JPH07303691A - Surface modifying medical material and its production - Google Patents

Abstract

PURPOSE:To provide a surface modifying medical material to modify the surface of a material without damaging the excellent features such as mechanical properties, etc., of the material itself and to which useful properties such as biocompatibility, etc., are bestowed, and its production method. CONSTITUTION:At least one kind of powder selected from a group of calcium, phosphorus, magnesium, fluorine, silicon, silver and carbon compounds is anchored or solid-solubilized to at least a part of the surface of a surface modifying medical material 1. The surface modifying medical material is manufactured by mechanically pressing, e.g. plast treating, the powder of at least one selected from the above-mentioned group to the medical material surface.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a novel surface-modified medical material, more specifically, a. It replaces the defect site of hard tissue such as bone or tooth caused by pathological or surgical cause, prostheses the function of the defect and induces the generation of new hard tissue around the surface-modified medical material, or B. Having biocompatibility such as binding to tissue, Suppress pathological calcification, c. A surface-modified medical metallic material or a surface-modified medical inorganic material useful for clinical applications such as exhibiting antibacterial properties.
Alternatively, it relates to a surface-modified medical polymer material.

[0002]

2. Description of the Related Art Medical materials are roughly classified into medical metal materials, medical inorganic materials, and medical polymer materials. These medical materials have different properties and therefore
It is appropriately used depending on its purpose and use.

Stainless steel metal represented by SUS316L and COP-1, C represented by HS21 and HS25
One of the major characteristics of medical metal materials represented by o-Cr alloys, stellite, titanium, titanium alloys, etc. is good mechanical properties. Metallic materials for medical use are the first choice for areas such as hip joints and artificial tooth roots where large forces are applied.

One of the major characteristics of the medical inorganic materials represented by apatite, tricalcium phosphate, alumina, zirconia, carbon, etc. is biocompatibility. Apatite, which is one of the inorganic materials for medical use, is a main component of living hard tissues such as bones and teeth, and is known to have extremely excellent properties such as being strongly bonded directly to bones. When a large amount of force is not applied and biocompatibility is emphasized, a medical inorganic material is the first choice.

Teflon, polyethylene, polysulfone,
One of the major characteristics of medical polymer materials represented by polysiloxane, polyester, polyamide and the like is flexibility. Flexible medical polymer materials are the first choice for artificial blood vessels and trachea.

However, these medical metal materials,
The medical inorganic material and the medical polymer material are not ideal materials, and have their respective drawbacks. Biocompatibility is one of the major problems for medical metal materials and medical polymer materials, and mechanical properties, especially brittleness, that is, the feature of being easily cracked and fragile, is a major problem for medical inorganic materials. Is one.

Utilizing the excellent characteristics of these medical materials,
Various conjugations have been investigated to improve problematic properties. Among these, properties such as biocompatibility are determined only by the surface properties of the medical material, and thus surface modification is a very effective method for improving biocompatibility of the material.

For example, in order to combine the excellent mechanical properties of medical metal materials with the excellent biocompatibility of inorganic medical materials,
A method of coating calcium phosphate on the surface of a metal material by plasma spraying has recently been attracting attention. However, plasma spraying requires expensive equipment, and the desired calcium phosphate coating may not be possible depending on the spraying conditions.

Further, in plasma spraying, the calcium phosphate powder is exposed to high temperature plasma in a part of the process, so that part of the surface of the calcium phosphate powder is decomposed into tetracalcium phosphate or calcium oxide. The decomposition product tetracalcium phosphate or calcium oxide is easily dissolved in body fluid such as blood, and as a result, the calcium phosphate film produced by plasma spraying has cracks. It is known that cracks in ceramics or glassy materials remarkably impair the mechanical properties of the material, and therefore calcium phosphate-coated medical metal materials produced by plasma spraying are not sufficiently satisfactory in terms of mechanical properties. There wasn't.

[0010]

The medical material alone having sufficient mechanical properties does not exhibit satisfactory biocompatibility. In order to combine sufficient mechanical properties with multiple useful properties such as biocompatibility, a method of modifying the surface of the medical material with a coating such as plasma spraying has been performed, but the device is expensive and sufficiently satisfactory. I couldn't get any good results. The present invention provides a surface-modified medical material in which useful properties such as biocompatibility are added by simply modifying the surface of the material without impairing the excellent mechanical properties of the material itself, and a method for producing the same. It is a thing.

