JPH0779833B2 - Γ-ray irradiation resistant body fluid treatment device - Google Patents
Γ-ray irradiation resistant body fluid treatment deviceInfo
- Publication number
- JPH0779833B2 JPH0779833B2 JP63199373A JP19937388A JPH0779833B2 JP H0779833 B2 JPH0779833 B2 JP H0779833B2 JP 63199373 A JP63199373 A JP 63199373A JP 19937388 A JP19937388 A JP 19937388A JP H0779833 B2 JPH0779833 B2 JP H0779833B2
- Authority
- JP
- Japan
- Prior art keywords
- body fluid
- fluid treatment
- treatment device
- formula
- housing case
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Description
【発明の詳細な説明】 ［産業上の利用分野］ 本発明は、人口腎臓、血漿口過器、血液浄化器、血漿分
離装置等の体液処理装置に関するものであり、特にγ線
照射に良好な耐久性を有する体液処理装置を提供するも
のである。TECHNICAL FIELD The present invention relates to a body fluid treatment device such as an artificial kidney, a plasma mouthpiece device, a blood purifier, and a plasma separation device, and is particularly suitable for γ-ray irradiation. A body fluid treatment device having durability.
［従来技術及び従来技術の課題］ 現在使用されている体液処理装置は、ハウジングケース
の内部には、多数の中空系膜が収納され該中空糸膜の両
端部は、ポッテング剤で固定され、ハウジングケースの
胴体部には、透析液等の体液処理液の導入口及び導出口
が設けられ、さらにハウジングケースの両側部に、血液
等の体液の導出口（導入口）を設けた封止部材が装着さ
れている。[Prior Art and Problems of Prior Art] In a body fluid treatment device currently in use, a large number of hollow membranes are housed inside a housing case, and both ends of the hollow fiber membranes are fixed with potting agents. The body of the case is provided with an inlet and an outlet for a body fluid treatment liquid such as a dialysate, and a sealing member provided with an outlet (inlet) for a body fluid such as blood on both sides of the housing case. It is installed.
通常、これらのハウジングケースは、ポリスチレン樹
脂、スチレンブタジエンコポリマー（以下スチレン系樹
脂）等のγ線に対し着色、強度劣化が少ない材料が使用
されている。Usually, these housing cases are made of a material such as polystyrene resin, styrene-butadiene copolymer (hereinafter referred to as styrene resin), which is less likely to be colored and deteriorated by γ-rays.
しかしながら、ポリスチレン樹脂は、強度面で弱く特に
人口腎臓等のハウジングケースで使用する際、使用前の
プライミング操作時において体液処理装置内の気泡を除
去する時あるいは使用後の返血操作の時において、操作
効率を良くするためにハウジングケースに衝撃を与える
ためクラックが発生して液漏れが生じる原因となってい
た。However, polystyrene resin is weak in strength, especially when used in a housing case such as an artificial kidney, when removing air bubbles in the body fluid treatment device during priming operation before use, or during blood returning operation after use, In order to improve the operation efficiency, a shock is applied to the housing case, which causes cracks and liquid leakage.
また輸送中にも何らかの衝撃が加わるので前記と同様の
トラブルがあとをたたない。Also, since some kind of impact is applied during transportation, the same troubles as described above will not occur.
他方、ポリカーボネート樹脂は、ポリスチレン樹脂のよ
うに強度劣化は少ないが、γ線を照射すると黄変が強く
透明感が要求されるハウジングケースに使用する際には
外観をそこない、衛生性を損なうことは言うまでもな
く、作業者に血液の流れが把握しにくい等の使用上の不
安を与えるものであった。On the other hand, polycarbonate resin has less strength deterioration like polystyrene resin, but when used in a housing case that is strongly yellowed when irradiated with γ-rays and has a transparent appearance, it has a poor appearance and impairs hygiene. Needless to say, it gives the worker anxiety in use, such as difficulty in grasping blood flow.
［課題を解決するための手段］ 以上の課題を解決するために本発明者らは鋭意検討を重
ねた結果次の発明に到達した。[Means for Solving the Problems] In order to solve the above problems, the inventors of the present invention have made extensive studies and arrived at the next invention.
本発明の体液処理装置は基本的に体液処理部材、ハ
ウジングケース封止部材から構成され、体液処理部材
としては、中空状もしくは平板状の半透膜、分離膜、口
過膜又は吸着剤等が使用され、半透膜、分離膜、口過膜
の材質は、エチレン−ビニルアルコール共重合体、ポリ
スルホン、ポリメチルメタクリレート等が使用される
が、耐γ線照射性を有するものであれば特にこれらの材
質に限定されるものではない。The body fluid treatment device of the present invention basically comprises a body fluid treatment member and a housing case sealing member, and as the body fluid treatment member, a hollow or flat plate semipermeable membrane, a separation membrane, a permeation membrane or an adsorbent is used. Used, as the material of the semipermeable membrane, the separation membrane, and the permeation membrane, ethylene-vinyl alcohol copolymer, polysulfone, polymethylmethacrylate, etc. are used. The material is not limited to.
吸着剤は天然又は合成高分子を被覆した活性炭、ガラス
ビーブ等が使用されるが、耐γ線照射性を有するもので
特にこれらに限定されるものではない。As the adsorbent, activated carbon coated with a natural or synthetic polymer, glass bead, or the like is used, but it has resistance to γ-ray irradiation and is not particularly limited thereto.
ハウジングケースは、両端の開口した筒状体から構成さ
れ、必要に応じて側部に例えば透析液等の体液処理液の
導入口と導出口が形成されている。The housing case is composed of a tubular body having openings at both ends, and an inlet and an outlet for a body fluid treatment liquid such as a dialysate are formed on the side portions as needed.
該ハウジングケースは、芳香族ポリカーボネート（Ａ）
と下記構成単位又は及びを有するコーポリエステ
ル（Ｂ）及び一般式で被わされるペンタエリスリトー
ルジフォスファイト系安定剤を配合し、かつ前記芳香族
ポリカーボネート（Ａ）と構成単位又は及びを有
するコーポリエステル（Ｂ）との下式で表わされる配
合比Ｒが、0.3≦Ｒ≦0.6の範囲に設定された組成物から
射出成形またはブロー成形等により形成される。The housing case is made of aromatic polycarbonate (A).
And a copolyester (B) having the following constitutional units or and and a pentaerythritol diphosphite stabilizer covered by the general formula, and a copolyester having the aromatic polycarbonate (A) and the constitutional units or and The composition ratio R represented by the following formula with (B) is formed by injection molding, blow molding, or the like from a composition in which 0.3 ≦ R ≦ 0.6 is set.
構成単位； 構成単位； （式中のｎは、２〜10の整数であり、Ｒは芳香族ジカル
ボン酸残基である。） 一般式； （式中のＲは、炭素数６以上の脂肪族、脂環族、または
芳香族性の炭化水素基である。） 式;R＝（Ｂ）／（Ａ） … Ｒが0.3以下では、γ線照射線量が大きい場合や体液処
理装置の製造後から使用時までの間に長時間経過した場
合、黄変等の変色を生じやすいので好ましくない。Building units; Building units; (In the formula, n is an integer of 2 to 10 and R is an aromatic dicarboxylic acid residue.) General formula; (R in the formula is an aliphatic, alicyclic, or aromatic hydrocarbon group having 6 or more carbon atoms.) Formula; R = (B) / (A) ... When R is 0.3 or less, γ If the radiation dose is high or if a long time elapses after the body fluid treatment device is manufactured and before it is used, discoloration such as yellowing is likely to occur, which is not preferable.
またＲが0.7以上では、黄変等の変色は激減するが、成
形性が悪くなるとともに強度が低下するので好ましくな
い。When R is 0.7 or more, discoloration such as yellowing is drastically reduced, but moldability is deteriorated and strength is lowered, which is not preferable.
封止部材は血液等の体液の導入口（導出口）が形成さ
れ、前記ハウジングと同一の組成を用いて射出成形等に
より形成される。The sealing member has an inlet (outlet) for introducing body fluid such as blood, and is formed by injection molding using the same composition as the housing.
［実施例］ 前述の（Ａ）、（Ｂ）、（Ｃ）を所定の割合に配合した
組成物を射出成形により、体液処理液の導入口及び導出
口を両側部に一体に成形したハウジングケース及び体液
の導入口（導出口）を有する封止部材を形成した。[Example] A housing case in which the inlet and outlet of the body fluid treatment liquid are integrally formed on both sides by injection molding of a composition in which the above-mentioned (A), (B), and (C) are mixed in a predetermined ratio. And a sealing member having an inlet (outlet) for body fluid was formed.
続いて、ハウジング内に、エチレン−ビニルアルコール
共重合体よになる中空糸膜を装填して、該ハウジングの
両端部に固定部材を装填して、両端からポリウレタンを
注入しながら、遠心力を付与し、ポリウレタンを固化さ
せた。Subsequently, a hollow fiber membrane made of an ethylene-vinyl alcohol copolymer is loaded into the housing, fixing members are loaded at both ends of the housing, and a centrifugal force is applied while injecting polyurethane from both ends. Then, the polyurethane was solidified.
前記固定部材を取り外して、固化したポリウレタンを切
断して、中空糸膜の両端部を開口させて封止部材を装着
した。The fixing member was removed, the solidified polyurethane was cut, both ends of the hollow fiber membrane were opened, and the sealing member was attached.
以上のようにして組み立てた体液処理装置について、γ
線照射等を行なって、 （１）ハウジングケースの構成部材自体の適合性試験 （２）モジュール化後の適合性試験を従来の体液処理装
置と比較しながら実施した。これらの結果を表１及び表
２に掲載する。Regarding the body fluid treatment device assembled as described above, γ
After irradiation with rays, etc., (1) the compatibility test of the constituent members of the housing case itself (2) the compatibility test after modularization was performed while comparing with the conventional body fluid treatment device. The results are shown in Tables 1 and 2.
表１及び表２から本発明は、体液処理装置として使用す
る際に要求される強度、耐熱性、耐γ線強度劣化性、非
着色性、ポリウレンタンとの接着性が良好であり、γ線
照射後の性能（強度の低下、着色、ポリウレタンの剥
離）の低下は認められず充分な性能を有するものである
ことが理解できる。From Table 1 and Table 2, the present invention has good strength, heat resistance, γ-ray strength deterioration resistance, non-coloring property, and adhesiveness with polyurethane which are required when used as a body fluid treatment device, and γ-ray irradiation It can be understood that the subsequent performances (reduction in strength, coloring, peeling of polyurethane) are not deteriorated and the performance is sufficient.
［発明の効果］ 以上説明したように本発明では、γ線照射後も強度の劣
化等がなく使用に際してもプライミング、返血操作時又
は、製品として出荷後も液漏れがなく使用に際して安心
して使用でき、また内部の液体の状況も容易に観察する
事ができる。 [Effects of the Invention] As described above, according to the present invention, there is no deterioration in strength even after γ-ray irradiation, and there is no liquid leakage even during priming or blood return operation during use or after shipment as a product, and use with confidence Moreover, the state of the liquid inside can be easily observed.
等の優れた効果を有する発明である。It is an invention having excellent effects such as.
Claims (1)
封入してなる体液処理装置であって、該ハウジングケー
スが、芳香族ポリカーボネート（Ａ）と下記構成単位
又は及びを有するコーポリエステル（Ｂ）及び一般
式で表わされるペンタエリスリトールジフォスファイ
ト系安定剤を配合し、かつ前記芳香族ポリカーボネート
（Ａ）と構成単位又は及びを有するコーポリエス
テル（Ｂ）との下式で表わされる配合比Ｒが、0.3≦
Ｒ≦0.6の範囲に設定された組成物から形成されてなる
耐γ線照射性体液処理装置。 構成単位； 構成単位； （式中のｎは、２〜10の整数であり、Ｒは芳香族ジカル
ボン酸残基である。） 一般式； （式中のＲは、炭素数６以上の脂肪族、脂環族、または
芳香族性の炭化水素基である。） 式;R＝（Ｂ）／（Ａ） …1. A body fluid treatment device in which a body fluid treatment member is enclosed in a housing case, wherein the housing case comprises an aromatic polycarbonate (A) and a copolyester (B) having the following structural units or and The pentaerythritol diphosphite stabilizer represented by the general formula is blended, and the blending ratio R represented by the following formula of the aromatic polycarbonate (A) and the copolyester (B) having a structural unit or and is 0.3. ≤
A γ-ray-irradiation-resistant body fluid treatment device formed from a composition in which R ≦ 0.6. Building units; Building units; (In the formula, n is an integer of 2 to 10 and R is an aromatic dicarboxylic acid residue.) General formula; (R in the formula is an aliphatic, alicyclic, or aromatic hydrocarbon group having 6 or more carbon atoms.) Formula; R = (B) / (A) ...
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63199373A JPH0779833B2 (en) | 1988-08-10 | 1988-08-10 | Γ-ray irradiation resistant body fluid treatment device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63199373A JPH0779833B2 (en) | 1988-08-10 | 1988-08-10 | Γ-ray irradiation resistant body fluid treatment device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0246855A JPH0246855A (en) | 1990-02-16 |
| JPH0779833B2 true JPH0779833B2 (en) | 1995-08-30 |
Family
ID=16406680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63199373A Expired - Fee Related JPH0779833B2 (en) | 1988-08-10 | 1988-08-10 | Γ-ray irradiation resistant body fluid treatment device |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0779833B2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3613484B2 (en) * | 1994-10-18 | 2005-01-26 | 住友ダウ株式会社 | Ionizing radiation resistant carbonate resin composition and medical component comprising the same |
| US20060287494A1 (en) * | 2005-06-17 | 2006-12-21 | Crawford Emmett D | Polyester compositions containing high amounts of cyclobutanediol and articles made therefrom |
| JP5088926B2 (en) | 2006-08-25 | 2012-12-05 | 住化スタイロンポリカーボネート株式会社 | Light diffusing polycarbonate resin composition excellent in flame retardancy and light diffusing plate comprising the same |
| US8426015B2 (en) | 2007-06-12 | 2013-04-23 | Styron Europe Gmbh | Clear and flame retardant polycarbonate resin film |
-
1988
- 1988-08-10 JP JP63199373A patent/JPH0779833B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0246855A (en) | 1990-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |