JPH0773605B2 - Priming method of plasma exchanger - Google Patents

Description

TECHNICAL FIELD The present invention relates to a priming method for a plasma exchanger.

[Prior Art] When using an artificial kidney, a plasma exchanger, etc., blood is smoothly introduced into the hollow fiber in the plasma exchanger module,
In addition, for the purpose of removing bubbles in the hollow fiber, an operation of filling the inside of the hollow fiber with a physiological saline solution before use, a so-called priming operation is performed.

As a method of this priming operation, conventionally, a physiological saline solution is introduced from one of the bundles of hollow fibers to the side where blood flows, that is, inside the hollow fibers.

[Problems to be Solved by the Invention] However, in the above-described conventional method, since air is present in the circuit of the physiological saline solution, air remains inside the hollow fiber or air is newly added from the outside. I was afraid to enter. Further, there is a problem that it takes time to remove air bubbles in the hollow fiber.

[Means for Solving the Problems] Then, the present inventors have conducted various studies in view of the above-mentioned conventional problems, and as a result, introduced a physiological saline solution from the outside of the porous hollow fiber and introduced it from the outside of the hollow fiber. It was found that the above-mentioned conventional problems can be solved by introducing a physiological saline solution to the inside,
The present invention has been completed.

That is, according to the present invention, a hydrophobic hollow fiber membrane is washed with a substance having good compatibility with water and a low surface tension, and the plasma exchange is performed using a hollow fiber plasma exchanger filled with sterile water. When priming a physiological saline solution into the vessel, the physiological saline solution is introduced to the outside of the hollow fiber inside the plasma exchanger, and then the physiological saline solution is permeated from the outside of the hollow fiber to the inside of the hollow fiber for priming. A method of priming a plasma exchanger is provided.

[Function] The physiological saline solution introduced into the outer side of the hollow fiber in the module such as the plasma exchanger enters the inner side of the hollow fiber through the fine pores uniformly formed in the entire hollow fiber. Therefore, unlike the conventional method of guiding the physiological saline from one end of the hollow fiber,
No air bubbles remain inside the hollow fiber, and it is possible to prevent air bubbles from entering from the outside. It is possible to reduce the priming time, which was conventionally 14 to 15 minutes, to less than half, within 5 minutes. Become. Furthermore, according to the method of the present invention, it becomes easy to replace the sterile water previously filled in the module with the physiological saline solution, and the priming time can be further shortened. The priming time is the sum of the time required to replace sterile water with physiological saline and the time required to remove air bubbles.

[Examples] Hereinafter, the present invention will be described in more detail with reference to Examples.
It will be clear that the invention is not limited to these examples.

FIG. 1 is an explanatory view showing a panel portion of the plasma exchange device.

In the figure, 10 is a plasma exchange module, 11 is a blood reservoir, and 12
Is a sampling bag, 13 is a drainage bag, 14 is a saline bottle, and 15 is an ACD bottle. Further, 16, 17, 18 are roller pumps, 19 is an ACD pump, 20 is a puncture portion, and 21 to 29 are clamp devices for interrupting the blood circuit.

ACD is a blood coagulation inhibitor that prevents blood from coagulating in the blood circuit, and physiological saline is a liquid having an osmotic pressure equal to that of blood, and both are colorless and transparent. The blood storage tank 11 is for temporarily storing blood after separating blood and plasma derived from a living body, and has a capacity of 300 ml.

The size of the device was such that the front surface of the panel section was about 400 × 500 mm, the lower side of the panel section was about the bed height, and the weight was 60 to 70 kg.

Next, the operation of the priming method in this device will be described.

Initially, the plasma exchange device is pre-filled with distilled water that is sterile water.

First, turn on the power and check whether there is any abnormality in each sensor and circuit. At this time, all pumps 16-18 are stopped,
All the clamp devices 21-29 are open. Next, the circuit is set. After that, the clamp devices 21 to 29 are all closed and the plasma exchange module 10 is set.

Turn on the priming switch.

Only open the clamp device 28, turn on the pump 18,
The distilled water initially filled in the module 10 is discarded in the drain bag 13. At this time, the module pressure solenoid valve (not shown) is open.

The ACD pump 19 rotates and guides the ACD liquid to the needle part 20. After that, the pump 19 is turned off.

The pump 18 is turned off, the clamp device 28 is closed, the clamp device 27 is opened, and the physiological saline solution is introduced into the plasma exchange module 10 from the physiological saline solution bottle 14. This naturally flows in due to gravity. At this time, the module pressure solenoid valve is open.

When the physiological saline is introduced to the upper part of the module 10, the clamp device 27 is closed.

The clamp devices 26 and 27 are opened and the module pressure solenoid valve is closed to fill the line from the module 10 to the drain bag 13 with the physiological saline solution. The filling is done naturally by gravity.

The clamp devices 24, 27, 28 are opened, and the line from the inlet side of the module 10 to the drain bag 13 is filled with physiological saline. This filling is also naturally performed by gravity.

Returning to the above operation, the ACD pump 19 is stopped and only the physiological saline solution is refilled in the same manner as in the operation. After that, the same operation is repeated until the above operation.

The clamp device 27 is opened, the pump 17 is reversed, and the line from the module 10 to the blood reservoir 11 is filled with physiological saline.

The clamp device 27 is closed and the pump 17 is stopped.

With the above, the priming operation is completed.Next, as the operation of the plasma exchange device, next, the conditioning operation for guiding the blood into the blood circuit and discharging the physiological saline solution, the plasma collection operation for separating the plasma from the blood, and finally the A blood returning operation for returning the blood in the blood circuit to the living body is performed.

Next, the hollow fiber membrane used in the plasma exchanger module of the present invention will be described. As the hollow fiber membrane, a hydrophobic hollow fiber membrane is compatible with water and has a small surface tension, for example, washed with a substance such as alcohol, and then filled with sterile water such as physiological saline or dust-free water. Every time, it is used as a hollow fiber membrane by substituting blood for use.

Further, the material of the hollow fiber is not particularly limited. Examples of materials made of polymer materials include polyolefins (high-density polyethylene, polypropylene, poly (4-methyl-pentene-1), etc.), fluorine-containing polymer compounds, polysulfones, polycarbonates, polyvinyl chloride, cellulose acetate, Examples thereof include porous hollow fibers such as polyacrylonitrile, polyvinyl alcohol, polymethylmethacrylate, and polyamide. Moreover, examples of the inorganic material include porous hollow fibers such as glass, ceramics and carbon. Among the above, a membrane made of polyolefin is preferable from the viewpoint of high hemolysis resistance. Outer diameter of porous hollow fiber,
The thickness of the peripheral wall and the hole diameter are not particularly limited, but generally the outer diameter is about 10 to 1000 μm, and the thickness of the peripheral wall is about 10 to about 50.
It is preferably 0 μm and the pore size is about 0.01 to about 7 μm.

Next, the specific results of the implementation of the priming method according to the present invention will be described.

(Example) The lowest position of the saline solution bottle 14 and the plasma exchange module 10
A polypropylene hollow fiber membrane (made by Ube Industries, Ltd., average pore diameter 0.37μ) washed with alcohol as the plasma exchange module 10 while maintaining the height difference of the blood outlet position at 100 mm
m, outer diameter 400 μm, inner diameter 300 μm, porosity 74%), and a physiological saline solution was introduced from the outside of the hollow fiber using a plasma exchange module with a membrane area of 0.3 m ² that was previously filled with 92 ml of sterile distilled water. Priming method.

As a result, in 2 minutes and 30 seconds, sterile distilled water was completely replaced with physiological saline in the plasma exchange module, and no air bubbles were seen inside the hollow fiber.

[Effects of the Invention] As described above, according to the priming method of the present invention, since the physiological saline is guided from the outside to the inside of the hollow fiber, air bubbles do not remain inside the hollow fiber, and the priming time is shortened. There is an effect that can be.

[Brief description of drawings]

FIG. 1 shows an explanatory view showing a panel portion of the plasma exchange device. 10 ... Plasma exchange module, 11 ... Blood reservoir, 12 ... Serum bag, 13 ... Drainage bag, 14 ... Saline bottle,
15 …… ACD bottle.

Claims (1)

[Claims] 1. A hydrophobic hollow fiber membrane is washed with a substance having good surface compatibility with water and a small surface tension, and a hollow fiber plasma exchanger filled with sterile water is used to perform physiological treatment on the plasma exchanger. When priming a saline solution, the physiological saline solution is introduced to the outside of the hollow fiber inside the plasma exchanger, and then the physiological saline solution is permeated from the outside of the hollow fiber to the inside of the hollow fiber for priming. Exchanger priming method.