[0011]

[Means for Solving the Problems] In order to solve the problems of the medical materials described in the previous section, the present investigators investigated various new medical materials, and as a result, calcium compounds, phosphorus compounds, magnesium compounds, and fluorine compounds. , A surface-modified medical material characterized in that at least one powder selected from the group consisting of a silicon compound, a silver compound, and a carbon compound is fixed or solid-solved on at least a part of the surface, biocompatibility, etc. It has been found that it is a useful medical material for clinical application, which exhibits excellent surface properties of, and has sufficient mechanical properties, and as its production method, a calcium compound, a phosphorus compound, a magnesium compound, a fluorine compound,
It has been found that a method for producing a surface-modified medical material in which at least one powder selected from the group of silicon compounds, silver compounds, and carbon compounds is mechanically pressed onto the surface of the medical material by blasting or the like is effective. The present invention has been completed.

That is, the surface-modified medical material and the method for producing the surface-modified medical material of the present invention are selected from the group of calcium compounds, phosphorus compounds, magnesium compounds, fluorine compounds, silicon compounds, silver compounds and carbon compounds. A surface-modified medical material, characterized in that at least one powder is fixed or solid-solved on at least a part of the surface, a calcium compound,
Method for producing surface-modified medical material in which at least one powder selected from the group consisting of phosphorus compounds, magnesium compounds, fluorine compounds, silicon compounds, silver compounds, and carbon compounds is mechanically pressed onto the surface of medical materials by blasting or the like ,.

The term "calcium compound" as used in the present invention means that a calcium element is contained in the compound, and includes metallic calcium, calcium oxide, calcium hydride, calcium hydroxide, apatite, tricalcium phosphate, tetracalcium phosphate, Examples include calcium hydrogen phosphate, calcium dihydrogen phosphate, calcium chloride, calcium acetate, calcium carbonate, calcium silicate and the like.

The phosphorus compound referred to in the present invention is a compound containing elemental phosphorus, and includes phosphorus, potassium phosphate, sodium phosphate, sodium dihydrogen phosphate, tricalcium phosphate, tetracalcium phosphate, Examples include calcium hydrogen phosphate and calcium dihydrogen phosphate.

The term "magnesium compound" as used in the present invention means a compound containing a magnesium element, such as metallic magnesium, magnesium oxide, magnesium hydroxide, magnesium dihydrogen phosphate, magnesium carbonate, magnesium chloride, magnesium fluoride, Examples include trimagnesium phosphate and magnesium silicate.

The fluorine compound referred to in the present invention is a compound containing elemental fluorine, and examples thereof include calcium fluoride, potassium fluoride, sodium fluoride, potassium hydrogen fluoride, magnesium fluoride and the like.

The term "silicon compound" as used in the present invention means that the compound contains elemental silicon, such as silicon, silicic acid,
Examples thereof include silicon oxide, silicon dioxide, potassium silicofluoride, sodium silicofluoride, and magnesium silicofluoride.

The term "silver compound" as used in the present invention means a compound containing a silver element, such as metallic silver, silver oxide, silver carbonate,
Examples are silver chloride and silver fluoride.

The carbon compound referred to in the present invention is a compound containing a carbon element, and examples thereof include carbon, zirconium carbide, titanium carbide and boron carbide. Drugs containing carbon such as antibacterial agents such as penicillin, cepham agents, sulfa agents, antiviral agents and steroids are also defined as carbon compounds.

The blasting process in the present invention means a blasting device such as a centrifugal projection type, an air projection type or a belt projection type for powders of calcium compounds, phosphorus compounds, magnesium compounds, fluorine compounds, silicon compounds, silver compounds, carbon compounds and the like. Is a method of mechanically pressing the powder onto the surface of the medical material. The air projection type is generally used, but this is a process of spraying powder by using compressed gas from a nozzle. Examples of the air projecting method include a direct air projecting method in which a tank containing the powder is directly pressurized, and an inductive air projecting method in which the powder is sucked using an ejector nozzle and the powder is sprayed.

The buff treatment in the present invention means calcium compound, phosphorus compound, magnesium compound, fluorine compound,
Between a buff that rotates at high speed and a medical material by using a buff configured as a rotating body of a flexible material such as cotton cloth, sisal, leather, or felt as a support for powder of silicon compound, silver compound, carbon compound, etc. In this method, the powder is mechanically pressed against the surface of the medical material by a mechanical force acting on the surface of the medical material.

