JP2930619B2 - Titanium or a titanium based alloy biological restoration part and a surface treatment - Google Patents

Titanium or a titanium based alloy biological restoration part and a surface treatment

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JP2930619B2
JP2930619B2 JP28257089A JP28257089A JP2930619B2 JP 2930619 B2 JP2930619 B2 JP 2930619B2 JP 28257089 A JP28257089 A JP 28257089A JP 28257089 A JP28257089 A JP 28257089A JP 2930619 B2 JP2930619 B2 JP 2930619B2
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titanium
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aqueous solution
based alloy
surface
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JPH03146679A (en )
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精一 塚本
春幸 川原
裕 野村
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春幸 川原
東邦チタニウム株式会社
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【発明の詳細な説明】 (産業上の利用分野) 本発明は歯科、外科等の医療分野に於て用いるチタンもしくはチタン基合金製生体修復部材、とりわけインプラント部材、例えば人工関節、骨接合部材、人工骨、人工歯根、義歯等の改良に関する。 BACKGROUND OF THE INVENTION (FIELD OF THE INVENTION) The present invention is a dental titanium or a titanium based alloy biological restoration part used At a medical field of surgery such as, inter alia implant member, for example, artificial joints, osteosynthesis member, artificial bone, artificial tooth root, relates to an improvement of dentures.

(従来の技術) 生体内に埋設される上記生体修復部材の表面と生体組織との界面に於ける初期接着は部材表面の性状によって異なる。 Interface in initial adhesion between the surface and the biological tissue (prior art) the biological restoration part that is embedded in the body depends properties of the component surface. 即ち、凹凸のない鏡面の場合は骨との結合力が低く当該組織による部材の支持が不充分である。 That is, in the case of no unevenness mirror is insufficient support member by the organization low bonding strength with the bone. 之に対して凹凸をもった粗面の場合は骨が細隙内に侵入・増殖して微少投錨効果(マイクロ−アンカーリング)を得ることができ、部材の骨内支持が強力なものとなる。 This bone case of the rough surface having irregularities against intrusion and proliferation into the slit to small anchor effect (micro - anchoring) can be obtained, intraosseous support member is a stronger . また比較的早期に必要な初期接着強度が得られる。 The initial adhesive strength can be obtained required a relatively early stage. この意に於て修復部材の表面に粗面加工を行なう技術は従来より採用されてきた所である。 Technique for roughening this intention At a surface of the restoration member is where has been adopted conventionally. すなわち、最も一般的な方法として機械加工による素肌のまゝか部材の表面にプラズマ溶射による粗面加工を行なうことがなされてきた。 That is, most common or the skin by machining a method ゝ or member surface is possible to perform surface roughening by plasma spraying have been made. しかし、前者の場合の欠点としては金属製加工具(切削、 However, the disadvantages of the former metal working tools (cutting,
研磨用等)からの異種金属が部材表面に転移して生体組織を汚染することが挙げられ、後者の場合は加工工程が複雑で加工費も嵩む。 Different metal from the polishing, etc.) is transferred to the surface of the member that can be mentioned of contaminating the biological tissue, in the latter case the processing steps increase the complexity and processing costs. このような点に鑑み特開昭55−12 JP Akira view of the above problems 55-12
0864によって金属製修復部材表面に10nm〜1000nm(0.01 10 nm to 1000 nm (0.01 to metal restoration part surface by 0864
μm〜1μm)の超微細毛孔を形成する試みが提案されたが、このような超微細毛孔を形成する加工技術は極めて面倒複雑でコスト高となり、また細胞との結合力も必ずしも充分ではない、と云う問題をなお残している。 Attempts to form a ultrafine hair follicles of Myuemu~1myuemu) was proposed, such processing techniques for forming the ultrafine hair follicles become extremely cumbersome complex and costly, also not always sufficient even binding force between the cells, and It has left a problem that still.

