as a main agent and an oxidizing agent such as hydrogen peroxide as a main agent. A two-part hair dye composition comprising a second agent is mainly used.

[0004]

However, since the oxidative dyes can dye hair of various colors and have excellent hair dyeing power and fastness, they are highly irritating, so that allergic or primary irritant contact is possible. Dermatitis causes various inflammatory diseases (rough skin, erythema, edema, pain, itch, hives, atopic dermatitis, etc.) to the scalp after dyeing and the skin during or after dyeing. Safety is an issue.

[0005] As an example thereof, patch test results of hair dye (oxidative hair dye) and changes in patients with melasma (Patch Test Research Group, Skin VOL.26, No.4 (1984) p.808-811)
, A patch test was performed on para-phenylenediamine, ortho-phenylenediamine, toluene-2,5-diamine hydrochloride, etc., which are widely used as the main components of hair dyes, and the most positive cases of ortho-phenylenediamine were also strong. As a positive result, paraphenylenediamine was raised, and in addition, 32 people participated in occupational dermatitis of the hands of a hairdresser and cosmetologist (Komimi Nagaki, Japan Society for Dermatological Chemistry 36th Western Branch General Assembly / Academic Convention (1984)). It was also reported that 15 people showed a positive reaction to those with irritant dermatitis due to cold perm solution and paraphenylenediamine, by conducting a patch test on occupational dermatitis patients with the hands of a hairdresser / cosmetologist. There is.

[0006] That is, paraphenylenediamine, which is a typical oxidative dye, is known as a sensitizing substance that causes allergic contact dermatitis because it has excellent dyeing properties on hair but easily binds to proteins. In Japan, prior to use as a hair dye, it is obliged to prepare a hair dye mixture by a commonly used method and conduct a skin test (patch test) for 48 hours. Therefore, the oxidative dyes containing para-phenylenediamine or its derivatives have very many safety problems when used alone.

Therefore, recently, Japanese Unexamined Patent Publication No. 1-275519
In JP-A-3-48612, a hair dye composition containing a cationic protein in paraphenylenediamine, and in JP-A-3-48612, a first agent containing a melanin precursor, an aromatic amine and the like and β-tyrosinase or mushroom extraction. Dyeing compositions using a liquid as a second agent have been developed. However, these drugs were not sufficient in terms of safety and effect.

[0008]

In view of these circumstances, the present inventors are effective in preventing and ameliorating contact dermatitis due to a paraphenylenediamine derivative used as a hair dyeing intermediate or a salt thereof, and further dyeing hair. We have been researching for natural plant ingredients that can maintain strength.

As a result, extraction obtained by extraction with one or more para-phenylenediamine derivatives or salts thereof and one or more solvents selected from water of comfrey leaves, hot water, lower alcohols and polyol organic solvents. The present inventors have found that a hair dye composition containing a substance is effective in preventing and improving contact dermatitis, suppressing skin inflammatory diseases, and can also maintain hair dyeing power, leading to the present invention. The process leading to the present invention will be described below.

Examples of the paraphenylenediamine derivative used in the present invention include paraphenylenediamine, parachloroorthophenylenediamine, N-phenylparaphenylenediamine, N, N-bishydroxyethylparaphenylenediamine and N-methyl. Paraphenylenediamine, N, N-dimethylparaphenylenediamine, N-ethylparaphenylenediamine, N-ethyl-
β-hydroxyethyl paraphenylenediamine, N, N
-Diethylparaphenylenediamine, 2-chloroparaphenylenediamine, 2-methoxyparaphenylenediamine, paramethoxymetaphenylenediamine, nitroparaphenylenediamine, paranitroorthophenylenediamine, etc. can be used, and as salts thereof, for example,
Paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine acetate, orthochlorparaphenylenediamine sulfate, paraphenylenediamine sulfate, and other commonly used hydrochlorides, sulfates, acetates, phosphates, propionates, lactates, Citrate can be used, and a general commercial product may be used.

The amount of the para-phenylenediamine derivative or salt thereof used in the present invention in the hair dye composition varies depending on the quality of the extract used and the expected degree of action, but it is usually the first. 0.00 based on the total amount of the agent
1 to 10% by weight (hereinafter, represented by% unless otherwise specified), preferably 0.2 to 5%. If the blending amount is less than 0.001%, the effect is not sufficient, and 10
If it is added in excess of%, it may cause various damages to hair and skin.

Similarly, the comfrey (Symp
hytum officinale Linne) is a European perennial plant of the genus Coccinaceae that originates from Europe and is distributed in Europe to West Siberia and Central Asia, and has a plant height of 40-90 cm.
White short coarse hairs throughout. The roots are spindle-shaped and branched, and the stems are branched and slightly finned. In addition, the leaves are oblong-ovate to acicular and sharply pointed. In the present invention, those obtained from comfrey leaves are preferable, and general commercial products may be used. Further, it may be obtained by culturing a microorganism. In addition, it is also possible to use crushed comfrey leaves, rhizomes and whole plants or their extracts.

Extraction from comfrey leaves is carried out raw or after drying and crushing, using an organic solvent, water or hot water as a solvent, and if necessary, adding an organic solvent or water. A mixed solvent may be used, and further, organic solvent extraction and water extraction may be used in combination. As the organic solvent, methanol, ethanol, n-butanol, acetone,
Examples include chloroform, ethyl acetate, n-hexane, 1,3-butylene glycol, propylene glycol and the like.

The extraction conditions are not particularly limited, but usually room temperature and heat extraction are preferred. After extraction, the solution may be filtered, concentrated and dried to be used as a solution, paste or powder. In many cases, it can be used as it is, but if necessary, purification treatments such as deodorization and decolorization may be added within the range of influence on its efficacy. As a purification treatment means for deodorization, decolorization, etc., an activated carbon column or the like may be used, and any ordinary means generally applied depending on the extraction substance may be arbitrarily selected.

The amount of the comfrey leaf extract used in the present invention to be added to the hair dye composition varies depending on the quality of the extract used and the expected degree of action, but is usually relative to the total amount of the first agent. 0.05-70%, preferably 1-50
% Is good. If the blending amount is less than 0.05%, the effect is not sufficient, and if the blending amount exceeds 70%, the effect commensurate with the amount cannot be expected.

Other dye intermediates include orthophenylenediamine, toluene-2,5-diamine, toluene-3,4-diamine, paratoluenediamine, paraaminodiphenylamine, 4,4'-diaminodiphenylamine, orthoamino. Para components such as phenol, paraaminophenol, paramethylaminophenol, paraaminoorthocresol, phloroglucin, 3,3′-iminodiphenyl, diphenylamine, 2,6-diaminopyridine, paraaminophenylsulfamic acid, and ortho components are also couplers. Examples of (modifiers) include toluene-2,4-diamine, metaaminophenol, metaphenylenediamine, α-naphthol, resorcin, 4-chlororesorcin, hydroquinone, pyrogallol and cate. In addition to the above-mentioned components in the hair dye base, meta components such as coal and phenols do not participate in the pigment formation reaction in order to maintain the quality of the product and enhance its usefulness. Examples of dyes that have an influence include 2-amino-4-nitrophenol and 2
-Amino-5-nitrophenol, nitro dyes such as 4-amino-2-nitrophenol and picramic acid,
Direct dyes such as 1,4-diaminoanthraquinone and any other commonly used dyes can be arbitrarily selected and can be used at the same time as the hair dye composition of the present invention.

Further, an oxidizing agent and a reducing agent used for dyeing hair can be arbitrarily selected as long as they are commonly used. For example, as the oxidizing agent, hydrogen peroxide, sodium persulfate, ammonium persulfate can be used. , Sodium perborate, Urea peroxide, Sodium percarbonate, Sodium tripolyphosphate peroxide, Sodium bromate, Potassium bromate, Sodium pyrophosphate phosphate, Sodium peroxyorthophosphate, Sodium silicate Hydrogen peroxide adduct, Sulfuric acid Sodium sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract and the like, and thioglycolic acid, cysteine, sulfite and the like can be used as reducing agents in the same manner.

