JPH07265352A - Patch agent - Google Patents
Patch agentInfo
- Publication number
- JPH07265352A JPH07265352A JP6062639A JP6263994A JPH07265352A JP H07265352 A JPH07265352 A JP H07265352A JP 6062639 A JP6062639 A JP 6062639A JP 6263994 A JP6263994 A JP 6263994A JP H07265352 A JPH07265352 A JP H07265352A
- Authority
- JP
- Japan
- Prior art keywords
- patch
- water
- sensitive adhesive
- pressure
- adhesive layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 24
- 229920003169 water-soluble polymer Polymers 0.000 claims abstract description 10
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims description 42
- 239000010410 layer Substances 0.000 claims description 36
- 239000003795 chemical substances by application Substances 0.000 abstract description 8
- 230000035699 permeability Effects 0.000 abstract description 7
- 208000003251 Pruritus Diseases 0.000 abstract description 6
- 230000007803 itching Effects 0.000 abstract description 6
- 230000000638 stimulation Effects 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 description 26
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 24
- 229920001577 copolymer Polymers 0.000 description 23
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 22
- 239000005977 Ethylene Substances 0.000 description 22
- 239000000853 adhesive Substances 0.000 description 21
- 230000001070 adhesive effect Effects 0.000 description 20
- -1 sorbitan aliphatic ester Chemical class 0.000 description 18
- 239000005020 polyethylene terephthalate Substances 0.000 description 13
- 229920000139 polyethylene terephthalate Polymers 0.000 description 13
- 206010040880 Skin irritation Diseases 0.000 description 12
- 235000011187 glycerol Nutrition 0.000 description 12
- 231100000475 skin irritation Toxicity 0.000 description 12
- 230000036556 skin irritation Effects 0.000 description 12
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 10
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 9
- 239000000203 mixture Substances 0.000 description 8
- 238000006116 polymerization reaction Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 239000004372 Polyvinyl alcohol Substances 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 229920002451 polyvinyl alcohol Polymers 0.000 description 6
- 229920002125 Sokalan® Polymers 0.000 description 5
- 229920001083 polybutene Polymers 0.000 description 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 4
- 239000012790 adhesive layer Substances 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 229920000159 gelatin Polymers 0.000 description 4
- 239000008273 gelatin Substances 0.000 description 4
- 235000019322 gelatine Nutrition 0.000 description 4
- 235000011852 gelatine desserts Nutrition 0.000 description 4
- 230000037307 sensitive skin Effects 0.000 description 4
- 239000005995 Aluminium silicate Substances 0.000 description 3
- 206010015150 Erythema Diseases 0.000 description 3
- 235000012211 aluminium silicate Nutrition 0.000 description 3
- 229910021538 borax Inorganic materials 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 231100000321 erythema Toxicity 0.000 description 3
- 238000004299 exfoliation Methods 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 3
- 235000010339 sodium tetraborate Nutrition 0.000 description 3
- 239000004328 sodium tetraborate Substances 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- 241000700199 Cavia porcellus Species 0.000 description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 2
- 108010076876 Keratins Proteins 0.000 description 2
- 102000011782 Keratins Human genes 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 229920001328 Polyvinylidene chloride Polymers 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 2
- 229960003511 macrogol Drugs 0.000 description 2
- 238000000691 measurement method Methods 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 235000010981 methylcellulose Nutrition 0.000 description 2
- 239000004014 plasticizer Substances 0.000 description 2
- 239000004584 polyacrylic acid Substances 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229940068918 polyethylene glycol 400 Drugs 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 239000005033 polyvinylidene chloride Substances 0.000 description 2
- 239000002356 single layer Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 description 1
- 101150108397 Abcd2 gene Proteins 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 229920003135 Eudragit® L 100-55 Polymers 0.000 description 1
- 229920003141 Eudragit® S 100 Polymers 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- YIVJZNGAASQVEM-UHFFFAOYSA-N Lauroyl peroxide Chemical compound CCCCCCCCCCCC(=O)OOC(=O)CCCCCCCCCCC YIVJZNGAASQVEM-UHFFFAOYSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- 239000004734 Polyphenylene sulfide Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 229920003082 Povidone K 90 Polymers 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000000305 astragalus gummifer gum Substances 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940105990 diglycerin Drugs 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- UQGFMSUEHSUPRD-UHFFFAOYSA-N disodium;3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane Chemical compound [Na+].[Na+].O1B([O-])OB2OB([O-])OB1O2 UQGFMSUEHSUPRD-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- GDCRSXZBSIRSFR-UHFFFAOYSA-N ethyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CCOC(=O)C=C GDCRSXZBSIRSFR-UHFFFAOYSA-N 0.000 description 1
- 239000005038 ethylene vinyl acetate Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000012812 general test Methods 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000003230 hygroscopic agent Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 description 1
- 229940117841 methacrylic acid copolymer Drugs 0.000 description 1
- IWVKTOUOPHGZRX-UHFFFAOYSA-N methyl 2-methylprop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.COC(=O)C(C)=C IWVKTOUOPHGZRX-UHFFFAOYSA-N 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920002239 polyacrylonitrile Polymers 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920000306 polymethylpentene Polymers 0.000 description 1
- 239000011116 polymethylpentene Substances 0.000 description 1
- 229920005672 polyolefin resin Polymers 0.000 description 1
- 229920000069 polyphenylene sulfide Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、絆創膏、テーピング等
の皮膚固定用に使用される貼付剤に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a patch used for skin fixing such as bandages and tapings.
