JPH08150215A - Medical appliance for supplying medicine - Google Patents

Abstract

PURPOSE: To provide a medical appliance for supplying medicines which can supply medicines to a wide area of the biomedical tissue by installing several solid needles at the top of the insertion part of the appliance to be inserted to the body. CONSTITUTION: The medical appliance 12 consists of a long operation wire 3, a needle fixing part 5 fixed at the top of the operation wire 3, and several solid needles fixed at regular intervals on the top surface of the needle fixing part 5. When genes or medicines are supplied to the affected part tissue 8 by this appliance 1, a medicine 7 is first applied to the surface of the solid needles 4, and at the same time, the medicine 7 is also kept in the space between each solid needle 4 by a capillary phenomenon or surface tension. The medical appliance 12 itself is stored in a movable tube 2. The appliance 1 in this condition is inserted to the body, and the top of the movable tube 2 is placed at the affected part tissue 8. And the needle fixing part 5 is pushed forward by the operation wire 3 so that the solid needles 4 are to be thrust into the affected part tissue 8 to be treated.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention is, for example, introduced into a body cavity through an endoscope and injects a drug such as a gene or gene inclusion body or a therapeutic agent (including a test agent) into a tissue site in the body cavity. The present invention relates to a treatment tool for drug administration.

[0002]

2. Description of the Related Art Recently, gene therapy research has been widely conducted. Gene therapy is a method in which a predetermined gene is introduced into a cell of a patient and the gene is expressed to perform the treatment. As a means for introducing this gene into the cells of a patient, there are a method of removing the cell from the living body, introducing the gene into the body and returning it to the body, and a method of directly introducing the gene into the living cells of the patient. There is. Whichever method is used, administration of a gene to a treatment site in a body cavity requires a special device.

[0003]

A technique for administering a gene to an affected area in a body cavity can be considered as, for example, Jitsukaihei 1
-68052 and Japanese Utility Model Publication No. 3-15081 are used.

However, in the procedure using such an endoscopic injection needle, the gene is locally injected only into an extremely narrow portion by one injection needle,
A wide range of sufficient therapeutic effects cannot be expected. Also,
In order to administer a gene over a wide area, it is necessary to repeat needle puncture in the body cavity many times, which requires a very difficult and troublesome procedure, and the burden on the patient is considerably large, which is not desirable. Absent.

On the other hand, a technique of simply and widely spreading the gene on the affected area is conceivable, but the gene easily flows after the spreading, and reliable treatment cannot be expected.

The present invention has been made in view of the above circumstances, and an object thereof is to provide a treatment tool for drug administration capable of reliably administering a drug over a wide range of a living tissue.

[0007]

Means and Actions for Solving the Problems In order to solve the above-mentioned problems, the present invention relates to a drug administration treatment instrument for inserting a drug into an affected tissue in a body cavity, wherein A plurality of solid needles to be inserted into the affected tissue are provided at the tip of the insertion portion to be inserted into.

[0008]

Since the treatment tool for drug administration having the above-mentioned structure is provided with a plurality of solid needles for injecting the drug into the affected tissue,
By inserting a solid needle into the affected tissue, a plurality of holes for injecting the drug into the affected tissue can be formed at one time, and the drug can be administered over a wide range of the affected tissue.

Further, since it has a plurality of solid needles, the drug can be held in the surface of the solid needle and in the gap between the solid needles by capillary action or surface tension. Therefore, it is not necessary to provide a means for supplying a drug, and the drug can be administered only by applying the drug to the solid needle, so that the amount of the drug used can be reduced. In this case, if a plurality of solid needles are punctured into the affected tissue,
Simultaneously with the puncture, the drug is injected into the affected tissue through a solid needle.

[0010]

Embodiments of the present invention will be described below with reference to the drawings. 1 to 3 show a first embodiment of the present invention. The treatment tool 1 for drug administration of the present embodiment is
A flexible tube 2 that can be inserted into a body cavity and a treatment tool body 12 that is inserted into the flexible tube 2 so as to be able to advance and retract.

The treatment instrument main body 12 includes a long operating wire 3
And a needle fixing member 5 fixed to the tip of the operation wire 3,
A plurality of solid needles 4 are fixed to the end surface of the needle fixing member 5 with a predetermined gap therebetween.

