JPH08143477A - Composition for dyeing bacterial plaque - Google Patents

Abstract

PURPOSE: To obtain a composition for dyeing bacterial plaque capable of visibly detecting bacterial plaque, by solubilizing a bacterial plaque-dyeing coloring matter in the liquid crystal phase of an aqueous surfactant solution to raise the selective dyeing ability of the coloring matter on bacterial plaque. CONSTITUTION: An aqueous surfactant solution is prepared at such concentrations that the surfactant form a liquid crystal phase and then incorporated with a bacterial plaque-dyeing coloring matter, esp. a tar-based xanthene coloring matter for use in foods, cosmetics and medicines to effect solubilizing (encapsulating) the coloring matter in the liquid crystal phase of the aqueous solution. The contents of the coloring matter and the surfactant in the aqueous solution are 0.02-5wt.% and 3-70wt.%, respectively. This aqueous solution is prepared, by a conventional means, into a dyeing liquid, gel, tablets, bacterial plaque agent, etc. By dyeing bacterial plaque with this coloring matter, the plaque can be easily observed with the naked eye and the dyeing speed on the plaque selectively accelerated; thus, this composition (aqueous solution) can be used as a means for detecting bacterial plaque for the purpose of efficiently removing it.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a plaque dyeing composition capable of visually detecting plaque by improving the selective dyeing property of the plaque dyeing dye on plaque.

[0002]

BACKGROUND OF THE INVENTION Dental plaque is a soft non-calcic bacterial deposit formed on the tooth surface, which is the main cause of oral diseases such as gingivitis and caries. Therefore, removal of this plaque is important in the prevention of these oral diseases, but it is difficult to determine whether or not it has been completely removed by ordinary cleaning means. A means for detecting is required. As a means for this, conventionally, a method of staining plaque with various dyes and detecting plaque adhering to the tooth surface has been performed.

However, a conventional plaque dyeing composition using a dyeing agent such as a dye or iodine is used not only for dyeing plaque but also for strongly dyeing gums and lips for a long time. I feel uncomfortable. In particular, in the case of a plaque dyeing composition using iodine, unpleasant taste and mucous membrane irritation at the time of use are strong, and in the case of a plaque dyeing composition using a fluorescent agent, it is necessary to confirm plaque. Fluorescent lamps are needed, and there is a problem in versatility.

The present invention has been made in view of the above circumstances, and improves the selective dyeing property of a pigment for dyeing plaque with respect to plaque, thereby removing plaque without dyeing unnecessary parts such as gums and lips. It is an object of the present invention to provide a composition for staining plaque, which enables visual detection.

[0005]

Means and Actions for Solving the Problems As a result of intensive studies to achieve the above object, the present inventor prepared an aqueous solution of a surfactant at a concentration at which the surfactant forms a liquid crystal phase,
When a pigment for dyeing plaque, especially a tar-based xanthene pigment, is added to the aqueous solution, the pigment is solubilized (encapsulated) in the liquid crystal phase (nanocapsule) of the aqueous solution of the surfactant, and the apparent physical chemistry of the pigment is obtained. It has been found that the various properties of the plaque are changed, the dyeing speed of the above-mentioned dye on plaque is significantly faster than the dyeing speed on gingiva and lips, and the apparent dyeing property of plaque is significantly increased.

That is, as is clear from the experimental examples described later, when a dye for dyeing plaque is added to a surfactant aqueous solution in the vicinity of the critical micelle concentration, the speed of dyeing plaque and the speed of dyeing gingiva, lips, etc. There is no difference, and the plaque cannot be dyed more clearly than the gums, lips, etc. within a predetermined time, and the detection of plaque becomes inaccurate.

However, when the aqueous solution of a surfactant forms a liquid crystal phase and the pigment for dyeing plaque is solubilized in the liquid crystal phase, the rate of dyeing plaque and the rate of dyeing gums, lips, etc. Therefore, the present invention has been completed by finding that the difference in color difference occurs and that plaque can be dyed more clearly than the gums, lips, etc. within a predetermined time such as about 1 minute.

Therefore, the present invention is characterized in that a plaque dyeing dye is solubilized in the liquid crystal phase of the aqueous surfactant solution in which the liquid crystal phase of the surfactant is formed. I will provide a.

The present invention will be described in more detail below. The plaque dyeing composition of the present invention comprises a plaque dyeing dye solubilized in a liquid crystal of an aqueous surfactant solution. In this case, as the above-mentioned pigment for staining plaque, tar-based xanthene pigments for food, cosmetics and pharmaceuticals are preferably used.
Examples of the tar-based xanthene dye include red 3
Red No. 104, Red No. 105, Red No. 106, Red No. 230 (1), Red No. 230 (2), Red No. 231,
Red No. 232, Yellow No. 202 (1), Yellow No. 202 (2)
No. 3, Daidai No. 207, etc., and among these, Red No. 3, Red No. 104, and Red No. 105 are preferable.

The amount of the above-mentioned dye compounded is 0.02 of the total composition.
% To 5% (weight%, the same applies below), particularly preferably 0.05 to 2%. If it is less than 0.02%, it may be difficult to identify plaque. It is uneconomical because the distinctiveness of dust cannot be expected.

Next, as the above-mentioned surfactant of the present invention,
As long as it is acceptable for use in the oral cavity and the molecular assembly in the aqueous solution can form a liquid crystal phase, any may be used,
For example, glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene castor oil, poly (oxyethylene) hydrogenated castor oil, poly Oxyethylene alkyl ether, polyoxyethylene phytosterol, polyoxyethylene phytostanol, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene lanolin, polyoxyethylene lanolin alcohol, polyoxyethylene alkylamine, poly Oxyethylene alkyl ether phosphoric acid, ethylene glycol monostearate It can be exemplified polyoxyethylene glycol, poly nonionic surface active agents such as (oxyethylene) isostearyl ether. Among these, poly (oxyethylene) hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, and glycerin fatty acid ester are preferably used.

The amount of these surfactants to be blended must be such that the molecular aggregate forms a liquid crystal phase when it is made into an aqueous solution, and depending on the type of surfactant and the amount of other components blended, the liquid crystal Although the amount of forming a phase is different, it cannot be said unconditionally, but it is usually preferably 3 to 70% of the total composition.

The composition of the present invention selectively solubilizes the above dye in the liquid crystal phase of the aqueous surfactant solution, thereby selectively accelerating the dyeing speed of the above dye on the plaque, thereby improving the dyeability within a predetermined time. It is possible to improve. In this case, the dye can be solubilized in the liquid crystal phase by adding and dissolving the dye in the surfactant.

The plaque dyeing composition of the present invention is prepared and applied as a dyeing solution, gel, tablet, dentifrice or the like. In this case, the composition for dyeing plaque of the present invention uses, as other components, appropriate components (additives and organic solvents) depending on the type of the composition within a range that does not destroy the liquid crystal phase of the aqueous surfactant solution. However, it can be prepared by a conventional method. For example,
Abrasives such as anhydrous silicic acid, calcium carbonate, calcium phosphate, aluminum hydroxide, ethanol, glycerin,
Thickeners such as sorbit and propylene glycol, sodium carboxymethyl cellulose (CMC), binders such as carrageenan and xanthan gum, sweeteners such as saccharin, and other preservatives, flavors, excipients and the like can be added.

[0015]

EFFECTS OF THE INVENTION According to the composition for dyeing plaque of the present invention, the plaque can be easily observed with the naked eye by dyeing the plaque with a dye, and the rate of dyeing the plaque within a predetermined time is selective. Thus, it is possible to obtain a composition for dyeing plaque, which has been improved in terms of usability such as dyeing to unnecessary places such as gingiva, which is a conventional drawback. Therefore, the plaque staining composition of the present invention can be widely used as a plaque detecting means for efficiently removing plaque.

[0016]

EXAMPLES The present invention will be specifically described below by showing experimental examples and examples, but the present invention is not limited to the following examples.

[Experimental Example] A dye (Red No. 104) was dissolved in an aqueous surfactant solution having the composition shown in Table 1 to a concentration of 1% by weight to prepare dyes of the present invention or comparative products. The selective dyeing property of the stain on the plaque was evaluated by the model experiment described below.

First, a dextran crosslinked powder was used as a model assuming dental plaque. Dextran crosslinked powder (trade name: Sephadex G-10) 0.1 g was added to 20 g of each of the above dyeing agent solutions collected in a suitable container, and stirred for about 1 minute (60 rpm). After stirring, 200 ml of pure water was added to this sample solution to stop the dyeing, this solution was immediately filtered, and the degree of dextran dyeing was visually evaluated according to the criteria shown below.

Next, a collagen film was used as a model assuming gingiva. A 1 cm × 1 cm collagen membrane (trade name: Nippi Cassing # 200) was dipped in 20 g of each of the above dyeing agent solutions collected in a suitable container, and the collagen membrane was immersed in 200 ml of pure water in a beaker. After rinsing well for 5 to 10 seconds and air-drying, the same evaluation as above was performed. <Evaluation criteria> 5: Extremely vivid dyeing 4: Vivid dyeing 3: Decolorization feeling 2: Slightly unclear 1: Extremely unclear 0: No dyeing

The results of these evaluations and the aqueous solutions of the respective surfactants were measured at room temperature with a polarizing microscope (trade name: Nikon OPT.
The results of confirming the molecular aggregation state (existence of liquid crystal phase) by observation with (IPHOT-PAL) are also shown in Table 1.

[0021]

[Table 1]

From Table 1, it can be seen that the dyeing agent (the product of the present invention) in which the molecular assembly of the aqueous solution of the surfactant forms a liquid crystal phase, the dyeing rate of the pigment on the dental plaque can be selectively accelerated for a predetermined time. It is recognized that the stainability of dental plaque is improved.

[Examples 1 to 10] Toothpastes (Examples 1 to 7) and plaque dyeing solutions (Examples 8 to 1) were prepared according to the compositions shown in Table 2.
0) was prepared. The unit in the table is% by weight.

[0024]

[Table 2]

Claims (2)

[Claims] 1. A composition for dyeing plaque, characterized in that a pigment for dyeing plaque is solubilized in the liquid crystal phase of an aqueous solution of a surfactant in which a liquid crystal phase of the surfactant is formed. 2. The composition for dyeing plaque according to claim 1, wherein a tar-based xanthene dye is used as a dye for dyeing plaque.