【０００２】[0002]
【従来の技術】絆創膏、皮膚面から薬物を生体内へ投与
する経皮吸収製剤等は長時間又は繰り返し皮膚の同一部
位に貼付する場合が多く、このような貼付によって膏体
や粘着剤による皮膚面のかゆみ、皮膚刺激や角質剥離等
が発生するという問題があった。この問題を解決するた
めに、角質剥離を起こさないような粘着力を有する粘着
剤層を用いることにより、皮膚からの剥離時に皮膚刺激
を与えないような製剤が提案されている（特開平５−６
５２２４号公報）。しかしながら、皮膚の過敏なヒトで
は、貼付剤を剥離後にかゆみ、紅斑の発生等の皮膚刺激
があり、角質剥離の減少や抑制だけではこのような皮膚
刺激に対処することができなかった。BACKGROUND OF THE INVENTION Adhesive plasters, percutaneous absorption preparations for injecting drugs into the living body from the skin surface, etc. are often applied to the same site on the skin for a long time or repeatedly. There was a problem that itching of the surface, skin irritation, exfoliation of keratin and the like occurred. In order to solve this problem, there has been proposed a formulation which does not cause skin irritation when peeled from the skin by using an adhesive layer having an adhesive force that does not cause exfoliation of the horny layer (Japanese Patent Laid-Open No. Hei 5- 6
5224). However, humans with sensitive skin have skin irritation such as itching and erythema after peeling off the patch, and such skin irritation cannot be coped with only by reducing or suppressing exfoliation of the keratin.
【０００３】[0003]
【発明が解決しようとする課題】本発明は、上記欠点に
鑑みてなされたものであって、その目的とするところ
は、皮膚の過敏なヒトに貼付しても、かゆみ、紅斑の発
生等の皮膚刺激の低い貼付剤を提供することにある。SUMMARY OF THE INVENTION The present invention has been made in view of the above-mentioned drawbacks, and an object thereof is to prevent itching, erythema, etc. even when applied to a person with sensitive skin. It is to provide a patch with low skin irritation.
【０００４】[0004]
【０００５】本発明で使用される粘着剤層は水溶性高分
子を主成分として形成される。上記水溶性高分子として
は、トラガントガム、澱粉、ゼラチン等の天然高分子；
メチルセルロース、エチルセルロース、カルボキシメチ
ルセルロース、ヒドロキシエチルセルロース、ヒドロキ
シプロピルセルロース、可溶性澱粉等の半合成高分子；
ポリビニルアルコール、ポリビニルピロリドン、ポリビ
ニルメタクリレート、ポリエチレンオキサイド、ポリエ
チレングリコール、ポリアクリル酸又はそれらの塩類又
はエステル類、架橋型ポリアクリル酸又はそれらのエス
テル類、カルボキシビニルポリマー又はその架橋物質等
の合成高分子の１種以上が挙げられる。The pressure-sensitive adhesive layer used in the present invention is mainly composed of a water-soluble polymer. Examples of the water-soluble polymer include natural polymers such as tragacanth gum, starch and gelatin;
Semi-synthetic polymers such as methyl cellulose, ethyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, soluble starch;
Polyvinyl alcohol, polyvinylpyrrolidone, polyvinyl methacrylate, polyethylene oxide, polyethylene glycol, polyacrylic acid or salts or esters thereof, cross-linked polyacrylic acid or esters thereof, carboxyvinyl polymers or cross-linked substances thereof One or more may be mentioned.
【０００６】上記粘着剤層の含水率は、低くなると水溶
性高分子に十分な貼付力が得られず、高くなると貼付剤
としての形状保持が難しくなるか、形状保持ができても
貼付剤剥離時に糸引きを起こすので、１〜５０重量％に
限定され、好ましくは２〜４５重量％である。When the water content of the pressure-sensitive adhesive layer is low, the water-soluble polymer does not have sufficient adhesive force, and when it is high, it becomes difficult to maintain the shape of the adhesive patch, or even if the shape can be retained, the adhesive agent is peeled off. Since stringing sometimes occurs, it is limited to 1 to 50% by weight, preferably 2 to 45% by weight.
【０００７】上記粘着剤層には、必要に応じて、室温で
液状の可塑剤が添加されてもよく、このような可塑剤と
しては、例えば、ソルビット、マンニット等の多価アル
コール；グリセリン、ジグリセリン、エチレングリコー
ル、ポリエチレングリコール、プロピレングリコール等
のグリコール類；ソルビタン脂肪族エステル又はその酸
化エチレン付加物などが好ましい。If necessary, a plasticizer which is liquid at room temperature may be added to the pressure-sensitive adhesive layer. Examples of such a plasticizer include polyhydric alcohols such as sorbit and mannitol; glycerin, Preferred are glycols such as diglycerin, ethylene glycol, polyethylene glycol and propylene glycol; sorbitan aliphatic ester or ethylene oxide adduct thereof.
【０００８】また、上記粘着剤層には、必要に応じて、
ホウ砂、カオリン、ケイ酸アルミニウム、二酸化チタン
などの充填剤が添加されてもよい。Further, the above-mentioned pressure-sensitive adhesive layer, if necessary,
Fillers such as borax, kaolin, aluminum silicate, titanium dioxide and the like may be added.
【０００９】本発明で使用される支持体は非透湿性のも
のであって、好ましくはさらに柔軟性を有するものであ
る。上記支持体の透湿度が大きくなると貼付剤中の水分
が支持体を通して蒸散して膏体が固くなり、皮膚が過敏
なヒトでは皮膚刺激が発現するので、透湿度（測定方
法：ＪＩＳ Ｚ０２３７）は１００ｇ／ｍ2 ／日以下が
好ましく、透湿度のできるだけ小さいものがより好まし
い。The support used in the present invention is non-moisture permeable and preferably more flexible. When the water vapor permeability of the above-mentioned support becomes large, the water content in the patch evaporates through the support and the plaster becomes hard, and skin irritation occurs in humans with sensitive skin. Therefore, the moisture permeability (measurement method: JIS Z0237) is It is preferably 100 g / m 2 / day or less, more preferably as low as possible water vapor permeability.