By using the treatment tool 1 for drug administration having the above-mentioned structure, a gene, a therapeutic agent or a test agent (hereinafter
Simply called a drug. ) Etc., first of all, the drug 7 is applied to the surface of the solid needle 4 in advance, and the drug is held in the gap 6 between the solid needles 4 by capillary action or surface tension. As shown in FIG. 1, the treatment instrument main body 12 is housed in the flexible tube 2. Then, in this state, the treatment tool 1 is introduced into the body via, for example, the channel of the endoscope, and the tip of the flexible tube 2 is guided to the affected tissue 8. When the distal end of the flexible tube 2 is positioned in front of the diseased tissue 8, this time,
The operation wire 3 is pushed forward, the needle fixing member 5 having the solid needle 4 ... Is made to protrude from the distal end opening of the flexible tube 2 (state (a) of FIG. 3), and the affected tissue 8 is solid. The needle 4 is punctured (state (b) of FIG. 3).

When a plurality of solid needles 4 are punctured in the affected tissue 8 in this manner, at the same time as the puncturing, the drug 7 is injected into the affected tissue 8 through the solid needles 4 ...

As described above, the treatment instrument 1 for drug administration according to the present embodiment is provided with the plurality of solid needles 4 for injecting the drug 7 into the affected tissue 9. A plurality of holes for injecting the drug 7 into the diseased tissue 8 can be formed at one time by inserting the ... into the diseased tissue 8 and the drug 7 can be administered over a wide range of the diseased tissue 8. Further, since it is sufficient to apply the drug 7 to the solid needle 4 and its surroundings, the usage amount of the drug 7 can be reduced.

FIGS. 4 and 5 show a second embodiment of the present invention. In the medical treatment tool 1a of the present embodiment, a cock 9 is provided on the side of the proximal end of the flexible tube 2, and a liquid feeding means 10 such as a syringe is connected to the cock 9. In the figure, 3 a is an operation member for pushing and pulling the operation wire 3, and this operation member 3 a is led out from the base end of the flexible tube 2. Further, the other structure is the same as that of the first embodiment.

When the drug 7 is administered to the diseased tissue 8 using the drug administration treatment tool 1a having such a configuration, first, as shown in FIG. 4, solid needles 4 ... In this state, the medicine is injected into the flexible tube 2 from the liquid feeding means 10, and the medicine 7 is ejected from the tip of the flexible tube 2. Also in this case, the drug 7 is injected and administered to the affected tissue 8 through the solid needles 4 ... Like the first embodiment.

It should be noted that such injection of the drug 7 can be performed while the solid needle 4 is being punctured in the affected tissue 8 as shown in FIG. 4, or the solid needle 4 is punctured as shown in FIG. You may do it in the removed state. In the latter case (in the case of Fig. 5)
The drug 7 sprayed from the tip of the flexible tube 2 permeates and diffuses directly into the diseased tissue 8 through a plurality of holes formed in the diseased tissue 8 by the puncture of the solid needle 4.

As described above, according to the treatment tool 1a for drug administration of the present embodiment, since the medicine 7 can be supplied from the hand side of the treatment tool 1a, a sufficient amount of the medicine 7 is delivered to the affected tissue. It can be administered.

FIG. 6 shows a third embodiment of the present invention. The treatment tool 1b for drug administration of the present embodiment includes a flexible tube 2 that can be inserted into a body cavity and a treatment tool main body 12a that is inserted into the flexible tube 2 so as to be able to move back and forth.

The treatment instrument main body 12a has a flexible injection tube 11 and a needle fixing member 5 fixed to the tip of the injection tube 11.
a and a plurality of solid needles 4, ..., which are fixed to the end surface of the needle fixing member 5a with a predetermined gap therebetween.

The needle fixing member 5a is formed with a drug delivery passage 60, one end of which communicates with the inner hole 11a of the injection tube 11 and the other end of which opens at the gap 6 between the solid needles 4. Further, a cock 9 is provided at the base end of the injection pipe 11, and a liquid feeding means 10 such as a syringe is connected to the cock 9.

