JPH0753394A - Sexual function-improving agent - Google Patents

Abstract

PURPOSE:To provide a sexual function-improving agent having a male sexual function-recovering action. CONSTITUTION:The medicinal agent contains Cnidii monnieri fructus and Rehmanniae radix, both having mutually different action functions, a prescription medicine containing Cuscutae semen and Schizandrae fructus, or their extracted ingredients as the active ingredients.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a sexual function improving agent for restoring male sexual function.

[0002]

2. Description of the Related Art Recently, Japanese and Chinese medicine is used for treating urological diseases,
It has come to be recognized that it is effective as a Western medical treatment aid, and even when it is used alone depending on the timing of treatment. And some of the traditional Chinese medicine is not only used as a supplement to Western medicine, but for example, renal keg pills such as Hachimi Maru and Goshi Kurki Maru are urinary disorders based on benign prostatic hyperplasia, urinary incontinence and male infertility,
It has come to be used as a main drug for the treatment of male dysfunctional persons. There is no significant sexual function improving effect in this renal keg.

[0003] Jikotoko is a dried fruit of the jellyfish of the Apiaceae family, and it is known that this Jokotoko extract has an androgen-like action, and it has an aphrodisiac effect during the mating phase of female mice. It is said to increase the weight of the uterus and ovaries. (Newly edited Japanese and Chinese medicine, Akamatsu Kaneyoshi) Jukujio is a Chinese herbal medicine that has been used for the purpose of blood supplementation and tonication since ancient times by drying the rhizomes of the sycamore sect. It is a herbal medicine that is blended in Renjiki pills such as “Hamimi Maru” and “Romijichi Huang Maru”. This mature yellow has no effect on improving sexual function.

[0004]

[Problems to be Solved by the Invention] There are some adult males whose sexual function is temporarily or urgently reduced due to changes in their eating habits, accumulation of stress, and the like. It has been found that males with reduced sexual function have reduced testosterone action, and therefore it is important to enhance the testosterone action in order to improve their sexual function. Therefore, the present invention has been made in view of such problems, and an object thereof is to provide a sexual function improving agent having a recovery action for male functions.

[0005]

In order to achieve the above-mentioned object, the sexual function improving agent of the present invention is improved in sexual function by blending a serpentine and a matured yellow or an extract thereof. As a result of intensive studies, the sexual function improving agent of the present invention was completed.

[0006]

EXAMPLE Next, the sexual function improving agent according to the present invention will be described. The active ingredient is a mixture of snake gourd or its extract, and ripe ground yellow or its extract. As the extract of Jellyfish, water, hot water, ethanol, extracted with a solvent used for extraction of usual herbal medicines such as hydrous ethanol, and then freeze drying, spray drying, vacuum drying or the like of the solvent. The extract obtained by removing can be mentioned. As for the maturity yellow, the mainly yellow or dough yellow steamed by adding sake is used.

[0007] Although the snake bed and its extract can be used as a dry powder or as an aqueous extract as they are, they are usually used in various formulations such as tablets, granules, capsules and liquids by using known formulation techniques. Orally administer in a pill form. For the matured yellow, various formulations, for example, those formulated into tablets, capsules, pills and the like may be orally administered by using ordinary formulation techniques. The doses of the bark and the ground yellow for improving sexual function are timely determined by the dose of the barb. The dose of Gabiko extract is 100 mg
In the case of ~ 1000 mg, the dose of ground yellow is in the range of 400 mg to 4000 mg.

Experimental Example 1 As a test drug for a test sample, 50 dried Jichoko was prepared by drying the mature fruits of the jellyfish of the Apiaceae family.
It was extracted with% ethanol and used. As the ground yellow, a mature ground yellow obtained by aging the material yellow was used.

As test animals, male Wistar rats were purchased at the age of 5 weeks, and after preliminary breeding for 1 week, or bilateral cryptorchid surgery was performed, and used after breeding for 3 weeks. After purchasing 6-week-old male mice and preliminarily breeding them for 2 weeks,
Alternatively, bilateral detained testicular surgery was performed and used after breeding for 3 weeks.

Test method: A group in which distilled water is orally administered to rats once a day for 30 days. A rat tortoise is orally administered to rats once a day for 30 days. Yellow) once a day,
1 group (Rabbitko + rabbit yokoko + omizo + jukucho) was given to group rats orally administered for 30 days.
Divide into groups that will be orally administered once a day for 30 days.

The amount of snake bed extract is (100 mg / kg, 300 mg /
kg, 1000mg / kg), and the amount of mature yellow is (400mg / kg, 800m
g / kg, 1000 mg / kg). The amount of schizandra is (180mg / k
g, 540 mg / kg, 1790 mg / kg), and the amount of rabbit filaments is (100 mg
/ Kg, 300 mg / kg, 1000 mg / kg).

[0012] Rat blood was collected, serum testosterone was measured by radioimmunoassay, the isolated submandibular gland protease activity associated with the improvement of sexual behavior was measured, and the testosterone activity was measured. The result was obtained as follows.

[0013]

[Table 1]

Experimental Example 2 As the test drug, the same serpentine as in Experimental Example 1 and the matured yellow are used. Mice are used as test animals. As a test method, mice were divided into the same groups as in Experimental Example 1, and each group was orally administered with the test drug once a day for 30 days, and the same experimental results as those of the rats were obtained.

