JP2648282B2 - Fungicide for MRSA - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001] Methicillin-resistant Staphylococcus aureus (Methicillin) to which almost all antibiotics are ineffective
-Resistant Staphylococcus
aureus, hereinafter abbreviated as "MRSA"), is developing into a major social problem. For example, infections in hospitals, nursing homes, and the like can cause serious situations affecting the lives of patients, so MRSA measures are being actively promoted by the Ministry of Health and Welfare. In addition, companies have developed a fungicide for MRSA itself,
The development of fiber materials and the like having a growth inhibitory effect on RSA has been extensively developed.

[0002] The present invention relates to a bactericide for microorganisms that easily acquire resistance to antibiotics.
More specifically, an object of the present invention is to provide an MR capable of exhibiting an excellent antibacterial effect over a long period without acquiring resistance.
An object of the present invention is to provide a bactericide for SA and a bactericidal polymer composition containing the same.

[0003] The present inventors have previously conducted research on an antibacterial composition based on silica gel, which is extremely effective against general bacteria and molds (Japanese Patent Application Laid-Open No. 3-252308,
JP-A-4-295406). While this research and development is ongoing, the antibacterial agent having a sterilizing layer consisting of aluminosilicate ionically bonded to the surface of silica gel pores (micropores and macropores) has a completely different basic structure from conventional antibiotics. Since the antibacterial and bactericidal mechanisms are different from each other, it has been found that they do not maintain resistance and exhibit extremely excellent bactericidal activity and antiproliferative effect on MRSA.
In addition, the present inventors have found that an MRSA bactericidal polymer having excellent performance can be obtained by dispersing the bactericide for MRSA of the present invention in the polymer, and completed the present invention.

Hereinafter, the present invention will be described in detail. In the present specification, the values of the metal content, the pore volume (PV), and the specific surface area (SSA) are represented by the values of the anhydrous antibacterial agent. Unless otherwise specified,% is% by weight.

[0005] The present invention provides an MR having, on the pore surface of silica gel, an aluminosilicate layer substituted with silver and optionally at least one metal selected from the group consisting of copper and zinc.
A fungicide for SA, wherein the fungicide has a pore volume of at least 0.3 cm ³ / g and a specific surface area of at least 10
The present invention relates to a fungicide for MRSA, which is characterized by being 0 m ² / g.

First, silica gel as a starting material used in the synthesis of the bactericide for MRSA of the present invention will be described.
As is well known, silica gel contains SiO ₂ as a main component,
An amorphous porous material represented by the general formula (SiO ₂ ) x (H ₂ O) y. The above x and y are each Si
It represents the number of molecules of O ₂ and H ₂ O. As is well known, silica gel has found widespread use as a desiccant, adsorbent, catalyst carrier, filler for paper, rubber, plastics, and the like. The silica gel used for preparing the bactericide for MRSA of the present invention is in the form of powder, particles, or molded (eg, pellets, tablets, spheres).
Any of them may be used, but it is desirable that the pores have a myriad of pores developed therein and have a large pore diameter (PD) and a large specific surface area (SSA). For example, preferably PV is at least 0.3 cm ³ / g as silica gel used in the present invention, 0.4 cm ³ / g or more of the more preferred. Further, it is desirable that the PD of the silica gel is as large as possible, but those having 50 ° or more can be preferably used, and those having 70 ° or more are more preferable. Next, regarding SSA of silica gel, at least 100 m ² /
g and more preferably 150 m ² / g or more.

The reason why the silica gel material having the above-mentioned properties is preferable as a raw material is as follows. Silica gel having the above physical properties is very porous, and its pore surface is very active and reactive. Using such silica gel, a chemical treatment is performed by the method described below to form a non-antibacterial layer composed of an aluminosilicate ion-bonded to the base of the silica gel on the active surface of the pores, and then ion-exchanges a sterilizing metal ion thereto. When forming an antimicrobial-sterilizing layer by keeping it stable, the chemical species involved in the reaction (Chemical species) and metal ions are rapidly diffused in the pores, and as a result, the chemical reaction is carried out on the pore surface of the silica gel. Has the advantage of proceeding smoothly.

Silver is indispensable as a metal having a bactericidal action used in the formation of the antibacterial-bactericidal layer of the present invention, and silver can be used alone, but if necessary, a group of antibacterial metals consisting of copper and zinc. It can be used in combination with at least one metal selected from the group consisting of:

In the present invention, the aluminosilicate layer (antibacterial) formed on the surface (pore surface) of the silica gel matrix has a composition represented by the following general formula.

[0010] Where x and y are the coefficients of the metal oxide and silicon dioxide, M is the ion-exchangeable metal, n is the valence of M, and Z is the number of water molecules. M is usually Li, N
It is a monovalent metal such as a or K, and may be NH ₄ ⁺ . M is, for example, Mg, Ca, Sr, Ba, Mn,
It may be partially or completely substituted by a divalent metal such as Ni, Co or Fe. The non-antibacterial aluminosilicate layer can be easily converted to a sterilizing layer by ion-exchange treatment with the above-mentioned metal ions having a sterilizing action.

The above-mentioned layer made of aluminosilicate (antibacterial) may be crystalline (zeolite) or amorphous, or both may be present together. The thickness and composition of the aluminosilicate layer can be adjusted by appropriately adjusting the physical properties and use amount of the silica gel raw material, the alkali concentration, the addition amount of the aluminate, the reaction temperature and the reaction time, and the like. Regardless of crystalline or amorphous, SiO of aluminosilicate layer
₂ / Al ₂ O ₃ molar ratio is preferably in the range of 1.4 to 40.

Next, a specific method for producing the bactericide for MRSA according to the present invention will be described. After performing a chemical reaction of silica gel having the above-described physical properties to form a non-antibacterial layer made of aluminosilicate on the surface of the pores of the silica gel, this is turned into an antibacterial layer and converted to a sterilizing layer to thereby obtain an MR layer.
A bactericide for SA can be prepared. The formation of the antibacterial layer is carried out by chemically treating porous silica gel with an alkaline solution and an aluminate solution. Examples of the former alkaline solution include NaOH, KOH, L
A solution of an alkali metal hydroxide such as iOH can be used, and the aqueous solution phase during the reaction is kept alkaline to perform the treatment. On the other hand, as the latter aluminate solution, for example, an aluminate solution of an alkali metal such as NaAlO ₂ , KAlO ₂ , or LiAlO ₂ can be used. The above-described chemical treatment of silica gel using the alkaline solution and the aluminate solution is performed at normal temperature or under heating. By performing such a chemical treatment, SiO ₂ present on the surface of the pores of the silica gel reacts with the aluminate to form an antibacterial aluminosilicate layer containing an ion-exchangeable metal on the surface of the silica gel pore. Formed. Since this layer is extremely stably fixed by ionic bonding with the base silica gel, no dropout from the base is observed. Next, the bactericide for MRSA of the present invention is prepared by ion-exchanging the non-antibacterial layer with the ions of the antibacterial metal. As a solution of the antibacterial metal ion, for example, AgNO ₃
AgNO ₃ —Zn (NO ₃ ) ₂ , AgNO ₃ −
Cu (NO ₃ ) ₂ , AgNO ₃ —Zn (NO ₃ ) ₂ —Cu
A nitrate mixture such as (NO ₃ ) ₂ , AgClO ₄ and Cu
A mixed solution of perchlorate such as (ClO ₄ ) ₂ or Zn (ClO ₄ ) ₂ can be used. Further, a mixed solution of Ag-acetate and Zn-acetate or Cu-acetate may be used. These antimicrobial metal ion-containing liquids are kept neutral to slightly acidic prior to ion exchange. In the antibacterial salt solution used for ion exchange in the present invention, of course, other antibacterial salts may coexist. The replacement ratio of the ion-exchangeable metal M in the non-antibacterial layer with the antibacterial metal ion is adjusted by adjusting the concentration and composition of the antibacterial salt solution to be used, and the reaction time, reaction temperature or pH during ion exchange. Can be adjusted as desired.

The bactericide for MRSA obtained by carrying out the antibacterial treatment by the above-mentioned chemical treatment is washed with water until no excessive antibacterial metal ion is found in the filtrate, and then heated at 100 ° C. to 110 ° C.
It is dried in the vicinity and the germicide for MRSA of the present application (water content about 3
%) Is finally prepared. When it is necessary to further reduce the water content depending on the use of the present agent, drying under reduced pressure is carried out, or the water content is easily reduced to 1% or less by heating to 200 to 350 ° C.