【００１０】上記支持体としては、例えば、アルミニウ
ム、ポリエチレン、ポリウレタン、ポリエチレンテレフ
タレート、ナイロン、ポリプロピレン、ポリ塩化ビニ
ル、エチレン−酢酸ビニル共重合体、ポリメチルメタク
リレート、ポリカーボネート、ポリ塩化ビニリデン、ポ
リビニルアルコール、ポリスチレン、フッ素樹脂、ポリ
アクリロニトリル、ポリイミド、ポリフェニレンサルフ
ァイド、ポリメチルペンテン、ポリブテン、接着性ポリ
オレフィン樹脂の単層フィルム又は二種以上の単層フィ
ルム積層体が用いられる。これらのフィルムには、ポリ
塩化ビニリデンが塗布されていてもよい。Examples of the support include aluminum, polyethylene, polyurethane, polyethylene terephthalate, nylon, polypropylene, polyvinyl chloride, ethylene-vinyl acetate copolymer, polymethylmethacrylate, polycarbonate, polyvinylidene chloride, polyvinyl alcohol, polystyrene. A single-layer film of fluororesin, polyacrylonitrile, polyimide, polyphenylene sulfide, polymethylpentene, polybutene, or an adhesive polyolefin resin, or a laminate of two or more single-layer films is used. Polyvinylidene chloride may be applied to these films.
【００１１】上記支持体上に粘着剤層を形成する方法と
しては、従来公知の粘着テ−プの製造方法が使用可能で
あり、例えば、溶剤塗工法等が挙げられる。As a method for forming the pressure-sensitive adhesive layer on the support, a conventionally known method for producing a pressure-sensitive adhesive tape can be used, and examples thereof include a solvent coating method.
【００１２】上記溶剤塗工法で粘着剤層を形成する場合
は、上記水溶性高分子を適当な溶剤で希釈し、得られた
溶液を支持体上に塗布乾燥する。また、この溶液を直接
支持体上に塗布せず、シリコン離型処理された離型紙上
に溶液を塗布乾燥して粘着剤層を形成した後、粘着剤層
上に支持体を密着させてもよい。この離型紙は粘着剤層
を保護するために使用時まで剥離せずに用いられてもよ
い。When the pressure-sensitive adhesive layer is formed by the solvent coating method, the water-soluble polymer is diluted with a suitable solvent, and the resulting solution is applied and dried on the support. Alternatively, the solution may not be directly applied to the support, but the solution may be applied and dried on a silicone release-treated release paper to form a pressure-sensitive adhesive layer, and then the support may be adhered to the pressure-sensitive adhesive layer. Good. The release paper may be used without being peeled off until it is used to protect the adhesive layer.
【００１３】[0013]
【実施例】次に、本発明の実施例を説明する。 （実施例１）ケン化度３６モル％、重合度６５０の部分
ケン化ポリビニルアルコール（日本合成化学社製「ゴー
セファイマーＬ７５１４」）１１２．５５ｇ、ポリエチ
レングリコール４００（日本油脂社製「マクロゴール４
００Ｒ」）１３７．５５ｇ、ホウ砂（和光純薬社製、四
ホウ酸ナトリウム）１．２５２ｇ及びエチレングリコー
ル（和光純薬社製）０．４０７ｇをサンプル瓶中に仕込
み、さらに水／メタノールの混合溶媒（重量比１：１）
１７０ｇを添加して４８時間ボールミルで混合して粘着
基剤溶液を得た。EXAMPLES Next, examples of the present invention will be described. (Example 1) 112.55 g of partially saponified polyvinyl alcohol ("Gosephimmer L7514" manufactured by Nippon Synthetic Chemical Industry Co., Ltd.) having a saponification degree of 36 mol% and a polymerization degree of 650, polyethylene glycol 400 ("Macrogol 4 manufactured by NOF Corporation").
00R ") 137.55 g, borax (manufactured by Wako Pure Chemical Industries, Ltd., sodium tetraborate) 1.252 g, and ethylene glycol (manufactured by Wako Pure Chemical Industries Ltd.) 0.407 g are charged in a sample bottle, and water / methanol is further mixed. Solvent (weight ratio 1: 1)
170 g was added and mixed by a ball mill for 48 hours to obtain an adhesive base solution.
【００１４】上記粘着基剤溶液をポリエチレンテレフタ
レートフィルムをシリコン離型処理した剥離紙上に、乾
燥後の厚さが５０μｍとなるように塗工した後、室温で
３０分間乾燥し、粘着剤層を形成した。次いで、アルミ
箔支持体上へ粘着剤層を密着させ貼付剤を作製した。The above adhesive base solution was applied on a release paper, which was treated with a silicone release film from a polyethylene terephthalate film, so that the thickness after drying was 50 μm, and then dried at room temperature for 30 minutes to form an adhesive layer. did. Then, the pressure-sensitive adhesive layer was brought into close contact with the aluminum foil support to prepare a patch.
