JPH0789823A - Emulsified composition - Google Patents
Emulsified compositionInfo
- Publication number
- JPH0789823A JPH0789823A JP5257635A JP25763593A JPH0789823A JP H0789823 A JPH0789823 A JP H0789823A JP 5257635 A JP5257635 A JP 5257635A JP 25763593 A JP25763593 A JP 25763593A JP H0789823 A JPH0789823 A JP H0789823A
- Authority
- JP
- Japan
- Prior art keywords
- cationized cellulose
- hyaluronic acid
- emulsified composition
- ratio
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Landscapes
- Cosmetics (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
Abstract
Description
【0001】[0001]
【産業上の利用分野】本発明は、従来の乳化剤を一切用
いない新規な乳化組成物に関するものであり、その目的
は安全性が高く、しかも安定で使用感の優れた乳化組成
物を提供することにある。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel emulsified composition which does not use any conventional emulsifier, and its purpose is to provide an emulsion composition which is highly safe, stable and has a good feeling in use. Especially.
【0002】[0002]
【従来の技術】一般に、乳化組成物を調製する場合、乳
化剤として非イオン性界面活性剤、アニオン性界面活性
剤または両性活性剤から選ばれた活性剤を使用する。し
かし、これらの活性剤は乳化力は優れていても、皮膚に
対する安全性が十分高いとは必ずしも言い切れない。そ
こで、更に安全性の高い乳化組成物を得るために、種々
の水溶性高分子を乳化剤として用いることが検討されて
きた。例えば、カチオン化セルロースとアニオンまたは
両性活性剤との組合せ(特開昭54−127882)、
アミノスルホン酸型両性イオン基を有するポリエステル
樹脂(特開昭57−21927)、水溶性高分子と粘土
鉱物との組合せ(特公昭61−43323)、カチオン
性セルロースと多価アルコールとの組合せ(特開昭61
−22005)、グリチルレチン酸系化合物とペクチ
ン、キサンタンガムなどとの組合せ(特公昭62−59
083)、などが知られている。2. Description of the Related Art Generally, when preparing an emulsified composition, an active agent selected from nonionic surfactants, anionic surfactants or amphoteric surfactants is used as an emulsifier. However, even if these active agents have excellent emulsifying power, they cannot be said to be sufficiently safe for the skin. Therefore, in order to obtain an emulsion composition with higher safety, it has been studied to use various water-soluble polymers as emulsifiers. For example, a combination of cationized cellulose and an anionic or amphoteric activator (JP-A-54-127882),
Aminosulfonic acid type zwitterionic group-containing polyester resin (JP-A-57-21927), a combination of a water-soluble polymer and a clay mineral (JP-B-61-43323), a combination of cationic cellulose and a polyhydric alcohol (PAT. Kaisho 61
-22005), a combination of a glycyrrhetinic acid compound and pectin, xanthan gum or the like (Japanese Patent Publication No. 62-59).
083), etc. are known.
【0003】[0003]
【発明が解決しようとする課題】しかしながら、前記の
いずれの場合も乳化力、安全性、使用性の全てに関して
満足できるものではない。なかんずく、系の粘度が低い
乳液でこれらが全て十分満足されるものは見当たらな
い。以上の経緯より、本発明者等は安全性および安定性
に優れ、しかも使用感の良好な乳化組成物を得ることを
目的として、鋭意研究した結果、本発明を完成するに至
った。However, none of the above cases is satisfactory in terms of emulsifying power, safety and usability. Above all, none of the emulsions having a low system viscosity are sufficiently satisfied. Based on the above background, the present inventors have conducted intensive studies for the purpose of obtaining an emulsion composition having excellent safety and stability and having a good feeling in use, and as a result, completed the present invention.
【0004】[0004]
【課題を解決するための手段】すなわち、本発明は、カ
チオン化セルロースとヒアルロン酸もしくはその塩とを
含有する乳化組成物である。本発明で用いるカチオン化
セルロ−スは、第4級窒素を含有するセルロースエーテ
ルであり、市販されている商品として、例えば、ユニオ
ンカーバイト社製ポリマ−JRや東邦化学工業社製カチ
ナールHC200等が挙げられる。カチオン化セルロ−
スは、一種を単独で配合しても、また二種以上を組み合
わせて配合してもよく、その配合量は0.1〜10.0
重量%、好ましくは0.5〜5.0重量%である。乳化
安定性は配合量の増加とともに良好となるが、10重量
%を超えると良好な使用性を有するものは調製しがた
い。また、カチオン化セルロ−スとともに加えるヒアル
ロン酸もしくはその塩類は、カチオン化セルロ−スに対
して、重量比で0.1〜0.4、好ましくは0.2〜
0.3の割合で配合する必要がある。重量比0.1未満
または0.4を超えると安定な乳化組成物が得られない
か、または良好な使用性が得られない。なお、ヒアルロ
ン酸の塩類としては、ナトリウム、カリウム等のアルカ
リ金属塩やアルカリ土類金属塩などが挙げられる。さら
に、本発明において用いる油相は、一般に医薬、化粧料
の分野において使用されるものであればよく、特に限定
はされない。油相の配合量は、カチオン化セルロ−スと
ヒアルロン酸(塩)との合計量に対して、重量比で0.
1〜30、化粧料としての使用性を考慮すると、0.5
〜20の割合が好ましい。さらに、本発明において用い
る水相には、一般に化粧料の水相として配合される成
分、例えば、保湿剤、増粘剤、pH調整剤を配合でき
る。本発明の乳化組成物は、従来の調整方法に従って調
整できるが、特に、カチオン化セルロース水溶液に油分
を添加し、ホモミキサーで乳化した後、これにヒアルロ
ン酸水溶液およびその他の水溶性成分を添加して、再度
ホモミキサー処理することにより、乳化粒子が均一でよ
り微細な乳化組成物が調整できる。That is, the present invention is an emulsified composition containing cationized cellulose and hyaluronic acid or a salt thereof. The cationized cellulose used in the present invention is a cellulose ether containing a quaternary nitrogen, and as commercially available products, for example, Polymer-JR manufactured by Union Carbide Co. or Katinal HC200 manufactured by Toho Chemical Industry Co., Ltd. Can be mentioned. Cationized cellulose
As for the soot, one kind may be added alone, or two or more kinds may be added in combination, and the amount thereof is 0.1 to 10.0.
% By weight, preferably 0.5 to 5.0% by weight. The emulsion stability becomes better as the blending amount increases, but if it exceeds 10% by weight, it is difficult to prepare one having good usability. The weight ratio of hyaluronic acid or salts thereof added together with the cationized cellulose to the cationized cellulose is 0.1-0.4, preferably 0.2-.
It is necessary to blend in a ratio of 0.3. If the weight ratio is less than 0.1 or exceeds 0.4, a stable emulsion composition cannot be obtained or good usability cannot be obtained. Examples of salts of hyaluronic acid include alkali metal salts such as sodium and potassium, alkaline earth metal salts and the like. Further, the oil phase used in the present invention is not particularly limited as long as it is generally used in the fields of medicine and cosmetics. The blending amount of the oil phase was 0.1% by weight with respect to the total amount of the cationized cellulose and hyaluronic acid (salt).
1-30, considering the usability as a cosmetic, 0.5
A ratio of -20 is preferred. Further, the aqueous phase used in the present invention can be blended with components that are generally blended as the aqueous phase of cosmetics, such as moisturizers, thickeners and pH adjusters. The emulsified composition of the present invention can be prepared according to a conventional preparation method, but in particular, an oil component is added to a cationized cellulose aqueous solution, the mixture is emulsified with a homomixer, and then a hyaluronic acid aqueous solution and other water-soluble components are added thereto. By performing homomixer treatment again, a finer emulsion composition having uniform emulsion particles can be prepared.