The barrel treatment referred to in the present invention is such that powders and medical materials such as calcium compound, phosphorus compound, magnesium compound, fluorine compound, silicon compound, silver compound and carbon compound are put in a barrel tank, and rotation, vibration, etc. Is a method of causing relative movement between the medical material and the powder to mechanically press the powder onto the surface of the medical material.

The term "fixed" as used in the present invention means a state in which powder obtained by mechanical pressure welding such as blasting, buffing, barreling, etc. is strongly fixed to the material surface. Therefore, in the present invention, the bonding mode between the film obtained by plasma spraying and the material surface is not defined as sticking. Therefore, the surface-treated medical material produced by plasma spraying is not included in the present invention. The bonding mode between the film obtained by applying an aqueous solution or the like and the material surface is adhesion and is not defined as sticking. Therefore, a surface-modified medical material produced by solution coating or the like is not included in the present invention.

However, the surface of the medical material is subjected to mechanical pressure contact such as blast treatment with a film component of the medical material, which is produced by plasma spraying or solution coating and has a surface covered with a film. The surface-modified medical material and the method for producing the same are included in the present invention.

The solid solution as referred to in the present invention means a state in which all or part of the powder component is contained in the medical material component by mechanical pressure contact such as blasting treatment, buffing treatment and barrel treatment. Solid solution occurs when two or more different substances come into contact with each other. When the powder comes into contact with the medical material by strong mechanical pressure contact such as blasting, part or all of the powder components are diffused on the surface of the medical material by atomic diffusion or the like and solid-dissolved. It should be noted that the definition of solid solution in the present invention does not require that the components are uniformly dissolved.

The present invention comprises the principles described below.

When the medical material is implanted in a living body, its surface comes into contact with body fluid. Even when the medical material comes into contact with hard tissue such as bone and soft tissue such as muscle, it is the surface of the medical material that comes into contact with these tissues, and in most cases, body fluid exists between them. Therefore, in order to improve the biocompatibility of the medical material, surface modification of the medical material may be considered. On the other hand, the mechanical properties of medical materials are determined as the average of the mechanical properties of the entire material,
Surface modification does not make a significant difference in their mechanical properties.

The surface-modified medical material in which the calcium compound and the phosphorus compound are fixed or solid-solved on at least a part of the surface is, for example, improved in hard tissue affinity of the medical material,
Alternatively, it is effective in promoting generation of hard tissue in contact with a medical material. This can be understood from the fact that apatite or the like is coated on the surface of the medical metal material by plasma spraying to improve biocompatibility of the hip joint or the like. Apatite, which is a component of hard tissue such as bone, is calcium phosphate, and it is known that a calcium phosphate compound exhibits a catalytic action in apatite formation. Further, the calcium compound and the phosphorus compound are dissolved in the body fluid from the surface of the surface-modified medical material, and as a result,
It is also suggested to increase the degree of supersaturation of body fluid with respect to apatite and promote the production of apatite.

The surface-modified medical material in which the magnesium compound and the phosphorus compound are fixed or solid-solved on at least a part of the surface is effective for preventing calcification on the surface of the medical material, for example. One of the reasons for this is that the magnesium compound suppresses the formation of apatite, which is the cause of calcification. It is known that some phosphorus compounds such as pyrophosphate also suppress the formation of apatite, which is a cause of calcification, like magnesium compounds.

The surface-modified medical material in which the fluorine compound is fixed or solid-dissolved on at least a part of the surface is effective for giving antibacterial property and low surface tension to the surface of the medical material, for example. This is one of the reasons that the fluorine compound has antibacterial properties and low surface tension.

The surface-modified medical material in which the silicon compound is adhered or solid-dissolved on at least a part of the surface is effective for giving an adhesive force to the surface of the medical material, for example. This is because the silicon compound has compounds with various functional groups,
One of the causes is that the silicon compound effectively acts on adhesion. In addition, it was recently reported that silicon compounds are effective in improving the affinity for hard tissue or promoting the formation of hard tissue. Therefore, it is suggested that the surface-modified medical material in which the silicon compound is adhered to at least a part of the surface may be a material having excellent hard tissue affinity or promoting hard tissue generation.

The surface-modified medical material in which the silver compound is fixed or solid-dissolved on at least a part of the surface is exemplified as being capable of imparting antibacterial property to the surface of the medical material. This is one of the reasons that the silver compound has antibacterial properties.

