JPH0788296B2 - Oily gel base - Google Patents
Oily gel baseInfo
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- JPH0788296B2 JPH0788296B2 JP2537288A JP2537288A JPH0788296B2 JP H0788296 B2 JPH0788296 B2 JP H0788296B2 JP 2537288 A JP2537288 A JP 2537288A JP 2537288 A JP2537288 A JP 2537288A JP H0788296 B2 JPH0788296 B2 JP H0788296B2
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- acid
- fatty acid
- oily gel
- gel base
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Description
【発明の詳細な説明】 「産業上の利用分野」 本発明は油性ゲル基剤に関し、さらに具体的には、ゲル
化剤としてデキストリン混合脂肪酸エステルを使用した
新規な油性ゲル基剤に関するものである。TECHNICAL FIELD The present invention relates to an oily gel base, and more specifically to a novel oily gel base using a dextrin mixed fatty acid ester as a gelling agent. .
「従来の技術」 例えば、フレグランスジャーナルNo.33（昭和53年11月2
5日、フレグランスジャーナル社発行）第26頁〜第31頁
（執筆者吉村淳）に記載されているように、デキストリ
ン脂肪酸エステルをゲル化剤として使用するのは公知で
あり、また、例えば特公昭60−22682号公報等に開示さ
れているように、ゲル化剤としてデキストリン脂肪酸エ
ステルを使用した軟膏基剤も公知である。“Conventional technology” For example, Fragrance Journal No. 33 (November 1978, 2
It is known to use dextrin fatty acid ester as a gelling agent, as described in pp. 26-31 (author Jun Atsushi Yoshimura), published on May 5, published by Fragrance Journal, Inc. As disclosed in JP-A-60-22682, an ointment base using a dextrin fatty acid ester as a gelling agent is also known.
「発明が解決しようとする課題」 しかしながら前者のように、流動パラフィンその他の流
動性非極性溶媒に、デキストリン脂肪酸エステル（以下
「DFE」と略称）を加えてゲル化した油性ゲルは充分に
滑らかでなく、経時的に粒子（ぶつぶつ）を生ずる問題
がある。"Problems to be solved by the invention" However, as in the former case, an oily gel formed by adding dextrin fatty acid ester (hereinafter referred to as "DFE") to liquid paraffin or other liquid non-polar solvent is sufficiently smooth. However, there is a problem that particles (crushing) are generated over time.
また、後者は流動パラフィンと非流動性鉱油系ワックス
にDFEを加えた軟膏基剤であり、このように非流動性鉱
油系ワックスを配合すると滑らかにはなるが、経時的な
粒子の析出を完全に防止できず、油性ゲルにワックスを
配合すると低温時（５℃）に硬くなり易い。In addition, the latter is an ointment base in which DFE is added to liquid paraffin and non-fluidic mineral oil wax. Blending non-fluidic mineral oil wax in this way makes it smooth, but complete precipitation of particles over time is achieved. However, if wax is added to the oily gel, it tends to become hard at low temperature (5 ° C).
本発明の目的は、前記のような課題を解決した油性ゲル
基剤を提供することにある。An object of the present invention is to provide an oily gel base that solves the above problems.
「課題を解決するための手段及び作用」 本発明者らは鋭意研究の結果、DFEをゲル化剤とする従
来の油性ゲル基剤における滑らかさの不足と、粒子析出
が、DFEの脂肪酸純度が高い（95重量％以上）ことに起
因することを見出し、本発明を完成させたもので、DFE
の脂肪酸組成を改善することにより前記問題点を解決し
た。“Means and Actions for Solving Problems” As a result of intensive research by the present inventors, the lack of smoothness in a conventional oily gel base having DFE as a gelling agent, particle precipitation, and fatty acid purity of DFE are We have found that it is due to high (95% by weight or more) and completed the present invention.
The above-mentioned problems were solved by improving the fatty acid composition of.
すなわち本発明は、従来の油性ゲル基剤におけるDFEに
代えて、炭素数が12から22であって脂肪酸組成が二種以
上の脂肪酸からなり、かつ、最大重量比を占める脂肪酸
の含有量が81重量％以下であるデキストリン混合脂肪酸
エステル（以下「DMFE」と略称）を１重量％以上用い、
流動パラフィンその他の流動性非極性溶媒をゲル化させ
ることにより、充分に滑らかで経時的な粒子析出がな
く、しかも、低温時（５℃）に硬くならない油性ゲル基
剤を得たものである。That is, the present invention, in place of DFE in the conventional oily gel base, the carbon number is 12 to 22 fatty acid composition consisting of two or more fatty acids, and the content of fatty acids occupying the maximum weight ratio is 81 Using 1% by weight or more of dextrin mixed fatty acid ester (hereinafter abbreviated as "DMFE") which is less than 1% by weight,
By gelling liquid paraffin or other fluid non-polar solvent, an oily gel base is obtained which is sufficiently smooth, does not precipitate particles over time, and does not become hard at low temperature (5 ° C.).
