JPH07218423A - Instrument for optically measuring liquid - Google Patents
Instrument for optically measuring liquidInfo
- Publication number
- JPH07218423A JPH07218423A JP6012654A JP1265494A JPH07218423A JP H07218423 A JPH07218423 A JP H07218423A JP 6012654 A JP6012654 A JP 6012654A JP 1265494 A JP1265494 A JP 1265494A JP H07218423 A JPH07218423 A JP H07218423A
- Authority
- JP
- Japan
- Prior art keywords
- liquid
- optical fiber
- suction
- space
- fiber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/15—Preventing contamination of the components of the optical system or obstruction of the light path
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1048—General features of the devices using the transfer device for another function
- G01N2035/1062—General features of the devices using the transfer device for another function for testing the liquid while it is in the transfer device
Landscapes
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Optical Measuring Cells (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、光ファイバを用いて検
体液など各種液体の光吸収、光散乱、蛍光や化学発光を
簡便に測定する光学的測定装置に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an optical measuring device for easily measuring light absorption, light scattering, fluorescence and chemiluminescence of various liquids such as a sample liquid using an optical fiber.
【０００２】[0002]
【従来の技術】光ファイバを用いて検体液の蛍光や化学
発光を測定する場合、この検体液を採取容器から測定用
に作られた光学的に透明な容器に一度移し変え、この測
定用容器内に光を照射して測定している。また、採取容
器内に収容された検体液中に直接光ファイバの端末を差
込んで測定する方法がとられることもある。2. Description of the Related Art When measuring fluorescence or chemiluminescence of a sample liquid using an optical fiber, the sample liquid is once transferred from a sampling container to an optically transparent container made for measurement, It measures by irradiating the inside with light. In addition, a method may be adopted in which the end of the optical fiber is directly inserted into the sample liquid contained in the collection container for measurement.
【０００３】[0003]
【発明が解決しようとする課題】測定用に作られた容器
を用いて液体を測定する場合は、この容器の壁の厚さ分
だけ検体液と光ファイバーは遠ざけられるため集光効率
が低下する。一方、検体液中に直接光ファイバを差し込
んで測定する場合は、光ファイバが汚染されるという問
題がある。When a liquid is measured using a container made for measurement, the sample liquid and the optical fiber are separated by the thickness of the wall of the container, so that the light collection efficiency decreases. On the other hand, when the optical fiber is directly inserted into the sample liquid for measurement, there is a problem that the optical fiber is contaminated.
【０００４】本発明は上記の問題点を解決したもので、
その目的は、光ファイバを用いて検体液を直接照射して
集光効率の高い測定を行ない、なおかつ光ファイバを汚
染することのない測定装置を提供することにある。The present invention solves the above problems,
It is an object of the present invention to provide a measuring apparatus that directly irradiates a sample liquid with an optical fiber to perform measurement with high light collection efficiency and does not contaminate the optical fiber.
【０００５】[0005]
【課題を解決するための手段】上記の目的を達成するた
め、本発明は光ファイバを用いた液体の光学的検出装置
において、光ファイバの端末に取付けられ、内部に空間
を有し、かつこの空間に通じる吸引口を有するチップ
と、当該空間に上記吸引口から被測定用の液体を吸入す
るため当該空間と連通された吸引手段を備えていること
を特徴とする。In order to achieve the above-mentioned object, the present invention is an optical optical liquid detecting device using an optical fiber, which is attached to the end of the optical fiber and has a space inside thereof. It is characterized by comprising a chip having a suction port that communicates with the space and a suction means that is in communication with the space for sucking the liquid to be measured from the suction port into the space.
【０００６】上記空間と上記吸引手段とは、上記光ファ
イバの内部または外部に形成される間隙を介して連通さ
せるとよい。この場合、光ファイバ内の間隙はバンドル
ファイバの各光ファイバ間の間隙によって形成し、ま
た、光ファイバの外部の間隙は、チップと一体の筒状チ
ップ取付け治具を光ファイバに嵌合することにより形成
するとよい。The space and the suction means may be communicated with each other through a gap formed inside or outside the optical fiber. In this case, the gap inside the optical fiber is formed by the gap between the optical fibers of the bundle fiber, and the gap outside the optical fiber is obtained by fitting the cylindrical chip mounting jig integrated with the chip to the optical fiber. It is good to form by.