The surface-modified medical material in which the carbon compound is fixed or solid-dissolved on at least a part of the surface is exemplified by giving antibacterial property to the surface of the medical material. This is one of the reasons that the carbon compounds have antibacterial properties. In addition, a surface-modified medical material in which a drug which is a carbon compound is adhered to at least a part of the surface can be used as a kind of drug delivery method because the drug is contained on the surface of the medical material.

Calcium compounds, phosphorus compounds, magnesium compounds, fluorine compounds, silicon compounds, silver compounds,
Although examples of surface modification with a carbon compound have been described above, it is considered that the properties of the compound are all imparted to the surface of the medical material. The calcium compound, phosphorus compound, magnesium compound, fluorine compound, silicon compound, silver compound, and carbon compound are dissolved on the surface as a catalyst or gradually dissolved from the surface of the surface-modified medical material to exhibit a desired action. It

The method of the present invention can be applied to compounds containing no calcium element, phosphorus element, magnesium element, fluorine element, silicon element, silver element and carbon, but calcium element, phosphorus element, magnesium element, elemental fluorine. When a medical material is treated with a compound containing no elemental silicon, elemental silver, and carbon, surface modification is not useful, or useful. For example, modifying the surface of a medical material with sodium chloride is not very useful.

The surface-modified medical material of the present invention is manufactured by the manufacturing method described below. Blast processing,
Buffing, barreling and the like are both methods in which powder is mechanically pressed against the surface of the medical material. For simplicity, only the case of blasting will be described below.

The material is shaped into a desired shape by known methods such as cutting, casting, cutting, sewing, and stitching. After that, at least one powder selected from the group consisting of a calcium compound, a phosphorus compound, a magnesium compound, a fluorine compound, a silicon compound, a silver compound, and a carbon compound is mechanically pressed onto the surface of the medical material by blasting or the like for treatment. . Before or after mechanically pressing at least one powder selected from the group consisting of calcium compounds, phosphorus compounds, magnesium compounds, fluorine compounds, silicon compounds, silver compounds, and carbon compounds on the surface of medical materials by blasting, etc. To
Sterilization and sterilization operations may be added as necessary.

For example, when the screw-shaped titanium is made to have the biocompatibility of apatite, the apatite powder is put into a blasting device or the like, and the screw-shaped titanium is blasted. There is no limitation on the air pressure used for blasting, but generally, the higher the air pressure, the greater the treatment effect, and therefore a sufficient effect can be obtained by a short treatment time. However, if the air pressure is too high, the shape of the raw material may be deformed, which is not preferable. The treatment time is determined in relation to the air pressure and the desired degree of treatment. Generally, the longer the treatment time is, the greater the treatment effect is, so that a sufficient effect can be obtained. However, if the processing time is too long, the shape of the raw material may be deformed, which is not preferable.

The powder to be blasted may contain at least one powder selected from the group consisting of calcium compounds, phosphorus compounds, magnesium compounds, fluorine compounds, silicon compounds, silver compounds and carbon compounds. Even a single compound, You may mix 2 or more types of powder. When two or more kinds of powders are mixed and used, it is preferable that both are sufficiently mixed in advance. Since most of the blasting devices take in only the powder in the vicinity of the powder inlet, the desired surface modification may not be possible if the powders are not sufficiently mixed.

It is also useful to blast one surface of the medical material with another powder, followed by blasting with another powder. In this case, at least one powder needs to be at least one powder selected from the group consisting of calcium compounds, phosphorus compounds, magnesium compounds, fluorine compounds, silicon compounds, silver compounds and carbon compounds.

It is also effective to pretreat the powder to be blasted. For example, when it is desired to modify the surface of a medical material with an antibiotic agent which is a carbon compound, there are cases where the surface modifying effect is not sufficient with the antibiotic agent which is a carbon compound alone. In such a case, for example, if apatite or the like is permeated into a solution containing an antibiotic, the antibiotic is adsorbed or absorbed on the surface of the apatite. Therefore, the surface of the medical material can be modified with the antibiotic agent by blasting the apatite or the like having the antibiotic agent adsorbed on the surface.

