JPH0246855A - Anti gamma-ray irradiation body liquid processing device - Google Patents
Anti gamma-ray irradiation body liquid processing deviceInfo
- Publication number
- JPH0246855A JPH0246855A JP63199373A JP19937388A JPH0246855A JP H0246855 A JPH0246855 A JP H0246855A JP 63199373 A JP63199373 A JP 63199373A JP 19937388 A JP19937388 A JP 19937388A JP H0246855 A JPH0246855 A JP H0246855A
- Authority
- JP
- Japan
- Prior art keywords
- body fluid
- body liquid
- formula
- aromatic polycarbonate
- housing case
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000005251 gamma ray Effects 0.000 title claims abstract description 9
- 239000007788 liquid Substances 0.000 title abstract description 8
- 125000003118 aryl group Chemical group 0.000 claims abstract description 6
- 239000004417 polycarbonate Substances 0.000 claims abstract description 6
- 229920000515 polycarbonate Polymers 0.000 claims abstract description 6
- 229920001634 Copolyester Polymers 0.000 claims abstract description 5
- 238000013329 compounding Methods 0.000 claims abstract 3
- 239000003381 stabilizer Substances 0.000 claims abstract 3
- GXURZKWLMYOCDX-UHFFFAOYSA-N 2,2-bis(hydroxymethyl)propane-1,3-diol;dihydroxyphosphanyl dihydrogen phosphite Chemical group OP(O)OP(O)O.OCC(CO)(CO)CO GXURZKWLMYOCDX-UHFFFAOYSA-N 0.000 claims abstract 2
- 210000001124 body fluid Anatomy 0.000 claims description 22
- 239000010839 body fluid Substances 0.000 claims description 22
- 239000000126 substance Substances 0.000 claims description 4
- 125000002723 alicyclic group Chemical group 0.000 claims description 2
- 125000001931 aliphatic group Chemical group 0.000 claims description 2
- 125000002029 aromatic hydrocarbon group Chemical group 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 239000000470 constituent Substances 0.000 claims 2
- 230000006866 deterioration Effects 0.000 abstract description 5
- 239000000463 material Substances 0.000 abstract description 5
- 239000000203 mixture Substances 0.000 abstract description 5
- 238000001746 injection moulding Methods 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 230000005855 radiation Effects 0.000 abstract description 2
- 238000010102 injection blow moulding Methods 0.000 abstract 1
- 238000000465 moulding Methods 0.000 abstract 1
- 239000012528 membrane Substances 0.000 description 7
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 229920002635 polyurethane Polymers 0.000 description 5
- 239000004814 polyurethane Substances 0.000 description 5
- 238000007789 sealing Methods 0.000 description 5
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 4
- 239000012510 hollow fiber Substances 0.000 description 4
- 229920005989 resin Polymers 0.000 description 4
- 239000011347 resin Substances 0.000 description 4
- 238000002845 discoloration Methods 0.000 description 3
- 229920005990 polystyrene resin Polymers 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 229920000219 Ethylene vinyl alcohol Polymers 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000004040 coloring Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 238000004383 yellowing Methods 0.000 description 2
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 238000000071 blow moulding Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000000385 dialysis solution Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 238000004382 potting Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 229920003048 styrene butadiene rubber Polymers 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
Abstract
Description
【発明の詳細な説明】
［産業上の利用分野］
本発明は、人工腎臓、血漿口過器、血液浄化器、血漿分
離装置等の体液処理装置に間するものであり、特に７ｍ
照射に良好な耐久性を有する体液処理装置を提供するも
のである。Detailed Description of the Invention [Industrial Field of Application] The present invention relates to body fluid processing devices such as artificial kidneys, plasma filtration devices, blood purifiers, plasma separation devices, etc.
The present invention provides a body fluid treatment device that has good durability against irradiation.
Ｃ従来技術及び従来技術の課題］
現在使用されている体液処理装置は、ハウジングケース
の内部には、多数の中空糸膜が収納され該中空糸膜の両
端部は、ポツテング剤で固定され、ハウジングケースの
胴体部には、透析液等の体液処理液の導入口及び導出口
が設けられ、さらにハウジングケースの両側部に、血液
等の体液の導出口（導入口）を設けた封止部材が装着さ
れている。C. Prior Art and Problems with the Prior Art] In the currently used body fluid treatment device, a large number of hollow fiber membranes are housed inside a housing case, both ends of the hollow fiber membranes are fixed with a potting agent, and the housing The body of the case is provided with an inlet and an outlet for a body fluid treatment liquid such as dialysis fluid, and a sealing member provided with an outlet (inlet) for body fluids such as blood is provided on both sides of the housing case. It is installed.