In addition to the above-mentioned components, the hair dye composition of the present invention is generally used for cosmetics, pharmaceuticals, quasi-drugs, etc., if necessary, within a range not impairing the effects of the present invention. Various components such as oils (animal and vegetable oils, mineral oils, ester oils, wax oils, silicone oils, higher alcohols, phospholipids, fatty acids, etc.), surfactants (anionic, cationic, amphoteric or nonionic interfaces) Activator), vitamins (vitamin A group, vitamin B group, folic acid, nicotinic acid, pantothenic acid, biotin, vitamin C group, vitamin D group, vitamin E group, other ferulic acid, γ-oryzanol, etc.), ultraviolet rays Absorbent (p-aminobenzoic acid, anthranil, salicylic acid, coumarin, benzotriazole, tetrazole, imidazoline, pyrimidine, dioxane, furan, pyrone Camphor, nucleic acid, allantoin and derivatives thereof, amino acid-based compounds, shikonin,
Baicalin, baicalein, berberine, etc.), antioxidants (stearate, nordihydroguaselethenoic acid, dibutylhydroxytoluene, butylhydroxyanisole, parahydroxyanisole, propyl gallate, sezamol, sezamolin, gossypol, etc.), thickeners (Hydroxyethyl cellulose, ethyl cellulose, carboxyethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxymethyl cellulose sodium, hydroxypropyl cellulose, nitrocellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinylpyrrolidone, polyvinyl methacrylate, polyacrylate, carboxyvinyl polymer, Gum arabic, gum tragacanth, agar, casein, dextrin, gelatin, Cutin, starch, alginic acid and salts thereof, etc.), humectants (propylene glycol, 1,
3-butylene glycol, polyethylene glycol, glycerin, chondroitin sulphate and its salts, hyaluronic acid and its salts, sodium lactate, etc.) and other lower alcohols, polyhydric alcohols, water-soluble polymers, pH adjusters, antiseptic and anti-biological agents. Agents, colorants, fragrances, cooling agents, stabilizers, animal / vegetable extracts, animal / vegetable proteins and their degradation products, animal / vegetable polysaccharides and their degradation products, animal / vegetable glycoproteins and their degradation Substances, metabolic components of microbial culture, blood flow promoters, anti-inflammatory agents, anti-inflammatory agents, anti-allergic agents, cell activating agents,
Amino acids and salts thereof, keratolytic agents, astringent agents, wound healing agents, foaming agents, deodorant / deodorant agents, etc. can also be used together.

Regarding the dosage form of the hair dye composition of the present invention,
According to the usual method, the dye intermediate (oxidizing dye) and the oxidizing agent are separately prepared into liquid preparations, cream-like / gel-like preparations or powder preparations among the bases, and they are mixed at the time of use. Formulation of a drug product, or after mixing a dye intermediate (oxidizing dye) and an oxidizing agent, make a cream-like or gel-like preparation or powder preparation, and use water or shampoo base, rinse base, treatment base at the time of use. In addition, it can be used as a one-component product adapted to be used, for example, hair dye, shampoo for hair dye, rinse for hair dye, treatment for hair dye, other, hair treatment for performing permanent and hair dye at the same time. It can also be used in the form of an agent or the like.

[0020]

EXAMPLES The present invention will be described in more detail with reference to the following examples, but the present invention is not limited thereto.