The antibacterial metal ions of Ag, Zn and Cu in the bactericide for MRSA prepared by the above-mentioned method are ionically bonded to the antibacterial to bactericidal layer formed on the surface of the pores of the silica gel matrix. Homogeneously distributed. Also, the bactericide for MRSA prepared by the above-mentioned synthesis method, PV
Is at least 0.3 cm ³ / g and SSA is at least 100 m ² / g.
It is essential for the rapid sterilization of SA. Since the bactericide according to the present invention has the above preferable physical property values, the diffusion rate of the antibacterial metal ions in the pores is extremely high, and almost all the antibacterial metal ions existing on the surface of the mother body come into rapid contact with MRSA and are effective. There is an advantage that a proper sterilization is performed. Furthermore, the effective utilization rate of the antibacterial metal in the present agent is very large, and therefore, it is possible to sterilize MRSA with a small amount of use.

In the above-mentioned method for synthesizing a fungicide for MRSA, silver in the fungicide for MRSA is, for example, 0.1 to 10%,
It is easy to keep the contents of zinc and copper in the range of 0.1 to 6%. In order to effectively sterilize MRSA, when the antibacterial metal in the present MRSA germicide is silver only, its content is desirably 0.2% or more. On the other hand, when the antibacterial metal in the bactericide for MRSA is composed of i) silver-copper ii) silver-zinc and iii) silver-copper-zinc, the antibacterial metal content has an excellent bactericidal activity against MRSA. In order to exert the effect, it is preferable to be in the following range.

In the case of (i): Ag ≧ 0.1%; Cu ≧ 1
% (Ii): Ag ≧ 0.1%; Zn ≧ 1% (iii): Ag ≧ 0.1%; Cu + Zn ≧ 1% The germicide for MRSA of the present invention is usually in the form of powder to particles. However, microorganisms that easily obtain resistance to antibiotics by secondary processing and adding them to suspensions, inorganic or polymer materials to form various molded products, foams, fiber forms, etc. It can be used in various fields that control the reproduction of spores. For example, application fields of this agent include water treatment, building materials, fibers, foods, medical treatments, and the like.

Further, the present invention provides an MRSA bactericidal polymer composition comprising the above-mentioned bactericide for MRSA and a polymer.

As the polymer used in the MRSA fungicidal polymer composition according to the present invention, both non-halogenated organic polymers and halogenated organic polymers can be used. The non-halogenated organic polymer is a synthetic or semi-synthetic non-halogenated organic polymer, and is not particularly limited. For example, thermoplastic synthetic polymers such as polyethylene, polypropylene, polystyrene, polyamide, polyester, polyvinyl alcohol, polycarbonate, polyacetal, ABS resin, acrylic resin, fluororesin, polyurethane elastomer, polyester elastomer, phenol resin, urea resin, melamine resin, Examples include thermosetting synthetic polymers such as unsaturated polyester resins, epoxy resins, and urethane resins, and regenerated or semi-synthetic polymers such as rayon, cupra, acetate, and triacetate. In order to further enhance the sterilizing and suppressing effects on MRSA, it is preferable to process the polymer composition into a molded product having a large surface area, such as a foam, a net, or a fiber. Examples of the fiber-forming polymer include synthetic polymers such as nylon 6, nylon 66, polyvinyl alcohol, polyethylene terephthalate, polybutylene terephthalate, polyacrylonitrile, polyethylene, polypropylene and copolymers thereof, rayon, cupra, acetate, and triacetate. Regenerated or semi-synthetic polymers are exemplified. Kneading the fungicide for MRSA of this application into polyester fiber,
It is also possible to use the antibacterial substance to bring about an MRSA proliferation inhibitory effect, or to use it in combination with regular esters, cotton, rayon and the like. On the other hand, the halogenated organic polymer used in the present invention is not particularly limited, but examples thereof include polyvinyl chloride and polyvinylidene chloride.

Next, the particle size of the bactericide for MRSA used in the MRSA bactericidal polymer composition according to the present invention will be described. There is no particular restriction on the particle size, but there is a preferred range depending on the application. For example, a fungicide for MRSA having a size of 50 to 100 mesh can be used in combination with a polymer, but if a more homogeneous dispersion in the polymer is required, a finer particle size, for example, 200 to 300 Mesh particles or finer particles of several microns to tens of microns may be used. When the MRSA bactericidal polymer composition according to the present invention is in the form of a thick molded product, for example, when applied to various containers, pipes, granules or thick denier fibers, the particle size of the bactericide for MRSA is as follows: For example, it may be several tens of microns or several hundred microns or more. On the other hand, in the case of molding into fine denier fiber or film, the particle diameter is preferably smaller, and for example, in the case of clothing fibers, the particle diameter is kept at 7 μm or less. It is desirable.

Other commonly used components can be added to the MRSA bactericidal polymer composition of the present invention. For example, polymerization catalysts, stabilizers, weathering (light) agents, flame retardants, improvers, brighteners, pigments (colorants), inorganic and organic fillers, various plasticizers, lubricants, and the like can be added as necessary. it can. The MRSA sterilization to the application of the antibacterial activity to the molded body may be performed on the entire polymer or, if necessary, on the polymer. For example, the molded body may have a multilayer structure, and its surface may be sterilized against MRSA. In the case of a fiber, the known conjugate spinning technique is used to apply the M
RSA germicidal polymer compositions can also be used.

The MRSA fungicidal polymer composition comprising the MRSA fungicide of the present invention and a polymer is MRS.
For the purpose of exhibiting a favorable deterrent effect and bactericidal effect on A, it is necessary that the bactericide for MRSA be contained in the polymer composition at least 0.2%.

Next, an embodiment of the present invention will be described.

Reference Example 1-2 (Synthesis of Intermediate Composition) In this reference example, a non-antibacterial intermediate composition composed of aluminosilicate is formed on the surface of the pores of silica gel obtained in the process of preparing a bactericide for MRSA. It is about an example.

Table 1 shows the synthesis conditions. In Example 1, a TB gel (silica gel manufactured by Toyoda Chemical Co., Ltd .: SSA = 450 cm ^{2 /} g; PV = 0.75 cm ³ ) was used as a starting material.
/ G; PD = 60 °), while the example-
In Example 2, FD gel (silica gel manufactured by Fuji Deveison Co., Ltd., SSA = 450 cm ² / g; P
V = 0.80 cm ³ / g; PD = 70 °). Water was added in the indicated amount to the indicated amount of the silica gel material (dry product), and then the resulting mixture was stirred and homogenized. Stirring was performed after an aqueous solution containing the indicated amount of sodium aluminate was added to the mixture. In this case, the pH of the aqueous phase at the end of the addition of the synthesis raw material was 12.7 in Example-1 and 12.3 in Example-2. In Example 1, the solution temperature was maintained at about 25 ° C., and the synthesis was performed for 14 hours under continuous stirring.
On the other hand, in Example 2, the liquid temperature was maintained at about 60 ° C., and the synthesis was performed for 10 hours under intermittent stirring. After completion of the synthesis reaction, the solid phase was filtered, which was then washed with warm water. Washing with warm water in this case was performed until the pH of the filtrate reached 10 or less. Water, after washing, solid phase 100
Drying at ゜ to 110 ° C. gave a dried product of the intermediate composition.

The analytical values of the obtained intermediate composition are shown in Table 1.

[0026]

[Table 1] Example 3-5 (Synthesis of bactericide for MRSA) In this example, ion exchange was performed using an intermediate composition prepared according to the production method of Reference Example 1-2, and the silica gel was used. The intermediate composition having a non-antibacterial layer formed on the surface of the pores of
A method for finally preparing a fungicide for RSA will be described.

Table 2 shows the conditions for synthesizing the bactericide for MRSA. In Example 3, an intermediate composition (Na = 4.31%; Al-5.00%) obtained by the method of Reference Example 2 was used.
0.17M AgNO ₃ -0.4M · Z for 20g
n (NO ₃ ) ₂ mixed solution (240 ml) was added,
The ion exchange reaction was carried out under stirring for 5 hours while maintaining the temperature at 0 ° C. The pH of the aqueous phase during ion exchange was maintained at 3.95 as indicated. In this embodiment, Ag = 2.
A fungicide for MRSA having a composition of 91% and Zn = 2.81% was obtained. In Example 4, the intermediate composition obtained by the method of Reference Example 1 (Na = 3.83%; Al = 3.
24%) 120 g of a 0.23 MAgNO ₃ solution was added to 120 g, and ion exchange was performed under stirring at room temperature under the indicated conditions, and finally a fungicide for MRSA having a composition of Ag = 5.04% was gotten. Further, Example-5
In the intermediate composition obtained by the method of Reference Example 1 (Na = 3.
63%; Al = 3.10%) 0.065 for 60 g
120 ml of a mixed solution of AgNO ₃ -0.20 M Cu (NO ₃ ) ₂ was added, ion exchange was carried out under stirring at 60 ° C. under the indicated conditions, and finally Ag = 2.19
%, Cu = 1.67%, a fungicide for MRSA was synthesized. MRS obtained in Examples 3, 4 and 5
The SSA value of the fungicide for A (measured by the B ₂ N ₂ gas adsorption method) is 329, 324 and 320 cm ^2, respectively.
/ G. The PV values were 0.73 and 0.6, respectively.
6 and 0.65 cm ³ / g.

[0028]

[Table 2] Test method for antibacterial activity against MRSA (i) Preparation of MRSA bacterial solution: 18 minutes at 37 ° C. on agar medium
The test cells cultured for a period of time were mixed with a phosphate buffer (1 / 15M;
The suspension was suspended at pH = 7.2) to prepare a 10 ⁸ cells / ml suspension, which was diluted as appropriate and used for the test.

(Ii) Test by Shake Flask Method (SF Method): When the germicidal agent for MRSA of the present invention is in the form of granular to powder, the antibacterial activity test is performed by the shake flask method (SF method: Sanitary processing of textile products). Test method considered by the council). That is, a predetermined amount of a test sample is placed in an Erlenmeyer flask containing 100 ml or 200 ml of a phosphate buffer, and a test bacterial suspension is added to the Erlenmeyer flask at a concentration of 10 ⁵ cells / ml. ± 2 ℃
And the number of MRSA bacteria was measured over time. Further, when the subject was the MRSA-containing bactericidal polymer (antibacterial fiber) of the present invention, the bactericidal test was carried out by the SF method.

(Iii) Test by drop method: When the specimen was a polymer molded article containing the bactericide for MRSA of the present invention, the antibacterial activity test was performed by the drop method. That is, the MRSA bacterial solution was dropped on each surface of the molded body and stored at 25 ° ± 2 ° C. In the measurement of the antibacterial activity, the number of bacteria was measured over time in the bacterial solution on the specimen.

Example 6 This example relates to a test for evaluating the antibacterial activity of the micropowder bactericide for MRSA of the present invention.

The compound was synthesized according to the above-mentioned Examples 3 to 5,
A fungicide B in which the TB gel intermediate composition is made into a micropowder of 100-200 mesh as a fungicide for MRSA obtained by antibacterial-sterilizing.
-1 (Ag = 3.45%; Zn = 1.69%) and B
An antibacterial activity test against MRSA was performed by SF method using two types of -2 (Ag = 2.25%; Zn = 1.87%). Table 3 shows the test conditions and test results.
As indicated, even with a small amount of this drug, MRSA
Was found to be completely killed in a very short time, within 20 minutes. Such a surprising effect of the present agent on MRSA is a remarkable matter of the present invention. Z-1 shown in Table 3 is a known finely powdered crystalline antibacterial zeolite [NaAgZ; Ag = 3.50%; Z = base (skeleton) of A-type zeolite], which is the present invention. Was used for the purpose of comparing the performance of the germicides for MRSA. Table 1 shows that the B-1 and B-2 germicides of the present invention exert much more power against MRSA than known antibacterial zeolites.
It is more obvious than 3. Table 3 also shows the control values of MRSA.

[0033]

[Table 3] Example 7 This example relates to an antibacterial activity evaluation test of the bactericide for MRSA in the form of coarse particles of the present invention.

M synthesized according to the above Examples 3 to 5
The fungicide for RSA was coarsely pulverized into coarse particles of 10 to 20 mesh. As shown in Table 4, C-2 (Ag =
2.77%) and 10 of C-3 (Ag = 4.33%).
An antibacterial activity evaluation test for MRSA was performed by SF method using two kinds of MRSA bactericides consisting of coarse particles of ２０20 mesh under the conditions described in Table-4. As indicated, both C-2 and C-3 fungicides exert excellent effects on MRSA, and the bacteria are 100% killed after 30 minutes. C-Blank displayed on the other hand
(For blank test; intermediate composition synthesized in Reference Example-1 [Na
= 4.83%; Al = 4.95% (antibacterial)] is MR
No antibacterial activity against SA.

[0035]

[Table 4] Example 8 This example relates to a trial production example of a polyester fiber containing a bactericide for MRSA and an antibacterial evaluation test thereof.

A dry product of the fungicide for MRSA (Ag = 2.91%; Zn = 2.81%; base: FD gel) experimentally produced in Example-3 was jet-pulverized to give an average particle diameter Dav =
2.5 μm fine powder was obtained. Further, the above fine powder is dried under reduced pressure at 250 ° C.
%.

Next, a polyethylene terephthalate chip having an intrinsic viscosity of 0.66 measured with a mixed solution of phenol and ethane tetrachloride in an equal weight at 20 ° C. was subjected to the above treatment, and the water content was 1%.
1% of the following fine powder of a bactericide for MRSA was added to polyester, and a spinning temperature of 285 ° C. and a discharge amount of 290 g /
at a spinning speed of 546 m / min from a 400-hole spinneret. The obtained undrawn subtow was bundled to obtain an undrawn fiber tow of about 2,000,000 denier. This is 7
It was stretched about 4 times at a temperature of 9 ° C., crimped and cut to give staples.

An antibacterial activity evaluation test of the obtained staples against MRSA was carried out by the SF method under the indicated conditions, and the results are shown in Table-5. In a test by the SF method using an antibacterial polyester fiber (staple: PF) containing 1% of the treated product of the bactericide for MRSA of Example-3, M
The RSA is completely dead after 30 minutes. From the test results, there is no doubt that the polyester fiber containing the bactericide for MRSA of the present application exhibits an excellent antibacterial effect on MRSA. P shown in Table-5
F (Blank) is a blank staple polyester staple without the fungicide of the present application.

[0039]

[Table 5] Example -9 This example relates to a trial production example of a low-density polyethylene (LDPE: Mirason 67P manufactured by Mitsui Petrochemical Co., Ltd.) containing the bactericide for MRSA of the present application and an antibacterial evaluation test thereof.

In this embodiment, as a germicide for MRSA, a crushed product of a germicide containing TB = 5.04% as an antibacterial metal based on the TB gel experimentally produced in Example-4 was used. Was. The disinfectant of Example 4 described above was pulverized using a jet pulverizer to obtain a fine powder having Dav = 2.7 μm. Next, the fine powder is dried under reduced pressure at 250 ° C.
Its moisture content was kept below 1%. The bactericide fine powder for MRSA which has been subjected to the above treatment and LDPE which has been dried in advance
Was collected and the resulting mixture was kneaded under heating at about 210 ° C. In this case LD
The content of the bactericide for MRSA in PE was maintained at 1.5% as described in Table-6. Next, the obtained admixture was molded under pressure using a molding machine to form a 50 × 50 m
m (about 2 mm thick).

Using the LDPE specimens described above, an evaluation test for MRSA was conducted by the drop method under the test conditions described in Table-6. As shown in Table-6,
The polymer sample containing 1.5% of the bactericide for MRSA of the present invention has an excellent effect on MRSA.
Note that the indicated LDPE-Blank is a sample 5 for blank test.
0 × 50 mm (thickness: about 2 mm) with no germicide added. This has no effect on MRSA.

[0042]

[Table 6] In short, the present invention is an MRSA having excellent bactericidal activity.
The present invention provides a bactericide for use per se and an MRSA bactericidal polymer containing the same, and it is believed that the contribution of the present invention is extremely large.

Claims (5)

(57) [Claims] 1. A bactericide for MRSA having an aluminosilicate layer substituted on a surface of silica gel with at least one metal selected from the group consisting of silver and optionally copper and zinc, the bactericide for MRSA comprising: Pore volume of at least 0.3 cm ³
/ G and a specific surface area of at least 100 m ² / g. 2. The M according to claim 1, wherein the antibacterial metal in the germicide for MRSA is silver only, and its content is at least 0.2% by weight of the antibacterial agent in an anhydrous state.
Fungicide for RSA. 3. The antibacterial metal in the bactericide for MRSA comprises: i)
Silver-copper, ii) silver-zinc, and iii) silver-copper-zinc, wherein the content of the antimicrobial metal is% by weight relative to the anhydrous antimicrobial agent, i) Ag ≧ 0.1%; Cu ≧ 1%, ii) Ag ≧ 0.1
%; Zn ≧ 1% and iii) Ag ≧ 0.1%; Cu + Zn
2. The MRSA according to claim 1, wherein ≧ 1%.
Disinfectant. 4. An MR according to claim 1, wherein:
An MRSA bactericidal polymer composition comprising a bactericide for SA and a polymer. 5. The bactericidal polymer composition according to claim 4, wherein the bactericide for MRSA is contained at least 0.2% by weight based on the polymer composition.