通常、これらのハウジングケースは、ポリスチレン樹脂
、スチレンブタジェンコポリマー（以下スチレン系樹脂
）等のγ線に対し着色、強度劣化が少ない材料が使用さ
れている。Usually, these housing cases are made of materials that are less susceptible to discoloration and strength deterioration due to gamma rays, such as polystyrene resin and styrene-butadiene copolymer (hereinafter referred to as styrene-based resin).
しかしながら、ポリスチレン樹脂は、強度面で弱く特に
人工腎臓等のハウジングケースで使用する際、使用前の
ブライミング操作時において体液処理装置内の気泡を除
去する時あるいは使用後の返血操作の時において、操作
効率を良くするためにハウジングケースに衝撃を与える
ためクラックが発生して液漏れが生じる原因となってい
た。However, polystyrene resin is weak in terms of strength, especially when used in housing cases such as artificial kidneys, when removing air bubbles from the body fluid treatment device during brimming operations before use, or during blood return operations after use. In order to improve operational efficiency, shocks are applied to the housing case, which causes cracks and liquid leaks.
また輸送中にも何らかの衝撃が加わるので前記と同様の
トラブルがあとをたたない。Moreover, since some kind of impact is applied during transportation, problems similar to those described above are likely to occur.
他方、スチレン系樹脂は、ポリスチレン樹脂のように強
度劣化は少ないが、γ線を照射すると黄変が強（透明感
が要求されるハウジングケースに使用する際には外観を
そこない、衛生性を損なうことは言うまでもなく、作業
者に血液の流れが把握しにくい等の使用上の不安を与＾
るものであった。On the other hand, styrene resin does not deteriorate in strength as much as polystyrene resin, but when irradiated with gamma rays, it yellows strongly (when used in housing cases that require transparency, it spoils the appearance and reduces hygiene). It goes without saying that it may cause damage, but it also causes anxiety when using it, such as making it difficult for workers to grasp the flow of blood.
It was something that
［課題を解決するための手段］
以上の課題を解決するために本発明者らは鋭意検討を重
ねた結果法の発明に到達した。[Means for Solving the Problems] In order to solve the above problems, the inventors of the present invention have conducted intensive studies and have arrived at the invention of a method.
本発明の体液処理装置は基本的に０体液処理部材、■ハ
ウジングケース■封止部材から構成され１体液処理部材
としては、中空状もしくは平板状の半透膜、分離膜、口
過膜又は吸着剤等が使用され、半透膜、分１１ｉ１膜、
口過膜の材質は、エチレン−ビニルアルコール共重合体
、ポリスルホン、ポリメチルメタクリレート等が使用さ
れるが、耐γ線照射性を有するものであれば特にこれら
の材質に限定されるものではない。The body fluid treatment device of the present invention basically consists of a body fluid treatment member, a housing case, and a sealing member. agents, etc. are used, semipermeable membranes, minute 11i1 membranes,
The material used for the membrane is ethylene-vinyl alcohol copolymer, polysulfone, polymethyl methacrylate, etc., but is not particularly limited to these materials as long as it has gamma ray irradiation resistance.
吸着剤は天然又は合成高分子を被覆した活性炭、ガラス
ビーブ等が使用されるが、耐γ線照射性を有するもので
特にこれらに限定されるものではない。The adsorbent used may be activated carbon coated with a natural or synthetic polymer, glass beads, etc., but is not particularly limited to these as long as it has gamma ray irradiation resistance.
ハウジングケースは、両端の開口した筒状体から構成さ
れ、必要に応じて側部に例えば透析液等の体液処理液の
導入口と導出口が形成されている。The housing case is composed of a cylindrical body with both ends open, and an inlet and an outlet for a body fluid processing liquid such as a dialysate are formed on the side as necessary.
該ハウジングケー又は、芳香族ポリカーボネート（Ａ）
と下記構成単位■又は■及び■を有するコーポリエステ
ル（Ｂ）及び一般式■で表わされるペンタエリスリトー
ルシフオスファイト系安定剤を配合し、かつ前記芳香族
ポリカーボネート（Ａ）と構成単位■又は■及び■を有
するコーポリエステル（Ｂ）との下式■で表わされる配
合比Ｒが、０．３≦Ｒ≦０．６の範囲に設定された組成
物から射出成形またはブロー成形等により形成される。The housing case or aromatic polycarbonate (A)
and a copolyester (B) having the following structural units ■ or ■ and It is formed by injection molding, blow molding, etc. from a composition in which the blending ratio R represented by the following formula (2) with the copolyester (B) having (2) is set in the range of 0.3≦R≦0.6.
