JPH069375A - Dividable connected tablet - Google Patents

Abstract

PURPOSE:To obtain a readily handleable dividable connected tablet capable of uniformizing a unit dose without a change in quality by adjacently connecting plural unit tablets and forming separable connected parts. CONSTITUTION:The dividable connected tablet is obtained by mutually adjacently locating unit tablets (2a) and (2b) composed of uncoated bare tablets or tablets coated with a coating part, connecting the adjacent unit tablets (2a) to (2b) with a joining agent (e.g. a synthetic adhesive or a natural adhesive) or by engagement and forming separable connected parts 4. Furthermore, the unit tablets (2a) and (2b) may be constructed from either the same or different ingredients.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a tablet which can be divided into two or more in the fields of foods, pharmaceuticals and the like.

[0002]

2. Description of the Related Art Generally, in the case of forming tablets in the fields of foods, pharmaceuticals, etc., the tablets are divided into two or more according to the usage and dose. As this type of dividable tablet, for example, the one described in JP-A-61-289027 is known. In this conventional example, a chamfered portion is provided on each peripheral edge of both upper and lower flat surfaces of the tablet, and a dividing groove is provided on the upper flat surface of the tablet.

On the other hand, recently, many studies have been conducted on drug release control systems (drug delivery systems). Furthermore, in recent years, for example, a formulation having a long-lasting property and a formulation having a fast-acting property are generally laminated or mixed.

[0004]

The above-mentioned conventional example is excellent in that the tablet can be easily divided into two by pressing the tablet from the upper side with the dividing groove facing downward, but the pressing force is oblique. When added, diagonal cracks are likely to run on the peripheral side surface, and as a result, the two divided bodies cannot be evenly divided, and the sizes of the two divided bodies are different, resulting in variations in unit dose.

On the other hand, in order to divide the tablet into two evenly, it is conceivable to make the dividing groove large and deep, but in this case, there is a possibility that it may be easily broken by the impact received during transportation or storage.

[0006] Further, in order to control the dissolution of the components of the tablet, etc., the entire tablet may be coated with a coating agent. In this case, the coating agent makes it even more difficult to divide the tablet into two equal parts. There is also a problem that uncoated uncoated tablet portions are exposed by the division, and the dissolution property cannot be controlled.

Further, in order to laminate a sustained-release preparation and a fast-acting preparation, it is complicated to adjust the weight of the both and the tableting pressure, and in some cases, the expected function is lost due to the variation of the tableting pressure. Often. Further, when the two preparations are mixed, the variation in the mixing ratio becomes a problem.

It is an object of the present invention to provide a dividable linked tablet which can make a unit dose uniform and to provide a linked tablet which can accurately and easily combine formulations having different functions to exert a high function. And

[0009]

In order to achieve the above object, the present invention has a dividable connecting tablet as follows.

(Invention of Claim 1) For example, as shown in any one of FIGS. 1 to 12, a plurality of unit tablets (2 ...) Are located adjacent to each other, and adjacent unit tablets (2. ) Are connected to each other, and the connecting portion (4) is formed so as to be separable.

(Invention of Claim 2) In the structure of Claim 1, for example, as shown in any one of FIG. 1 to FIG. 10 and FIG. 12, the unit tablets (2.2) adjacent to each other are bonded together.
(3) is joined by joining, and the joining portion (4) by this joining agent (3) is formed so as to be rupturable.

(Invention of Claim 3) In the structure of claim 1, for example, as shown in FIG. 11, adjacent unit tablets (2
And (2) are connected by engaging each other, and the connecting portion (4) is separably formed.

(Invention of Claim 4) In the constitution of any one of Claims 1 to 3, as shown in, for example, any one of FIGS. 1 to 5 or FIG. 11, a unit tablet (2 ) Consists of uncoated plain tablets.

(Invention of Claim 5) In the constitution of any one of Claims 1 to 3, at least one of the unit tablets (2) is as shown in, for example, any one of Figures 6 to 9. One consists of coated tablets coated with coating (7).