(発明が解決しようとする課題) 本発明は凡そ上記問題点の除去に鑑みなされたもので、チタンもしくはチタン基合金製生体修復部材の表面と骨組織との微少投錨効果を確立するためには細胞の初期部材の表面接着が優れた粗面構造を作成する必要がある。 (0007) The present invention has been made in view of the approximate removal of the problem, in order to establish a small anchoring effect between the surface and the bone tissue of the titanium or titanium-based alloy biological repair member surface adhesion of the initial members of the cell needs to create a good rough surface structure. しかもその粗面構造の作成方法は簡易で生産性が良く安価である上に面粗度をコントロールし易い生体修復部材並びにその表面処理法をこゝに提供せんとするものである。 Moreover the method of creating a rough surface structure is intended to provide St. biological repair members and their surface treatment easily control the surface roughness on a cheap good productivity by simple to this ゝ.

(課題を解決するための手段) 本発明はチタンもしくはチタン基合金製生体修復部材の少なくとも埋入部表面を1〜6wt%濃度のフッ化水素酸(HF)水溶液と、1〜10wt%濃度の過酸化水素(H (SUMMARY for a) the invention and 1~6Wt% concentration of hydrofluoric acid (HF) aqueous solution at least implanting part surface of the titanium or titanium-based alloy biological restoration part, over the 110 wt.% Concentration hydrogen oxidation (H
2 O 2 )液との混合水溶液に浸漬処理することにより、平均孔径1〜10μm、平均深さ0.5〜5μmの不定形の微細な凹みを設けて成るチタンもしくはチタン基合金製生体修復部材に関する。 By immersed in a mixed aqueous solution of 2 O 2) solution, the average pore size 1 to 10 [mu] m, about titanium or titanium-based alloy biological restoration part comprising providing irregular fine depressions average depth 0.5 to 5 [mu] m. 更に、本発明は、上記混合水溶液に浸漬処理するに先立って、上記の埋入部表面を前処理として、1〜6wt%濃度のフッ化水素酸(HF)水溶液により酸処理をすることを含む。 Furthermore, the present invention includes, prior to immersing into the mixed aqueous solution, as a pretreatment of the above implanting part surface, the acid treatment with hydrofluoric acid (HF) aqueous solution 1~6Wt% concentration. 本発明はまた、上記酸処理が前処理として1〜6wt%濃度のフッ化水素酸(HF) The present invention also provides, 1~6wt% concentration of hydrofluoric acid the acid treatment as a pretreatment (HF)
水溶液に上記埋入部表面を30秒〜3分間浸漬処理をすること、続いて後処理として1〜6wt%濃度のフッ化水素酸水溶液と1〜10wt%濃度の過酸化水素(H 2 O 2 )液との混合水溶液に10〜60秒浸漬処理をすることよりなるチタンもしくはチタン基合金製生体修復部材の表面処理法に関する。 The implanting part surface to a 30 seconds to 3 minutes immersion treatment in an aqueous solution, followed by 1~6Wt% concentration aqueous solution of hydrofluoric acid and 110 wt.% Concentration of hydrogen peroxide as a post-treatment (H 2 O 2) relating to the surface treatment method of titanium or a titanium based alloy biological restoration part consists in 10 to 60 seconds immersed in a mixed aqueous solution of liquid.

