JPH07149376A - Flexible bag with faucet containing solute-filled bag - Google Patents

Abstract

PURPOSE:To adjust and preserve a large amount of highly accurate sterile solution at the place of its usage in a simple, inexpensive manner. CONSTITUTION:A sterile solution bag is provided with a flexible bag (outer bag) 1 having an upper faucet 2 and a lower faucet 3, a bag 5 having a broken line 6, filled with a specific amount of solute and fixed within the flexible bag 1 at one to a few places and, as required, a stirrer (the use of magnetic stirrer to stir the solution) within the flexible bag. By the use of the bag, a large amount of a highly accurate sterile solution can be adjusted and preserved for a long period of time at the place of its usage in a simple, inexpensive manner.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION This invention relates to a closed dilute solution preparation.

[0002]

2. Description of the Related Art Conventionally, medical solutions, drinking water and the like, which require aseptic operation, are produced as finished products at manufacturing plants. Injectables, powder crystals, etc. may dissolve in the field, but these are small volumes. In recent years, there has been an increasing demand for preparing a large amount of solution on site by the powder method, but as a result of the open method, aseptic preparation of a large amount of solution is impossible.

[0003]

At present, aseptic medical solutions and drinking water are manufactured in factories and can be delivered to the site, but transportation, labor, and storage costs are high. In recent years, in order to reduce these costs and labor, there has been an increasing demand for on-site solution preparation from powder. At the present stage, when preparing a large amount of solution from powder etc., it is inevitable to air contact and pollution because it is an open system. Therefore, aseptic solution preparation is not possible. The present invention aims to aseptically prepare and store a large amount of a dilute solution of a desired concentration aseptically without contacting the air with a large amount of solution in the field.

[0004]

[Means for Solving the Problems]

A. The outer bag (1) has a fixed capacity, and the stopcock (2) is on the top.
Alternatively, a flexible bag having an injection needle insertion portion (2 ') and a lower mouth stopcock (3) provided at the bottom. When the concentration of the prepared solution is important, a flexible net is attached to the flexible bag to prevent extension. B. In the outer bag (1), a part of the inner bag (5) enclosing a certain amount of solute or a string or the like is fixed (4) to the outer bag (1). C. The inner bag (5) is provided with a broken line (6) so that the inner bag (5) can be ruptured by manual pressure from the outer bag (1) to allow the enclosed contents (solute) to be released. Alternatively, the inner bag (5) is made of a material that dissolves in a diluent. Inner bag When enclosing solutes that cannot be mixed when filled with solutes, or solutes that require the order of dissolution, the required number of inner bags (55'5 ")
) Is also built in. D. When it is necessary to stir the solution by using a magnetic stirrer, the stirrer (7) is enclosed in the flexible bag (1).

[0005]

[Action]

A. By making the outer bag (1) a flexible bag, it becomes easy to deaerate or evacuate the air and gas inside the bag. Stopcock (2) (or injection needle entry part (2 ') on the outer bag
Is convenient for degassing and solution preparation, for discharging mixed air and gas, and for collecting and injecting chemicals. B. By fixing (4) the inner bag (5) enclosing the solute to the outer bag (1), it is possible to prevent the inner bag (5) from floating during solution stirring and drainage. C. By providing the inner bag (5) with the broken line (6),
It is possible to facilitate the rupture of the bag and the release of the solute from the outer bag due to hand pressure. Inner bag When solutes that cannot be mixed when filled with solutes or several kinds of solutes that require solute order are built-in, the required number of inner bags (5, 5 ', 5 ")
It is possible to prepare complicated solutions by incorporating (...) In the same manner. D. By incorporating a stirrer in the outer bag (flexible bag) (1), a magnetic stirrer can be used to perform closed stirring in a sealed bag. As described above, by using this bag, injection of the diluent,
In solution preparation such as stirring, completely closed operation becomes possible, and aseptic solution preparation becomes easy.