(Invention of Claim 6) In the configuration of claim 2, as shown in any one of FIG. 6 to FIG.
At least one of the unit tablets (2) is a coated tablet coated with the coating agent (7), and the coating agent (7) is composed of the bonding agent (3).・ 2) The two are joined together and connected.

(Invention of Claim 7) In the structure of Claim 5 or Claim 6, the coating material (7) is composed of components different from each other.

(Invention of Claim 8) In the constitution of any one of Claims 1 to 3, as shown in FIG. 10, for example, the whole of a plurality of unit tablets (2) connected to each other is coated. It is covered by (7).

(Invention of Claim 9) In the structure of claim 1, for example, as shown in FIG. 12, a plurality of unit tablets (2) connected to each other are composed of different components.

[0019]

Function The adjacent unit tablets (2) are firmly connected by the connecting part (4), but the unit tablets (2, 2) on both sides of this connecting part (4) have stress such as bending. When added, the connected tablets (1) are separated at this connecting part (4) and each unit tablet (2.
It is divided into 2).

The unit tablet used in the present invention may be of any shape and can be easily distinguished from other types of tablets. For example, caplets, oblongs, ovals, rectangles, almonds, pillows, arrowheads, bullets, polygons such as triangles and squares, semicircles, hearts, cylinders, donuts, diamonds, or These shapes can be applied to divided shapes.

In addition, the surface shape of the unit tablet can be such that the corners can be formed into curved surfaces, and the flat surface can be a convex ordinary curved surface, a sugar-coated curved surface, a two-step curved surface, or a concave surface. Furthermore, it is also possible to form button-shaped projections or holes, or split grooves on the surface.

It is desirable that the surface shape of the unit tablets when engaging and connecting the unit tablets with each other should avoid a complicated shape such as a screw structure or a shape that is easily damaged, but a combination of a hole and a protrusion inserted into the hole. Alternatively, any shape can be adopted as long as the shapes are engageable with each other, such as a combination of a groove and a ridge engaged with the groove.

These unit tablets may be combined tablets of one kind to make a linked tablet, but it is also possible to combine plural kinds of unit tablets. For example, the sustained-release preparation and the fast-acting preparation can be formed into unit tablets while being controlled individually, and these unit tablets can be combined into one linked tablet without impairing the function of each unit tablet. In this case, even if divided into individual unit tablets and taken
Alternatively, the tablets may be taken as they are without being divided.

It is desirable to avoid, as the bonding agent for bonding the unit tablets, one that is impregnated into the unit tablets and deteriorates the tablets, but any substance which can be interposed between the unit tablets and bonded can be used. It may be a synthetic adhesive, a natural adhesive, a pressure-sensitive adhesive, a dental adhesive based on polyfunctional methacrylate, or a viscous substance that produces viscosity when a solvent such as water or alcohol is added.

Specific examples of the synthetic adhesive include the following.・ As thermosetting resin adhesives, chemically reactive urea resin, melamine resin, phenol resin, epoxy resin,
Polyester resin, polyimide, etc. -As a thermoplastic resin adhesive, solvent volatilization solvent-type vinyl acetate resin, emulsion-type vinyl acetate resin, vinyl chloride-vinyl acetate copolymer resin, nitrocellulose, acrylic-vinyl acetate copolymer resin, ethylene-vinyl acetate Cooling (hot melt), such as copolymer resin, chemical reaction type cyanoacrylate, anaerobic acrylic resin, urethane resin, etc.
Type ethylene-vinyl acetate copolymer resin, polyamide, polyester, etc., pressure sensitive acrylic resin, etc.

As a synthetic rubber adhesive, solvent volatilization type chloroprene rubber, nitrile rubber, recycled rubber, latex, etc., chemical reaction type urethane rubber, etc., cooling (hot melt) type polystyrene-polyisoprene-polystyrene block Copolymers, pressure-sensitive butyl rubber, polyisobutylene rubber, silicone, etc. -Chemical reaction type vinyl-phenolic, rubber-phenolic, epoxy-phenolic, nylon-epoxy, nitrile-epoxy, etc. as the polymer alloy adhesive.

Specific examples of the natural adhesive include the following.・ Solvent volatilizing starch, casein, dextrin, gum arabic, etc., cooling (hot melt) asphalt,
Pressure sensitive complex polysaccharides such as glue and rosin, natural rubber, etc.

Specific examples of the pressure-sensitive adhesive include the following. -As a rubber-based pressure-sensitive adhesive, a mixture of an elastomer with a tackifier, a softening agent, an antioxidant, etc. -Synthetic products such as acrylic acid esters as acrylic adhesives. -Silicone type adhesives made from silicone rubber and silicone resin, such as water-based emulsion type, oligomer type and hot melt type.・ In addition, polyether adhesives, polyurethane adhesives, etc. In addition, these adhesives can also be used after being processed into a tape or sheet shape.

As the viscous substance which is made viscous by water,
Specific examples include the following. As a polymer having a carboxyl group, an acrylic acid-based polymer or the like having acrylic acid as a constituent monomer, and as a salt thereof, a sodium salt, a potassium salt,
Monovalent and divalent salts such as magnesium salt and calcium salt. -As cellulose ethers, sodium carboxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methyl cellulose,
Crystalline cellulose, sodium carboxymethyl cellulose, etc.・ As natural viscous substances, mucin, agar, gelatin,
Pectin, carrageenan, sodium alginate, locust bingham, chitin, chitosan, tragacanth powder, etc. -Polyethylene glycol having a molecular weight of 200,000 or more.

Examples of the viscous substance which produces viscosity by an organic solvent such as alcohol include the following. -Hydroxypropyl cellulose, hydroxypropyl methyl cellulose, ethyl cellulose, hydroxypropyl methyl cellulose phthalate, hydroxymethyl cellulose acetate succinate, acrylic acid copolymer, shellac, waxes and the like.

In the present invention, the above viscous substance can be used for the coating agent for coating the unit tablet or the linked tablet. When applied to unit tablets, the unit tablets can be joined and joined by wetting the surface of the coating agent with water or a solvent.

In the present invention, the coating agent for coating the unit tablet or the linked tablet may be composed of a single component, or two or more kinds may be appropriately combined. Further, the coating is not limited to one layer, and it is also possible to form two or more layers. Furthermore, it is of course possible to coat the unit tablets with different coating agents so that the elution properties of the unit tablets are different.

In the coating agent, in addition to adjusting the coating amount in order to control the drug dissolution, lipids such as fatty acid and its salt, aliphatic higher alcohol, fatty acid glycerin ester and its hardened oil, and HLB are adjusted. It may also contain polyglycerin fatty acid ester.

The components of the coating agent include polyethylene glycol and hydrogenated castor oil as a coating aid, lactose, sugars such as granulated sugar and starch as a bulking agent, tar colorant as a colorant, caramel, red iron oxide, titanium oxide, and the like. Sweetening agents such as riboflavin, flavoring agents, and the like may be added as a corrigent.

The drug used in the plain tablet or the coating agent of the present invention may not have physiological activity, but the components are not particularly limited as the physiologically active substance used as the main drug. Two or more of these main drugs may be mixed in one unit tablet, and
Different active drugs may be put in separate unit tablets and linked.

Specific examples of the drug used as the main drug include the following. -As central nervous system drugs, diazepam, idebenone, aspirin, ibuprofen, paracetamol, naproxen, piroxicam, diclofenac, indomethacin, sulindac, lorazepam, nitrazepam, phenytoin, acetaminophen, etenzamid, ketoprofen, etc.・ As cardiovascular drugs, molsidomine, vinpocetine,
Propranolol, methyldopa, dipyridamole, furosemide, triamterene, nifedipine, atenolol, spironolactone, metoprolol, pindolol, captopril, isosorbide nitrate and the like.

As a respiratory drug, 3- (imidazo
[1,2-b] Pyridazine-6-y1) oxy-2,2-dimethyl-propanesulfonamide hydrochloride, amlexanox, dextromethorphan hydrobromide, theophylline, pseudoephedrine, salbutamol, guaifenicin, phenylpropanol hydrochloride Amines etc. -As digestive system drugs, benzimidazole-based drugs such as lansoprazole and omeprazole, cimetidine, ranitidine, pancreatin, bisacodyl, 5-aminosalicylic acid, sucralfate, etc.

As antibiotics and chemotherapeutic agents, cephalexin, cefaclor, cefradine, amoxicillin, pivampicillin, bacampicillin, dicloxacillin, erythromycin, erythromycin stearate, lincomycin, doxycycline, trimethoprim / sulfamethoxazole and the like. -As metabolic drugs, serrapeptase, lysozyme chloride, adenosine triphosphate, glypenclamide, potassium chloride and the like.

As vitamin drugs, retinol acetate, retinol palmitate, vitamin A oil, liver oil, strong liver oil, ergocalciferol, cholecalciferol, d-α-tocopherol succinate, d1-succinate
α-tocopherol, d1-α-tocopherol calcium succinate, d-α-tocopherol acetate, d1 acetate
-Α-tocopherol, d-α-tocopherol, d1
-Α-tocopherol, thiamine hydrochloride, thiamine nitrate,
Bisthiamine nitrate, thiamine disulfide, thiamine dicetyl sulfate ester salt, dicetiamine hydrochloride, fursultiamine hydrochloride, octotiamine, shicotiamine, bis-butyamine, fursultiamine, prosultiamine, benfotiamine, flavin adenine dinucleotide sodium, riboflavin, Riboflavin sodium phosphate,
Riboflavin butyrate, pyridoxine hydrochloride, pyridoxal phosphate, hydroxocobalamin hydrochloride, hydroxocobalamin acetate, cyanocobalamin, hydroxocobalamin,
Ascorbic acid, calcium ascorbate, sodium ascorbate, nicotinic acid, nicotinic acid amide, panthenol, calcium pantothenate, sodium pantothenate, biotin, potassium aspartate magnesium / equivalent mixture, inositol hexanicotinate,
Ursodesoxycholic acid, L-cysteine hydrochloride, L-
Cysteine, orotic acid, etc. -In addition, antacids and crude drugs.

As an additive together with the main drug, or as a drug used alone, an additive generally blended in producing an oral solid preparation can be freely used.
Specifically, the following may be mentioned. -As excipients, lactose, corn starch, sucrose, talc, crystalline cellulose, mannitol, light anhydrous silicic acid,
Magnesium carbonate, calcium carbonate, L-cystine,
Porous substance, etc. -As a binder, hydroxypropylcellulose, hydroxypropylmethylcellulose, pregelatinized starch, partially pregelatinized starch, methylcellulose, carboxymethylcellulose, polyvinylpyrrolidone, pullulan, dextrin, gum arabic, gelatin, etc.

As a disintegrant, low-substituted hydroxypropylcellulose, carboxymethylcellulose calcium, starches, croscarmellose, crospovidone, etc. -Magnesium stearate, calcium stearate, etc. as lubricants. -In addition, the above-mentioned coloring agents and flavoring agents.

[0042]

Embodiments of the present invention will be described below with reference to the drawings, but the present invention is not limited to these embodiments.

(First Example) In FIG. 1, (A) is a front view of a connected tablet, and (B) is a sectional view taken along the line BB of (A).

First, 2860 g of lactose and 1 corn starch
220 g and hydroxypropyl cellulose 120 g
Each in a vertical granulator, 400r
After mixing for 1 minute at pm, 500 g of distilled water is added and granulated for 10 minutes. Next, this granulated product is vacuum dried at 40 ° C. for 10 hours and then pulverized by a power mill. Then, 3885 g of the obtained pulverized product, 533 g of crystalline cellulose, and 22 g of magnesium stearate were placed in a tumbler mixer, and 1
Mix for minutes to obtain 4422 g of mixed powder.

Next, a process for producing a unit tablet from 400 g of the mixed powder described above using a rotary tableting machine will be described.
First, using a rotary tableting machine consisting of a punch having a diameter of 6 mm and a lower surface of the lower punch having a radius of 5 mm and a flat surface having a lower surface of the upper punch, one tablet from the mixed powder has a height of 170 mg and a height of 5 mm. About 500 tablets of 0.0 mm shell-shaped unit tablets (2a) are obtained. Further, using the above rotary tableting machine having the upper surface of the lower pestle formed into a flat surface, about 200 tablets of a cylindrical unit tablet (2b) each having 170 mg and a thickness of 4.8 mm are obtained from the mixed powder.

The obtained unit tablets are, as shown in FIG. 1 (A), one shell-shaped unit tablet (2a) arranged on each side of the cylindrical unit tablet (2b), and each unit tablet (2a. A vinyl acetate resin emulsion adhesive (3) is applied and bonded between 2b).

In this case, as shown in FIG. 1 (B), the adhesive (3) is applied to the end faces of the unit tablets (2a, 2b) which are in contact with each other. The agent (3) may be applied only to the central portion of this end face, or may be applied to the entire end face. Further, as in the modified example shown in FIG. 2, both unit tablets (2a, 2b) can be joined by applying the adhesive (3) in a band shape around the connecting portion (4).

Each unit tablet (2a ・ 2b ・ 2a) by the above joining
Are connected to each other to give a caplet-shaped linked tablet (1) having a weight of 510 mg, a long diameter of 14.6 mm and a short diameter of 6 mm. In addition, when this joint tablet (1) was divided one week after the production, it was broken at the joint portion (4) and two shell-shaped unit tablets (2a) and one cylindrical unit tablet ( It returned to the state of 2b).

FIGS. 3 to 11 show different embodiments, and a structure different from that of the first embodiment will be described. In these embodiments, the elements having the same configurations as those in the first embodiment are designated by the same reference numerals.

(Second Embodiment) As shown in FIG. 3, the first
The two cannonball-shaped unit tablets (2a) used in the examples are attached to the bottom surface (5) of one unit tablet (2a) and the tip of the other unit tablet (2a).
(6) is adjacent to each other and connected by joining. In this case, as the bonding agent (3), an acrylic acid-based viscous substance to which a small amount of water is added to make it sticky is used. This connected tablet (1) was divided into two after one week, and
(4) Broken and two shell-shaped unit tablets (2a ・ 2a) before connection
Returned to the state.

FIGS. 4 and 5 show a modification of the second embodiment, in which two shell-shaped unit tablets (2a) are respectively attached to the bottom surface (5.
5) shows the case where they are joined adjacent to each other and the case where they are joined adjacent to each other at their tips (6.6).

Thus, even if the same unit tablet (2) is used, the connecting tablet can be changed by changing the position of the connecting portion (4).
The shape of (1) can be changed to make it easier to distinguish from other types of tablets.

(Third Embodiment) In this embodiment, 400 g of the mixed powder used in the first embodiment is tableted using the above rotary tableting machine, one tablet having a weight of 70 mg and a height of 2 mg. About 3000 round bullet-shaped tablets were obtained. Put 2000 cannonball-shaped tablets in the coating device, and control the blast temperature to about 80 ℃ and the product temperature to about 40 ℃.
(7) was sprayed and coated. The coating agent (7) used here is
A composition having 18 g of hydroxypropylmethyl cellulose, 2 g of titanium oxide and 180 g of distilled water was prepared in advance.

After spraying a predetermined amount of coating agent (7),
By drying for several minutes as it is, a coated unit tablet (2c) of 80 mg per tablet is obtained. This coated unit tablet (2c),
As shown in FIG. 6, the tips (6, 6) are made to be adjacent to each other, and a small amount of water is added to the abutting portion to connect the both coated unit tablets (2c, 2c) by joining, and the connecting tablet It is what obtained (1). When the linked tablet (1) was divided into two after one week, it was divided into two coated unit tablets (2c · 2c) before being linked.

7 and 8 show a modification of the third embodiment, in which the connecting portions of the same unit tablet are changed.

(Fourth Embodiment) As shown in FIG. 9, this is composed of laminated tablets in which unit tablets (2d) are laminated in three layers, which are coated with a coating agent (7) to form a rectangular parallelepiped. . And 2
This is a rectangular unit tablet (2d) joined in a T shape.

(Fifth Embodiment) This is as shown in FIG.
The unit tablet (2e) is formed in a shape obtained by dividing the lens shape into two, and two half lens-shaped unit tablets (2e), a bonding agent (3)
The lens-shaped joined tablet (1) is covered with the coating agent (7).

(Sixth Embodiment) This is as shown in FIG.
Three unit tablets (2f) are located adjacent to each other, and adjacent unit tablets (2f) are connected by engaging each other. That is, in FIG. 11, (A) is a vertical sectional front view of the connected tablet, and (B) is a left side view. Each unit tablet
(2f) is formed in a disk shape, and a button-shaped projection (8a) is formed at the center of one side surface, and a fitting hole (8b) is formed at the center of the other side surface. Then, as shown in FIG.
The button-shaped protrusions (8a) of the unit tablets (2f) on the center and the right side are engaged with the fitting holes (8b) of the unit tablets (2f) on the left and the center, respectively, and are connected by this engagement to form a connected tablet ( 1) is formed.

Adjacent unit tablets can be separated by the connecting portions (4) engaged with each other, and when a force is applied in the direction of separating the unit tablets (2f), the unit tablets (2f) are separated and divided into unit tablets (2f). To be done. In this embodiment, the plain tablets are used as the unit tablets, but coated tablets can also be used. Further, since the unit tablet of the present embodiment is provided with the engaging projections on one surface and the engaging holes on the other surface, it is possible to connect unit tablets having the same shape in an arbitrary number. Even unit tablets having different shapes, such as a combination of a unit tablet provided with only a fitting protrusion and a unit tablet provided with only an engagement hole, can be combined into a linked tablet if they can be engaged with each other.

(Seventh Example) 45 g of ibuprofen, 54.5 g of hydroxypropylmethylcellulose and 0.5 g of magnesium stearate were placed in a mortar and mixed,
A mixed powder was obtained. 100 mg of this mixed powder was compressed by static compression using an autograph at a compression pressure of 1 ton / punch,
A unit tablet (2 g) having a length of 5 mm and a width of 5 mm shown in FIG. 12 was obtained.

On the other hand, 7.5 g of phenylpropanolamine hydrochloride and 4.8 g of dextromethorphan hydrobromide were added.
g, 70 g of hydroxypropylmethyl cellulose, 17.2 g of crystalline cellulose, and 0.5 g of magnesium stearate, and the above-mentioned unit tablet (2 g) is prepared by the same production method as above.
A unit tablet (2h) having a dissolution rate slower than that of the above was obtained.

Both unit tablets (2 g
2h) were adhered to each other with a silicone adhesive (3) to obtain a linked tablet (1). The obtained linked tablet (1) has a weight of 200.
mg, long diameter 10 mm, short diameter 5 mm oblong shape, the connection part (4) was once peeled off, but the original connection tablet (1) was restored by reattaching both.

[0063]

The present invention has the following effects because it is configured and operates as described above. (Invention of Claim 1) The unit tablets are firmly connected at the connecting portion, and are easy to handle as a connected tablet. Further, since the connecting portion can be separated when the connected tablet is divided, the division is easy and the unit tablet does not break. As a result, the divided unit tablets are not chipped due to division, and the unit dose can be made uniform. Moreover, since the quality of the unit tablet of the connected tablet remains as it is, the quality of the unit tablet does not change due to division.

(Invention of Claim 2) Since the unit tablets can be connected simply by joining them with a joining agent, they can be joined easily and can be joined by joining ones having an arbitrary shape. It can be set freely. On the other hand, when the connected tablet is divided, the connecting portion made of the bonding agent is broken, so that the unit tablet is not broken, the division is easy, and the unit dose can be made uniform.

(Invention of Claim 3) Since the unit tablets are simply engaged and connected, they can be easily connected and can be separated very easily. Moreover, since the separation is performed only by releasing this engagement, the unit tablet is not damaged during the division, and the unit dose can be made uniform.

(Invention of Claim 4) Since the unit tablets are not coated, the dissolution of the main drug is good, and even in the case of such plain tablets, the unit tablets are firmly connected.
It is easy to handle as a linked tablet.

(Invention of Claim 5) Since the connecting portion of the unit tablet is separated at the time of division, even if the coated tablet is used as the unit tablet, formation of the connected tablet and division into unit tablets are extremely easy. You can do it. Moreover, since the coating agent remains as it is on the divided unit tablets and the plain tablet portion is not exposed, the dissolution of the main drug can be controlled even after the division.

(Invention of Claim 6) Further, when the unit tablets are coated with a coating material composed of a bonding agent such as an adhesive substance, the surface of the unit tablets can be easily wet by a solvent such as water or alcohol. Can be joined to.

(Invention of Claim 7) When each unit tablet is coated with a coating agent having different components from each other, each unit tablet is coated with different properties such as enteric and gastric or water and insoluble. Since the dissolution of the main drug can be controlled for each unit tablet, the drug effect can be effectively exerted as the entire linked tablet.

(Invention of Claim 9) When the components of each unit tablet are different from each other, the unit tablets formed accurately and easily while individually managing each unit tablet are combined without impairing their functions. Can be combined into a single linked tablet. Further, in this case, it may be divided into individual unit tablets and taken or may be taken as it is as a linked tablet without being divided, so that the linked tablet can exhibit complicated and high functionality.

[Brief description of drawings]

FIG. 1 shows a first embodiment, FIG. 1A is a front view of a connected tablet, and FIG. 1B is a sectional view taken along the line BB of FIG.

FIG. 2 is a partially cutaway front view of a connected tablet showing a modified example of the first embodiment.

FIG. 3 is a front view of a connected tablet showing a second embodiment.

FIG. 4 shows a modification of the second embodiment and is a diagram corresponding to FIG.

FIG. 5 shows another modification of the second embodiment and is a diagram corresponding to FIG.

FIG. 6 is a vertical cross-sectional front view of the upper half of the connected tablet according to the third embodiment.

FIG. 7 shows a modification of the third embodiment and is a diagram corresponding to FIG.

FIG. 8 is a vertical sectional front view of a lower half portion of a connected tablet, showing another modification of the third embodiment.

FIG. 9 is a perspective view of a connected tablet showing a fourth embodiment.

FIG. 10 is a partially cutaway perspective view of a connected tablet showing a fifth embodiment.

FIG. 11 shows a sixth embodiment, (A) is a vertical sectional front view of a linked tablet, and (B) is a right side view of the linked tablet.

12A and 12B show a seventh embodiment, FIG. 12A is a plan view of a linked tablet, and FIG. 12B is a front view of the linked tablet.

[Explanation of symbols]

1 ... Connection tablet, 2 ... Unit tablet, 3 ... Binder, 4 ... Connection part, 7 ... Coating agent.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Toshio Kashihara 3-5706 Matsugaoka, Senriyama, Suita City, Osaka Prefecture

Claims (9)

[Claims] 1. A dividable connected tablet, wherein a plurality of unit tablets are positioned adjacent to each other, adjacent unit tablets are connected to each other, and the connecting portion is formed to be separable. 2. The dividable linked tablet according to claim 1, wherein adjacent unit tablets are joined together by joining with a joining agent, and the joining portion formed by the joining agent is formed to be rupturable. 3. The dividable connected tablet according to claim 1, wherein adjacent unit tablets are connected by engaging each other, and the connecting portion formed by this engagement is formed to be separable. 4. The dividable linked tablet according to any one of claims 1 to 3, wherein each unit tablet is an uncoated plain tablet. 5. The dividable linked tablet according to any one of claims 1 to 3, wherein at least one of the unit tablets comprises a coated tablet coated with a coating agent. 6. The method according to claim 2, wherein at least one of the unit tablets is a coated tablet coated with a coating agent, the coating agent is constituted by a jointing agent, and the unit tablets are joined and connected by the coating agent. The dividable linked tablet as described. 7. The dividable linked tablet according to claim 5 or 6, wherein the coating agent comprises different components. 8. The dividable linked tablet according to claim 1, wherein the plurality of unit tablets linked to each other are entirely coated with a coating agent. 9. The dividable linked tablet according to claim 1, wherein the plurality of unit tablets linked to each other are components different from each other.