【００１５】（実施例２）実施例１と同様にして形成さ
れた粘着剤層を、支持体として用いられたポリエチレン
テレフタレートフィルムとエチレン・酢酸ビニル共重合
体フィルムとの積層体（日本マタイ社製「ＲＣＬ０２５
０６ＮＸ ＫＴ−４５−Ｙ」）のエチレン・酢酸ビニル
共重合体フィルム側に密着させて貼付剤を作製した。Example 2 A pressure-sensitive adhesive layer formed in the same manner as in Example 1 was used as a support to laminate a polyethylene terephthalate film and an ethylene / vinyl acetate copolymer film (manufactured by Nippon Matai Co., Ltd.). "RCL025
06NX KT-45-Y ") was adhered to the ethylene / vinyl acetate copolymer film side to prepare a patch.
【００１６】（実施例３）実施例１と同様にして形成さ
れた粘着剤層を、支持体として用いられたポリエチレン
フィルム（中部積水化工社製）に密着させて貼付剤を作
製した。(Example 3) A pressure-sensitive adhesive layer formed in the same manner as in Example 1 was brought into close contact with a polyethylene film (manufactured by Chubu Sekisui Chemical Co., Ltd.) used as a support to prepare a patch.
【００１７】（実施例４）水／メタノールの混合溶媒に
代えてメタール単体１７０ｇを溶媒として使用し、室温
に代えて１０５℃で３０分間乾燥して粘着剤層を形成し
たこと以外は、実施例１と同様にして粘着剤層を形成
し、この粘着剤層を支持体として用いられたポリエチレ
ンテレフタレートフィルムとエチレン・酢酸ビニル共重
合体フィルムとの積層体のエチレン・酢酸ビニル共重合
体フィルム側に密着させて貼付剤を作製した。Example 4 Example 4 was repeated except that 170 g of methal simple substance was used as a solvent instead of the water / methanol mixed solvent, and the pressure-sensitive adhesive layer was formed by drying at 105 ° C. for 30 minutes instead of room temperature. A pressure-sensitive adhesive layer was formed in the same manner as in 1, and the pressure-sensitive adhesive layer was formed on the ethylene / vinyl acetate copolymer film side of the laminate of the polyethylene terephthalate film and the ethylene / vinyl acetate copolymer film used as a support. A patch was prepared by bringing them into close contact with each other.
【００１８】（実施例５）室温に代えて６０℃で３０分
間乾燥して粘着剤層を形成したこと以外は、実施例１と
同様にして粘着剤層を形成し、この粘着剤層を支持体と
して用いられたポリエチレンテレフタレートフィルムと
エチレン・酢酸ビニル共重合体フィルムとの積層体のエ
チレン・酢酸ビニル共重合体フィルム側に密着させて貼
付剤を作製した。Example 5 A pressure-sensitive adhesive layer was formed in the same manner as in Example 1 except that the pressure-sensitive adhesive layer was formed by drying at 60 ° C. for 30 minutes instead of room temperature, and the pressure-sensitive adhesive layer was supported. A patch was prepared by bringing the polyethylene terephthalate film used as a body and an ethylene / vinyl acetate copolymer film into close contact with the ethylene / vinyl acetate copolymer film side.
【００１９】（実施例６）エタノール中にポリビニルピ
ロリドン（東京化成社製「ＰＶＰ−Ｋ９０」）９０ｇを
少量ずつ２０００ｒｐｍで攪拌しながら添加し、ミック
スロータで２時間攪拌した。この溶液に、メタクリル酸
メチル−メタクリル酸共重合体（重量比２：１、Ｒｏｈ
ｍ Ｐｈａｒｍａ社製「ＥＵＤＲＡＧＩＴ Ｌ−１００
−５５」）及びアクリル酸エチル−メタクリル酸メチル
共重合体（重量比１：１、ＲｏｈｍＰｈａｒｍａ社製
「ＥＵＤＲＡＧＩＴ Ｓ−１００」）をそれぞれ５ｇず
つ５０ｇの精製水中に懸濁化した液を添加し、ミックス
ローターで一晩攪拌した。この混合液１５０ｇに、グリ
セリン７５ｇ及びエタノール６２ｇを加えて再度ミック
スローターで攪拌して粘着基剤を得た。上記粘着基剤か
ら、室温に代えて６０℃で３０分間乾燥したこと以外
は、実施例１と同様にして粘着剤層を形成し、この粘着
剤層を支持体として用いられたポリエチレンテレフタレ
ートフィルムとエチレン・酢酸ビニル共重合体フィルム
との積層体のエチレン・酢酸ビニル共重合体フィルム側
に密着させて貼付剤を作製した。(Example 6) 90 g of polyvinylpyrrolidone ("PVP-K90" manufactured by Tokyo Chemical Industry Co., Ltd.) was added to ethanol little by little with stirring at 2000 rpm, and the mixture was stirred with a mix rotor for 2 hours. Methyl methacrylate-methacrylic acid copolymer (weight ratio 2: 1, Roh
m Pharma company "EUDRAGIT L-100
-55 ") and ethyl acrylate-methyl methacrylate copolymer (weight ratio 1: 1," EUDRAGIT S-100 "manufactured by RohmPharma Co., Ltd.) were added to each in an amount of 5 g in 50 g of purified water, Stir overnight in mix rotor. To 150 g of this mixed solution, 75 g of glycerin and 62 g of ethanol were added, and the mixture was again stirred with a mix rotor to obtain an adhesive base. A polyethylene terephthalate film was formed from the above-mentioned pressure-sensitive adhesive base in the same manner as in Example 1 except that the pressure-sensitive adhesive layer was dried at 60 ° C. for 30 minutes instead of room temperature, and the pressure-sensitive adhesive layer was used as a support. A patch was prepared by bringing the laminate with an ethylene / vinyl acetate copolymer film into close contact with the ethylene / vinyl acetate copolymer film side.
【００２０】（実施例７）精製水１０ｇにカルボキシビ
ニルポリマー（和光純薬社製「ＨＩＶＩＳ−ＷＡＫＯ１
０４」）０．６ｇを室温中で攪拌しながら徐々に加えて
懸濁させた。この懸濁液を攪拌しながら５％塩化カルシ
ウム（ナカライテスク社製、無水塩化カルシウム）水溶
液２ｍｌを加え、さらにグリセリン（和光純薬社製）
０．３ｇを加えて混合し粘着基剤を得た。上記粘着基剤
から、室温に代えて６０℃で３０分間乾燥したこと以外
は、実施例１と同様にして粘着剤層を形成し、この粘着
剤層を支持体として用いられたポリエチレンテレフタレ
ートフィルムとエチレン・酢酸ビニル共重合体フィルム
との積層体のエチレン・酢酸ビニル共重合体フィルム側
に密着させて貼付剤を作製した。Example 7 Carboxyvinyl polymer (“HIVIS-WAKO1” manufactured by Wako Pure Chemical Industries, Ltd. was added to 10 g of purified water.
04 ") at room temperature with stirring to gradually add 0.6 g to suspend. While stirring this suspension, 2 ml of a 5% aqueous solution of calcium chloride (Nacalai Tesque, anhydrous calcium chloride) was added, and glycerin (Wako Pure Chemical Industries, Ltd.) was added.
0.3 g was added and mixed to obtain an adhesive base. A polyethylene terephthalate film was formed from the above-mentioned pressure-sensitive adhesive base in the same manner as in Example 1 except that the pressure-sensitive adhesive layer was dried at 60 ° C. for 30 minutes instead of room temperature, and the pressure-sensitive adhesive layer was used as a support. A patch was prepared by bringing the laminate with an ethylene / vinyl acetate copolymer film into close contact with the ethylene / vinyl acetate copolymer film side.
【００２１】（実施例８）精製水２０ｇにヒドロキシプ
ロピルセルロース（和光純薬社製「ＨＩＶＩＳ−ＷＡＫ
Ｏ１０４」）０．６ｇを室温中で攪拌しながら徐々に加
えて懸濁させた。この懸濁液を攪拌しながらプロピレン
グリコール（和光純薬社製）０．２ｇを加え、さらにグ
リセリン（和光純薬社製）０．２ｇを加えて混合し粘着
基剤を得た。上記粘着基剤から、室温に代えて６０℃で
３０分間乾燥して粘着剤層を形成したこと以外は、実施
例１と同様にして粘着剤層を形成し、この粘着剤層を支
持体として用いられたポリエチレンテレフタレートフィ
ルムとエチレン・酢酸ビニル共重合体フィルムとの積層
体のエチレン・酢酸ビニル共重合体フィルム側に密着さ
せて貼付剤を作製した。Example 8 Hydroxypropyl cellulose ("HIVIS-WAK" manufactured by Wako Pure Chemical Industries, Ltd. was added to 20 g of purified water.
0.6 g of (O104 ") was gradually added to the suspension at room temperature with stirring. While stirring this suspension, 0.2 g of propylene glycol (manufactured by Wako Pure Chemical Industries, Ltd.) and 0.2 g of glycerin (manufactured by Wako Pure Chemical Industries, Ltd.) were added and mixed to obtain an adhesive base. A pressure-sensitive adhesive layer was formed in the same manner as in Example 1 except that the pressure-sensitive adhesive base was dried at 60 ° C. for 30 minutes instead of room temperature to form a pressure-sensitive adhesive layer, and the pressure-sensitive adhesive layer was used as a support. A patch was prepared by contacting the laminate of the polyethylene terephthalate film and the ethylene / vinyl acetate copolymer film used to the side of the ethylene / vinyl acetate copolymer film.
【００２２】（実施例９）５０〜７０℃に加温した水２
５ｇにゼラチン１５ｇを加え膨潤させた後、ポリビニル
アルコール（和光純薬社製、重合度５００）７ｇ及びグ
リセリン（和光純薬社製）１０ｇを加え、この温度を保
ちながら攪拌して溶解させ、次いで、カオリン（ナカラ
イテスク社製）１７ｇを添加しよく攪拌して分散させ
た。さらに、グリセリン２０ｇに分散させたポリアクリ
ル酸ナトリウム（和光純薬社製、重合度２２，０００〜
７０，０００）１ｇ、メチルセルロース（ナカライテス
ク社製「＃１５００」）２ｇ及びポリブテン（Ａｌｄｒ
ｉｃｈ Ｃｈｅｍｉｃａｌ社製）３ｇを添加、混合して
ペースト状の粘着基剤を得た。上記粘着基剤から、実施
例１と同様にして粘着剤層を形成し、この粘着剤層を支
持体として用いられたポリエチレンテレフタレートフィ
ルムとエチレン・酢酸ビニル共重合体フィルムとの積層
体のエチレン・酢酸ビニル共重合体フィルム側に密着さ
せて貼付剤を作製した。(Example 9) Water 2 heated to 50 to 70 ° C
After adding 15 g of gelatin to 5 g and swelling, 7 g of polyvinyl alcohol (manufactured by Wako Pure Chemical Industries, degree of polymerization 500) and 10 g of glycerin (manufactured by Wako Pure Chemical Industries) were added and dissolved by stirring while maintaining this temperature. , Kaolin (manufactured by Nacalai Tesque, Inc.) 17 g was added and well stirred to disperse. Furthermore, sodium polyacrylate dispersed in 20 g of glycerin (manufactured by Wako Pure Chemical Industries, polymerization degree 22,000-
70,000) 1 g, methylcellulose (“# 1500” manufactured by Nacalai Tesque, Inc.) 2 g, and polybutene (Aldr
3 g (manufactured by ich Chemical Co.) was added and mixed to obtain a paste-like adhesive base. A pressure-sensitive adhesive layer was formed from the above-mentioned pressure-sensitive adhesive base in the same manner as in Example 1, and ethylene of a laminate of a polyethylene terephthalate film and an ethylene / vinyl acetate copolymer film, which was used as a support for the pressure-sensitive adhesive layer, was prepared. A patch was prepared by making it adhere to the vinyl acetate copolymer film side.
【００２３】（実施例１０）５０〜７０℃に加温した水
４７ｇにゼラチン１０ｇを加え膨潤させた後、カルボキ
シビニルポリマー（和光純薬社製「ＨＩＶＩＳ−ＷＡＫ
Ｏ１０４」）２ｇ、グリセリン（和光純薬社製）１０ｇ
及びポリエチレングリコール４００（日本油脂社製「マ
クロゴール４００Ｒ」）３ｇを加え、この温度を保ちな
がら攪拌して溶解させ、次いで、ケイ酸アルミニウム
（和光純薬社製）８ｇを添加しよく攪拌して分散させ
た。さらに、グリセリン１５ｇに分散させたポリアクリ
ル酸ナトリウム（和光純薬社製、重合度２２，０００〜
７０，０００）２ｇ及びポリブテン（Ａｌｄｒｉｃｈ
Ｃｈｅｍｉｃａｌ社製）３ｇを添加、混合してペースト
状の粘着基剤を得た。上記粘着基剤から、実施例１と同
様にして粘着剤層を形成し、この粘着剤層を支持体とし
て用いられたポリエチレンテレフタレートフィルムとエ
チレン・酢酸ビニル共重合体フィルムとの積層体のエチ
レン・酢酸ビニル共重合体フィルム側に密着させて貼付
剤を作製した。(Example 10) 10 g of gelatin was added to 47 g of water heated to 50 to 70 ° C to swell it, and then carboxyvinyl polymer ("HIVIS-WAK" manufactured by Wako Pure Chemical Industries, Ltd.
O104 ") 2 g, glycerin (Wako Pure Chemical Industries, Ltd.) 10 g
And 3 g of polyethylene glycol 400 (“Macrogol 400R” manufactured by NOF CORPORATION) are stirred and dissolved while maintaining this temperature, and then 8 g of aluminum silicate (manufactured by Wako Pure Chemical Industries) is added and well stirred. Dispersed. Furthermore, sodium polyacrylate dispersed in 15 g of glycerin (manufactured by Wako Pure Chemical Industries, polymerization degree 22,000-
70,000) 2 g and polybutene (Aldrich
3 g (Chemical) was added and mixed to obtain a paste-like adhesive base. A pressure-sensitive adhesive layer was formed from the above-mentioned pressure-sensitive adhesive base in the same manner as in Example 1, and ethylene of a laminate of a polyethylene terephthalate film and an ethylene / vinyl acetate copolymer film using this pressure-sensitive adhesive layer as a support was used. A patch was prepared by making it adhere to the vinyl acetate copolymer film side.
【００２４】（実施例１１）５０〜７０℃に加温した水
５２ｇにポリビニルピロリドン（東京化成社製「ＰＶＫ
−Ｋ９０」）５ｇ及びポリビニルアルコール（和光純薬
社製、重合度５００）３ｇを混合し、さらにグリセリン
（和光純薬社製）１０ｇを加え、この温度を保ちながら
攪拌して溶解させ、次いで二酸化チタン（Ａｌｄｒｉｃ
ｈ Ｃｈｅｍｉｃａｌ社製）１ｇを添加しよく分散させ
た。次いで、グリセリン２０ｇに分散させたポリアクリ
ル酸ナトリウム（和光純薬社製、重合度２２，０００〜
７０，０００）２ｇ及びポリブテン（Ａｌｄｒｉｃｈ
Ｃｈｅｍｉｃａｌ社製）５ｇを添加、混合してペースト
状の粘着基剤を得た。上記粘着基剤から、実施例１と同
様にして粘着剤層を形成し、この粘着剤層を支持体とし
て用いられたポリエチレンテレフタレートフィルムとエ
チレン・酢酸ビニル共重合体フィルムとの積層体のエチ
レン・酢酸ビニル共重合体フィルム側に密着させて貼付
剤を作製した。(Example 11) Polyvinylpyrrolidone (“PVK” manufactured by Tokyo Kasei Co., Ltd. was added to 52 g of water heated to 50 to 70 ° C.).
-K90 ") 5 g and polyvinyl alcohol (manufactured by Wako Pure Chemical Industries, Ltd., polymerization degree 500) 3 g are further mixed, and 10 g of glycerin (manufactured by Wako Pure Chemical Industries Ltd.) is further added, and the mixture is stirred while maintaining this temperature to dissolve it, and then dioxide. Titanium (Aldric
1g (made by h Chemical) was added and well dispersed. Then, sodium polyacrylate dispersed in 20 g of glycerin (manufactured by Wako Pure Chemical Industries, polymerization degree 22,000-
70,000) 2 g and polybutene (Aldrich
5 g (Chemical) was added and mixed to obtain a paste-like adhesive base. A pressure-sensitive adhesive layer was formed from the above-mentioned pressure-sensitive adhesive base in the same manner as in Example 1, and ethylene of a laminate of a polyethylene terephthalate film and an ethylene / vinyl acetate copolymer film, which was used as a support for the pressure-sensitive adhesive layer, was prepared. A patch was prepared by making it adhere to the vinyl acetate copolymer film side.
【００２５】（比較例１）支持体として軟質塩化ビニル
（徳山積水化学社製「エスメディカ」）フィルムを使用
したこと以外は、実施例１と同様にして、貼付剤を作製
した。Comparative Example 1 A patch was prepared in the same manner as in Example 1 except that a soft vinyl chloride (“Smedica” manufactured by Tokuyama Sekisui Chemical Co., Ltd.) film was used as a support.
【００２６】（比較例２）アクリル酸２−エチルヘキシ
ル３４８．５ｇ（７５モル％）、ポリビニルピロリドン
７０ｇ（２５モル％）と１，６−ヘキサングリコールジ
メタクリレート４０ｍｇをセパラブルフラスコに仕込
み、さらに酢酸エチル４１８．５ｇを加えてモノマー濃
度を５０重量％に調整した。この溶液を窒素雰囲気下で
６０℃に加温し、２ｇの過酸化ラウロイルをシクロヘキ
サン１００ｇに溶解した溶液を１０分割し、反応初期の
５時間の間にその１／１０を添加し、その後１／１０ず
つ１時間毎に反応系に添加した。別途、酢酸エチル２５
０ｇを用意し、反応系の温度上昇、粘度を観察しながら
合計３２時間重合して粘着基剤を得た。上記粘着基剤に
酢酸エチルを添加して固形分濃度２８重量％に調整した
粘着基剤溶液から、６０℃で３０分間乾燥し実施例１と
同様にしてて粘着剤層を形成し、この粘着剤層を支持体
として用いられたポリエチレンテレフタレートフィルム
とエチレン・酢酸ビニル共重合体フィルムとの積層体の
エチレン・酢酸ビニル共重合体フィルム側に密着させて
貼付剤を作製した。(Comparative Example 2) 348.5 g (75 mol%) of 2-ethylhexyl acrylate, 70 g (25 mol%) of polyvinylpyrrolidone and 40 mg of 1,6-hexaneglycol dimethacrylate were charged in a separable flask, and ethyl acetate was further added. The monomer concentration was adjusted to 50% by weight by adding 418.5 g. This solution was heated to 60 ° C. under a nitrogen atmosphere, a solution of 2 g of lauroyl peroxide dissolved in 100 g of cyclohexane was divided into 10 portions, 1/10 of which was added during the initial 5 hours of the reaction, and then 1 / 10 were added to the reaction system every hour. Separately, ethyl acetate 25
0 g was prepared, and polymerization was carried out for a total of 32 hours while observing the temperature rise and viscosity of the reaction system to obtain an adhesive base. Ethyl acetate was added to the above-mentioned adhesive base to prepare a solid adhesive concentration of 28% by weight, and the adhesive base solution was dried at 60 ° C. for 30 minutes to form an adhesive layer in the same manner as in Example 1. A patch was prepared by bringing the agent layer into close contact with the ethylene / vinyl acetate copolymer film side of a laminate of a polyethylene terephthalate film used as a support and an ethylene / vinyl acetate copolymer film.
【００２７】（比較例３）５０〜７０℃に加温した水６
０ｇにゼラチン７ｇを加えて膨潤させた後、カルボキシ
メチルセルロースナトリウム（ナカライテスク社製）４
ｇ、ポリビニルピロリドン（東京化成社製「ＰＶＫ−Ｋ
９０」）１ｇ、ポリビニルアルコール（和光純薬社製、
重合度５００）２ｇ及びグリセリン（和光純薬社製）１
０ｇを加え、この温度を保ちながら攪拌して溶解させ、
次いでカオリン（ナカライテスク社製）４ｇを添加しよ
く分散させた。次いで、グリセリン１０ｇに分散させた
ポリブテン（Ａｌｄｒｉｃｈ Ｃｈｅｍｉｃａｌ社製）
２ｇを添加、混合してペースト状の粘着基剤を得た。上
記粘着基剤から、実施例１と同様にして粘着剤層を形成
し、この粘着剤層を支持体として用いられたポリエチレ
ンテレフタレートフィルムとエチレン・酢酸ビニル共重
合体フィルムとの積層体のエチレン・酢酸ビニル共重合
体フィルム側に密着させて貼付剤を作製した。(Comparative Example 3) Water 6 heated to 50 to 70 ° C
After swelling by adding 7 g of gelatin to 0 g, sodium carboxymethyl cellulose (manufactured by Nacalai Tesque) 4
g, polyvinylpyrrolidone (“PVK-K” manufactured by Tokyo Kasei Co., Ltd.
90 ") 1 g, polyvinyl alcohol (manufactured by Wako Pure Chemical Industries,
Polymerization degree 500) 2 g and glycerin (manufactured by Wako Pure Chemical Industries) 1
0 g was added and dissolved while stirring at this temperature,
Next, 4 g of kaolin (manufactured by Nacalai Tesque) was added and well dispersed. Next, polybutene dispersed in 10 g of glycerin (manufactured by Aldrich Chemical Co.)
2 g was added and mixed to obtain a pasty adhesive base. A pressure-sensitive adhesive layer was formed from the above-mentioned pressure-sensitive adhesive base in the same manner as in Example 1, and ethylene of a laminate of a polyethylene terephthalate film and an ethylene / vinyl acetate copolymer film using this pressure-sensitive adhesive layer as a support was used. A patch was prepared by making it adhere to the vinyl acetate copolymer film side.
【００２８】貼付剤の性能評価 上記実施例及び比較例で得られた貼付剤につき、下記の
評価を行いその結果を表１に示した。 （１）透湿度測定 ＪＩＳ Ｚ０２３７に準拠してカップに吸湿剤１５ｇを
入れ、支持体をカップに取り付けた。貼付剤試料周辺を
パラフィンで密封し２４時間後にその重量変化を測定し
て透湿度を算出した。 Performance Evaluation of Patches The patches obtained in the above Examples and Comparative Examples were evaluated as follows, and the results are shown in Table 1. (1) Moisture Permeability Measurement According to JIS Z0237, 15 g of a hygroscopic agent was put in a cup, and the support was attached to the cup. The periphery of the patch sample was sealed with paraffin and the weight change was measured after 24 hours to calculate the moisture permeability.
【００２９】（２）含水率測定 日本薬局方（一般試験法、水分測定法）に準拠して、平
沼全自動水分測定システム装置（平沼産業社製）を使用
して、直径１ｃｍの円形（面積３．１４ｃｍ2）に打ち
抜いた貼付剤中の水分量を測定し、下式より粘着剤層の
含水率を算出した。含水率（％）＝（貼付剤中の水分量
／貼付剤中の粘着剤量）×１００(2) Measurement of water content According to the Japanese Pharmacopoeia (general test method, water content measurement method), using a Hiranuma fully automatic water content measurement system device (manufactured by Hiranuma Sangyo Co., Ltd.), a circle (area of 1 cm in diameter) The water content in the patch punched out to 3.14 cm 2 ) was measured, and the water content of the pressure-sensitive adhesive layer was calculated from the following formula. Moisture content (%) = (water content in patch / amount of adhesive in patch) × 100
【００３０】（３）モルモット皮膚刺激性試験 ハートレイ系５週齢のモルモットの腹側部を毛刈りし、
貼付剤を４８時間閉塞貼付した。剥離３０分後、Ｄｒａ
ｉｚｅの判定基準に従って皮膚刺激性の判定を行い、そ
の平均値を求めた。(3) Guinea pig skin irritation test A Ventral region of a Hartley type 5 week old guinea pig was shaved,
The patch was closed and applied for 48 hours. 30 minutes after peeling, Dra
The skin irritation was determined according to the size criterion, and the average value was calculated.
【００３１】（４）ヒト皮膚刺激性試験 健常人男子２０名（被試験者）の上腕内部に、直径２ｃ
ｍの円形（面積３．１４ｃｍ2 ）に打ち抜いた貼付剤を
４８時間閉塞貼付した。剥離後、その皮膚刺激性を本邦
パッチテスト研究班の判定法に従って評価し、評価の総
和を被試験者総数で割り、１００をかけて皮膚刺激指数
を算出した。(4) Human skin irritation test: 20 normal males (test subjects) had a diameter of 2c inside the upper arm.
The patch, which was punched out in a circle of m (area: 3.14 cm 2 ), was closed and applied for 48 hours. After the peeling, the skin irritation was evaluated according to the judgment method of the Japanese patch test research group, the total evaluation was divided by the total number of test subjects, and 100 was calculated to calculate the skin irritation index.
【００３２】[0032]
【表１】 [Table 1]
【００３３】[0033]
【発明の効果】本発明の貼付剤の構成は、上述の通りで
あり、水溶性高分子を主成分とする粘着基剤と透湿性の
低い支持体を使用することにより、皮膚の過敏なヒトに
貼付しても、かゆみ、紅斑の発生等の皮膚刺激性が低
い。The composition of the patch of the present invention is as described above, and by using an adhesive base containing a water-soluble polymer as a main component and a support having low moisture permeability, a person with sensitive skin can Even if it is applied to, it has low skin irritation such as itching and erythema.
Claims (1)
分とする含水率１〜５０重量％の粘着剤層が形成されて
いることを特徴とする貼付剤。1. A patch comprising a moisture-impermeable support and a pressure-sensitive adhesive layer containing a water-soluble polymer as a main component and having a water content of 1 to 50% by weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6062639A JPH07265352A (en) | 1994-03-31 | 1994-03-31 | Patch agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6062639A JPH07265352A (en) | 1994-03-31 | 1994-03-31 | Patch agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH07265352A true JPH07265352A (en) | 1995-10-17 |
Family
ID=13206107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6062639A Pending JPH07265352A (en) | 1994-03-31 | 1994-03-31 | Patch agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH07265352A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6303700B1 (en) | 1997-04-30 | 2001-10-16 | Coloplast A/S | Adhesive agent and use of such adhesive agent |
| JP2008507495A (en) * | 2004-07-23 | 2008-03-13 | ラボラトリオ イタリアノ バイオチミコ ファルマセウティコ リザファルマ ソシエタ ペル アチオニ | Device for transdermal delivery of active body |
| JP2015017063A (en) * | 2013-07-11 | 2015-01-29 | 藤森工業株式会社 | Method for producing percutaneous absorption patch, and percutaneous absorption patch |
| JP2018043995A (en) * | 2017-12-06 | 2018-03-22 | 藤森工業株式会社 | Percutaneous absorption patch |
-
1994
- 1994-03-31 JP JP6062639A patent/JPH07265352A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6303700B1 (en) | 1997-04-30 | 2001-10-16 | Coloplast A/S | Adhesive agent and use of such adhesive agent |
| JP2008507495A (en) * | 2004-07-23 | 2008-03-13 | ラボラトリオ イタリアノ バイオチミコ ファルマセウティコ リザファルマ ソシエタ ペル アチオニ | Device for transdermal delivery of active body |
| JP2015017063A (en) * | 2013-07-11 | 2015-01-29 | 藤森工業株式会社 | Method for producing percutaneous absorption patch, and percutaneous absorption patch |
| JP2018043995A (en) * | 2017-12-06 | 2018-03-22 | 藤森工業株式会社 | Percutaneous absorption patch |
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