【0005】[0005]
【実施例】つぎに本発明について、実施例を挙げてさら
に詳細に説明する。配合量は重量%で示す。 <試験例1>(実施例1〜4、比較例1〜6) 表1に示す乳化剤を用いて乳化組成物を調製し、調製直
後の粘度および50°Cにおける乳化安定性を評価し
た。油分としては、ジイソステアリン酸グリセリンを乳
化組成物全量に対して10%配合し、残部は水で調整し
た。乳化は、ホモミキサーを用いて、5000rpm、
5分間、室温で行った。なお、表1の安定性の欄の日数
は、目視で分離が認められる迄の50°Cでの保存日数
である。表1の結果より、乳化剤配合量が同じ場合には
初期粘度はあまり差がなく、安定性に及ぼす粘度の影響
は無視でき、カチオン化セルロースとヒアルロン酸とを
特定の比率で組合せることにより、乳化安定性が飛躍的
に向上することが明らかとなった。なお、比較例5、6
には特開昭61−22005 記載のカチオン性セルロースと多
価アルコールとの組合せによる乳化例を示したが、実施
例はこれらに比べても長期間安定なものであった。EXAMPLES Next, the present invention will be described in more detail with reference to examples. The compounding amount is shown by weight%. <Test Example 1> (Examples 1 to 4, Comparative Examples 1 to 6) An emulsified composition was prepared using the emulsifiers shown in Table 1, and the viscosity immediately after the preparation and the emulsion stability at 50 ° C were evaluated. As the oil content, glycerin diisostearate was blended in an amount of 10% with respect to the total amount of the emulsion composition, and the balance was adjusted with water. The emulsification was performed using a homomixer at 5000 rpm,
Performed for 5 minutes at room temperature. The number of days in the stability column of Table 1 is the number of days of storage at 50 ° C until the separation is visually recognized. From the results in Table 1, when the emulsifier content is the same, there is little difference in the initial viscosity, and the effect of viscosity on stability can be ignored, and by combining cationized cellulose and hyaluronic acid in a specific ratio, It was revealed that the emulsion stability was dramatically improved. In addition, Comparative Examples 5 and 6
In JP-A-61-22005, there is shown an emulsification example using a combination of a cationic cellulose and a polyhydric alcohol, but the examples were stable even for a long period of time.
【0006】[0006]
【表1】 [Table 1]
【0007】本発明により、乳化安定性が飛躍的に向上
する理由は、次の様に考えられる。カチオン化セルロー
スは油・水界面に配向することができ、これ単独でも乳
化は可能であるが、通常用いられる界面活性剤のような
強固な界面膜を形成することはできず、経時安定性が良
好なものは得られない。しかしながら、この系にアニオ
ン性の高分子であるヒアルロン酸(塩)を添加すると、
ヒアルロン酸も油・水界面に配向してカチオン化セルロ
ースと電荷を打ち消しあい、より強固な複合的界面膜を
形成するため、乳化安定性が飛躍的に向上するものと考
えられる。また、本発明は、乳化剤として高分子物質を
用いるものであるから、従来の界面活性剤に比べて経皮
吸収が抑制され、さらに高分子物質の組合せによって電
荷的に中和される方向になるため皮膚刺激が低減し、皮
膚への安全性も優れたものである。The reason why the emulsion stability is dramatically improved by the present invention is considered as follows. Cationized cellulose can be oriented at the oil / water interface and can be emulsified by itself, but it cannot form a strong interfacial film like a commonly used surfactant and has stability over time. You can't get a good one. However, if hyaluronic acid (salt), which is an anionic polymer, is added to this system,
It is considered that hyaluronic acid is also oriented at the oil / water interface and cancels the charge with the cationized cellulose to form a stronger composite interfacial film, so that the emulsion stability is dramatically improved. In addition, since the present invention uses a polymer substance as an emulsifier, percutaneous absorption is suppressed as compared with a conventional surfactant, and the combination of polymer substances tends to neutralize the charge. Therefore, skin irritation is reduced and the safety to the skin is excellent.
【0008】<試験例2>(実施例5〜14、比較例7〜
12) 次に、各種の油に対する乳化能を調べた。実施例の乳化
剤としてはカチオン化セルロースとヒアルロン酸の比率
を1:0.25とし、配合量は2%とした。結果を表2
に示すが、極性の異なるいずれの油についても安定な乳
化物が調製できた。特に、従来より乳化が難しいとされ
ている極性油およびシリコンオイルでも安定性良好な乳
化物が調製できた。なお、比較例7〜12には特開昭61−
22005 記載のカチオン性セルロースと多価アルコールと
の組合せによる乳化例を示した。<Test Example 2> (Examples 5 to 14, Comparative Example 7 to
12) Next, the emulsifying ability for various oils was investigated. As the emulsifier in the examples, the ratio of cationized cellulose to hyaluronic acid was 1: 0.25, and the compounding amount was 2%. The results are shown in Table 2.
As shown in Fig. 2, stable emulsions could be prepared for all oils having different polarities. In particular, an emulsion with good stability could be prepared even with polar oils and silicone oils, which have been considered difficult to emulsify in the past. In addition, in Comparative Examples 7 to 12, JP-A-61-
22005 shows an example of emulsification by the combination of cationic cellulose and polyhydric alcohol described.
【0009】[0009]
【表2】 [Table 2]
【0010】 従来の製法に従い調製した本乳液は、50°Cおよび5
°Cで1ヵ月放置後も状態に変化はなく安定であり、使
用性も良好であった。[0010] The emulsion prepared according to the conventional manufacturing method has a temperature of 50 ° C and 5 ° C.
After being left for 1 month at ° C, the state was stable and stable, and the usability was good.
【0011】[0011]
【発明の効果】本発明の乳化組成物は、カチオン化セル
ロースとヒアルロン酸もしくはその塩とを含有し、安定
性、安全性、使用性に優れたものである。The emulsion composition of the present invention contains cationized cellulose and hyaluronic acid or a salt thereof, and is excellent in stability, safety and usability.
Claims (2)
しくはその塩とを含有する乳化組成物。1. An emulsified composition containing cationized cellulose and hyaluronic acid or a salt thereof.
しくはその塩との配合比が1:0.1〜0.4である請
求項1記載の乳化組成物。2. The emulsion composition according to claim 1, wherein the compounding ratio of cationized cellulose and hyaluronic acid or a salt thereof is 1: 0.1 to 0.4.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5257635A JPH0789823A (en) | 1993-09-21 | 1993-09-21 | Emulsified composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5257635A JPH0789823A (en) | 1993-09-21 | 1993-09-21 | Emulsified composition |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH0789823A true JPH0789823A (en) | 1995-04-04 |
Family
ID=17308983
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP5257635A Withdrawn JPH0789823A (en) | 1993-09-21 | 1993-09-21 | Emulsified composition |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH0789823A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20130006290A (en) | 2011-07-07 | 2013-01-16 | 가부시키가이샤 미르본 | Oil-in-water type emulsion |
JP2019189549A (en) * | 2018-04-24 | 2019-10-31 | 株式会社 資生堂 | Thick aqueous cosmetic |
JP2022036987A (en) * | 2016-01-04 | 2022-03-08 | アヘンシア プブリカ エンプレサリアル サニタリア ホスピタル デ ポニエンテ | Composition for use in treatment of mucous membrane lesions using endoscopic resection |
-
1993
- 1993-09-21 JP JP5257635A patent/JPH0789823A/en not_active Withdrawn
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20130006290A (en) | 2011-07-07 | 2013-01-16 | 가부시키가이샤 미르본 | Oil-in-water type emulsion |
JP2013018708A (en) * | 2011-07-07 | 2013-01-31 | Milbon Co Ltd | Oil-in-water emulsion |
JP2022036987A (en) * | 2016-01-04 | 2022-03-08 | アヘンシア プブリカ エンプレサリアル サニタリア ホスピタル デ ポニエンテ | Composition for use in treatment of mucous membrane lesions using endoscopic resection |
JP2019189549A (en) * | 2018-04-24 | 2019-10-31 | 株式会社 資生堂 | Thick aqueous cosmetic |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
A300 | Application deemed to be withdrawn because no request for examination was validly filed |
Free format text: JAPANESE INTERMEDIATE CODE: A300 Effective date: 20001128 |