Experimental Results The serum testosterone concentration in the group administered with distilled water alone was about 100 ng / dl. Serum testosterone concentration in the group administered only the snake bed extract was 300 mg / k
The highest dose was g, 177 ng / dl,
Serum testosterone concentrations were low in the groups administered with 100 mg / kg and 1000 mg / kg of Gingko extract. That is, the serum testosterone concentration was significantly increased in the group administered with 300 mg / kg of Rhododactylus compared with the normal group and the control group. Along with that, sexual behavior changed.

[0016] In the group administered with the extract of Ripe silkworm and schizandra mixed with Jukujiocho, in the group of administration with 800 mg / kg of Jukujiocho extract, there was no change in serum testosterone concentration, but sexual behavior was slightly active. Was transformed. In the group to which the compounded extract obtained by further adding the Torchiko extract to the above-mentioned mixed extract was administered, the serum testosterone concentration was the highest and the sexual behavior became active.

[0017] In addition to the above-mentioned formulation containing the extract, the serum testosterone concentration can be increased by mixing and administering the serpentine extract with the kidney extract pills such as Rokumichi-gan, Hachimiji-gan, and Goshikakugan. Accompanied by this, sexual activity became active. No toxicity was observed in any of the compounding agents in the toxicity test, and it was confirmed that they could be used safely. From the above, it was found that the ground yellow extract does not increase serum testosterone concentration, but plays an important role in activating sexual behavior. That is, it was confirmed that the action of the ripe ground yellow extract was to enhance the action of testosterone.

[0018]

Since the sexual function improving agent according to the present invention is as described above, it has the following effects. Serpentine and its extract have the effect of increasing blood testosterone concentration. The effect of testosterone, which was increased by the serpentine, was enhanced by the mature yellow and the sexual function could be improved accordingly. This is because the amount of steroid receptors is increased by the ground yellow extract component and thus the testosterone action is enhanced.

[0019] Renjikigan have no significant sexual function-improving effect, but it is recognized that the addition of Jokotoko to these Kikikigan, whose constituent crude drug is Jukucho, provides a strong mixing effect. Was given. This is because Jukucho and the like have no action to increase the serum steroid concentration, but activate the receptor function that binds to the steroid, and therefore enhance the effect of the serum steroid increased by the component of the extract of Serpentus gooseii. That is, the mixture of the snake bed and its extract and the mature yellow is the result of the experiment,
It was confirmed to be excellent as a sexual function improver.

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[Procedure amendment]

[Submission date] December 15, 1993

[Procedure Amendment 1]

[Document name to be amended] Statement

[Name of item to be corrected] Claim 1

[Correction method] Change

[Correction content]

[Procedure Amendment 2]

[Document name to be amended] Statement

[Name of item to be corrected] 0002

[Correction method] Change

[Correction content]

[0002]

2. Description of the Related Art Recently, Japanese and Chinese medicine is used for treating urological diseases,
It has come to be recognized that it is effective as a Western medical treatment aid, and even when it is used alone depending on the timing of treatment. And some of the Japanese and Chinese medicines are not only supplementary use of Western medicine, but, for example, Kami-Kigan pills such as Hamimaru and Goshisha-Kenjin-Kigan are
It has come to be used as a main drug for treatment of urination disorder due to benign prostatic hyperplasia, urinary incontinence, male infertility, and male dysfunction. There is no significant sexual function improving effect in this renal keg.

[Procedure 3]

[Document name to be amended] Statement

[Name of item to be corrected] 0005

[Correction method] Change

[Correction content]

[0005]

In order to achieve the above-mentioned object, the sexual function improving agent of the present invention comprises a sexual function by combining a snake bed and jukujiko, rabbit yam and omizo, or extract components thereof. As a result of intensive studies, they have completed the sexual function improving agent of the present invention.

[Procedure amendment 4]

[Document name to be amended] Statement

[Correction target item name] 0006

[Correction method] Change

[Correction content]

[0006]

EXAMPLE Next, the sexual function improving agent according to the present invention will be described. The active ingredient is a mixture of Jakotoko, jukucho, or extract thereof, or Ryokoshigo or Schisandra or extract thereof. As the extract of Jellyfish, water, hot water, ethanol, extracted with a solvent used for extraction of usual herbal medicines such as hydrous ethanol, and then freeze drying, spray drying, vacuum drying or the like of the solvent. The extract obtained by removing can be mentioned. As for the maturity yellow, the mainly yellow or dough yellow steamed by adding sake is used.

[Procedure Amendment 5]

[Document name to be amended] Statement

[Correction target item name] 0017

[Correction method] Change

[Correction content]

Serum testosterone concentration was obtained by mixing and administrating a serpentine extract with a Kampo extract such as Rokumichi-ogan, Hachimiji-ogan and Goshajinki-gan, in addition to the above-mentioned formulas containing the extract. As a result, sexual activity became active. No toxicity was observed in any of the compounding agents in the toxicity test, and it was confirmed that they could be used safely. From the above, it was revealed that the ground yellow extract does not increase the serum testosterone concentration, but plays an important role in activating sexual behavior. That is, it was confirmed that the action of the matured yellow-yellow extract is to increase testosterone or to enhance the action of testosterone.

Claims (2)

[Claims] 1. A sexual function improving agent comprising, as an active ingredient, a serpentine and ground yellow (ripe ground yellow), or a mixture thereof. 2. A sexual function-improving agent comprising as an active ingredient a composition which forms a snake bed and ground yellow (ripe ground yellow) or a mixture of these extract ingredients.