Example 1: Contact dermatitis inhibition (improvement) test [Test method] The test was carried out with reference to the Maximization test method (new toxicity test and safety evaluation, Soft Science). The sensitization was performed by intradermal injection and application. First, an emulsion (E-FCA) in which equal amounts of distilled water and Freund's Complete Adjuvant were mixed with the dorsal skin of the neck (about 2 x 4 cm) of a pre-sheared animal (body weight around 400 g, Hartley female guinea pig, 5 animals), Also, 5% (w /
v) Paraphenylenediamine solution adjusted to a concentration (hereinafter, PPD) as a test drug, and further E-FCA
Three samples of the test drug emulsified and suspended in each of 0.1m
L injections were intradermally injected symmetrically. One week later, sodium lauryl sulfate (10% in vaseline (w /
v)) was applied, and on the next day, the test drug was applied to the same site for 48 hours by occluding patch. Two weeks after this, the application was performed by applying a patch. That is, in the flank of the animal that was previously shaved, 24 samples of 2 specimens were prepared by mixing the test drug with a sample (50% ethanol extract of comfrey leaves) and the test drug with a control (50% ethanol solution only). Time-blocking patch was applied. The judgment is
After skin application, skin reaction 24 hours and 48 hours later,
Comparative examination of the degree of dermatitis of the sample site and the control site,
The results are shown in Table 1. [Preparation of sample and control] Sample: 50% ethanol extract of comfrey leaves. Control: 50% ethanol solution.

[Evaluation Criteria] No reaction ・ ・ ・ 0 Scattered mild erythema ・ ・ ・ 1 Moderate diffuse erythema ・ ・ ・ 2 Intense erythema and edema ・ ・ ・ 3

[0023]

[Table 1]

[Test Results] As shown in Table 1, it was confirmed that the compound containing the PPD of the present invention and the comfrey leaf extract had an effect of improving contact dermatitis as compared with the control. .

Example 2 Contact Dermatitis Inhibition (Preventive Action) Test [Test Method] Dorsal skin (approximately 2 ×) of the neck of an animal previously shaved (a body weight of about 400 g, 5 Hartley female guinea pigs)
4 cm) with distilled water and Freund's Complete Adjuvant in an equal amount (E-FCA), or with ethanol to add 5
% (W / v) concentration of PPD mixed with a sample (comfrey leaf 50% 1,3-butylene glycol extract) (test drug), and test drug emulsified and suspended in E-FCA Of 3
Seed samples were injected intradermally, 0.1 mL each, symmetrically. One week later, sodium lauryl sulfate (10% (w / v) in petrolatum) was applied to the intradermal injection site, and the test drug was occluded on the same site the next day for 48 hours. Two weeks after this, the application was performed by applying a patch. That is, on the flank of an animal that had been previously shaved, a test drug was applied with a patch of PPD adjusted to a concentration of 1% with ethanol for 24 hours. Judgment was made based on the skin reaction 24 hours and 48 hours after the application of the patch, and the control (50% 1,3-butylene glycol solution alone) was similarly treated at the time of sensitization to determine the group and degree of dermatitis. Comparative examination was conducted in the same manner as the evaluation criteria of Example 1, and the results are shown in Table 2. [Preparation of sample and control] Sample: 50% 1,3-butylene glycol extract of comfrey leaves. Control: 50% 1,3-butylene glycol solution.

[0026]

[Table 2]

[Test Results] As shown in Table 2, it was confirmed that the mixture of the PPD of the present invention and the comfrey leaf extract has an effect of preventing contact dermatitis as compared with the control. .

Example 3: Effect of Comfrey on hair dyeing effect [Test method] A hair dye composition was prepared by mixing the following dye solution (Table 3) and 6% hydrogen peroxide solution in a ratio of 1: 1. A white wool cloth for JIS fastness test and white YAK hair were dyed for 20 minutes, washed with a 1% sodium lauryl sulfate solution and dried, and then the hair dyeing effect was measured.
Regarding the hair dyeing effect of the white wool cloth, the degree of color was measured by a color difference meter (CR-200: manufactured by Minolta Co., Ltd.), and the results are shown in Table 4. In Table 4, L means lightness, and the smaller the value, the darker the color tone,
“A” and “b” mean hues, and the larger the value of a, the stronger the red color on the positive side, and the smaller the value, the stronger the green color on the negative side.
In addition, as the value of b is larger, yellow is stronger on the positive side, and as it is smaller, blue is stronger on the negative side, and C means saturation, and the smaller the value is, the darker the color tone is.
The evaluation of the hair dyeing effect on white YAK hair was evaluated according to the following evaluation criteria, and the results are shown in Table 5.