（以下余白）
構成単位■；
構成単位■；
（式中のｎは、２〜ｌＯのＮ数であり、Ｒは芳香族ジカ
ルボン酸残基である。）
一般式■：
（式中のＲは、炭素数６以上の脂肪族、脂環族、または
芳香族性の炭化水素基である。）式■； Ｒ＝ （Ｂ
）／ （Ａ） ・・・■Ｒが０．３以下
では、γ線照射線量が大きい場合や体液処理装置の製造
後から使用時までの間に長時間経過した場合、黄変等の
変色が生じやすいので好ましくない。(Space below) Structural unit ■; Structural unit ■; (n in the formula is the number of N from 2 to 1O, and R is an aromatic dicarboxylic acid residue.) General formula ■: (R in the formula , is an aliphatic, alicyclic, or aromatic hydrocarbon group having 6 or more carbon atoms.) Formula ■; R= (B
)/ (A)... ■When R is 0.3 or less, discoloration such as yellowing may occur if the γ-ray irradiation dose is large or if a long period of time has passed between the manufacture of the body fluid treatment device and the time of use. This is not preferable because it is easy to cause this.
またＲが０．７以上では、黄変等の変色は激減するが、
成形性が悪くなるとともに強度が低下するので好ましく
ない。Moreover, when R is 0.7 or more, discoloration such as yellowing is drastically reduced,
This is not preferable because moldability deteriorates and strength decreases.
封止部材は血液等の体液の導入口（導出口）が形成され
、前記ハウジングと同一の組成を用いて射出成形等によ
り形成される。The sealing member has an inlet (outlet) for body fluids such as blood, and is formed by injection molding or the like using the same composition as the housing.
［実施例］
前述の（Ａ）、（Ｂ）、（Ｃ）を所定の割合に配合した
組成物を射出成形により、体液処理液の導入口及び導出
口を両側部に一体に成形したハウジングケース及び体液
の導入口（導出口）を有する封止部材を形成した。[Example] A housing case in which an inlet and an outlet for a body fluid treatment liquid are integrally molded on both sides by injection molding a composition containing the above-mentioned (A), (B), and (C) in a predetermined ratio. A sealing member having a body fluid inlet (outlet) was formed.
続いて、ハウジング内に、エチレン−ビニルアルコール
共重合体よになる中空糸膜を装填して、該ハウジングの
両端部に固定部材を装着して、両端からポリウレタンを
注入しながら、遠心力を付与し、ポリウレタンを固化さ
せた。Next, a hollow fiber membrane made of ethylene-vinyl alcohol copolymer is loaded into the housing, fixing members are attached to both ends of the housing, and centrifugal force is applied while polyurethane is injected from both ends. The polyurethane was then solidified.
前記固定部材を取り外して、固化したポリウレタンを切
断して、中空糸膜の両端部を開口させて封止部材を装着
した。The fixing member was removed, the solidified polyurethane was cut, both ends of the hollow fiber membrane were opened, and a sealing member was attached.
以上のようにして組み立てた体液処理装置について、γ
線照射等を行なって、
（１）ハウジングケースの構成部材自体の適合性試験
（２）モジュール化後の適合性試験を従来の体液処理装
置と比較しながら実施した。これらの結果を表１及び表
２に掲載する。Regarding the body fluid treatment device assembled as described above, γ
(1) Compatibility test of the components of the housing case itself (2) Compatibility test after modularization was conducted while comparing with conventional body fluid treatment devices. These results are listed in Tables 1 and 2.
表１及び表２から本発明は、体液処理装置として使用す
る際に要求される強度、耐熱性、耐γ線強度劣化性、非
着色性、ポリウレタンとの接着性が良好であり、γ線照
射後の性能（強度の低下、着色、ポリウレタンとの剥１
ｉ１）の低下は認められず充分な性能を有するものであ
ることが理解できる。From Tables 1 and 2, the present invention has good strength, heat resistance, resistance to γ-ray strength deterioration, non-coloring property, and good adhesion to polyurethane when used as a body fluid treatment device, and has good properties when used as a body fluid treatment device. Later performance (decreased strength, coloring, peeling from polyurethane 1)
It can be seen that no decrease in i1) was observed, indicating that the product had sufficient performance.