【０００７】さらに、吸引手段は制御装置と接続し、こ
の制御装置の出力信号によって液体の上記空間への吸引
量または吸引速度を制御可能に設けるとよい。Further, it is preferable that the suction means is connected to a control device, and the suction amount or the suction speed of the liquid into the space can be controlled by an output signal of the control device.
【０００８】[0008]
【作用】上記の構成によると、チップの吸引口を被測定
用の液体中に少し浸漬し、吸引手段によりチップ内の空
間の空気を吸引することにより、液体は当該空間に吸引
される。このとき、空間内の液面とファイバ端面との間
隔が所定寸法になった時点で吸引手段を駆動停止する。
こうすることで、光ファイバの端面を汚染することな
く、しかも、液体を直接照射して集光効率を高くし、液
体の吸収、散乱だけでなく、蛍光や化学発光を簡便で高
感度に測定することが可能となる。According to the above structure, the suction port of the chip is slightly dipped in the liquid to be measured, and the air in the space inside the chip is sucked by the suction means, whereby the liquid is sucked into the space. At this time, when the distance between the liquid surface in the space and the fiber end surface reaches a predetermined dimension, the driving of the suction means is stopped.
By doing this, without contaminating the end face of the optical fiber, the liquid can be directly irradiated to enhance the light collection efficiency, and not only the absorption and scattering of the liquid but also the fluorescence and chemiluminescence can be easily measured with high sensitivity. It becomes possible to do.
【０００９】さらに、上記チップ内で特定物質を検出す
るための反応を進行させる場合、被測定用の液体の吸引
速度を制御することで最適な検出条件を設定することが
可能かつ容易である。Further, when the reaction for detecting the specific substance is advanced in the chip, it is possible and easy to set the optimum detection condition by controlling the suction speed of the liquid to be measured.
【００１０】[0010]
【実施例】以下本発明の実施例を図を参照して説明す
る。Embodiments of the present invention will now be described with reference to the drawings.
【００１１】光ファイバ１はＹ字型の３ｍｍφ 〜７ｍ
ｍφ の分岐光ファイバで、第１の分岐ファイバ１ａの
端部は、被測定液を励起するための略２５０ｎｍ〜１８
００ｎｍの光を導入するため、キセノンランプまたはハ
ロゲンランプからなる光源２に導かれている。第２の分
岐ファイバ１ｂの端部は、被測定液（後述する）からの
光をフォトンカウンター、フォトンマルチチャンネルア
ナライザーなどからなる光検出器３にガイドすべく当該
光検出器３に導かれている。[0011] The optical fiber 1 of the Y-shaped 3mm φ ~7m
In the branch optical fiber m phi, the ends of the first branch fiber 1a is approximately for exciting the target solution 250nm~18
In order to introduce the light of 00 nm, it is guided to the light source 2 composed of a xenon lamp or a halogen lamp. The end of the second branch fiber 1b is guided to the photodetector 3 so as to guide the light from the liquid to be measured (described later) to the photodetector 3 including a photon counter, a photon multi-channel analyzer and the like. .
【００１２】第１の分岐ファイバ１ａと第２の分岐ファ
イバ１ｂが融合した光ファイバ１の端末には、先端がテ
ーパ部４ａとされた筒状のチップ取付け治具４が、光フ
ァイバ１との間に間隙５を有して嵌合され、かつ固定さ
れている。At the end of the optical fiber 1 in which the first branch fiber 1a and the second branch fiber 1b are fused, a cylindrical chip mounting jig 4 having a tapered portion 4a at the end is connected to the optical fiber 1. They are fitted and fixed with a gap 5 therebetween.