(作用) 前処理としてのフッ化水素酸(HF)水溶液はチタンもしくはチタン基合金製生体修復部材の表面酸化膜はもとより加工工程中に受けた異種金属の汚染を十分に洗浄化し得ると共に後記の限定条件のものを用いることによって平均孔径1〜10μm、平均深さ0.5〜5μmの不定形の微細な凹みを多設することができる。 (Action) before the treatment of hydrofluoric acid (HF) aqueous solution described later with can sufficiently cleaned the surface oxide film as well contamination dissimilar metals which received during the processing steps of a titanium or a titanium based alloy biological restoration part the average pore size of 1~10μm by using those limiting conditions, it is possible to multi-set fine dents of amorphous average depth 0.5 to 5 [mu] m. またHF濃度、浸漬時間の調整により上記孔径、深さを可変して面粗度をコントロールすることが可能である。 The HF concentration, by adjusting the immersion time is possible to control the surface roughness and the pore size, the depth variable to. HFの濃度を1〜6w 1~6w the concentration of HF
t%の範囲のものとするのは1%未満の場合は孔径が1 To those of the t% range is pore diameter of less than 1% 1
μmに達せず、6%を超えると逆に大きくなって10μm Not reach μm, increases in reverse and when it is more than 6% 10μm
を超えてしまうからである。 This is because exceeds. 而して平均孔径が1μm未満の場合は細胞の接着力が低くなり、10μmを超えると組織細胞(その大きさは10〜100μmと云われている) If Thus to an average pore size of less than 1μm the lower the adhesion cells, more than 10μm and tissue cells (its size is said to 10 to 100 [mu] m)
より大きくなる場合があり、この場合は細胞が凹みの谷底に付着して山部を跨がないので接着強度が十分に得られないと云う理由による。 It may be larger, for reasons this case referred to as adhesive strength does not cross the ridges attached to the valley bottom of the recessed cell can not be sufficiently obtained. 平均深さが0.5〜5μmの範囲である理由は0.5μmを下廻る時は骨と部材間における投錨効果が減少し、5μmを上廻る場合は投錨力はあがるものの凹みの稜線部にシャープエッジや尖鋭とげが出来易く、組織刺戟性(発展的には発癌のトリガーとなる)が出てくるからである。 Why the average depth is in the range of 0.5~5μm is reduced anchoring effect between the bone and the member when Shitamawaru a 0.5 [mu] m, Ya sharp edge ridge portion of the recess of the anchor force will go up as if of more than 5μm easily it can be sharp thorns, organization stimulable (in evolutionary is the carcinogenesis of trigger) because there is coming out. 浸漬時間を30秒〜3分としたのは、30秒未満の場合は凹みの深さが浅すぎて処理前の汚染層を十分に除去しきれない傾向があり、3分を超えると凹みの深さが深くなりすぎて前記したようにシャープエッジや尖鋭とげが多くなるためである。 The immersion time was 30 seconds to 3 minutes, tend to not be fully purged of contamination layer pretreatment is too shallow depth of the recess in the case of less than 30 seconds, the recess exceeds 3 minutes sharp edges and sharp thorns as described above the depth becomes too deep because the increases.

後処理としてのHF及びH 2 O 2混合水溶液浸漬は前処理によって形成された微細な凹みに発現するシャープエッジ、尖鋭とげをなめらかにする作用をなす。 HF and H 2 O 2 mixed aqueous solution immersion sharp edges that express a fine recess formed by the pre-processing as a post-treatment, an action to smooth the sharp barbs. 後の実施例でも述べる如くこの混合水溶液に代ってH 2 O 2水溶液単味の場合はシャープエッジ、尖鋭とげの平滑化に役立たない。 Sharp edges, not help smooth the sharp barbs For aqueous H 2 O 2 plain on behalf of the mixed aqueous solution as described in the examples below. H 2 O 2の濃度を1〜10wt%としたのは、1wt%未満の場合はHF単味と同じ程度の効果、即ちシャープエッジ、 H 2 The concentration of O 2 was 110 wt.%, If less than 1 wt% of the same extent as HF plain effect, i.e. sharp edge,
尖鋭とげの除去作用が不充分であり、10wt%を超えると孔径を大としてしまい新しいシャープエッジ、尖鋭とげが発現し易い傾向となるからである。 Is insufficient removal action of sharp thorns, because more than 10 wt% when a new sharp edge will be large pore size, the sharp barb becomes tendency expressed. 浸漬時間を10〜60 The immersion time from 10 to 60
秒としたのは10秒に満たないときは効果が不充分であり、逆に60秒より長くなるとシャープエッジ、尖鋭とげが現われてくるからである。 When less than did the seconds to 10 seconds effects is insufficient, because sharp edges becomes longer than 60 seconds Conversely, the sharp barbs emerge.

(実施例) 以下に本発明の実施例を比較例及び実験例ともども表1に示す。 Examples of the present invention (Embodiment) The following Comparative Examples and Experimental Examples in company Table 1.

表1の結果を添付図面代用の電子顕微鏡写真(以下単に写真と略す)を参照しながら表1の順について説明する; (1)鏡面仕上げのまゝの無処理の比較例1のものは写真1の如くショット打痕、クレバス(この他写真外であるが隠蔽穴)があり、結合組織の接着を考慮した際不適である。 With reference to the results of Table 1 to the accompanying drawings substitute electron micrograph (hereinafter simply referred to as picture) will be described sequentially in Table 1; (1) photograph of Comparative Example 1 of untreated mirror finish or ゝ1 as shot dent, there is crevasse (although this other photo out hiding holes), is unsuitable when considering adhesion connective tissue.

(2)比較例1のものをHF処理をしたものは写真2の如く酸蝕による多くのピットが発現するが、孔縁がシャープエッジ(白い稜線部)をなしており組織への刺戟性を考慮する時、望ましくない。 (2) those things Comparative Example 1 was the HF treatment express many pits by San蝕 as photo 2, the stimulation of the hole edge has no sharp edges (white edge line portion) tissue when considering, undesirable.

(3)実施例1の如く比較例2のHF処理時間を1/2とし、これに続いてHF+H 2 O 2の混合液に浸漬したものは写真3のようにシャープエッジが大部分とれて(白い稜線部がボヤけてきている)尖鋭とげはない。 (3) and 1/2 HF treatment time of Comparative Example 2 as in Example 1, following which those immersed in a mixed solution of HF + H 2 O 2 is taken sharp edge largely as shown in the photograph 3 ( been white ridge line is blurred is) sharp thorn is not.

(4)実施例2の如く比較例2のHF処理と同一条件とし続いて上記混合液処理を行なったものは写真4の如くシャープエッジ、尖鋭とげは不在でベストモードを示している。 (4) the same conditions as HF treatment of Comparative Example 2 as a to subsequently be as sharp edges of those photo 4 was subjected to the mixed solution treatment Example 2, pointed thorns represents the best mode in the absence.

(5)HF処理を実施例2の2倍時間かけて実施例2と同一の混合液処理を行なった実施例3のものは写真5の如くピット孔径が約2倍に増大すると共に大きなピットの中に小さな(1〜3μm)のピットが認められシャープエッジ、尖鋭とげが殆どない。 (5) the pit hole diameter as photos 5 things over HF treatment twice time of Example 2 Example 2 and Example 3 was subjected to the same liquid mixture processing of large pits with an increase of about 2-fold a small pit was observed sharp edge of (1~3μm), there is little sharp thorn in.

(6)HFの濃度を前実施例の1/2とし同じ混合液処理をした実施例4のものは写真6に示す如く孔径の変化は小さい。 (6) The change in pore size as shown in Photo 6 that of Example 4 in which the concentration of HF is 1/2 the previous example was the same mixture process is small. シャープエッジ、尖鋭とげは若干あるがこの程度では心配に値しない。 Sharp edge, sharp thorns are some, but not worth the worry in this degree.

(7)HFの濃度を実施例1〜3の2倍にし混合液処理を同じにした実施例5のものは写真7の如く概ね実施例4 (7) generally example as photo 7 those of Example 5 the concentration was doubled mixed solution process of Examples 1 to 3 in the same HF 4
のものと同じ所見である。 Is the same findings as those of.

(8)後処理液としてH 2 O 2水溶液単独を用い後処理時間を1分とした実験例1のものは写真8の如く孔径が減少しこれと共に多くのシャープエッジ、尖鋭とげの発現がみられる。 (8) post-treatment solution as aqueous H 2 O 2 alone was used as pore size decreases many sharp edges with which the photo 8 those of Experimental Example 1 was 1 minute post-processing time, the sharp barbs expression observed It is.

(9)実験例1の後処理液を用い後処理時間を15秒とした実験例2のものは写真9より明らかなように実験例1 (9) Experimental Experimental Example As is apparent from the photograph 9 that of Example 1 of the post-treatment liquid Experimental Example 2 a post-treatment time was 15 seconds using a 1
とほゞ同様な所見となっている。 Mining Isuzu has the same findings.

(10)実施例1〜5に於て、HFの濃度もしくは浸漬時間を変えることによってピットの孔径(面粗度)を変えることが出来る。 (10) Example At a 1-5, by varying the concentration or immersion time of HF can change a pore size of pits (surface roughness).

以上を更にまとめると; a)HF処理によって平滑な表面が酸蝕されて多数のピットが形成され、続いてHFとH 2 O 2との混合液による後処理によって上記ピットの稜縁が平滑にされるも、HFの濃度が低過ぎてもくシャープエッジ、尖鋭とげが復元する傾向にある。 Further summary; a) a number of pits are San蝕a smooth surface by HF treatment is formed, followed by ridge edge of the pit by post-treatment with a mixture of HF and H 2 O 2 is smooth also, there is a tendency that sharp edge which the concentration of HF is rather be too low, the sharp thorns to restore.

b)後処理液としてHFを含まずH 2 O 2単独の場合は何故かシャープエッジ、尖鋭とげの消去に役立たない。 b) why sharp edge in the case of H 2 O 2 alone free of HF as a post-processing solution, not help erase sharp barbs.

c)前処理のHFの濃度、処理時間の調整により、ピットの孔径を変えられる。 c) concentration of HF pretreatment, by adjusting the processing time, can change the diameter of the pits.

d)本発明法の後処理液を用いた場合、銀灰色の素地色は全て銀白色に輝いて見ばえが良好である。 When using the post-treatment liquid d) the method of the present invention, appearance is good all matrix color silvery gray is shining silver-white.

(発明の効果) 本発明は叙述より理解されたように、チタンもしくはチタン基合金製生体修復部材の埋入部表面に酸処理による平均孔径1〜10μm、平均深さ0.5〜5μmの不定形の微細な凹みを多設することによって、結合組織の当該表面に対する接着強度が優れ且つ見ばえの良い特徴を付与し得たものであり、またその酸処理も前処理として通常のフッ化水素酸による酸蝕を行ない、これに後続して後処理として同フッ化水素酸と過酸化水素との混合液による処理をすればよいので方法的にも簡易で生産性がよく且つ前処理としてのHFの濃度もしくは処理時間を変えることにより表面粗さを変えることが出来る…等の優れた利益がある。 (Effect of the Invention) The present invention as understood from the description, the average by acid treatment in the implanting part surface of the titanium or titanium-based alloy biological restoration part pore size 1 to 10 [mu] m, the average depth 0.5~5μm amorphous fine by multi-set the Do recess is intended adhesive strength to the surface of connective tissue were able to better and impart good characteristics looking, also by conventional hydrofluoric acid as a pretreatment also the acid treatment performs San蝕, the HF as well and pretreatment productivity by simple even mixture by treatment methodological it is sufficient for the same hydrofluoric acid and hydrogen peroxide as subsequent to the post-processing to It has excellent benefits of can ... etc. to alter the surface roughness by changing the concentration or treatment time.

【図面の簡単な説明】 BRIEF DESCRIPTION OF THE DRAWINGS

第1図は鏡面仕上げのままの無処理の比較例1の表面の結晶の構造を示す電子顕微鏡写真(×2000)、第2図は比較例2の表面の結晶の構造を示す電子顕微鏡写真(× Figure 1 is an electron micrograph showing the structure of the crystal of Comparative Example 1 the surface of the untreated left mirror finish (× 2000), an electron micrograph FIG. 2 showing the structure of the crystal surface of the comparative example 2 ( ×
2000)、第3図は実施例1の表面の結晶の構造を示す電子顕微鏡写真(×2000)、第4図は実施例2の表面の結晶の構造を示す電子顕微鏡写真(×2000)、第5図は実施例3の表面の結晶の構造を示す電子顕微鏡写真(×20 2000), Figure 3 is an electron micrograph showing the structure of the crystal of the surface of Example 1 (× 2000), an electron micrograph (× 2000 Fig. 4 showing the structure of the crystal of the surface of Example 2), the 5 figures electron micrograph showing the structure of the crystal of the surface of the example 3 (× 20
00)、第6図は実施例4の表面の結晶の構造を示す電子顕微鏡写真(×2000)、第7図は実施例5の表面の結晶の構造を示す電子顕微鏡写真(×2000)、第8図は実験例1の表面の結晶の構造を示す電子顕微鏡写真(×200 00), FIG. 6 is an electron micrograph showing the structure of the crystal of the surface of Example 4 (× 2000), seventh electron micrograph (× 2000 figure showing the structure of the crystal of the surface of the Example 5), the 8 an electron micrograph (× 200 figure showing the structure of the crystal of the surface of experimental example 1
0)、第9図は実験例2の表面の結晶の構造を示す電子顕微鏡写真(×2000)である。 0), FIG. 9 is an electron micrograph showing the structure of the crystal of the surface of Experimental Example 2 (× 2000).

───────────────────────────────────────────────────── フロントページの続き (56)参考文献 特開 昭55−120864(JP,A) 特開 平3−47264(JP,A) (58)調査した分野(Int.Cl. 6 ,DB名) C23F 1/00 - 1/46 A61C 8/00 A61L 27/00 A61F 2/28 ────────────────────────────────────────────────── ─── of the front page continued (56) reference Patent Sho 55-120864 (JP, a) JP flat 3-47264 (JP, a) (58 ) investigated the field (Int.Cl. 6, DB name) C23F 1/00 ​​- 1/46 A61C 8/00 A61L 27/00 A61F 2/28

Claims (5)

    (57)【特許請求の範囲】 (57) [the claims]
  1. 【請求項1】チタンもしくはチタン基合金製生体修復部材の少なくとも埋入部表面を、1〜6wt%濃度のフッ化水素酸(HF)水溶液と、1〜10wt%濃度の過酸化水素(H 2 O 2 )液との混合水溶液に浸漬処理することにより、 1. A least implanting part surface of the titanium or titanium-based alloy biological restoration part, and hydrofluoric acid (HF) aqueous solution 1~6Wt% concentration, 110 wt.% Concentration of hydrogen peroxide (H 2 O by immersed in a mixed aqueous solution of 2) solution,
    平均孔径1〜10μm、平均深さ0.5〜5μmの不定形の微細な凹みを設けて成るチタンもしくはチタン基合金製生体修復部材。 Average pore size 1 to 10 [mu] m, titanium comprising providing irregular fine depressions average depth 0.5~5μm or a titanium based alloy biological restoration part.
  2. 【請求項2】チタンもしくはチタン基合金製生体修復部材の少なくとも埋入部表面を、1〜6wt%濃度のフッ化水素酸水溶液で酸処理した後、1〜6wt%濃度のフッ化水素酸水溶液と、1〜10wt%濃度の過酸化水素液との混合水溶液に浸漬処理することにより、平均孔径1〜10μ The method according to claim 2, wherein at least implanting part surface of the titanium or titanium-based alloy biological restoration part, after acid treatment with hydrofluoric acid aqueous solution 1~6Wt% concentration hydrofluoric acid aqueous solution 1~6Wt% concentration by immersed in a mixed aqueous solution of hydrogen peroxide solution of 110 wt.% concentration, average pore size 1~10μ
    m、平均深さ0.5〜5μmの不定形の微細な凹みを設けて成るチタンもしくはチタン基合金製生体修復部材。 m, titanium comprising providing irregular fine depressions average depth 0.5~5μm or a titanium based alloy biological restoration part.
  3. 【請求項3】チタンもしくはチタン基合金製生体修復部材の少なくとも埋入部表面を、1〜6wt%濃度のフッ化水素酸(HF)水溶液と、1〜10wt%濃度の過酸化水素(H 2 O 2 )液との混合水溶液に浸漬処理することにより、 Wherein at least implanting part surface of the titanium or titanium-based alloy biological restoration part, and hydrofluoric acid (HF) aqueous solution 1~6Wt% concentration, 110 wt.% Concentration of hydrogen peroxide (H 2 O by immersed in a mixed aqueous solution of 2) solution,
    平均孔径1〜10μm、平均深さ0.5〜5μmの不定形の微細な凹みを設けるチタンもしくはチタン基合金製生体修復部材の表面処理方法。 Average pore diameter 1 to 10 [mu] m, a surface treatment method of titanium provided amorphous fine depressions average depth 0.5~5μm or a titanium based alloy biological restoration part.
  4. 【請求項4】チタンもしくはチタン基合金製生体修復部材の少なくとも埋入部表面を、1〜6wt%濃度のフッ化水素酸水溶液で酸処理した後、1〜6wt%濃度のフッ化水素酸水溶液と、1〜10wt%濃度の過酸化水素液との混合水溶液に浸漬処理することにより、平均孔径1〜10μ At least implanting part surface 4. A titanium or titanium-based alloy biological restoration part, after acid treatment with hydrofluoric acid aqueous solution 1~6Wt% concentration hydrofluoric acid aqueous solution 1~6Wt% concentration by immersed in a mixed aqueous solution of hydrogen peroxide solution of 110 wt.% concentration, average pore size 1~10μ
    m、平均深さ0.5〜5μmの不定形の微細な凹みを設けるチタンもしくはチタン基合金製生体修復部材の表面処理方法。 m, the surface treatment method of titanium provided amorphous fine depressions average depth 0.5~5μm or a titanium based alloy biological restoration part.
  5. 【請求項5】上記のフッ化水素酸水溶液による酸処理時間が30秒〜3分間であり、上記の混合水溶液による浸漬処理時間が10〜60秒間である請求項4に記載のチタンもしくはチタン基合金製生体修復部材の表面処理方法。 5. an acid treatment time by the hydrofluoric acid aqueous solution 30 seconds to 3 minutes, a titanium or titanium based of claim 4 immersion treatment time by mixing the above aqueous solution is 10 to 60 seconds the surface treatment method of the alloy biological restoration part.
JP28257089A 1989-10-30 1989-10-30 Titanium or a titanium based alloy biological restoration part and a surface treatment Expired - Lifetime JP2930619B2 (en)

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JP2740071B2 (en) * 1992-03-31 1998-04-15 日新製鋼株式会社 Method for producing a sintered metal implants
US7048870B1 (en) 1993-12-20 2006-05-23 Astrazeneca Ab Metallic implant and process for treating a metallic implant
ES2230553T3 (en) * 1994-11-30 2005-05-01 Implant Innovations, Inc. Preparation of an implant surface.
US6652765B1 (en) * 1994-11-30 2003-11-25 Implant Innovations, Inc. Implant surface preparation
EP1023910A1 (en) * 1999-01-29 2000-08-02 Institut Straumann AG Preparation of osteophilic surfaces for metallic prosthetic devices anchorable to bone
CA2387580A1 (en) * 1999-10-15 2001-04-26 Mount Sinai Hospital Synthetic substrate for tissue formation
EP1434607A1 (en) * 2001-10-11 2004-07-07 Straumann Holding AG Osteophilic implants
US8251700B2 (en) * 2003-05-16 2012-08-28 Biomet 3I, Llc Surface treatment process for implants made of titanium alloy
WO2006091582A3 (en) 2005-02-24 2007-03-01 Implant Innovations Inc Surface treatment methods for implants made of titanium or titanium alloy
JP4628168B2 (en) * 2005-04-14 2011-02-09 株式会社ネオス Roughening treatment method of a metal surface
US20090008365A1 (en) * 2007-07-06 2009-01-08 Depuy Products, Inc. Microtextured Implants and Methods of Making Same
EP2022447A1 (en) 2007-07-09 2009-02-11 Astra Tech AB Nanosurface

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