In the blast treatment, at least one powder selected from the group consisting of calcium compound, phosphorus compound, magnesium compound, fluorine compound, silicon compound, silver compound and carbon compound is mechanically applied to the surface of medical material by utilizing a gas flow. It is not necessary to use air for the blast treatment, as it is one of the methods of performing pressure contact and treatment. There is no problem to use more inert argon gas, nitrogen gas or the like for the purpose of preventing the oxidation of the surface of the medical material.

When at least one powder selected from the group consisting of a calcium compound, a phosphorus compound, a magnesium compound, a fluorine compound, a silicon compound, a silver compound and a carbon compound is mechanically pressed onto the surface of the medical material by blasting or the like. It is also effective to apply a solvent or solution to the treated surface or change the environment such as the water vapor pressure. For example, when the water vapor pressure is increased when blasting a titanium plate with tetracalcium phosphate and calcium hydrogen phosphate powder, some apatite, which is thought to have been formed by the reaction between tetracalcium phosphate and calcium hydrogen phosphate, is also generated. To do.

Calcium compounds, phosphorus compounds, magnesium compounds, fluorine compounds, silicon compounds, silver compounds,
When at least one powder selected from the group of carbon compounds is mechanically pressed onto the surface of the medical material by blasting or the like, the treatment temperature is not limited in the present invention. It is generally known that the higher the processing temperature, the higher the element diffusion rate, but the risk of complicating the processing apparatus and denaturing the material increases.

The present invention will be described in more detail by way of examples.

The surface properties of the surface-modified medical material were analyzed using a wavelength dispersive X-ray microanalyzer (hereinafter referred to as XMA). In addition, prior to the analysis, the surface-modified medical material after the surface treatment was sufficiently washed by repeating ultrasonic cleaning in acetone of 10 cc per 1 cm 2 of the treated area 10 times. For example, a medical material having a treated area of 2 square centimeters is ultrasonically cleaned in 20 cc of acetone for 1 minute, the acetone is exchanged, and further ultrasonically cleaned in fresh 20 cc of acetone for 1 minute. This ultrasonic cleaning
The operation of acetone exchange was repeated 10 times. Hereinafter, this cleaning operation is called acetone ultrasonic cleaning. When the antibiotic was used as a powder, the antibiotic eluted in distilled water was analyzed by liquid chromatography.

[0047]

Example 1 Apatite powder was mechanically pressed against a metal titanium plate using a sandblasting device. The processing time was 10 seconds per square centimeter. After the ultrasonic treatment of the treated metal titanium plate with acetone, the surface of the metal titanium plate was subjected to XMA analysis, and peaks of calcium and phosphorus were detected in addition to titanium. The molar ratio of calcium to phosphorus was almost the same as that of the apatite powder.

[0048]

Example 2 After the titanium metal plate was ultrasonically cleaned with acetone, the surface of the metal titanium plate was analyzed by XMA. No peaks other than titanium were detected.

[0049]

Example 3 Tricalcium phosphate powder was mechanically pressed against a metal titanium plate using a blasting device. The processing time was 10 seconds per square centimeter. After the ultrasonic treatment of the treated metal titanium plate with acetone, the surface of the metal titanium plate was subjected to XMA analysis, and peaks of calcium and phosphorus were detected in addition to titanium. The molar ratio of calcium to phosphorus was almost the same as the molar ratio of tricalcium phosphate powder.

[0050]

Example 4 Apatite powder was mechanically pressed against a metallic stainless plate using a blasting device. The processing time is 1
It was set to 10 seconds per square centimeter. After the treated metal stainless steel plate was ultrasonically cleaned with acetone, the surface of the metal stainless steel plate was analyzed by XMA. Calcium and phosphorus peaks were detected in addition to the stainless steel components. The molar ratio of calcium to phosphorus was almost the same as that of the apatite powder.

[0051]

[Example 5] Apatite powder was mechanically pressure-contacted to a metal bitarium plate using a blasting device. The processing time was 10 seconds per square centimeter. After the ultrasonic treatment of the treated metal vitalium plate with acetone, the surface of the metal vitalium plate was subjected to XMA analysis, whereupon peaks of calcium and phosphorus were detected in addition to the components of the vitalium.
The molar ratio of calcium to phosphorus was almost the same as that of the apatite powder.

[0052]

Example 6 Apatite powder was mechanically pressed against a Teflon plate using a blasting device. The processing time was 10 seconds per square centimeter. After the treated Teflon plate is ultrasonically cleaned with acetone, the surface of the Teflon plate is subjected to XM.
In the A analysis, calcium and phosphorus peaks were detected in addition to the Teflon component. The molar ratio of calcium to phosphorus was almost the same as that of the apatite powder.