（以下余白）
［発明の効果］
以上説明したように本発明では、γ線照射後も強度の劣
化等がなく使用に際してもブライミング、返血操作時又
は、製品として出荷後も液漏れがなく使用に際して安心
して使用でき、また内部の体液の状況も容易に観察する
事ができる。(Left below) [Effects of the Invention] As explained above, the present invention has no deterioration in strength even after irradiation with gamma rays, and there is no leakage during briming, blood return operations, or even after shipment as a product. It can be used with peace of mind and the state of internal body fluids can be easily observed.
等の優れた効果を有する発明である。This invention has excellent effects such as:
特許出願人 川澄化学工業株式会社
手
続
補
正
書
（自発）
昭和６３年
８月２０日
２、発明の名称
耐γ線照射性体液処理装置
３、補正をする者
事件との関係 出願人
住所（居所）
〒１４０
東京部品用区南大井３丁目２８番１５号補 正 の
内 容
１ 本願の明細書第４頁第２行中「スチレン系樹脂」と
あるのを「ポリカーボネート樹脂」と訂正する。Patent applicant: Kawasumi Chemical Industry Co., Ltd. Procedural amendment (voluntary) August 20, 1988 2, Title of invention: Gamma-ray radiation resistant body fluid treatment device 3, Person making the amendment: Relationship with the case: Applicant's address (residence) Contents of Amendment No. 15, 3-28-15, Minami-Oi, Tokyo Parts Industry Ward, Tokyo 140 Part 1: In the second line of page 4 of the specification of the present application, the term ``styrene resin'' is corrected to ``polycarbonate resin.''
Claims (1)
体液処理装置であって、該ハウジングケースが、芳香族
ポリカーボネート（Ａ）と下記構成単位（１）又は（１
）及び（２）を有するコーポリエステル（Ｂ）及び一般
式（３）で表わされるペンタエリスリトールジフォスフ
ァイト系安定剤を配合し、かつ前記芳香族ポリカーボネ
ート（Ａ）と構成単位（１）又は（１）及び（２）を有
するコーポリエステル（Ｂ）との下式（４）で表わされ
る配合比Ｒが、０．３≦Ｒ≦０．６の範囲に設定された
組成物から形成されてなる耐γ線照射性体液処理装置。 構成単位（１）； ▲数式、化学式、表等があります▼・・・（１） 構成単位（２）； ▲数式、化学式、表等があります▼・・・（２） （式中のｎは、２〜１０の整数であり、Ｒは芳香族ジカ
ルボン酸残基である。） 一般式（３）； ▲数式、化学式、表等があります▼・・・（３） （式中のＲは、炭素数６以上の脂肪族、脂環族、または
芳香族性の炭化水素基である。）式（４）；Ｒ＝（Ｂ）
／（Ａ）・・・（４）[Scope of Claims] A body fluid treatment device comprising a body fluid treatment member sealed inside a housing case, the housing case comprising aromatic polycarbonate (A) and the following structural unit (1) or (1).
