JPH0782110A - Bactericidal agent for mrsa - Google Patents

Abstract

PURPOSE:To obtain a bactericldal and antibacterial agent having completely different basic structure and different antibacterial and bactericidal mechanisms from the conventional antibiotics, free from the resistance to MRSA and exhibiting extremely excellent bactericidal activity against MRSA and suppressing activity against the proliferation of the microorganisms. CONSTITUTION:A bactericidal agent for the use of MRSA is composed of silica gel with the surface on which is placed the layer of aluminosilicate substituted with silver and optionally at least one kind of metal selected from the group of copper and zinc. In the bactericidal agent, the fine hole area is at least 0.3cm<3>/g and the specific surface area is at least 100m<2>/g. A polymer composition having bactericidal activity against MRSA contains the bactericidal agent and a polymer.

Description

Detailed Description of the Invention

[0001] Methicillin-resistant Staphylococcus aureus (Methicillin) for which almost all antibiotics are ineffective
-Resistant Staphylococcus
aureus (hereinafter abbreviated as “MRSA”) is becoming a major social problem. For example, infection in hospitals, nursing homes, and the like can cause serious situations that are life-threatening for patients, so MRSA measures are being actively promoted mainly by the Ministry of Health and Welfare. In addition, companies have developed MRSA disinfectant itself
Development of fiber materials and the like having an effect of suppressing proliferation against RSA has been extensively developed.

[0002] The present invention relates to a bactericide for microorganisms that easily acquire resistance to antibiotics.
More specifically, an object of the present invention is to provide an MR capable of exerting an excellent antibacterial effect for a long period of time without acquiring resistance.
It is intended to provide a sterilizing agent for SA and a sterilizing polymer composition containing the same.

The present inventors previously conducted research on an antibacterial composition using silica gel as a matrix, which is extremely effective against general bacteria and molds (Japanese Patent Laid-Open No. 252308/1993).
JP-A-4-295406). While continuing this research and development, an antibacterial agent having a bactericidal layer made of aluminosilicate ion-bonded to the surface of silica gel pores (micropores and macropores) has a completely different basic structure from conventional antibiotics. Since the antibacterial to bactericidal mechanisms are also different from each other, the inventors have found that they do not maintain resistance and exert a very excellent bactericidal activity and antiproliferative effect against MRSA, and arrived at the present invention.
At the same time, it was found that an MRSA bactericidal polymer having excellent performance can be obtained by dispersing the MRSA bactericidal agent of the present invention in a polymer, and the present invention was completed.

The present invention will be described in detail below. In addition, in the present specification, the values of the metal content, the pore volume (PV) and the specific surface area (SSA) are expressed as the values for the anhydrous antibacterial agent. Further, unless otherwise specified,% means% by weight.

The present invention provides an MR having an aluminosilicate layer substituted on the surface of the pores of silica gel with silver and optionally at least one metal selected from the group consisting of copper and zinc.
A germicide for SA, which has a pore volume of at least 0.3 cm ³ / g and a specific surface area of at least 10
It relates to a fungicide for MRSA, which is characterized in that it is 0 m ² / g.

First, the starting silica gel used for the synthesis of the MRSA germicide of the present invention will be described.
As is well known, silica gel has SiO ₂ as a main component,
It is an amorphous porous material represented by the general formula (SiO ₂ ) x (H ₂ O) y. Where x and y are each Si
It represents the number of molecules of O ₂ and H ₂ O. As is well known, silica gel has found widespread use as a desiccant, an adsorbent, a catalyst carrier, a filler for paper, rubber, plastics, and the like. By the way, silica gel used in the preparation of the fungicide for MRSA of the present invention is in the form of powder, particles, or a molded form (eg pellets, tablets, spheres).
Any of the above may be used, but it is desirable that they have a large number of capillary pores developed therein, and that the pore diameter (PD) and the specific surface area (SSA) are large. For example, preferably PV is at least 0.3 cm ³ / g as silica gel used in the present invention, 0.4 cm ³ / g or more of the more preferred. Further, the PD of silica gel is preferably as large as possible, but those having a particle size of 50 Å or more are preferably used, and those having a particle size of 70 Å or more are more preferable. Next, regarding SSA of silica gel, at least 100 m ² /
g is preferable, and 150 m ² / g or more is more preferable.

The reason why the silica gel material having the above-mentioned characteristics is preferable as a raw material is based on the following. The silica gel having the above-mentioned physical property values is very porous, and the surface of the pores thereof is very active and highly reactive. Using such silica gel, a chemical treatment is carried out by the method described below to form an antibacterial layer composed of an aluminosilicate ion-bonded with the silica gel matrix on the active surface of the pores, and then a sterilizing metal ion is ion-exchanged therewith. When the antibacterial to bactericidal layer is formed by being stably retained, the chemical species (Chemical species) and metal ions involved in the reaction are rapidly diffused in the pores, resulting in the chemical reaction on the pore surface of silica gel. In, there is an advantage of proceeding smoothly.

Silver is indispensable as a metal having a bactericidal action used in the formation of the antibacterial to bactericidal layer of the present application, and silver can be used alone, but if necessary, a group of antibacterial metals composed of copper and zinc. It can also be used in combination with at least one metal selected from the above.

In the present invention, the aluminosilicate layer (non-antibacterial) formed on the surface (pore surface) of the silica gel matrix has a composition represented by the following general formula.

[0010] Here, x and y are coefficients of the metal oxide and silicon dioxide, M is an ion-exchangeable metal, n is the valence of M, and Z is the number of water molecules. M is usually Li, N
It is a monovalent metal such as a or K, and may be NH ₄ ⁺ . Further, M is, for example, Mg, Ca, Sr, Ba, Mn,
It may be partially or completely replaced by a divalent metal such as Ni, Co or Fe. The antibacterial aluminosilicate layer is easily converted into a bactericidal layer by performing an ion exchange treatment with the metal ions having the bactericidal action described above.

The aluminosilicate layer (non-antibacterial) described above may be crystalline (zeolite) or amorphous, or both may coexist. The thickness and composition of this aluminosilicate layer can be adjusted by appropriately adjusting the physical properties and amount of the silica gel raw material, the alkali concentration, the amount of aluminate added, the reaction temperature, the reaction time and the like. SiO in the aluminosilicate layer, whether crystalline or amorphous
_{The 2} / Al ₂ O ₃ molar ratio is preferably in the range of 1.4-40.

Next, a specific method for producing the MRSA germicide according to the present invention will be described. After the chemical reaction of silica gel having the above-mentioned physical properties is carried out to form an antibacterial layer made of aluminosilicate on the surface of the pores of silica gel, the antibacterial layer is converted into a bactericidal layer for MR.
A bactericide for SA can be prepared. The antibacterial layer is formed by chemically treating porous silica gel with an alkaline solution and an aluminate solution. Examples of the former alkaline solution include NaOH, KOH, L
A solution of an alkali metal hydroxide such as iOH can be used, and the aqueous phase at the time of the reaction is kept alkaline to perform the treatment. On the other hand, as the latter aluminate solution, for example, an alkali metal aluminate solution such as NaAlO ₂ , KAlO ₂ , or LiAlO ₂ can be used. The above-mentioned chemical treatment of silica gel using the alkaline solution and the aluminate solution is performed at room temperature or under heating. By carrying out such a chemical treatment, SiO ₂ existing on the surface of the pores of silica gel reacts with aluminate, and the non-antibacterial aluminosilicate layer containing the ion-exchangeable metal is formed on the surface of the pores of silica gel. Is formed. Since this layer is ionically bonded to the silica gel of the matrix and is fixed very stably, no detachment from the matrix is observed. Next, the antibacterial agent for MRSA of the present invention is prepared by subjecting the antibacterial layer to ion exchange using the ions of the antibacterial metal. Examples of the solution of antibacterial metal ions include AgNO ₃
Single _{solution, AgNO 3 -Zn (NO 3)} 2, AgNO 3 -
_{Cu (NO 3) 2, AgNO} 3 -Zn (NO 3) 2 -Cu
A mixture of nitrates such as (NO ₃ ) ₂ , AgClO ₄ and Cu
A mixed solution of perchlorates such as (ClO ₄ ) ₂ or Zn (ClO ₄ ) ₂ can be used. Further, a mixed solution of Ag-acetate and Zn-acetate or Cu-acetate may be used. These antibacterial metal ion-containing liquids are kept neutral to slightly acidic prior to ion exchange. Of course, other antibacterial salts may coexist in the antibacterial salt solution used for ion exchange in the present invention. The substitution rate of the ion-exchangeable metal M in the antibacterial layer with the above-mentioned antibacterial metal ion is adjusted by adjusting the concentration and composition of the antibacterial salt solution to be used, the reaction time at the time of ion exchange, the reaction temperature or pH. Can be adjusted as desired.

The antibacterial agent for MRSA obtained by carrying out the above-mentioned chemical treatment for antibacterial activity is washed with water until no excessive antibacterial metal ions are observed in the filtrate, and then at 100 ° to 110 ° C.
After drying in the vicinity, the sterilizing agent for MRSA of the present application (water content of about 3
%) Is finally prepared. When it is necessary to further reduce the water content depending on the use of this agent, the water content can be easily reduced to 1% or less by drying under reduced pressure or heating at 200 ° to 350 ° C.

The antibacterial metal ions of Ag, Zn and Cu in the sterilizing agent for MRSA prepared by the above-mentioned method are ionically bonded to the antibacterial to sterilizing layer formed on the pore surface of the silica gel matrix, and in a preferable state. It is evenly distributed. Also, PV of MRSA bactericide prepared by the above-mentioned synthetic method
Is at least 0.3 cm ³ / g and SSA is at least 100 m ² / g.
It is essential for the rapid sterilization of SA. Since the bactericide according to the present invention has the above-mentioned preferable physical property values, the diffusion rate of antibacterial metal ions in the pores is extremely high, and almost all antibacterial metal ions existing on the surface of the mother body are effective by rapidly contacting with MRSA. There is an advantage that various sterilization is performed. Furthermore, the effective utilization rate of the antibacterial metal in this drug is very large, and therefore, MRSA can be sterilized with a small amount.

In the above-mentioned method of synthesizing the sterilizing agent for MRSA, the silver in the sterilizing agent for MRSA is, for example, 0.1 to 10%,
It is easy to keep the contents of zinc and copper in the range of 0.1 to 6%. In order to effectively sterilize MRSA, when the antibacterial metal in the MRSA fungicide is only silver, its content is preferably 0.2% or more. On the other hand, when the antibacterial metal in the sterilizer for MRSA is composed of i) silver-copper ii) silver-zinc and iii) silver-copper-zinc, the content of the antibacterial metal shows excellent sterilizing power against MRSA. In order to exert the effect, it is preferably within the following range.

In the case of (i): Ag ≧ 0.1%; Cu ≧ 1
% (Ii): Ag ≧ 0.1%; Zn ≧ 1% When (iii): Ag ≧ 0.1%; Cu + Zn ≧ 1% The sterilizer for MRSA of the present invention is usually in the form of powder to particles. However, microorganisms that easily acquire resistance to antibiotics by secondary processing of these and adding them to suspensions, minerals or polymers to form various molded bodies, foams, fiber forms, etc. It can be used in various fields to suppress the reproduction of For example, examples of application fields of this agent include water treatment, building materials, fibers, foods, and medical care.

The present invention further provides an MRSA bactericidal polymer composition containing the above-mentioned MRSA bactericide and a polymer.

As the polymer used in the MRSA bactericidal polymer composition of the present invention, both non-halogenated organic polymers and halogenated organic polymers can be used. The non-halogenated organic polymer is a synthetic or semi-synthetic non-halogenated organic polymer and is not particularly limited. For example, thermoplastic synthetic polymers such as polyethylene, polypropylene, polystyrene, polyamide, polyester, polyvinyl alcohol, polycarbonate, polyacetal, ABS resin, acrylic resin, fluororesin, polyurethane elastomer, polyester elastomer, phenol resin, urea resin, melamine resin, Examples thereof include thermosetting synthetic polymers such as unsaturated polyester resins, epoxy resins and urethane resins, and regenerated or semi-synthetic polymers such as rayon, cupra, acetate and triacetate. In order to further strengthen the sterilizing and suppressing effects on MRSA, it is preferable to process the polymer composition into a molded article having a large surface area, for example, a foam, a net or a fiber. Examples of the fiber-forming polymer include synthetic polymers such as nylon 6, nylon 66, polyvinyl alcohol, polyethylene terephthalate, polybutylene terephthalate, polyacrylonitrile, polyethylene, polypropylene and copolymers thereof, rayon, cupra, acetate, triacetate. And the like, or a semi-synthetic polymer. Knead the sterilizing agent for MRSA of the present application into polyester fiber,
It is also possible to use an antibacterial product to bring about the MRSA growth inhibitory effect, or to use it in combination with regular ester, cotton, rayon and the like. On the other hand, the halogenated organic polymer used in the present invention is not particularly limited, but examples thereof include polyvinyl chloride and polyvinylidene chloride.

Next, the particle size of the MRSA germicide used in the MRSA germicidal polymer composition of the present invention will be described. There is no limitation on the particle diameter, but there is a preferable range depending on the use. For example, a MRSA fungicide having a size of 50 to 100 mesh can be used as a mixture with a polymer, but when a more homogeneous dispersion in a polymer is required, a finer particle size, for example, 200 to 300 can be used. Particles of mesh or finer particles of several microns to tens of microns may be used. When the MRSA bactericidal polymer composition according to the present invention is in the form of a thick molded body, for example, when it is applied to various containers, pipes, granules or thick denier fibers, the particle size of the MRSA bactericide is For example, it may be several tens of microns or several hundreds of microns or more. On the other hand, when molding into fine denier fibers or films, it is desirable that the particle size is smaller. For example, in the case of clothing fibers, keep the particle size below 7 microns. Is desirable.

Other commonly used ingredients may be included in the MRSA germicidal polymer composition of the present invention. For example, polymerization catalysts, stabilizers, weathering (light) agents, flame retardants, improvers, brighteners, pigments (colorants), inorganic and organic fillers and various plasticizers, lubricants, etc. may be added as necessary. it can. The MRSA sterilization to imparting antibacterial activity to the molded body may be carried out on the entire polymer, or may be carried out partially on the polymer, if necessary. For example, the molded body may have a multi-layer structure, and its surface can be sterilized against MRSA. Further, in the case of fibers, the M of the present invention is applied to the core-sheath portion and the sheath portion of the cross-sectional yarn by utilizing a known conjugate spinning technique.
RSA biocidal polymer compositions can also be used.

The MRSA bactericidal polymer composition mainly composed of the bactericide for MRSA of the present invention and the polymer is MRS.
For the purpose of exerting a preferable deterrent effect and bactericidal activity on A, it is necessary to contain the bactericide for MRSA in an amount of at least 0.2% with respect to the polymer composition.

Next, examples of the present invention will be described.

Reference Example 1-2 (Synthesis of Intermediate Composition) In this Reference Example , synthesis of an intermediate composition having antibacterial properties made of aluminosilicate on the surface of the pores of silica gel obtained in the process of preparing the germicide for MRSA is prepared. For example.

Table 1 shows the synthesis conditions. In Example-1, TB gel (silica gel manufactured by Toyota Kako Co., Ltd .: SSA = 450 cm ^{2 /} g; PV = 0.75 cm ³ ) was used as a starting material.
/ G; PD = 60Å) is used as an amount, while example-
In No. 2, as a starting material, FD gel (Silica gel manufactured by Fuji Devewson Co., Ltd., SSA = 450 cm ² / g; P
The stated amount of V = 0.80 cm ³ / g; PD = 70Å) was used. The specified amount of water was added to the specified amount of silica gel material (dry product), and then the resulting mixture was stirred to homogenize. An aqueous solution containing the indicated amount of sodium aluminate was added to the mixture, followed by stirring. In this case, the pH of the aqueous phase at the end of addition of the synthetic raw materials was 12.7 in Example-1 and 12.3 in Example-2. In Example-1, the liquid temperature was maintained at about 25 ° C., the synthesis was performed for 14 hours under continuous stirring,
On the other hand, in Example-2, the liquid temperature was maintained at about 60 ° C., and synthesis was carried out for 10 hours under intermittent stirring. After completion of the synthesis reaction, the solid phase was filtered and then it was washed with warm water. The washing with warm water in this case was carried out until the pH of the filtrate reached 10 or less. Water, solid phase after washing is 100
The intermediate product was dried to obtain a dried product of the intermediate composition.

The analytical values of the obtained intermediate composition are shown in Table 1.

[0026]

[Table 1] Example 3-5 (Synthesis of sterilizing agent for MRSA) In this example, the intermediate composition prepared according to the production method of Reference Example 1-2 was used to carry out ion exchange of the intermediate composition to obtain the above-mentioned silica gel. The antibacterial to sterilization of the intermediate composition having the antibacterial layer formed on the pore surface of
A method for finally preparing a bactericide for RSA will be shown.

The synthesis conditions of the sterilizing agent for MRSA are shown in Table 2. In Example-3, the intermediate composition (Na = 4.31%; Al-5.00%) 1 obtained by the method of Reference Example 1 was used.
0.17M AgNO ₃ -0.4M · Z for 20g
240 ml of n (NO ₃ ) ₂ mixture was added and the reaction temperature was adjusted to 6
The ion exchange reaction was carried out with stirring for 5 hours while maintaining the temperature at 0 ° C. The pH of the aqueous phase during ion exchange was maintained at 3.95 as indicated. In this embodiment, Ag = 2.
A fungicide for MRSA having a composition of 91% and Zn = 2.81% was obtained. In Example-4, the intermediate composition obtained by the method of Reference Example 1 (Na = 3.83%; Al = 3.
24%) 120 g, 240 ml of 0.23 MAg NO ₃ solution was added, and ion exchange was carried out at room temperature under agitation under stirring, and finally a germicide for MRSA having a composition of Ag = 5.04%. was gotten. Further Example-5
Then, the intermediate composition obtained by the method of Reference Example 1 (Na = 3.
63%; Al = 3.10%) 0.065 for 60 g
120 ml of a mixture of MAgNO ₃ −0.20M Cu (NO ₃ ) ₂ was added, and under the indicated conditions, ion exchange was carried out at 60 ° C. under stirring, and finally Ag = 2.19.
%, Cu = 1.67%, a fungicide for MRSA was synthesized. MRS obtained in Examples 3, 4 and 5
The SSA value (measured by BET N ₂ gas adsorption method) of the sterilizing agent for A is 329, 324 and 320 cm ^2, respectively.
/ G. The PV values are 0.73 and 0.6, respectively.
6 and 0.65 cm ³ / g.

[0028]

[Table 2] Method for testing antibacterial activity against MRSA (i) Preparation of MRSA bacterial solution: 18 at 37 ° C in agar medium
The test cells that had been cultured for a period of time were treated with a phosphate buffer (1 / 15M;
The suspension was suspended in pH = 7.2) to prepare a suspension of 10 ⁸ cells / ml, which was diluted at appropriate times and used for the test.

(Ii) Test by Shake Flask Method (SF Method): When the MRSA fungicide of the present invention is in the form of granules to powder, the antibacterial activity test thereof is performed by the shake flask method (SF method: sanitary processing of textile products). The test method examined by the council). That is, a predetermined amount of the test sample was placed in an Erlenmeyer flask containing 100 ml or 200 ml of a phosphate buffer solution, and a test bacterial suspension was added to the Erlenmeyer flask at a concentration of -10 ⁵ cells / ml. ± 2 ° C
After shaking, the number of MRSA bacteria was measured over time. Further, even when the subject is the MRSA-containing bactericidal polymer (antibacterial fiber) of the present invention, the bactericidal test was carried out by the SF method.

(Iii) Test by the drop method: When the test object was a polymer molding containing the fungicide for MRSA of the present invention, the antibacterial activity test was conducted by the drop method. That is, the MRSA bacterial solution was dropped on each surface of the molded body and stored at 25 ° ± 2 ° C. When measuring the antibacterial activity, the number of bacteria was measured over time in the bacterial liquid on the specimen.

Example 6 This example relates to an antibacterial activity evaluation test of the micropowder germicidal agent for MRSA of the present invention.

Synthesized according to the above Examples 3 to 5,
Antibacterial agent for MRSA obtained by sterilizing the TB gel intermediate composition as an antibacterial agent in the form of fine powder of 100 to 200 mesh B
-1 (Ag = 3.45%; Zn = 1.69%) and B
-2 (Ag = 2.25%; Zn = 1.87%) was used to test the antibacterial activity against MRSA by the SF method. The test conditions and test results are shown in Table 3.
As shown, even if a small amount of this drug is used, MRSA
Was found to die completely within a very short time, within 20 minutes. Such a surprising effect of this drug on MRSA is a matter of special note to the present invention. Z-1 shown in Table 3 is a known fine powdery crystalline antibacterial zeolite [NaAgZ; Ag = 3.50%; Z = matrix of A-type zeolite (skeleton)], which is the present invention. Was used for the purpose of performance comparison of the fungicide for MRSA. The B-1 and B-2 fungicides of the present invention exert far superior power to MRSA as compared with known antibacterial zeolites.
More obvious than 3. In addition, Table 3 also shows the control value of MRSA.

[0033]

[Table 3] Example 7 This example relates to an antibacterial activity evaluation test of the coarse particle sterilizing agent for MRSA of the present invention.

M synthesized according to the above Examples 3 to 5
The bactericide for RSA was coarsely crushed to obtain coarse particles of 10 to 20 mesh. As shown in Table-4, C-2 (Ag =
2.77%) and C-3 (Ag = 4.33%) 10
An antibacterial activity evaluation test against MRSA was carried out by the SF method under the conditions shown in Table 4 by using two kinds of sterilizing agents for MRSA consisting of coarse particles of ˜20 mesh. As indicated, both C-2 and C-3 fungicides exerted an excellent effect on MRSA, with the bacterium being 100% dead at 30 minutes. C-Blank displayed on the other hand
(For blank test; intermediate composition synthesized in Reference Example-1 [Na
= 4.83%; Al = 4.95% (non-antibacterial)] is MR
It has no antibacterial activity against SA.

[0035]

[Table 4] Example-8 This example relates to a trial production of a polyester fiber containing a germicide for MRSA and an antibacterial activity evaluation test thereof.

A dried product of the MRSA fungicide (Ag = 2.91%; Zn = 2.81%; mother: FD gel) produced in Example 3 was jet-pulverized to have an average particle diameter Dav =
It was a fine powder of 2.5 μm. Further, the fine powder is dried under reduced pressure at 250 ° C., and the water content in the fine powder is 0.5.
It was kept below%.

Next, a polyethylene terephthalate chip having an intrinsic viscosity of 0.66 measured with a mixed solution of phenol-tetrachloroethane and the like at 20 ° C. was treated as described above, and the water content was 1%.
1% of the following fine powder of a sterilizer for MRSA was added to polyester, and the spinning temperature was 285 ° C. and the discharge rate was 290 g /
Melt spinning was performed from a spinneret having 400 holes at a spinning speed of 546 m / min for min. The obtained undrawn sub-tow was bundled into an undrawn fiber tow of about 2 million denier. This is 7
It was stretched to about 4 times at a temperature of 9 ° C., crimped, and then cut into staples.

An antibacterial activity evaluation test of the obtained staple against MRSA was carried out by the SF method under the indicated conditions, and the results are shown in Table-5. In the SF method test using the antibacterial polyester fiber (staple: PF) containing 1% of the treated product of the MRSA germicide of Example-3, M
The RSA is completely dead after 30 minutes. From the results of this test, there is no doubt that the polyester fiber containing the antibacterial agent for MRSA of the present invention exhibits an excellent antibacterial effect against MRSA. P shown in Table-5
F (Blank) is a polyester staple for blank test, which has no bactericide added thereto.

[0039]

[Table 5] Example-9 This example relates to a prototype of a low-density polyethylene (LDPE: Mirason 67P manufactured by Mitsui Petrochemical Co., Ltd.) molded product containing the antibacterial agent for MRSA of the present application and an antibacterial activity evaluation test thereof.

In this example, as a germicide for MRSA, a pulverized product of the germicide containing the TB gel produced in Example-4 as a matrix and containing Ag = 5.04% as an antibacterial metal was used. It was The bactericide of the above-mentioned Example-4 was pulverized by using a jet pulverizer to obtain a fine powder having Dav = 2.7 μm. Next, the fine powder is dried under reduced pressure at 250 ° C.,
Its water content was kept below 1%. Microbicide fine powder for MRSA that has been subjected to the above treatment and LDPE previously dried
Was collected and the resulting mixture was kneaded under heating at about 210 ° C. LD in this case
The content of MRSA fungicide in PE was kept at 1.5% as described in Table-6. Next, the obtained mixture is pressure-molded using a molding machine to obtain 50 × 50 m.
It was processed into a molded body of m (thickness of about 2 mm).

An evaluation test for MRSA was carried out by the drop method under the test conditions shown in Table 6 using the above LDPE sample. As shown in Table-6,
The polymer sample containing 1.5% of the sterilizing agent for MRSA of the present invention exhibits an excellent effect on MRSA.
The LDPE-Blank shown is the sample 5 for blank test.
It is 0 × 50 mm (thickness about 2 mm) and has no bactericide added. It has no effect on MRSA.

[0042]

[Table 6] In summary, the present invention is an MRSA having excellent bactericidal activity.
The present invention provides a germicidal agent itself and an MRSA germicidal polymer containing the germicidal agent, and the contribution of the present invention is believed to be extremely large.

Claims (5)

[Claims] 1. A fungicide for MRSA, comprising an aluminosilicate layer substituted on the surface of silica gel with at least one metal selected from the group consisting of silver and optionally copper and zinc, which comprises: Pore volume of at least 0.3 cm ³
/ G and a specific surface area of at least 100 m ² / g. 2. The M according to claim 1, wherein the antibacterial metal in the MRSA germicide is only silver, and the content thereof is at least 0.2% by weight of the anhydrous antibacterial agent.
Fungicide for RSA. 3. The antibacterial metal in the MRSA germicide comprises i)
I) Ag ≧ 0.1%; Cu composed of silver-copper, ii) silver-zinc, and iii) silver-copper-zinc, the content of the antibacterial metal is% by weight based on the anhydrous antibacterial agent, respectively. ≧ 1%, ii) Ag ≧ 0.1
%; Zn ≧ 1% and iii) Ag ≧ 0.1%; Cu + Zn
MRSA according to claim 1, characterized in that ≧ 1%.
Disinfectant. 4. The MR according to any one of claims 1 to 3.
An MRSA germicidal polymer composition comprising a SA germicide and a polymer. 5. The MRSA germicidal polymer composition according to claim 4, wherein the germicidal agent for MRSA is contained in an amount of at least 0.2% by weight based on the polymer composition.