【００１３】チップ取付け治具４の先端には、吸引口６
を有するとともに、内部に空間７を有するテーパ型チッ
プ８を当てがい、それぞれのテーパ部４ａ，８ａを接着
することで両部材が固定されている。チップ取付け治具
４からは、吸引端部１０ａがその周壁を貫いて上記の間
隙５に連通している吸引チューブ１０が導出されてお
り、この吸引チューブ１０の他端に吸引装置１１が接続
されている。光検出器３及び、吸引装置１１の駆動部は
それぞれ制御装置１２と電気的に接続されている。A suction port 6 is provided at the tip of the chip mounting jig 4.
Both members are fixed by applying a tapered tip 8 having a space 7 therein and bonding the respective tapered portions 4a and 8a. A suction tube 10 having a suction end portion 10a penetrating its peripheral wall and communicating with the above-mentioned gap 5 is led out from the tip mounting jig 4, and a suction device 11 is connected to the other end of this suction tube 10. ing. The photodetector 3 and the driving unit of the suction device 11 are electrically connected to the control device 12, respectively.
【００１４】本実施例の装置を用いて検体液を測定する
には、まずテーパ型チップ８の吸引口６が採取容器に収
容された検体液（図示せず）の液面とほぼ接する程度
に、テーパ型チップ８の先端を当該検体液中に少し浸漬
する。In order to measure the sample liquid using the apparatus of this embodiment, first, the suction port 6 of the tapered tip 8 is brought into contact with the liquid surface of the sample liquid (not shown) contained in the sampling container. The tip of the tapered tip 8 is slightly dipped in the sample liquid.
【００１５】つづいて、吸引装置１１を駆動し、間隙５
と吸引チューブ１０を介してテーパ型チップ８内の空間
７の空気を吸引すると、空間７が負圧となり吸引口６か
らこの空間７に測定に必要な量の検体液１３が分取され
る。この場合、テーパ型チップ８内の検体液１３の液面
１４が、ファイバ端面１５と極めて接近できる（間隔Ｌ
は約３．０ｍｍ以下）ように当該検体液１３の吸引量と
吸引速度とが設定されている。具体的に説明すると、本
実施例では、検体液１３の吸引量は１００μＬ〜１ｍ
Ｌ、吸引速度は０．１ｍＬ／ｓｅｃに設定されている。Subsequently, the suction device 11 is driven to move the gap 5
When the air in the space 7 in the tapered tip 8 is sucked through the suction tube 10, the space 7 becomes a negative pressure and the amount of the sample liquid 13 required for measurement is dispensed from the suction port 6 into the space 7. In this case, the liquid surface 14 of the sample liquid 13 in the tapered tip 8 can be extremely close to the fiber end surface 15 (interval L
Is about 3.0 mm or less), the suction amount and the suction speed of the sample liquid 13 are set. More specifically, in the present embodiment, the suction amount of the sample liquid 13 is 100 μL to 1 m.
L, the suction speed is set to 0.1 mL / sec.
【００１６】なお、吸引量の設定については、例えばテ
ーパ型チップ８内に液面センサ（図示せず）を設け、こ
の液面センサの信号を制御装置１２で処理し、制御装置
１２からの信号で吸引装置１１の駆動源の駆動を微調整
することで行なうことができる。For setting the suction amount, for example, a liquid level sensor (not shown) is provided in the tapered tip 8, the signal of this liquid level sensor is processed by the controller 12, and the signal from the controller 12 is set. Can be performed by finely adjusting the drive of the drive source of the suction device 11.
【００１７】その後、光源２からの励起光を、第１の分
岐ファイバ１ａと光ファイバ１を通してファイバ端面１
５から被測定用の検体液１３に照射し、この光照射に伴
なう検体液１３からの蛍光を光ファイバ１と第２の分岐
ファイバ１ｂを通して光検出器３に導く。この光検出器
３の内部では、励起光を除去するため、干渉フィルター
や分光装置による波長選択が行なわれ、目的物質である
検体液１３の蛍光のみが測定される。After that, the excitation light from the light source 2 passes through the first branch fiber 1a and the optical fiber 1 and the fiber end face 1
The sample liquid 13 to be measured is irradiated from 5 and the fluorescence from the sample liquid 13 accompanying this light irradiation is guided to the photodetector 3 through the optical fiber 1 and the second branch fiber 1b. Inside the photodetector 3, wavelengths are selected by an interference filter or a spectroscopic device in order to remove the excitation light, and only the fluorescence of the sample liquid 13 which is the target substance is measured.
【００１８】なお、上記の測定で、光検出器３内部での
波長選択を励起光波長に合わせることで、被測定液の濁
度測定も可能になる。In the above measurement, the turbidity of the liquid to be measured can be measured by adjusting the wavelength selection inside the photodetector 3 to the wavelength of the excitation light.
【００１９】上記一連の操作つまり、検体液の吸引、励
起光の照射、蛍光の測定等は制御装置１２の設定に従っ
て自動で行なわれ、測定結果の表示、記録も同時に行な
われる。The above series of operations, that is, the suction of the sample liquid, the irradiation of the excitation light, the measurement of the fluorescence and the like are automatically performed according to the setting of the control device 12, and the measurement results are displayed and recorded at the same time.
【００２０】上記の測定に際し、検体液１３の液面１４
がファイバ端面１５に極めて接近した位置に設定できる
ので、検体液１３からの蛍光は再現性よく高感度に検出
される。During the above measurement, the liquid surface 14 of the sample liquid 13
Can be set at a position extremely close to the fiber end face 15, so that fluorescence from the sample liquid 13 can be detected with high reproducibility and high sensitivity.
【００２１】なお、本実施例では、テーパ型チップ８内
の空間７を吸引するための間隙５は、光ファイバ１の外
周部と筒状のチップ取付け治具４との間に形成されてい
るが、間隙の形成手段はこれに限定されない。例えば多
数の光ファイバを束ねて形成されるバンドルファイバ
（図示せず）内の間隙を利用して上記テーパ型チップ８
内の空間７を吸引するようにしてもよい。その他、吸引
チューブを空間７に直接導く（図示せず）ことも可能で
あり、その場合は上記の間隙５も不要である。In this embodiment, the gap 5 for sucking the space 7 in the tapered tip 8 is formed between the outer peripheral portion of the optical fiber 1 and the cylindrical tip mounting jig 4. However, the means for forming the gap is not limited to this. For example, the taper type chip 8 is utilized by utilizing a gap in a bundle fiber (not shown) formed by bundling a large number of optical fibers.
The internal space 7 may be sucked. Besides, it is also possible to directly guide the suction tube to the space 7 (not shown), and in that case, the above-mentioned gap 5 is also unnecessary.
【００２２】[0022]
【発明の効果】以上説明したように、本発明に係る液体
の光学的測定装置によれば、光ファイバの端面から被測
定液の液面に直接励起光を照射して集光効率を高くし、
液面の蛍光や化学発光を高感度に検出でき、しかもファ
イバ端面が液体と僅か離れているので光ファイバが汚染
されることがない。また、ファイバ端面と液面との間の
微小な間隙設定が、ファイバ端面に取付けたチップ内の
空間を吸引するという手段により簡易に実現できる。さ
らに、被測定液内の特定な物質を検出するため反応を進
行させる場合は、この被測定液の吸引速度を制御するこ
とで最適な検出条件を設定することが容易である。As described above, according to the optical liquid measuring device of the present invention, the excitation light is directly irradiated from the end face of the optical fiber to the liquid surface of the liquid to be measured to enhance the light collecting efficiency. ,
Fluorescence and chemiluminescence on the liquid surface can be detected with high sensitivity, and since the fiber end surface is slightly separated from the liquid, the optical fiber is not contaminated. Further, setting of a minute gap between the fiber end surface and the liquid surface can be easily realized by means of sucking the space in the chip attached to the fiber end surface. Furthermore, when the reaction is allowed to proceed to detect a specific substance in the liquid to be measured, it is easy to set the optimum detection condition by controlling the suction speed of the liquid to be measured.