[Evaluation Criteria] Almost not dyed 0 dyed in light gray 1 dyed in gray brown 2 dyed in brown 3 dyed in black brown ... 4

[0030]

[Table 3]

[0031]

[Table 4]

[Test Results] As shown in Table 4, the white wool cloth containing the PPD of the present invention and the comfrey leaf extract has almost the same color as the comparative product (white wool cloth containing PPD alone). The degree (numerical value) was shown, and it was confirmed that the hair dyeing power can be maintained.

[0033]

[Table 5]

[Test Results] As shown in Table 5, the white YAK hair containing the PPD of the present invention and the comfrey leaf extract had almost the same evaluation as the comparative product (white YAK hair containing PPD alone). It was confirmed that the hair dyeing power could be maintained.

Example 4: Fading effect test [Test method] The white wool cloth and the white YAK wool for the JIS dyeing fastness test, which were dyed in the above-mentioned Example 3, were treated with the acidic and basic properties shown in Table 6 below. 40 ° C in artificial sweat, 18
After soaking for a time, washing with water and drying, the color fading effect was measured.
Regarding the fading effect of the white wool cloth, the degree of color was measured by the same color difference meter as in Example 3, and the results are shown in Table 7. Further, the effect of fading the white YAK hair was evaluated by the same evaluation criteria as in Example 3 above, and the results are shown in Table 8.

[0036]

[Table 6]

[0037]

[Table 7]

[Test Results] As shown in Table 7, the white wool cloth containing the PPD of the present invention and the comfrey leaf extract was used as a comparative product even after being dipped in acidic and basic artificial sweat, washed and dried. It was confirmed that the degree of color (numerical value) was almost the same as (white wool cloth containing PPD alone), and that the hair dyeing power could be maintained.

[0039]

[Table 8]

[Test Results] As shown in Table 8, the white YAK hair containing the PPD of the present invention and the comfrey leaf extract was used as a comparative product even after being dipped in acidic and basic artificial sweat, washed and dried. The same evaluation as that of (white YAK hair containing PPD alone) was obtained, and it was confirmed that the hair dyeing power can be maintained.

Example 5: Use effect test Using the hair dye composition shown in Example 3 above, adult males and females (20 persons) with occupational dermatitis of the hands of a hairdresser and cosmetologist were usually used as panelists. A use effect test was carried out by freely using the product for 2 months as in the case of using it.
The evaluation method was evaluated according to the following criteria. The results are shown in Table 9 and the numerical values in the table represent the number of people. "Rough skin improvement effect" Effective: Rough skin was improved. Slightly effective: Roughness of the skin was slightly improved. Ineffective: No change from before use.

[0042]

[Table 9]

[Test Results] As shown in Table 9, the hair dye composition containing the PPD of the present invention and the comfrey leaf extract is effective because it gives very good results in improving rough skin. It was confirmed.

Example 6: Safety test [Primary skin irritation test] Rabbits with hair removed from the ethanol extract, 1,3-butylene glycol extract and propylene glycol extract of comfrey leaves (3 animals per group) ,body weight
About 3,800 g) was applied to the skin. Judgment is 24, 48, 7 after pasting
At 2 hours, erythema and edema were used as indexes by the primary irritation scoring method. As a result, all animals were judged to be negative without any erythema or edema. [Skin cumulative irritation test] Similarly, the flank flanks of the comfrey leaf ethanol extract, 1,3-butylene glycol extract, and propylene glycol extract were shaved (2 × 4 cm ² ).
Hartley guinea pigs (female, 5 per group, weight 32)
(About 0 g) was applied to the skin once a day, 5 times a week, 0.5 ml / animal. The application was carried out for 4 weeks, and the hair removal was performed on the last application day of each week. Judgment was performed on the day after the last day of each week, using erythema and edema as an index by the primary irritation scoring method. As a result, in all animals, erythema and edema were not observed for 1 to 4 weeks after application, and it was determined to be negative.