[0006]

【Example】

Example 1 FIG. 1 is a plan view of a solute-filled bag (inner bag) (5) and a flexible bag (outer bag) (1) with a stopcock. The outer bag (I) is provided with an upper stopcock (2) or a needle sampling and injecting part (2 ') and a lower stopcock (3), and if the concentration of the prepared solution is emphasized, add a wire mesh to the flexible bag. Prevents the flexible bag from expanding. The solute-filled inner bag (5) is fixed (4) to the outer bag (1). The inner bag (5) is provided with a broken line that can be ruptured by hand pressure from the outer bag (1). Air or gas inside the outer bag (flexible bag) (1) is discharged or evacuated,
Cover the upper stopcock and the lower stopcock with a plastic bag.
Perform sterilization with a wire.

[0007]

[Embodiment 2] In FIG. 2, several inner bags (5 ′) and (5 ″) are fixedly incorporated in the above bag (FIG. 1), and further a stirring bar (7).
Is built in.

[Embodiment 3] FIG. 3 shows an example of use of this bag (FIG. 2).
This bag was set in a stirrer equipped with a magnetic stirrer (9) at the bottom of a basket (8) corresponding to a fixed capacity flexible bag (1), and an injection liquid pipe (10) was connected to a lower mouth stopcock (3). It is a figure. If the bottom tap of this bag is covered with a plastic bag and sterilized, it can be aseptically connected by disinfecting the tip of the injecting liquid pipe during use.

[0008]

EFFECTS OF THE INVENTION In order to save a large amount of cost such as transportation cost, labor and storage when a product (solution) is shipped from a factory, a method and apparatus for aseptically adjusting a solution in a quantity larger than that of powder has been recently used on site. Although it is under development, there is no device that can perform sterilization of these devices by performing the process of automatic weighing of powder, mixing of diluting liquid, stirring, storage, etc. in a closed and aseptic manner in the future. Even if the device is manufactured, it is large and expensive. In the bag of the present invention,
A large amount of an aseptic solution having a desired concentration can be prepared by using a degassed, vacuumed, or sterilized bag and aseptically connecting and injecting a sterilized dilution water injection pipe to the bottom opening stopcock of the bag. Further, since the stirrer incorporated in the bag can be indirectly rotated and stirred by a magnetic stirrer, it is possible to stir the solution in the closed bag in a closed manner to adjust the uniform solution in the bag. Moreover, since this bag is a closed type, it can be stored for a long period of time. As described above, by adjusting the solution from the powder on site, it is possible to reduce the transportation cost, labor, storage, etc. when the solution product is received. That is, by using this bag, it is possible to prepare a large amount of aseptic solution having a desired concentration with a simple device and operation at a low cost in the field. In addition, the solution is stored in a closed bag, which enables long-term storage.

[Brief description of drawings]

FIG. 1 is a plan view of a flexible bag (1) having a solute-containing bag (5) and a stopcock according to the present invention.

[Fig. 2] A solute-filled bag and agitator in which one to several bags (5), (5 '), and (5 ") are fixedly incorporated in the bag (1) of the present invention, and an agitator (7) is additionally incorporated. It is a top view of a flexible bag with a stopcock with a child.

FIG. 3 is an example of use of the bag of the present invention (FIG. 2).

[Explanation of symbols]

 1. Outer bag (flexible bag) 2. Upper stopcock 3. Lower mouth stopcock 4. Inner bag fixed 5. Inner bag (5) 6. Inner bag broken line 2 '. Injection needle sampling and injection section 7. Stirrer 8. Basket for this bag 9. Magnetic stirrer 10. Diluent injection pipe

Claims (1)

[Claims] 1. A flexible bag (outer bag) with a fixed capacity (outer bag) (1) in which a fixed amount of solute is enclosed and a bag (inner bag) (2) with a broken line is fixedly incorporated. A flexible bag with a stopcock that has a built-in solute-filled bag.