なお、前記特公昭60−22682号にも明示されているよう
に、ゲル化剤にDFEを用いることの主要な効果として、
軟膏基剤組成物からの液状物質の分離防止があるが、前
述のような混合脂肪酸組成のDMFEを用いる場合も、液状
物質の分離防止効果は全く阻害されない。Incidentally, as clearly shown in Japanese Patent Publication No. 60-22682, as the main effect of using DFE as a gelling agent,
Although there is prevention of separation of the liquid substance from the ointment base composition, the effect of preventing separation of the liquid substance is not impaired at all even when DMFE having the mixed fatty acid composition as described above is used.
「各組成分の例示及び油性ゲル基剤の製法」 本発明におけるDMFEに使用されるデキストリンは、天然
デンプンを分解処理して得られ、平均重合度が５〜50グ
ルコース単位のものである。"Exemplification of Each Composition and Method for Producing Oily Gel Base" The dextrin used in DMFE in the present invention is obtained by decomposing natural starch and has an average degree of polymerization of 5 to 50 glucose units.
DMFEを得る方法としては、上記デキストリンに混合脂肪
酸クロライド又は混合脂肪酸無水物を反応させて得るの
が一般的である。As a method for obtaining DMFE, it is general to obtain it by reacting the above dextrin with a mixed fatty acid chloride or a mixed fatty acid anhydride.
本発明に係る油性ゲル基剤は前述のように、流動性非極
性溶媒中に、炭素数が12から22である二種以上の脂肪酸
からなり、かつ最大重量比を占める脂肪酸の含有量が81
重量％以下である脂肪酸組成のデキストリン混合脂肪酸
エステルを１重量％以上含ませたものであるが、混合脂
肪酸としては、好ましくはラウリン酸，ミリスチン酸，
パルミチン酸，ステアリン酸，アラキジン酸及びベヘン
酸の中の二種以上を混合した脂肪酸組成のものを使用す
る。As described above, the oily gel base according to the present invention, in the fluid non-polar solvent, is composed of two or more fatty acids having 12 to 22 carbon atoms, and the content of fatty acids occupying the maximum weight ratio is 81.
1% by weight or more of a dextrin mixed fatty acid ester having a fatty acid composition of not more than% by weight. The mixed fatty acid is preferably lauric acid, myristic acid,
Use a fatty acid composition that is a mixture of two or more of palmitic acid, stearic acid, arachidic acid, and behenic acid.
DMFEの配合量は、当該油性ゲル基剤の用途により前述の
範囲（ゲル基剤全重量の１％以上）内で適宜設定すべき
であるが、ローション剤に使用する場合は１〜８重量
％、軟膏剤の場合は８〜20重量％、スチック及び坐剤等
の場合は20〜30重量％それぞれ配合すれば充分である。The blending amount of DMFE should be appropriately set within the above range (1% or more of the total weight of the gel base) depending on the use of the oily gel base, but 1 to 8% by weight when used as a lotion. It is sufficient to add 8 to 20% by weight in the case of ointment and 20 to 30% by weight in the case of stick and suppository.
流動性非極性溶媒としては、例えば炭化水素（例えば流
動パラフィン、軽質流動パラフィン、スクワラン等）、
不飽和高級脂肪酸（例えばオレイン酸、リノール酸、リ
ノレイン酸等）、高級脂肪酸エステル（例えばミリスチ
ン酸イソプロピル、ミリスチン酸オクチルドデシル、オ
レイン酸オクチルドデシル等）等を一種又は二種以上用
いる。Examples of the fluid non-polar solvent include hydrocarbons (eg liquid paraffin, light liquid paraffin, squalane, etc.),
One or more unsaturated higher fatty acids (eg, oleic acid, linoleic acid, linoleic acid), higher fatty acid esters (eg, isopropyl myristate, octyldodecyl myristate, octyldodecyl oleate, etc.) are used.
本発明に係る油性ゲル基剤は、例えば、DMFE粉末を、流
動性非極性溶媒に分散させた後、90〜100℃程度で加熱
溶解し、これを室温まで冷却して製造することができ
る。The oily gel base according to the present invention can be produced, for example, by dispersing DMFE powder in a fluid non-polar solvent, heating and dissolving it at about 90 to 100 ° C, and cooling it to room temperature.
また、界面活性剤や非流動性鉱油系ワックス等と併用す
ることができる。Further, it can be used in combination with a surfactant or a non-fluidic mineral oil wax.
「実施例−１」 DMFE（パルミチン酸67重量％、ステアリン酸31重量％）
13.5gを流動パラフィン86.5gに加えて室温で混合し、10
0℃の蒸気浴で撹拌しながら加温し、均質に溶融した後
に200号篩（日本薬局方）で篩過し、脱気後室温まで冷
却して油性ゲル基剤を製造し、この冷却の過程で適当な
容器に充填して軟膏基剤とした。"Example-1" DMFE (67% by weight of palmitic acid, 31% by weight of stearic acid)
Add 13.5 g to 86.5 g of liquid paraffin and mix at room temperature.
After heating with stirring in a 0 ° C steam bath and melting it homogeneously, it is sieved with a No. 200 sieve (Japanese Pharmacopoeia), degassed and then cooled to room temperature to produce an oily gel base. In the process, it was filled in a suitable container to give an ointment base.
「実施例−２」 DMFE（ステアリン酸32重量％、ベヘン酸65重量％）13.5
gを流動パラフィン86.5gに加えて室温で混合し、以下実
施例−１と同要領で油性ゲル基剤を製造し、軟膏基剤と
した。"Example-2" DMFE (32% by weight of stearic acid, 65% by weight of behenic acid) 13.5
g was added to 86.5 g of liquid paraffin and mixed at room temperature, and an oily gel base was produced in the same manner as in Example 1 below to obtain an ointment base.
「実施例−３」 DMFE（パルミチン酸46重量％、ステアリン酸15重量％、
ベヘン酸36重量％）13.5gを流動パラフィン86.5gに加え
て室温で混合し、以下実施例−１と同要領で油性ゲル基
剤を製造し、軟膏基剤とした。"Example-3" DMFE (46% by weight of palmitic acid, 15% by weight of stearic acid,
Behenic acid (36% by weight) (13.5 g) was added to liquid paraffin (86.5 g) and mixed at room temperature to prepare an oily gel base in the same manner as in Example-1 to give an ointment base.
「実施例−４」 DMFE（パルミチン酸67重量％、ステアリン酸31重量％）
3gを流動パラフィン97gに加えて室温で混合し、以下実
施例−１と同要領で油性ゲル基剤を製造してローション
基剤とした。"Example-4" DMFE (67% by weight of palmitic acid, 31% by weight of stearic acid)
3 g of liquid paraffin was added to 97 g of liquid paraffin and mixed at room temperature, and an oily gel base was produced in the same manner as in Example 1 to prepare a lotion base.
「実施例−５」 DMFE（パルミチン酸81重量％、ステアリン酸16重量％）
13.5gを使用し、実施例−１と同じ要領で油性ゲル基剤
を製造して軟膏基剤とした。"Example-5" DMFE (81% by weight of palmitic acid, 16% by weight of stearic acid)
An oily gel base was produced in the same manner as in Example 1 using 13.5 g to prepare an ointment base.
「試験例−１」 実施例−1,2,3,4,5で調製した油性ゲル基剤をそれぞれ
試料1,2,3,4,5とし、次の試料６〜８を用意した。"Test Example-1" The oily gel bases prepared in Examples-1,2,3,4,5 were used as Samples 1,2,3,4,5, and the following Samples 6 to 8 were prepared.
試料6.実施例−１に準じ、DMFEに代えてDFE（パルミチ
ン酸96重量％、ステアリン酸３重量％）を用いて調製し
た。Sample 6. According to Example-1, it was prepared by using DFE (96% by weight of palmitic acid, 3% by weight of stearic acid) instead of DMFE.
試料7.実施例−１に準じ、DMFEに代えてDFE（パルミチ
ン酸96重量％、ステアリン酸３重量％）13.5gと、流動
パラフィン86.5gに代えて流動パラフィン43.25gと白色
ワセリン43.25gを用いて調製した。Sample 7. According to Example-1, 13.5 g of DFE (96% by weight of palmitic acid, 3% by weight of stearic acid) was used instead of DMFE, and 43.25 g of liquid paraffin and 43.25 g of white petrolatum were used instead of 86.5 g of liquid paraffin. Prepared.
試料8.DMFEを用いないで、流動パラフィン50gと白色ワ
セリン50gを用いて調製した。Sample 8. Prepared using 50 g of liquid paraffin and 50 g of white petrolatum without using DMFE.
試料１〜８につき、低温庫（５℃）及び室温（10〜35
℃）にて経時変化試験を実施し、表−１（５℃）及び表
−２（10〜35℃）の結果を得た。For samples 1-8, low temperature chamber (5 ℃) and room temperature (10-35
C.) and the results of Table-1 (5.degree. C.) and Table-2 (10-35.degree. C.) were obtained.
表−1,2で表わしたとおり、DFEの単一脂肪酸の純度が95
重量％以上と高い場合には外観が滑らかでなく、経時的
に粒子の析出が認められたが、炭素数が12から22である
二種以上の脂肪酸を混合した場合、表−１及び表−２に
示したように、最大重量比を占める脂肪酸の含有量が81
重量％以下にしたDMFEを用いた場合は、外観が滑らかで
あり経時的な粒子の析出も認められなかった。単一脂肪
酸の最大重量比が前記以外である場合は、当該重量比を
増大させるにしたがって物性の滑らかさがなくなる傾向
を示した。また粒子の析出については、白色ワセリンの
配合により減少傾向を示すが、充分に防止されなかっ
た。As shown in Tables 1 and 2, the purity of the single fatty acid of DFE is 95
When the content was as high as more than 10% by weight, the appearance was not smooth and precipitation of particles was observed over time, but when two or more kinds of fatty acids having 12 to 22 carbon atoms were mixed, Table-1 and Table- As shown in Fig. 2, the fatty acid content of the maximum weight ratio is 81%.
When DMFE was used in an amount of not more than 10% by weight, the appearance was smooth and no precipitation of particles was observed over time. When the maximum weight ratio of the single fatty acid was other than the above, the physical properties tended to become less smooth as the weight ratio was increased. Regarding the precipitation of particles, the addition of white petrolatum tended to decrease, but it was not sufficiently prevented.
「実験例−２」 試験例−１で用いた試料１〜3,5と試料６〜８を、それ
ぞれ25gアルミチューブ（口径6mm、胴径22mm）に充填
し、低温（５℃）下において、第１図のように固定盤１
上に蝶板状のアダプター２を設置し、それぞれの試料を
充填したアルミチューブ３をアダプター２内に挟み、ア
ダプター２の上方より荷重を一定の速度で次第に増し
て、チューブ３内の試料がチューブ３の注出口より出始
めた時の荷重をレオメーターで測定し、この荷重の平均
値（同一試料を十個用意して各個につき測定した場合の
平均値）を求めたところ表−３の結果を得た。 "Experimental Example-2" Samples 1 to 3 and 5 and Samples 6 to 8 used in Experimental Example-1 were filled in 25 g aluminum tubes (caliber 6 mm, barrel diameter 22 mm), respectively, and at low temperature (5 ° C), Fixed platen 1 as shown in Fig. 1
The butterfly plate-shaped adapter 2 is installed on the top, the aluminum tubes 3 filled with the respective samples are sandwiched in the adapter 2, and the load is gradually increased from above the adapter 2 at a constant speed so that the sample in the tube 3 is a tube. The load at the time of starting from the spout of No. 3 was measured with a rheometer, and the average value of this load (the average value when ten identical samples were prepared and measured for each) was calculated. Got
DFE,流動パラフィンゲルの粒子析出は、白色ワセリンの
配合によってある程度防止できても、表−３の結果で明
らかなように（特に白色ワセリンを配合した試料７）、
低温時（５℃）において、硬さの温度依存性が低いとい
うゲル特性が半減して硬くなる。Although the precipitation of DFE and liquid paraffin gel particles can be prevented to some extent by blending white petrolatum, as is clear from the results in Table 3 (particularly, sample 7 containing white petrolatum),
At low temperature (5 ° C.), the gel characteristic that the temperature dependence of hardness is low becomes half and becomes hard.
しかしながら、前述のような脂肪酸組成のDMFEをゲル化
剤として使用することにより、粒子析出を抑制しつつ低
温時でも軟らかさを保つ油性ゲル基剤が得られた。However, by using DMFE having a fatty acid composition as described above as a gelling agent, an oily gel base was obtained which suppressed particle precipitation and kept softness even at low temperatures.
「発明の効果」 本発明によれば、DFEの脂肪酸組成を炭素数が12から22
である二種以上の混合脂肪酸とし、かつ各単一脂肪酸の
純度を81重量％以下にしたゲル化剤を使用することによ
って、滑らかでしかも経時的な粒子析出のない油性ゲル
基剤を得ることができた。 According to the present invention, the fatty acid composition of DFE has 12 to 22 carbon atoms.
By using a gelling agent containing two or more kinds of mixed fatty acids, each of which has a purity of 81% by weight or less, a smooth oil-based gel base without particle precipitation can be obtained. I was able to.
特に油性軟膏基剤として使用するゲル基剤にあっては、
ワックス等の配合の必要性がなくなり、硬さの温度依存
性が低いというゲル特性を半減しないで、低温時でも軟
らかさを保つ基剤を得ることができる。Especially for gel bases used as oily ointment bases,
It is possible to obtain a base material that maintains softness even at low temperature without eliminating the need for compounding wax or the like and not halving the gel characteristic that hardness has low temperature dependence.
第１図は試料の押出し試験に使用した装置の側面図であ
る。FIG. 1 is a side view of the apparatus used for the sample extrusion test.
───────────────────────────────────────────────────── フロントページの続き (72)発明者 小阪 忠 東京都豊島区高田３丁目24番１号 大正製 薬株式会社内 (72)発明者 桜井 道世 東京都豊島区高田３丁目24番１号 大正製 薬株式会社内 (72)発明者 中島 敏貴 東京都豊島区高田３丁目24番１号 大正製 薬株式会社内 (72)発明者 吉村 淳 千葉県千葉市新港17番地 千葉製粉株式会 社内 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Tadashi Kosaka 3-24-1, Takada, Toshima-ku, Tokyo Taisho Pharmaceutical Co., Ltd. (72) Inventor Michiyo Sakurai 3-24-1, Takada, Toshima-ku, Tokyo Within Taisho Pharmaceutical Co., Ltd. (72) Inventor Toshiki Nakajima 3-24-1 Takada, Toshima-ku, Tokyo Inside Taisho Pharmaceutical Co., Ltd. (72) Inventor Atsushi Yoshimura 17 Shinko, Chiba City, Chiba Milling Company
Claims (2)
である二種以上の脂肪酸組成からなり、かつ最大重量比
を占める脂肪酸の含有量が81重量％以下である、デキス
トリン混合脂肪酸エステルを１重量％以上含む油性ゲル
基剤。1. A liquid non-polar solvent having 12 to 22 carbon atoms.
An oily gel base comprising 1% by weight or more of a dextrin-mixed fatty acid ester, which is composed of two or more kinds of fatty acid composition and is 81% by weight or less in content of the fatty acid occupying the maximum weight ratio.
脂肪酸組成が、ラウリン酸，ミリスチン酸，パルミチン
酸，ステアリン酸，アラキジン酸及びベヘン酸の中の二
種以上である、請求項１に記載の油性ゲル基剤。2. The oily gel base according to claim 1, wherein the fatty acid composition of the dextrin mixed fatty acid ester is two or more selected from lauric acid, myristic acid, palmitic acid, stearic acid, arachidic acid and behenic acid. .
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2537288A JPH0788296B2 (en) | 1988-02-05 | 1988-02-05 | Oily gel base |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2537288A JPH0788296B2 (en) | 1988-02-05 | 1988-02-05 | Oily gel base |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01203319A JPH01203319A (en) | 1989-08-16 |
| JPH0788296B2 true JPH0788296B2 (en) | 1995-09-27 |
Family
ID=12164007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2537288A Expired - Lifetime JPH0788296B2 (en) | 1988-02-05 | 1988-02-05 | Oily gel base |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0788296B2 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3019191B2 (en) * | 1995-04-05 | 2000-03-13 | 千葉製粉株式会社 | Novel dextrin fatty acid ester and its use |
| US5635165A (en) * | 1995-09-27 | 1997-06-03 | Helene Curtis, Inc. | Antiperspirant deodorant compositions |
| KR100388695B1 (en) | 1998-02-04 | 2003-06-25 | 다이요 가가꾸 가부시끼가이샤 | Fat solidifying agent, fats and foods |
| US20180311357A1 (en) * | 2015-12-28 | 2018-11-01 | Sekisui Chemical Co., Ltd. | External preparation and method for producing same |
| KR20230002871A (en) | 2020-04-29 | 2023-01-05 | 인테그리티 바이오-케미칼스, 엘엘씨 | Fatty acid reaction products of dextrin or dextran formulated with surfactants |
-
1988
- 1988-02-05 JP JP2537288A patent/JPH0788296B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH01203319A (en) | 1989-08-16 |
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