[0053]

Example 7 Apatite powder was mechanically pressed against a graphite plate using a blasting device. The processing time was 10 seconds per square centimeter. After the treated graphite plate was ultrasonically cleaned with acetone, the surface of the graphite plate was analyzed by XMA. Calcium and phosphorus peaks were detected in addition to the graphite components. The molar ratio of calcium to phosphorus was almost the same as that of the apatite powder.

[0054]

Example 8 Apatite powder was mechanically pressed against a Teflon cloth using a blasting device. The processing time was 10 seconds per square centimeter. After the treated Teflon cloth is ultrasonically cleaned with acetone, the surface of the Teflon plate is XM
In the A analysis, calcium and phosphorus peaks were detected in addition to the Teflon component. The molar ratio of calcium to phosphorus was almost the same as that of the apatite powder.

[0055]

Example 9 Teflon cloth was mechanically pressed against a powder of cefazolin, which is an antibiotic, using a blasting device. The processing time was 1 minute per 1 cm 2. The treated Teflon cloth was subjected to ultrasonic cleaning with acetone, and then the Teflon cloth was immersed in distilled water. Cefazolin was detected when the distilled water was analyzed 24 hours after the immersion.

[0056]

Example 10 Magnesium oxide powder was mechanically pressed against a metal titanium plate using a blasting machine. The processing time was 10 seconds per square centimeter. After the treated metallic titanium plate was ultrasonically cleaned with acetone, the surface of the metallic titanium plate was subjected to XMA analysis, whereupon peaks of magnesium other than titanium were detected.

[0057]

Example 11 Calcium fluoride powder was mechanically pressed against a metal titanium plate using a blasting device. The processing time was 10 seconds per square centimeter. After the treated metallic titanium plate was ultrasonically cleaned with acetone, the surface of the metallic titanium plate was subjected to XMA analysis, and peaks of calcium and fluorine were detected in addition to titanium.

[0058]

Example 12 Silicon dioxide powder was mechanically pressed against a metal titanium plate using a blasting device. The processing time is 1
It was set to 10 seconds per square centimeter. After the treated metal titanium plate was ultrasonically cleaned with acetone, the surface of the metal titanium plate was subjected to XMA analysis, and silicon peaks were detected in addition to titanium.

[0059]

Example 13 A silver oxide powder was mechanically pressed against a metal titanium plate using a blasting machine. The processing time was 10 seconds per square centimeter. After the treated metallic titanium plate was ultrasonically cleaned with acetone, the surface of the metallic titanium plate was subjected to XMA analysis, and a peak of a silver element was detected in addition to titanium.

[0060]

[Example 14] Apatite powder was pressed against a metal titanium plate with a cotton ball by hand pressure so as to rub it. The processing time was 10 minutes per square centimeter. After the ultrasonic treatment of the treated metal titanium plate with acetone, the surface of the metal titanium plate was subjected to XMA analysis, and peaks of calcium and phosphorus were detected in addition to titanium. However, the peaks of calcium and phosphorus were smaller than those in Example 1. The molar ratio of calcium to phosphorus was almost the same as that of the apatite powder.

Claims (4)

[Claims] 1. A calcium compound, a phosphorus compound, a magnesium compound, a fluorine compound, a silicon compound, a silver compound,
A surface-modified medical material characterized in that at least one powder selected from the group of carbon compounds is fixed or solid-solved on at least a part of the surface. 2. A calcium compound, a phosphorus compound, a magnesium compound, a fluorine compound, a silicon compound, a silver compound,
The surface-modified medical material according to claim 1, wherein at least one powder selected from the group of carbon compounds is a calcium compound. 3. A calcium compound, a phosphorus compound, a magnesium compound, a fluorine compound, a silicon compound, a silver compound,
The method for producing a surface-modified medical material according to claim 1, wherein at least one powder selected from the group of carbon compounds is mechanically pressed onto the surface of the medical material. 4. A calcium compound, a phosphorus compound, a magnesium compound, a fluorine compound, a silicon compound, a silver compound,
The method for mechanically pressure-contacting at least one powder selected from the group of carbon compounds on the surface of a medical material is blast treatment, and the method for producing a surface-modified medical material according to claim 3.