) and (2) and a pentaerythritol diphosphite stabilizer represented by the general formula (3), and the aromatic polycarbonate (A) and the structural unit (1) or (1). ) and copolyester (B) having (2), the compounding ratio R represented by the following formula (4) is set in the range of 0.3≦R≦0.6. γ-ray irradiation body fluid treatment device. Constituent unit (1); ▲There are mathematical formulas, chemical formulas, tables, etc.▼...(1) Constituent unit (2); ▲There are mathematical formulas, chemical formulas, tables, etc.▼...(2) (n in the formula is , is an integer from 2 to 10, and R is an aromatic dicarboxylic acid residue.) General formula (3); ▲There are numerical formulas, chemical formulas, tables, etc.▼...(3) (R in the formula is It is an aliphatic, alicyclic, or aromatic hydrocarbon group having 6 or more carbon atoms.) Formula (4); R=(B)
/(A)...(4)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63199373A JPH0779833B2 (en) | 1988-08-10 | 1988-08-10 | Γ-ray irradiation resistant body fluid treatment device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63199373A JPH0779833B2 (en) | 1988-08-10 | 1988-08-10 | Γ-ray irradiation resistant body fluid treatment device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0246855A true JPH0246855A (en) | 1990-02-16 |
| JPH0779833B2 JPH0779833B2 (en) | 1995-08-30 |
Family
ID=16406680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63199373A Expired - Fee Related JPH0779833B2 (en) | 1988-08-10 | 1988-08-10 | Γ-ray irradiation resistant body fluid treatment device |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0779833B2 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996011984A1 (en) * | 1994-10-18 | 1996-04-25 | Sumitomo Dow Limited | Ionizing radiation-resistant carbonate resin composition and medical parts produced therefrom |
| JP2008543424A (en) * | 2005-06-17 | 2008-12-04 | イーストマン ケミカル カンパニー | Blood treatment container comprising a polyester composition formed from 2,2,4,4-tetramethyl-1,3-cyclobutanediol and 1,4-cyclohexanedimethanol |
| US7960450B2 (en) | 2006-08-25 | 2011-06-14 | Styron Europe Gmbh | Flame retardant and light diffusing polycarbonate resin composition and light diffusing sheet thereof |
| US8426015B2 (en) | 2007-06-12 | 2013-04-23 | Styron Europe Gmbh | Clear and flame retardant polycarbonate resin film |
-
1988
- 1988-08-10 JP JP63199373A patent/JPH0779833B2/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996011984A1 (en) * | 1994-10-18 | 1996-04-25 | Sumitomo Dow Limited | Ionizing radiation-resistant carbonate resin composition and medical parts produced therefrom |
| JP2008543424A (en) * | 2005-06-17 | 2008-12-04 | イーストマン ケミカル カンパニー | Blood treatment container comprising a polyester composition formed from 2,2,4,4-tetramethyl-1,3-cyclobutanediol and 1,4-cyclohexanedimethanol |
| JP2008546603A (en) * | 2005-06-17 | 2008-12-25 | イーストマン ケミカル カンパニー | Food storage container comprising a polyester composition formed from 2,2,4,4-tetramethyl-1,3-cyclobutanediol and 1,4-cyclohexanedimethanol |
| US7960450B2 (en) | 2006-08-25 | 2011-06-14 | Styron Europe Gmbh | Flame retardant and light diffusing polycarbonate resin composition and light diffusing sheet thereof |
| US8426015B2 (en) | 2007-06-12 | 2013-04-23 | Styron Europe Gmbh | Clear and flame retardant polycarbonate resin film |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0779833B2 (en) | 1995-08-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4265760A (en) | Device for dilution and delivery of in vivo chemicals | |
| CA2237658C (en) | Method and apparatus for reprocessing dialyzers | |
| JPS5841862B2 (en) | medical equipment | |
| JPS6356449A (en) | Chemically stabilized film | |
| ES2318030T3 (en) | MEDICAL TUBES MANUFACTURED FROM A POLIBUTADIEN MATERIAL. | |
| JPH02180264A (en) | Film for moistureproof treatment | |
| BRPI0406891B1 (en) | detachable polymeric layer structure as well as an overbag container | |
| JPH0246855A (en) | Anti gamma-ray irradiation body liquid processing device | |
| Szycher | Szycher's dictionary of biomaterials and medical devices | |
| US3616930A (en) | Semipermeable membranes | |
| CN107096090A (en) | Store the container of the medicine of such as insulin | |
| Serota et al. | Effects of structure on permeability of substituted anilines from aqueous solutions through polyethylene | |
| JP2672051B2 (en) | Method for manufacturing blood purification device | |
| Deane et al. | Multiple use of hemodialyzers | |
| Twardowski | Dialyzer reuse—part I: Historical perspective | |
| Team | Evaluation of extractables from product-contact surfaces | |
| Blass | The role of poly (vinyl chloride) in healthcare | |
| Gal et al. | Disinfection of regenerated dialyzers with ozone | |
| Mardiyana et al. | Chitosan-starch cross-linked citric acid as adsorptive hemodialysis membrane | |
| ATE395897T1 (en) | METHOD FOR PREPARING A MEDICAL SOLUTION FOR PRODUCING A MEDICATION FOR PERITONEAL DIALYSIS | |
| JP4309620B2 (en) | Artificial dialyzer | |
| JP2002045420A (en) | Blood cleaning device, blood cleaning method and dialyzate package | |
| JPH08299433A (en) | Method for preparing blood processing device and the blood processing device | |
| Ogden | Clinical responses to new and reprocessed hemodialyzers | |
| JP2754203B2 (en) | Sterilization method for body fluid treatment device and sterilized body fluid treatment device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |