JPH0812964A - Powder aerosol composition - Google Patents

Abstract

PURPOSE:To provide a powder aerosol composition which, once applied to the intended area, is difficultly separable from the area as compared with the conventional. CONSTITUTION:This composition is one mainly consisting of a powder agent, an oil and fat component and a monohydric lower alcohol and used in combination with a propellent, wherein the amount of the powder agent used is about 30 to about 80wt.% based on the total composition, the amount of the oil and fat component used is about 2 to about 60wt.% based on the total of the powder agent and the oil and fat component, and the amount of the monohydric lower alcohol used is about 10 to about 90wt.% based on the total weight of the oil and fat component and the monohydric lower alcohol.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a powder aerosol composition containing a powder agent according to its purpose of use.

[0002]

2. Description of the Related Art Conventionally, a powder aerosol composition according to various purposes (for example, antiperspirant after sports, simple disinfection and drying of abrasions, treatment of athlete's foot, etc.) has been prepared by subjecting a powder aerosol composition to a target site (skin or affected area). Aerosol spray is known. Among them, there were some that were mixed with a large amount of powder agents expected to have effects depending on the purpose of use.

This aerosol composition mainly contains a powder agent and an oil / fat component which disperses / dissolves the powder agent and attaches it to a target site, and is used by being filled with liquefied petroleum gas as a propellant in a spray. It Then, the powder agent is mixed in a ratio of about 30% by weight to about 80% by weight with respect to the total amount of the powder aerosol composition (excluding the propellant). In use, the powder aerosol composition is sprayed onto the target site by means of a propellant which is also filled in the spray. Then, the volatile component evaporates, and the powder agent and the fat and oil component adhere to and remain on the target site to exert their effects.

However, many of the powdered agents that have adhered together with the oil and fat component sometimes fall off from the target site when they move. In this case, the powder agent cannot effectively exhibit the expected effect.

[0005]

SUMMARY OF THE INVENTION Therefore, the present invention
An object of the present invention is to provide a powder aerosol composition in which the powder agent attached to the target site is less likely to fall off than in the past.

[0006]

Means for Solving the Problems As a result of intensive studies to solve the above problems, the present inventor has found that a powder aerosol composition mainly containing a powder agent, an oil and fat component and a monohydric lower alcohol, Used in combination with a powder formulation, the powder formulation containing about 30% by weight of the total amount of the powder aerosol composition.
From about 2% to about 60% by weight based on the total amount of the powder agent and the oil / fat component, and the oil / fat component and the monohydric lower alcohol are mixed. Since the monohydric lower alcohol is blended in an amount of about 10% by weight to about 90% by weight with respect to the total amount, it was found that the powder agent adhered to the target site is less likely to drop than before, and the present invention is realized. It has been completed.

The powder agent is blended in an amount of about 30% by weight to about 80% by weight with respect to the total amount of the powder aerosol composition. This is because it is blown away and scattered, and it is difficult to uniformly adhere to the target site, and in the present invention, it is intended that the powder agent is mixed in a large amount, and if it exceeds about 80% by weight, injection itself as an aerosol is difficult. Because it becomes.

When the amount of the oil and fat component is about 2 to 60% by weight based on the total amount of the powder agent and the oil and fat component, the reason is that if the amount is less than about 2% by weight, This is because it is difficult for the powdered agent to adhere, and when it exceeds about 60% by weight, a greasy feeling of oil and fat is given to a target portion, and a problem in use feeling occurs.

The reason why the monohydric lower alcohol is blended in an amount of about 10% by weight to about 90% by weight based on the total amount of the oil / fat component and the monohydric lower alcohol is that it is less than about 10% by weight. The reason is that the powder agent is likely to fall off from the adhered target site as in the conventional case, and if it exceeds about 90% by weight, the powder agent is impaired in the adhesive action of the fat and oil component and it becomes difficult to adhere to the target site.

As the monohydric lower alcohol, for example, isopropyl alcohol, ethyl alcohol and the like can be used. When isopropyl alcohol is used, the dispersibility / solubility of the powder agent and the compatibility of the oil / fat component with the propellant are improved. It has the advantage of being excellent. The boiling point of isopropyl alcohol is 82.4 ° C, and its freezing point is -8.
4 ° C.

As the oil and fat component, for example, isopropyl myristate, liquid paraffin, octyl myristate, dodecyl myristate, silicone oil, isopropyl palmitate, etc. can be used. There is an advantage that it is excellent in compatibility with lower alcohols and that the powder agent can be suitably attached to the target site. In addition, isopropyl myristate is a lower alcohol ester of a higher fatty acid synthesized from myristic acid and isopropanol, and its freezing point is 3 to 8 ° C.

As the propellant, for example, liquefied petroleum gas, dimethyl ether, trichloromonofluoromethane, dichlorotetrafluoroethane, trichlorotrifluoromethane and the like can be used.

[0013]

The present invention has the above-mentioned structure and has the following effects.

It is possible to provide a powder aerosol composition in which a powder agent attached to a target site is less likely to fall off than in the past.

[0015]

EXAMPLES The constitution of the present invention will be described below with reference to examples. (Examples 1 to 9) In this example, talc as a powder agent (which is blended as a base together with other powder agents exhibiting an effect and also has an effect as a hygroscopic agent) and isopropyl myristate as an oil and fat component, A powder aerosol composition was prepared using isopropyl alcohol as the monohydric lower alcohol. Table 1 shows the compounding ratio (% by weight) of each composition to the total amount of the powder aerosol composition and liquefied petroleum gas.

The value in parentheses in the talc column is the ratio of talc to the total amount of the powder aerosol composition (the total amount of the powder agent, the oil and fat component, and the monohydric lower alcohol, not including liquefied petroleum gas). In the column of isopropyl myristate, the value in parentheses in the column of () in the column of isopropyl myristate represents the blending ratio (wt%) of isopropyl myristate to the total amount of talc and isopropyl myristate. The numerical value shows the compounding ratio (wt%) of isopropyl alcohol to the total amount of isopropyl myristate and isopropyl alcohol. (Comparative Examples 1 to 8) Powder aerosol compositions were prepared in the same manner as in the above Examples. Here, the blending ratio of talc in Comparative Examples 1 to 3 is 20% by weight with respect to the total amount of the powder aerosol composition (excluding liquefied petroleum gas as in the above Examples). Further, in Comparative Examples 4 to 8, isopropyl alcohol, which is a monohydric lower alcohol, was not blended.

Table 2 shows the blending ratio (% by weight) of each composition with respect to the total amount of the powder aerosol composition and liquefied petroleum gas. The meaning of the numbers in parentheses in each column is shown in Table 1.
Is the same as (Example 10) In this example, a quick-drying powder aerosol composition for disinfecting and drying a wound such as a scratch was prepared. Table 3 shows the compounding ratio (% by weight) of each composition to the total amount of the powder aerosol composition and liquefied petroleum gas.

The value in parentheses in the column of powder formulation is the formulation of the powder formulation with respect to the total amount of the powder aerosol composition (the total amount of the powder formulation, the oil / fat component and the monohydric lower alcohol, not including the liquefied petroleum gas). In the isopropyl myristate column, the value in parentheses indicates the blending ratio (wt%) of isopropyl myristate to the total amount of the powder and isopropyl myristate. The numerical value in the parentheses indicates the compounding ratio (% by weight) of isopropyl alcohol to the total amount of isopropyl myristate and isopropyl alcohol.

In this example, 6 parts of the powder aerosol composition was added to the total amount of the powder aerosol composition (the total amount of the powder agent, the oil / fat component and the monohydric lower alcohol, not including the liquefied petroleum gas).
It contains 4% by weight. Here, acrinol formulated as a powder agent exerts an effect as a bactericidal agent, zinc oxide exerts an effect as an astringent, dibucaine hydrochloride exerts an effect as a local anesthetic, and allantoin acts as a healing accelerator. , And naphazoline hydrochloride exerts its effect as a vasoconstrictor.

29% by weight of isopropyl myristate is added to the total amount of the above powdery agent and isopropyl myristate which is a fat and oil component.

Further, 30% by weight of isopropyl alcohol is added to the total amount of isopropyl myristate and isopropyl alcohol which is the monohydric lower alcohol. (Comparative Example 9) In the same manner as in the above-mentioned example, a powder aerosol composition of immediate dryness for disinfecting and drying a wound such as a scratch was prepared. Table 3 shows the compounding ratio (% by weight) of each composition to the total amount of the powder aerosol composition and liquefied petroleum gas. In addition, the meaning of the numerical value in () of each column is the same as the above.

In this comparative example, isopropyl alcohol, which is a monohydric lower alcohol, is not mixed. Example 11 In this example, a quick-drying powdered aerosol composition for treating athlete's foot was prepared. Table 4 shows the compounding ratio (% by weight) of each composition with respect to the total amount of the powder aerosol composition and liquefied petroleum gas. The meaning of the numerical value in parentheses in each column is the same as in Table 3.

In this example, 6 parts of the powdered aerosol composition was added to the total amount of the powdered aerosol composition (the total amount of the powdered material, the oil / fat component and the monohydric lower alcohol, not including the liquefied petroleum gas).
Contains 4% by weight. Here, clotrimazole compounded as a powder agent exerts an effect as an antifungal agent, lidocaine exerts an effect as a local anesthetic, dipotassium glycyrrhizinate exerts an effect as an anti-inflammatory agent,
Chlorhexidine hydrochloride exerts its effect as a fungicide,
Zinc oxide exerts its effect as an astringent, and talc functions as a hygroscopic agent.

22% by weight of isopropyl myristate was added to the total amount of the above powder formulation and isopropyl myristate, which is a fat and oil component.

50 wt% of isopropyl alcohol is added to the total amount of isopropyl myristate and isopropyl alcohol which is the monohydric lower alcohol. (Comparative Example 10) A quick-drying powder aerosol composition for treating athlete's foot was prepared in the same manner as in the above Example. Table 4 shows the compounding ratio (% by weight) of each composition with respect to the total amount of the powder aerosol composition and liquefied petroleum gas. The meaning of the numerical value in the parentheses in each column is the same as above.

In this comparative example, isopropyl alcohol, which is a monohydric lower alcohol, is not mixed.

The powder aerosol compositions of the above Examples and Comparative Examples were filled into a spray together with liquefied petroleum gas by a known method. Liquefied petroleum gas is a colorless transparent volatile liquid, which is a mixture of propane, butane, and isobutane, and its boiling point is -42.07 to -0.50 ° C. (Evaluation test) Using each of the sprays filled with the above powder aerosol composition, an evaluation test regarding uniform adhesion to a target site and prevention of falling was performed as follows. Evaluation Test Regarding Uniform Adhesion Pig skin (Mitsui Pharmaceutical Co., Ltd., trade name Metaskin) is immersed in distilled water, and attached to a glass plate to prevent wrinkling as much as possible and dried. Stand this glass plate vertically, 5c
The spray was sprayed from the distance of m for about 5 seconds so as to be perpendicular to the pig skin on the glass plate surface. It should be noted that the valves and buttons were not clogged in each of the Examples and Comparative Examples during the injection.

When observing the state of adhesion of the powder agent to pig skin,
In each of the examples, the powder agent was adhered to the substantially circular region with almost the same film thickness, but in each of the comparative examples, the central portion of the substantially circular region was slightly raised like a mountain. The powder agent adhered. Further, in Comparative Examples 1 to 3, the powder agent adhered in a state of being scattered in a wide range by the injection gas pressure. That is, it was confirmed that each of the examples adhered more uniformly to the target site than each of the comparative examples. Evaluation test on falling-off prevention property Next, after drying the powder agent of each Example and each comparative example adhered to pig skin for 5 minutes, it was bent so that the part to which the powder agent adhered was a mountain fold, and the powder agent Was observed. As a result, in each of the examples, almost no powder was removed, whereas in each of the comparative examples, the central region was peeled off in a circular shape. In particular, in Comparative Examples 4 to 8, the powder agent adhered was peeled off in the form of lumps.

That is, according to the above two types of evaluation tests,
It can be seen that the powder of each example has an advantage that it is excellent in so-called usability, as compared with the powder of each comparative example, in that the powder agent uniformly adheres to the target site with a substantially constant film thickness and is hard to drop off.

Therefore, the powder aerosol composition of this example is advantageous in that it exhibits excellent utility and sustainability.

By the way, the oil and fat component and the monohydric lower alcohol are mixed and compatible to disperse and dissolve the powder, but the oil and fat component (the freezing point thereof is usually about 3 to 8 ° C.) is monohydric lower. Since it is mixed with alcohol (its freezing point is usually about -80 ° C), its freezing point is lowered.

Liquefied petroleum gas (its boiling point is usually about -50 to
(About 0 ° C.) evaporates while depriving the composition of heat of vaporization due to a rapid pressure change between the inside and the outside of the spray can during opening and injection. At this time, the temperature of the composition is 0 to -30 ° C.
Although the composition is cooled to the vicinity, the composition in which the freezing point of the oil and fat component is lowered does not solidify, and the powder is in a state of being dispersed in the mixed liquid of the monohydric lower alcohol and the oil and fat component.

After spraying, most of the liquefied petroleum gas evaporates by the time the composition reaches the target site, but the monohydric lower alcohol is deprived of the heat of vaporization by the liquefied petroleum gas and hardly evaporates. It reaches the attachment site in a state of being compatible with the components. Therefore, the powder agent adheres to the target site in a state of being dispersed in the mixed liquid of the monohydric lower alcohol and the fat and oil component. Also,
Since the mixture of the monohydric lower alcohol, the oil / fat component, and the powder agent still maintains the fluidity when attached to the target site, it is uniformly diffused to the target site by the injection pressure. Then, the monohydric lower alcohol (its boiling point is usually about 80 ° C.) is gradually evaporated, and the oil and fat component in which the powder agent is dispersed remains at the target site.

On the other hand, when, for example, a monohydric lower alcohol is not blended, the fat and oil component is rapidly cooled by the heat of vaporization of liquefied petroleum gas, and the powdered substance is embraced and solidified into a fine lump. Attach to the site. In other words, it is thought that the fine lumps in which the fat and oil components solidify and enclose the powder agent do not have fluidity and accumulate in the central area of the adhesion site, and the powder agent has a mountain-like swelling state. To be

In other words, according to the present embodiment, the dispersed powder agent adheres more uniformly to the sprayed target area than in the conventional case, and the powder agent does not form a lump, so it falls off from the adhered area over time. Therefore, it is considered that the effect of the active ingredient of the powder formulation lasts longer than before.

[0036]

[Table 1]

[0037]

[Table 2]

[0038]

[Table 3]

[0039]

[Table 4]

Claims (3)

[Claims] 1. A powder aerosol composition mainly containing a powder, an oil and fat component, and a monohydric lower alcohol,
Used in combination with a propellant, the powder is about 30% to about 80% by weight of the total powder aerosol composition.
The oil and fat component is blended in an amount of about 2 wt% to about 60 wt% with respect to the total amount of the powder agent and the oil and fat component, and the total amount of the oil and fat component and the monohydric lower alcohol is blended. A powder aerosol composition comprising a monohydric lower alcohol in an amount of about 10% by weight to about 90% by weight. 2. The powder aerosol composition according to claim 1, wherein isopropyl alcohol is used as the monohydric lower alcohol. 3. The powder aerosol composition according to claim 1, wherein isopropyl myristate is used as the oil and fat component.