When injecting the drug 7 into the affected tissue 8 using the drug administration treatment tool 1b having such a configuration, as shown in the figure, the liquid delivery is performed with the solid needles 4 ... The medicine 7 may be injected from the means 10 into the inner hole 11a of the injection tube 11. Drug 7 injected into the inner hole 11a of the injection tube 11
Is the solid needle 4 through the drug delivery passage 60 of the needle fixing member 5a.
It is ejected toward the affected tissue 8 from the gap 6 between the two. Therefore, also in the case of this embodiment, the same effect as that of the second embodiment can be obtained.

FIG. 7 shows a fourth embodiment of the present invention. The drug administration treatment instrument 1c of the present embodiment includes a flexible tube 2 that can be inserted into a body cavity, and a treatment instrument main body 12b that is inserted into the flexible tube 2 so as to advance and retract.

The treatment instrument main body 12b is composed of a long operating wire 3
And a needle fixing member 5 fixed to the tip of the operation wire 3,
A plurality of elastic solid needles 13 fixed to the end surface of the needle fixing member 5.
…. In this case, the elastic solid needle 13 ...
Has a bending tendency such that its tip end side expands in the radial direction of the flexible tube 2. Therefore, the elastic solid needles 13 are pressed against the inner surface of the flexible tube 2 to expand and contract in the state of being accommodated in the flexible tube 2, but once they are projected from the flexible tube 2, The tip end side largely expands in the radial direction due to the bending tendency.

A liquid feeding means (not shown) is connected to the base end of the flexible tube 2.

When injecting the drug 7 into the affected tissue 8 using the drug administration treatment tool 1c having such a structure, first, as shown in FIG. 7A, the elastic solid needles 13 ... In the state of being housed in the tube 2, the treatment tool 1c is introduced into the body via, for example, the channel of the endoscope, and the tip of the flexible tube 2 is guided to the affected tissue 8.

When the distal end of the flexible tube 2 is positioned in front of the affected tissue 8, this time, the operating wire 3 is pushed forward to project the elastic solid needles 13 ... To In this state, the operation wire 3 is further pushed forward to pierce the tip of the elastic solid needle 13 ... into the affected tissue 8 (state (b) of FIG. 7). Then, in this punctured state, this time, the drug 7 is injected into the flexible tube 2 from the hand side by the liquid feeding means, and the drug 7 is administered to the affected tissue 8 along the solid needles 13 (FIG. 7 (c) state).

As described above, according to the drug administration treatment tool 1c of this embodiment, the solid needles 13 are opened, so that the drug 7 can be administered over a wide range of the affected tissue.

FIG. 8 shows a fifth embodiment of the present invention. The drug administration treatment instrument 1d of the present embodiment includes a flexible tube 2 that can be inserted into a body cavity, and a treatment instrument body 12c that is inserted into the flexible tube 2 so as to be able to move back and forth.

The treatment instrument main body 12c is composed of a flexible injection tube 11 and a plurality of elastic needle bodies 14 ... Fixed to the tip of the injection tube 11. As shown in (b) of FIG. 8, each elastic needle body 14 is composed of an outer tube 16 and an elastic solid needle 13 inserted into the outer tube 16. Further, a constant space 15 is formed between the solid needle 13 and the tube 16, and this space 15
Communicates with the inner hole 11a of the injection pipe 11. Each solid needle 13 ... Has a bending tendency so that the tip end side thereof widens in the radial direction of the flexible tube 2 as in the fourth embodiment. Further, the tip of the solid needle 13 ... Is the tube 16 ...
Protruding from the tip of. A liquid feeding means (not shown) is connected to the base end of the injection pipe 11.

When injecting the medicine 7 into the affected tissue 8 using the medicine administration treatment tool 1d having such a configuration, first, the treatment tool is accommodated in the flexible tube 2 with the elastic needle bodies 14 ... 1
d is introduced into the body through a channel of an endoscope,
The tip of the flexible tube 2 is guided to the affected tissue 8.

When the distal end of the flexible tube 2 is positioned in front of the affected tissue 8, this time, the injection needle 11 is pushed forward so that the elastic needle bodies 14 ... To do. In this state, the injection tube 11 is further pushed forward, and the tip of the elastic solid needle 13 ... Is inserted into the affected tissue 8. Then, in this puncturing state, this time, the medicine 7 is injected into the injection tube 11 from the hand side by the liquid feeding means. As a result, the drug 7 is sprayed from the inner hole 11a in the injection tube 11 through the space 15 of the elastic needle body 14 ... From the tip of the tube 16 ... And is delivered to the affected tissue 8 through the solid needle 13. (State of FIG. 8).

As described above, according to the treatment tool 1d for drug administration of this embodiment, since the drug 7 is ejected from the close distance to the affected tissue 8 through the tube 16, there is no waste of the drug 7.

9 and 10 show a sixth embodiment of the present invention. As shown in FIG. 9, the drug administration treatment tool 1e of the present embodiment includes a flexible sheath 17 and a pair of forceps portions 18 and 18 provided at the distal end of the flexible sheath 17 and opened and closed by a link mechanism. It consists of A plurality of solid needles 4 ... Are fixed to the inner surface 18a of the forceps portions 18, 18.

To administer the drug 7 to the affected tissue 8 using the drug administration treatment tool 1e having such a structure, first, the surface of the solid needle 4 and the inner surfaces 18a of the forceps parts 18, 18 are first prepared. With the drug 7 applied, the treatment tool 1e is introduced into the body via, for example, the channel of the endoscope and guided to the affected tissue 8 (state (a) in FIG. 10). And the affected tissue 1
The forceps 18 and 18 are closed by the link mechanism in a state where the forceps 8 and 18 are positioned between the forceps 18 and 18 (the state of FIG. 10B). As a result, the solid needles 4 are inserted into the diseased tissue 8 while the affected tissue 18 is sandwiched between the forceps 18, 18, and the solid needle 4 and the inner surfaces 18a of the forceps 18, 18 are applied. The drug 7 that has been delivered is delivered to the affected tissue 8 through the solid needle 4.

As described above, according to the treatment tool 1e for drug administration of the present embodiment, the drug 7 is administered while gripping the affected tissue 8, so that the drug 7 can be reliably administered to the affected tissue 8. it can.

11 and 12 show a seventh embodiment of the present invention. Treatment tool for drug administration 1f of the present embodiment
Has a drug container 19 inside the forceps 18, 18 in the sixth embodiment. Further, on the inner surface 18a of the forceps parts 18, 18, a plurality of outflow ports 20 communicating with the medicine container 19 are provided between the solid needles 4 ... An injection port 21 that communicates with the storage unit 19 is provided. In addition, the other configurations are the sixth.
The same as the embodiment of

When the drug 7 is administered to the affected tissue 8 using the drug administration treatment tool 1f of this embodiment, the injection port 2 is previously prepared.
The medicine 7 is injected into the medicine container 19 through 1.
Then, the affected part tissue 8 is sandwiched between the forceps parts 18, 18, and the sixth
The drug 7 is administered to the affected tissue 8 in the same manner as in Example 1.

As described above, according to the present embodiment, since the medicine 7 can be contained in the medicine container 19, a larger amount of the medicine 7 can be administered than in the sixth embodiment.

13 and 14 show the eighth embodiment of the present invention. 1 g of a treatment instrument for drug administration according to the present embodiment
Is a modification of the seventh embodiment, in which the passage 23 is formed in the forceps parts 18, 18. The passage 23 communicates with the outflow ports 20 ... And the injection port 21, and the injection port 21 is connected to the drug supply pipes 22, 22. As shown in FIG. 13, these drug supply pipes 22, 22 extend parallel to the flexible sheath 17 to the proximal side, and FIG.
As shown in (4), there is one that communicates with the drug supply paths 29, 29 of the proximal member 28 connected and fixed to the proximal side of the flexible sheath 17. In this case, the operation wire 27 that operates the link mechanism that opens and closes the forceps 18, is inserted into the flexible sheath 17 and the proximal member 28.

When the drug 7 is administered to the diseased tissue 8 using the drug administration treatment tool 1g having such a structure, the diseased tissue 8 is sandwiched between the forceps 18, 18 as in the sixth embodiment. With the actual needle 4 inserted into the affected tissue 8, the medicine 7 is supplied from the hand to the medicine supply pipes 22, 22 or the medicine supply passage 29,
Send within 29. The medicine 7 sent into the medicine supply pipes 22, 22 or the medicine supply passages 29, 29 is grasped by the grasping portions 18, 18
It is ejected from the outlet 20 through the passage 23 and is administered to the affected tissue 8.

According to this embodiment, since the drug 7 can be supplied from the hand side, a sufficient amount of the drug 7 can be administered to the affected tissue 8.

A drug administration treatment tool 1h shown in FIG. 15 has a sheath 33, a tubular bending portion 32 connected to the distal end of the sheath 33 and capable of performing a bending operation, and a tubular puncture fixed to the distal end of the bending portion 32. And a needle 31. The puncture needle 31 has a plurality of side holes 37 ...

An operating portion 34 is connected to the proximal end portion of the sheath 33. The operation portion 34 is provided with an operation knob 38 for bending the bending portion 32.
By rotating 8, the bending portion 32 can be bent in two directions or four directions. Also,
A base 35 is provided at the base end of the operating portion 34.
A pressure pump 36 is connected to 5.

When the drug 7 is administered to the affected tissue 8 using the drug administration treatment tool 1h having such a configuration, first, the puncture needle 31 is inserted into the affected tissue 8 (see (a) of FIG. 15). State), in this state, the pressure pump 36 is driven to supply the drug 7 into the sheath 33. This makes the drug 7
Is inside the sheath 33, inside the curved portion 32, and the puncture needle 31.
And is ejected from the side hole 37 of the puncture needle 31. At this time, the bending knob 3 is operated by rotating the operation knob 38.
By continuously bending 2 in multiple directions, the puncture needle 31 is swung to administer the drug 7 over a wide range of the affected tissue 8 (see (b) of FIG. 15).

As described above, in this embodiment, since the puncture needle 31 can be turned by continuously bending the bending portion 32 in multiple directions, the drug 7 can be administered over a wide range of the affected tissue 8. You can

The medical treatment tool 1i shown in FIG. 16 comprises a sheath 33 and a plurality of puncture needle bodies 30 ... Connected to the distal end of the sheath 33.

Each puncture needle body 30 is composed of a bellows-like curved portion 41 capable of performing a bending operation, and a tubular puncture needle 31 fixed to the tip of the curved portion 41. The puncture needle 31
Are formed with a plurality of side holes 37 ...

An operating portion 34 is connected to the proximal end portion of the sheath 33. The operation portion 34 is provided with an operation handle 42 for bending the bending portion 32. By bending the operation handle 42 forward and backward in the axial direction, the bending portion 41 can be bent or extended. You can do it. Further, the operating portion 34 is provided with a base 35, and a pressure pump 36 is connected to the base 35.

When the drug 7 is administered to the affected tissue 8 using the drug administration treatment tool 1i having such a configuration, first, all the puncture needles 31 ... Are inserted into the affected tissue 8 ((( State (a)), in this state, the pressure pump 36 is driven to supply the drug 7 into the sheath 33. As a result, the medicine 7 is stored inside the sheath 33, inside the bending portion 41,
The side hole 37 of the puncture needle 31 is sent to the inside of the puncture needle 31.
Injected from. At this time, the operation handle 42 is moved forward and backward in the axial direction to bend or extend the bending portion 41 to open and close the plurality of puncture needles 31 ..., and administer the drug 7 over a wide range of the affected tissue 8. Yes (Fig. 16
(B)).

As described above, in this embodiment, the bending / extending operation of the bending portion 41 is repeated, whereby the puncture needle 3
Since 1 ... Can be operated over a wide range, the drug 7 can be administered over a wide range of the affected tissue 8.

The medical treatment instrument 1j shown in FIG. 17 is made of, for example, a resin and has an outer sheath needle 52 having a relatively soft tip portion 51 having a plurality of side holes 55.
And a guide wire 54 made of a shape memory alloy that can be inserted into the outer sheath needle 52 and that is memorized so as to form a spiral shape 53 at body temperature and form a linear shape at high temperature. The outer sheath needle 52 has an outer sheath needle 52.
A pressure pump 57 for injecting the medicine 7 is connected therein, and a shape control circuit 58 for controlling the shape of the guide wire 54 is electrically connected to the guide wire 54.

To administer the drug 7 to the affected tissue 8 using the drug administration treatment tool 1j having such a configuration, first, the switch 58a of the shape control circuit 58 is turned on to linearize the guide wire 54, The sheath needle 52 and the guide wire 5
Puncture the affected tissue 8 in combination with 4 (state (a) of FIG. 17).

Next, while driving the pressure pump 57 to inject the drug 7 into the outer sheath needle 52, the shape control circuit 5
The switch 58a of No. 8 is turned off. As a result, the linearized guide wire 54 becomes a spiral shape 53 due to the body temperature, and along with this, the distal end portion 5 of the outer sheath needle 52.
1 also becomes a spiral shape (state of (b) of FIG. 17). As a result, the side holes 55 are arranged in a wide area, and the medicine 7
Is administered. When treatment is completed, switch 58a to O
N, the guide wire 54 is linearized, and the outer sheath needle 52 is removed from the affected tissue 8.

With this structure as well, the drug 7 can be administered over a wide range of the affected tissue 8.

The medical treatment tool 1k shown in FIG. 18 does not have the guide wire 54 as shown in FIG. 17, but has the outer sheath needle 52.
Of at least the tip portion 51 is formed of a shape memory material. In the treatment tool 1k having such a configuration, the outer sheath needle 52
Is punctured into the affected tissue 8 and the same operation as described in FIG. 17 is performed. Since the guide wire 54 is not used, the operation becomes easier.

The configurations described above can provide various configurations shown in the following sections. 1. In a therapeutic instrument for drug administration, which is inserted endoscopically into a body cavity and administers a drug to an affected tissue in the body cavity, the affected tissue is inserted into the tip of an insertion portion inserted into the body cavity. A treatment instrument for drug administration, comprising a plurality of solid needles.

2. Item 2. The drug administration according to Item 1, wherein the plurality of solid needles are arranged at appropriate intervals so that the drug applied to them is held by capillary action or surface tension. Treatment tool.

According to the construction of the second term, the drug to be administered is securely held by the solid needle.

3. An outer cylinder, and an insertion portion as a sliding member that has the plurality of solid needles at its tip and that moves back and forth in the outer cylinder to project and retract the plurality of solid needles from the outer cylinder. A treatment tool for drug administration according to item 1.

According to the third structure, since the solid needle can be housed in the outer cylinder, when it is inserted into the channel of the endoscope,
Solid needle does not damage the channel.

4. 4. The drug administration treatment instrument according to claim 3, wherein the insertion portion is a tubular member having an inner hole, and the inner hole is opened at the proximal ends of the plurality of solid needles.

According to this structure, the medicine can be reliably supplied to the site where the solid needle is located through the inner hole of the insertion portion.

5. The plurality of solid needles are made of an elastic member having a bending tendency so that the tip end side is expanded in the opening direction, and expand when they are projected from the outer cylinder. A treatment tool for drug administration according to item 1.

According to this structure, since the solid needle is expanded, the drug can be administered in a wider range.

6. The treatment instrument for drug administration according to the third and fifth aspects, wherein the outer cylinder has a supply means for supplying a drug to a proximal end side thereof.

According to this structure, since the medicine can be delivered from the outer cylinder, a sufficient quantity of medicine can be administered.

7. The plurality of solid needles has a tubular member that forms a conduit with the solid needle to cover the solid needle,
The treatment tool for drug administration according to claim 5, wherein the tubular member communicates with an inner hole of the insertion portion.

According to this structure, since the drug is administered at the tip of the solid needle, the drug can be effectively administered without waste.

8. 2. The drug administration treatment instrument according to claim 1, wherein the plurality of solid needles are provided on a pair of forceps portions that are opened and closed by a link mechanism.

According to this structure, the solid needle can be reliably fixed to the affected tissue.

9. Item 9. The drug administration treatment instrument according to Item 8, wherein the plurality of solid needles are provided on an inner surface of at least one forceps portion of the pair of forceps portions.

According to this structure, the solid needle can be reliably fixed to the affected tissue.

10. Item 10. The forceps part having a plurality of solid needles has a pouring port for an injection substance on an inner surface, an injection port for an injection substance on an outer surface, and a storage part for the injection substance inside. A treatment tool for drug administration.

According to this structure, it is possible to administer a larger amount of drug than when the drug is applied to the solid needle. 11. The forceps part having the plurality of solid needles has a pouring port for an injectate on the inner surface, and the pouring port communicates with a pipe line that is provided to extend in the axial direction of the insertion part and is connected to the drug supply means. The medical treatment instrument for drug administration according to item 9, wherein

According to this structure, since the drug can be delivered from the duct, sufficient drug can be administered.

12. In a therapeutic instrument for drug administration, which is inserted endoscopically into a body cavity and administers a drug to an affected tissue in the body cavity, the affected tissue is inserted into the tip of an insertion portion inserted into the body cavity. A treatment instrument for drug administration, comprising a plurality of solid needles and a supply means for supplying a drug to the solid needles.

13. Item 13. The therapeutic device for drug administration according to any one of Items 1 to 12, wherein the drug is a gene for gene therapy.

[0079]

As described above, since the treatment instrument for drug administration of the present invention has a plurality of solid needles for injecting a drug into the affected tissue, the solid needle is pierced into the affected tissue. By inserting, a plurality of holes for injecting the drug into the affected tissue can be formed at one time, and the drug can be administered over a wide range of the affected tissue.

Further, since it has a plurality of solid needles, it is possible to hold the drug in the surface of the solid needle and in the gap between the solid needles by capillarity or surface tension. Therefore, it is not necessary to provide a means for supplying a drug, and the drug can be administered only by applying the drug to the solid needle, so that the amount of the drug used can be reduced.

[Brief description of drawings]

FIG. 1 is a cross-sectional view of essential parts of a medical-medical-treatment instrument according to a first embodiment of the present invention.

FIG. 2 is a perspective view showing a main part of a medical-medical-treatment instrument according to the first embodiment of the present invention.

FIG. 3 is a cross-sectional view showing how a drug is administered to an affected tissue using the drug administration treatment tool of FIG.

FIG. 4 is a cross-sectional view of a main part of a treatment tool for drug administration according to a second embodiment of the present invention, which is a cross-sectional view showing how a drug is administered to an affected tissue.

FIG. 5 is a cross-sectional view showing a manner of using the treatment tool for drug administration of FIG. 4 to administer a drug to an affected tissue by another means.

FIG. 6 is a cross-sectional view of essential parts of a medical-medical-treatment instrument according to a third embodiment of the present invention.

FIG. 7 is a cross-sectional view showing a manner of administering a drug to an affected tissue by using the drug administration treatment tool according to the fourth example of the present invention.

FIG. 8 is a cross-sectional view showing the manner of administering a drug to the affected tissue using the drug administration treatment tool according to the fifth embodiment of the present invention.

FIG. 9 is a perspective view showing a main part of a medical-medical-treatment tool according to a sixth embodiment of the present invention.

FIG. 10 is a cross-sectional view showing how to administer a drug to the affected tissue using the drug administration treatment tool of FIG.

FIG. 11 is a perspective view showing a main part of a medical-medical-treatment instrument according to a seventh embodiment of the present invention.

12 is a partial cross-sectional view showing in detail the inside of a grip portion of the medical-medical-treatment instrument shown in FIG.

FIG. 13 is a cross-sectional view showing the main parts of a medical-medical-treatment tool according to an eighth embodiment of the present invention.

FIG. 14 is a cross-sectional view showing the main parts of a treatment tool for drug administration according to an eighth embodiment of the present invention.

FIG. 15 is a configuration diagram showing a preferred first example of a treatment tool for drug administration.

FIG. 16 is a configuration diagram showing a preferred second example of the treatment tool for drug administration.

FIG. 17 is a configuration diagram showing a preferred third example of the treatment tool for drug administration.

FIG. 18 is a configuration diagram showing a preferred fourth example of the treatment tool for drug administration.

[Explanation of symbols]

1, 1a, 1b, 1c, 1d, 1e, 1f, 1g ... Treatment tool for drug administration, 4 ... Solid needle.

 ─────────────────────────────────────────────────── ─── Continuation of front page (72) Inventor Yutaka Yunuma 2-43-2 Hatagaya, Shibuya-ku, Tokyo Inside Olympus Optical Co., Ltd. (72) Inventor Yoshinao Daimei 2-43-2 Hatagaya, Shibuya-ku, Tokyo No. Olympus Optical Co., Ltd. (72) Inventor Yasuhiro Ueda 2-43-2 Hatagaya, Shibuya-ku, Tokyo Olympus Optical Co., Ltd.

Claims (1)

[Claims] 1. A treatment instrument for drug administration, which is inserted into a body cavity and administers a drug to a diseased tissue in the body cavity, wherein a plurality of parts are inserted into the diseased tissue at a tip of an insertion portion inserted into the body cavity. A treatment instrument for drug administration, which is provided with a solid needle.