[Production of various hair dye compositions] The hair dye compositions of the present invention were produced. An example of the formulation is shown below, but it can be produced by adjusting the pH and the like by a conventional method, and only the blending amount is shown. The use of the hair dye composition according to the present invention is not limited to these.

Example 7 Hair Dye Composition Weight% First Agent Paraphenylenediamine 1.0 Isopropanol 9.0 Oleic Acid 15.0 Sodium Sulfite 0.1 Ammonia Water (28%) 10.0 Comfrey Leaf Extraction liquid (1,3-butylene glycol extract) 10.0 Made up to 100% with purified water. Second agent Hydrogen peroxide water 4.0 Hydrogen peroxide stabilizer Suitable amount Made to be 100% with purified water.

Example 8 Hair Dye Composition Weight% First Agent (Component A) Paraphenylenediamine 3.0 2,4-Diaminoanisole 1.3 1,5-Diaminodiphenylamine 0.1 4-Nitro- Ortho-phenylenediamine 0.1 Isopropanol 79.0 1st agent (B component) Oleic acid 20.0 Polyoxyethylene sorbitan monooleate 10.0 Propylene glycol 20.0 Comfrey leaf extract (pro-propylene glycol extract) 5.0 Sulfurous acid Sodium 0.1 The above components A and B were made 100% with purified water. Second agent 6% hydrogen peroxide water 6.0 Made up to 100% with purified water. Third Agent Aqueous citric acid solution 10.0 To 100 parts of the above first agent, 70 parts of the second agent and 0.4 parts of the third agent are mixed to obtain a solution having a pH of 6.

Example 9 Hair Dye Composition% Weight% First Agent Paraphenylenediamine 1.4 Nitroparaphenylenediamine 0.8 Paranitroorthophenylenediamine 0.2 Pyrogallol 0.3 Resorcin 0.4 Comfrey leaf Extraction solution (hot water extract) 10.0 Lauryl sulfate triethanolamine 5.0 Coconut oil fatty acid diethanolamide 5.0 Oleic acid 20.0 Ammonia water (28%) 8.0 Isopyranol 10.0 Edetate 0.1 It was made 100% with purified water. Second agent Hydrogen peroxide water (35%) 18.0 Cetanol 3.0 Polyoxyethylene cetyl ether 2.0 Hydrochloric acid water (pH 3) was added to 100%.

Example 10: Hair Treatment Agent% by Weight First Agent Paraphenylenediamine Comfrey Extract (Ethanol: 1,3-Vetyleneglycol = 1: 1 Extract) 8.0 Thioglycolic Acid 1.0 L-Cysteine Acid solution 8.0 Resorcinol 0.7 Sodium sulfite 0.3 Ammonia water 10.0 Surfactant 0.5 L-Ascorbic acid 0.5 Made to 100% with purified water. Second agent Hydrogen peroxide water 4.0 Hydrogen peroxide stabilizer Suitable amount Made to be 100% with purified water.

[0050]

The hair dye composition containing one or more of the para-phenylenediamine derivative of the present invention or a salt thereof and a comfrey leaf extract can prevent and improve contact dermatitis, thereby improving the scalp. And various inflammatory diseases of the skin (rough skin, erythema, edema, pain, itchiness, urticaria, atopic dermatitis, etc.) and can maintain hair dyeing power. Therefore, it can be applied to hair dyes, shampoos for hair dyes, rinses for hair dyes, treatment agents for hair dyes, and hair treatment agents for simultaneously performing permanent and hair dyes.

Claims (1)

[Claims] 1. An extract obtained by extraction with one or more paraphenylenediamine derivatives or salts thereof and one or more solvents selected from water of comfrey leaves, hot water, lower alcohols and polyol organic solvents. A hair dye composition comprising: