JPH0789823A - Emulsified composition - Google Patents

Abstract

PURPOSE:To obtain an emulsified composition excellent in safety and stability and having excellent usability. CONSTITUTION:An emulsified composition contains a cationized cellulose of a quaternary nitrogen-containing cellulose ether and hyaluronic acid or its salt at a ratio of l:0.1-0.4, preferably 1:0.2-0.3 in terms of the weight ratio of the former to the latter. The compounding ratio of the cationized cellulose in the composition is in the range from 0.1wt.% to 10.0wt.%, preferably from 0.5wt.% to 5.0wt.% and the compounding ratio of the oil phase to the total of the cationized cellulose and hyaluronic acid or its salt is 0.1-30, preferably 0.5-20 in terms of weight ratio. An emulsified composition having uniform and fine emulsified particles is prepared by compounding a cationized cellulose solution with oil component, homogenizing with a homogenizer followed by adding a hyaluronic acid aqueous solution and other water-soluble components and repeatedly treating with the homogenizer.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel emulsified composition which does not use any conventional emulsifier, and its purpose is to provide an emulsion composition which is highly safe, stable and has a good feeling in use. Especially.

[0002]

2. Description of the Related Art Generally, when preparing an emulsified composition, an active agent selected from nonionic surfactants, anionic surfactants or amphoteric surfactants is used as an emulsifier. However, even if these active agents have excellent emulsifying power, they cannot be said to be sufficiently safe for the skin. Therefore, in order to obtain an emulsion composition with higher safety, it has been studied to use various water-soluble polymers as emulsifiers. For example, a combination of cationized cellulose and an anionic or amphoteric activator (JP-A-54-127882),
Aminosulfonic acid type zwitterionic group-containing polyester resin (JP-A-57-21927), a combination of a water-soluble polymer and a clay mineral (JP-B-61-43323), a combination of cationic cellulose and a polyhydric alcohol (PAT. Kaisho 61
-22005), a combination of a glycyrrhetinic acid compound and pectin, xanthan gum or the like (Japanese Patent Publication No. 62-59).
083), etc. are known.

[0003]

However, none of the above cases is satisfactory in terms of emulsifying power, safety and usability. Above all, none of the emulsions having a low system viscosity are sufficiently satisfied. Based on the above background, the present inventors have conducted intensive studies for the purpose of obtaining an emulsion composition having excellent safety and stability and having a good feeling in use, and as a result, completed the present invention.

[0004]

That is, the present invention is an emulsified composition containing cationized cellulose and hyaluronic acid or a salt thereof. The cationized cellulose used in the present invention is a cellulose ether containing a quaternary nitrogen, and as commercially available products, for example, Polymer-JR manufactured by Union Carbide Co. or Katinal HC200 manufactured by Toho Chemical Industry Co., Ltd. Can be mentioned. Cationized cellulose
As for the soot, one kind may be added alone, or two or more kinds may be added in combination, and the amount thereof is 0.1 to 10.0.
% By weight, preferably 0.5 to 5.0% by weight. The emulsion stability becomes better as the blending amount increases, but if it exceeds 10% by weight, it is difficult to prepare one having good usability. The weight ratio of hyaluronic acid or salts thereof added together with the cationized cellulose to the cationized cellulose is 0.1-0.4, preferably 0.2-.
It is necessary to blend in a ratio of 0.3. If the weight ratio is less than 0.1 or exceeds 0.4, a stable emulsion composition cannot be obtained or good usability cannot be obtained. Examples of salts of hyaluronic acid include alkali metal salts such as sodium and potassium, alkaline earth metal salts and the like. Further, the oil phase used in the present invention is not particularly limited as long as it is generally used in the fields of medicine and cosmetics. The blending amount of the oil phase was 0.1% by weight with respect to the total amount of the cationized cellulose and hyaluronic acid (salt).
1-30, considering the usability as a cosmetic, 0.5
A ratio of -20 is preferred. Further, the aqueous phase used in the present invention can be blended with components that are generally blended as the aqueous phase of cosmetics, such as moisturizers, thickeners and pH adjusters. The emulsified composition of the present invention can be prepared according to a conventional preparation method, but in particular, an oil component is added to a cationized cellulose aqueous solution, the mixture is emulsified with a homomixer, and then a hyaluronic acid aqueous solution and other water-soluble components are added thereto. By performing homomixer treatment again, a finer emulsion composition having uniform emulsion particles can be prepared.

[0005]

EXAMPLES Next, the present invention will be described in more detail with reference to examples. The compounding amount is shown by weight%. <Test Example 1> (Examples 1 to 4, Comparative Examples 1 to 6) An emulsified composition was prepared using the emulsifiers shown in Table 1, and the viscosity immediately after the preparation and the emulsion stability at 50 ° C were evaluated. As the oil content, glycerin diisostearate was blended in an amount of 10% with respect to the total amount of the emulsion composition, and the balance was adjusted with water. The emulsification was performed using a homomixer at 5000 rpm,
Performed for 5 minutes at room temperature. The number of days in the stability column of Table 1 is the number of days of storage at 50 ° C until the separation is visually recognized. From the results in Table 1, when the emulsifier content is the same, there is little difference in the initial viscosity, and the effect of viscosity on stability can be ignored, and by combining cationized cellulose and hyaluronic acid in a specific ratio, It was revealed that the emulsion stability was dramatically improved. In addition, Comparative Examples 5 and 6
In JP-A-61-22005, there is shown an emulsification example using a combination of a cationic cellulose and a polyhydric alcohol, but the examples were stable even for a long period of time.

[0006]

[Table 1]

The reason why the emulsion stability is dramatically improved by the present invention is considered as follows. Cationized cellulose can be oriented at the oil / water interface and can be emulsified by itself, but it cannot form a strong interfacial film like a commonly used surfactant and has stability over time. You can't get a good one. However, if hyaluronic acid (salt), which is an anionic polymer, is added to this system,
It is considered that hyaluronic acid is also oriented at the oil / water interface and cancels the charge with the cationized cellulose to form a stronger composite interfacial film, so that the emulsion stability is dramatically improved. In addition, since the present invention uses a polymer substance as an emulsifier, percutaneous absorption is suppressed as compared with a conventional surfactant, and the combination of polymer substances tends to neutralize the charge. Therefore, skin irritation is reduced and the safety to the skin is excellent.

<Test Example 2> (Examples 5 to 14, Comparative Example 7 to
12) Next, the emulsifying ability for various oils was investigated. As the emulsifier in the examples, the ratio of cationized cellulose to hyaluronic acid was 1: 0.25, and the compounding amount was 2%. The results are shown in Table 2.
As shown in Fig. 2, stable emulsions could be prepared for all oils having different polarities. In particular, an emulsion with good stability could be prepared even with polar oils and silicone oils, which have been considered difficult to emulsify in the past. In addition, in Comparative Examples 7 to 12, JP-A-61-
22005 shows an example of emulsification by the combination of cationic cellulose and polyhydric alcohol described.

[0009]

[Table 2]

[0010] The emulsion prepared according to the conventional manufacturing method has a temperature of 50 ° C and 5 ° C.
After being left for 1 month at ° C, the state was stable and stable, and the usability was good.

[0011]

The emulsion composition of the present invention contains cationized cellulose and hyaluronic acid or a salt thereof, and is excellent in stability, safety and usability.

Claims (2)

[Claims] 1. An emulsified composition containing cationized cellulose and hyaluronic acid or a salt thereof. 2. The emulsion composition according to claim 1, wherein the compounding ratio of cationized cellulose and hyaluronic acid or a salt thereof is 1: 0.1 to 0.4.