【図１】実施例に係る液体の光学的測定装置の説明図で
ある。FIG. 1 is an explanatory diagram of an optical liquid measuring device according to an embodiment.
【図２】図１のＡ部の拡大断面図である。FIG. 2 is an enlarged cross-sectional view of a portion A of FIG.
１…光ファイバ、２…光源、３…光検出器、４…チップ
取付け治具、５…間隙、６…吸引口、７…空間、８…テ
ーパ型チップ、１１…吸引装置、１２…制御装置、１３
…液体。1 ... Optical fiber, 2 ... Light source, 3 ... Photodetector, 4 ... Chip mounting jig, 5 ... Gap, 6 ... Suction port, 7 ... Space, 8 ... Tapered chip, 11 ... Suction device, 12 ... Control device , 13
…liquid.
───────────────────────────────────────────────────── フロントページの続き (72)発明者 川口 成治 神奈川県綾瀬市早川2743−１ 東ソー株式 会社内 (72)発明者 坂本 裕一郎 東京都豊島区高田３−41−８ 中外製薬株 式会社内 (72)発明者 本島 久也 東京都豊島区高田３−41−８ 中外製薬株 式会社内 (72)発明者 増子 正行 静岡県浜松市市野町1126番地の１ 浜松ホ トニクス株式会社内 (72)発明者 早川 毅 静岡県浜松市市野町1126番地の１ 浜松ホ トニクス株式会社内 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Naruharu Kawaguchi 2743-1, Hayakawa, Ayase-shi, Kanagawa Tosoh Corporation (72) Inventor Yuichiro Sakamoto 3-41-8 Takada, Toshima-ku, Tokyo Chugai Pharmaceutical Co., Ltd. (72) Inventor Hisaya Motoshima 3-41-8 Takada, Toshima-ku, Tokyo Chugai Pharmaceutical Co., Ltd. (72) Inventor Masayuki Masuko 1 126-1, Nomachi, Hamamatsu, Shizuoka Prefecture Hamamatsu Photonics KK (72) Invention Takeshi Hayakawa 1 Hamamatsu Photonics Co., Ltd. 1 No. 1126 Nomachi, Hamamatsu City, Shizuoka Prefecture
Claims (5)
置において、光ファイバの端末に取付けられ、内部に空
間を有し、かつこの空間に通じる吸引口を有するチップ
と、前記空間に前記吸引口から被測定用の液体を吸入す
るため当該空間と連通された吸引手段を備えてなる液体
の光学的測定装置。1. A liquid optical detection device using an optical fiber, wherein the tip is attached to the end of the optical fiber, has a space inside, and has a suction port communicating with this space, and the suction in the space. An optical measuring device for a liquid, comprising suction means communicating with the space for sucking the liquid to be measured from the mouth.
外部に形成される間隙を介して前記吸引手段と連通され
てなる請求項１記載の液体の光学的測定装置。2. The optical measuring apparatus for liquid according to claim 1, wherein the space is communicated with the suction means through a gap formed inside or outside the optical fiber.
は、前記チップと一体の筒状のチップ取付け治具を前記
光ファイバに嵌合することにより形成される間隙である
請求項１記載の液体の光学的測定装置。3. The gap formed outside the optical fiber is a gap formed by fitting a cylindrical chip mounting jig integral with the chip to the optical fiber. Liquid optical measuring device.
は、バンドルファイバの各光ファイバ間に形成される間
隙である請求項１記載の液体の光学的測定装置。4. The optical liquid measuring device according to claim 1, wherein the gap formed inside the optical fiber is a gap formed between the optical fibers of the bundle fiber.
の吸引量または吸引速度を制御可能な制御装置に接続さ
れている請求項１ないし４のいずれかに記載の液体の光
学的測定装置。5. The liquid optical measuring apparatus according to claim 1, wherein the suction means is connected to a control device capable of controlling a suction amount or a suction speed of the liquid into the space. .
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6012654A JP2706616B2 (en) | 1994-02-04 | 1994-02-04 | Liquid optical measuring device |
| EP95300194A EP0666472A2 (en) | 1994-02-04 | 1995-01-12 | Device for optically measuring liquids |
| US08/378,369 US5523845A (en) | 1994-02-04 | 1995-01-25 | A fiber optic device for measuring liquids which are drawn into an end of the device to a predetermined distance from the end of the optical fibers |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6012654A JP2706616B2 (en) | 1994-02-04 | 1994-02-04 | Liquid optical measuring device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH07218423A true JPH07218423A (en) | 1995-08-18 |
| JP2706616B2 JP2706616B2 (en) | 1998-01-28 |
Family
ID=11811356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6012654A Expired - Fee Related JP2706616B2 (en) | 1994-02-04 | 1994-02-04 | Liquid optical measuring device |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US5523845A (en) |
| EP (1) | EP0666472A2 (en) |
| JP (1) | JP2706616B2 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000043751A1 (en) * | 1999-01-25 | 2000-07-27 | Laboratory Of Molecular Biophotonics | Pipette adaptor, pipette for absorbance measurement, tip, and method and apparatus for absorbance measurement |
| JP2001297699A (en) * | 2000-04-17 | 2001-10-26 | Matsushita Electric Ind Co Ltd | Method and device for producing liquid-cooled cathode- ray tube |
| JP2009092413A (en) * | 2007-10-04 | 2009-04-30 | Frontier Lab Kk | Polymer sample analyzer |
| JP2011064702A (en) * | 2004-08-02 | 2011-03-31 | Furukawa Electric Co Ltd:The | Specimen optical information recognizing device and method of recognizing the same |
| JP2013224950A (en) * | 2008-12-25 | 2013-10-31 | Universal Bio Research Co Ltd | Method for pretreating specimen, and method for assaying bio-related substance |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08338849A (en) * | 1995-04-11 | 1996-12-24 | Precision Syst Sci Kk | Method for detecting suction of liquid and dispenser being controlled by the method |
| DE19535046C2 (en) * | 1995-09-21 | 1998-04-16 | Eppendorf Geraetebau Netheler | Handheld device for pipetting and photometric measurement of samples |
| GB9606367D0 (en) * | 1996-03-26 | 1996-06-05 | United Utilities Plc | Optical instrument |
| ES2224347T3 (en) * | 1998-05-01 | 2005-03-01 | F. Hoffmann-La Roche Ag | APPARATUS TO SIMULTANEOUSLY CONTROL THE REACTIONS THAT HAVE PLACED A PLURALITY OF REACTION CONTAINERS. |
| US6254830B1 (en) * | 1999-11-05 | 2001-07-03 | The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations | Magnetic focusing immunosensor for the detection of pathogens |
| EP1754048A1 (en) * | 2003-12-08 | 2007-02-21 | Sentronic GmbH Gesellschaft für Optische Messsysteme | Sensitive system for detecting chemical and/or physical state changes inside packaged media |
| DE102007059167A1 (en) * | 2007-12-06 | 2009-06-10 | Synentec Gmbh | Pipette tip for use in e.g. pipetting device in laboratory, has wall comprising transparent region, where transparent region is formed as coplanar measuring windows in optical quality |
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| CN104749157B (en) * | 2013-12-27 | 2019-02-19 | 同方威视技术股份有限公司 | The method and apparatus that safety inspection is carried out to liquid article |
| EP3605112A4 (en) * | 2017-03-28 | 2021-01-20 | Universal Bio Research Co., Ltd. | Photometric dispensing nozzle unit, photometric dispensing apparatus, and photometric dispensing method |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS615450U (en) * | 1984-06-14 | 1986-01-13 | 三菱重工業株式会社 | particle detection device |
| JPH04324344A (en) * | 1991-04-24 | 1992-11-13 | Hitachi Cable Ltd | Early detection method of dissolved gas in insulating oil of of-cable connection |
| JP3052662U (en) * | 1998-03-26 | 1998-09-29 | ソマール株式会社 | Printed circuit board cover lay film pressing sheet |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US3814081A (en) * | 1971-04-02 | 1974-06-04 | Olympus Optical Co | Optical measuring catheter |
| EP0038912B1 (en) * | 1980-04-23 | 1983-05-18 | Contraves Ag | Canula with sensing means |
| US4488814A (en) * | 1981-09-28 | 1984-12-18 | Miles Laboratories, Inc. | Apparatus for and method of optical absorbance and fluorescent radiation measurement |
| US4622974A (en) * | 1984-03-07 | 1986-11-18 | University Of Tennessee Research Corporation | Apparatus and method for in-vivo measurements of chemical concentrations |
| CH660633A5 (en) * | 1984-11-06 | 1987-05-15 | Battelle Memorial Institute | Analysis apparatus for determining optical materials solution. |
| JPS61134648A (en) * | 1984-12-06 | 1986-06-21 | Mitsubishi Electric Corp | Water quality measuring instrument |
| US4757194A (en) * | 1986-10-10 | 1988-07-12 | Oxbridge, Inc. | Methods and apparatus for sensing the mechanical application of force |
| JPH07113638B2 (en) * | 1989-07-14 | 1995-12-06 | 松下電器産業株式会社 | Immunoassay method and immunosensor |
-
1994
- 1994-02-04 JP JP6012654A patent/JP2706616B2/en not_active Expired - Fee Related
-
1995
- 1995-01-12 EP EP95300194A patent/EP0666472A2/en not_active Ceased
- 1995-01-25 US US08/378,369 patent/US5523845A/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS615450U (en) * | 1984-06-14 | 1986-01-13 | 三菱重工業株式会社 | particle detection device |
| JPH04324344A (en) * | 1991-04-24 | 1992-11-13 | Hitachi Cable Ltd | Early detection method of dissolved gas in insulating oil of of-cable connection |
| JP3052662U (en) * | 1998-03-26 | 1998-09-29 | ソマール株式会社 | Printed circuit board cover lay film pressing sheet |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000043751A1 (en) * | 1999-01-25 | 2000-07-27 | Laboratory Of Molecular Biophotonics | Pipette adaptor, pipette for absorbance measurement, tip, and method and apparatus for absorbance measurement |
| US6396584B1 (en) | 1999-01-25 | 2002-05-28 | Hamamatsu Photonics K.K. | Pipette adapter, absorbance measuring pipette, tip, absorbance measuring apparatus, and absorbance measuring |
| JP2001297699A (en) * | 2000-04-17 | 2001-10-26 | Matsushita Electric Ind Co Ltd | Method and device for producing liquid-cooled cathode- ray tube |
| JP2011064702A (en) * | 2004-08-02 | 2011-03-31 | Furukawa Electric Co Ltd:The | Specimen optical information recognizing device and method of recognizing the same |
| JP2009092413A (en) * | 2007-10-04 | 2009-04-30 | Frontier Lab Kk | Polymer sample analyzer |
| JP4660799B2 (en) * | 2007-10-04 | 2011-03-30 | フロンティア・ラボ株式会社 | Polymer sample analyzer |
| JP2013224950A (en) * | 2008-12-25 | 2013-10-31 | Universal Bio Research Co Ltd | Method for pretreating specimen, and method for assaying bio-related substance |
| US9182395B2 (en) | 2008-12-25 | 2015-11-10 | Universal Bio Research Co., Ltd. | Method for pretreating specimen and method for assaying biological substance |
| JP2017072603A (en) * | 2008-12-25 | 2017-04-13 | ユニバーサル・バイオ・リサーチ株式会社 | Biological substance measuring device |
| US9753032B2 (en) | 2008-12-25 | 2017-09-05 | Universal Bio Research Co., Ltd. | Method for pretreating specimen and method for assaying biological substance |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0666472A3 (en) | 1995-09-06 |
| US5523845A (en) | 1996-06-04 |
| EP0666472A2 (en) | 1995-08-09 |
| JP2706616B2 (en) | 1998-01-28 |
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Legal Events
| Date | Code | Title | Description |
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| LAPS | Cancellation because of no payment of annual fees |