JPH067721Y2 - Plasmapheresis thermostat - Google Patents

Description

[Detailed Description of the Invention] << Industrial Application Field >> The present invention relates to plasmapheresis adopted for treatment of various medical conditions such as blood diseases, and is undesirable from plasma in blood (plasma). The present invention relates to a constant temperature bath suitable for selectively separating desired components to be removed efficiently when the plasma is passed through a desired filter under low temperature or high temperature to remove solute.

<< Prior Art >> As is known, in the conventional plasmapheresis, a desired solute is removed by filtering the plasma at a low temperature or at a high temperature with a filter. (Japanese Patent Laid-Open No. 57-31869), for example, in the case of the above-mentioned low temperature filtration, by passing a tube through which plasma flows through a container containing ice, immediately before the entrance of a predetermined filter, I try to exchange it.

Therefore, according to the above-mentioned conventional example, not only the plasma cannot be kept under the most desirable temperature condition, but also ice must be added during continuous use for a long time, and the tube is placed under the cooling condition. It takes a lot of work, and the filter is not in the cooling condition.

<Problems to be solved by the invention> In view of the above-mentioned conventional plasmapheresis, the present invention focuses on the advantage of utilizing a constant temperature bath, and claims
In (1), a heat exchanger and the like are appropriately provided in the heat insulating tank main body, and a filter and a heat exchanger tube are set at appropriate positions in the main body so that the filter and the heat exchange tube can be set in and out freely.
By providing each tube attachment, not only the tube but also the temperature control of the filter can be accurately and easily performed, and it is easy and easy to replace the filter during use. The purpose is to enable rapid implementation.

Next, in claim (2), not only is the opening / closing door configured to have a double structure to obtain a heat insulating effect, but also by opening the outer door, the inside of the heat insulating tank main body is passed through the inner transparent door. , It is possible to visually check the door in the closed state, so that it is possible to confirm the leakage of plasma.

Further, in claim (3), the heat exchange tube,
In order to load the heat insulation tank body from the outside to the inside, the insertion and holding port for the tube is provided in the end face of the opening of the body so that the opening / closing door of the heat insulation tank body is simply opened. It is possible to put in and take out the heat exchange tubes, and to make it easier to attach and detach heat exchange tubes and the like.

<< Means for Solving the Problem >> The present application, in order to achieve the above-mentioned object, in claim (1),
A heat exchanger chamber and an adjacent chamber are provided in the heat-insulating tank main body provided with an opening / closing door, and the heat exchanger chamber,
A cooling heat exchanger, a heating heat exchanger, a fan and a temperature sensor are provided, and the output side of the electric controller connected to the temperature sensor is connected to the cooling heat exchanger and the heating heat exchanger. A constant temperature for plasmapheresis, wherein the adjacent chamber is provided with a filter fitting and a tube fitting in which the filter and the heat exchanging tube are detachably mountable in the closed state of the opening / closing door. A tank is intended to be provided, and in claim (2), the opening and closing door in claim (1) has a double structure of an outer door and an inner see-through door.

Further, the constant temperature bath of claim (3) is the same as that of the above claim (1), in which the opening and closing door presses the end face of the main body opening.
A configuration is added in which the insertion / holding opening of the heat exchange tube is provided in a recessed manner.

<Operation> When using the constant temperature bath according to claim (1), open the opening / closing door and attach the filter and the heat exchange tube to the filter attachment and the tube attachment provided in the adjacent chamber of the heat insulation bath main body, respectively. Then, the electric controller receives the output signal from the temperature sensor and controls ON / OFF of one of the cooling heat exchanger and the heating heat exchanger, and the electric controller receives the output signal from the temperature sensor. The temperature is maintained at the set temperature, and at this time, the fan agitates cold air or warm air to equalize the temperature inside the adiabatic tank body.

When it is desired to replace the filter or the heat exchanger tube, the opening / closing door may be opened to remove the filter and the tube from the filter fixture and the heat exchange tube, respectively.

According to claim (2), if only the outer door of the opening / closing door is opened, the inner see-through door still closes the main body opening, and the inside of the heat-insulating tank main body remains blocked from the outside, The inside of the main body can be seen through, and an unexpected trouble such as plasma leakage from the heat exchange tube or the like can be visually confirmed.

Further, according to the constant temperature bath of claim (3), when the filter and the heat exchange tube are taken out from the heat insulating bath main body, if the opening / closing door is opened, the tube is inserted and pinched on the end face of the main body opening. Since it is only stored in the mouth, it can be taken out of the heat-insulating tank main body at the same time as opening the door, and it can be easily and quickly attached in the same manner.

<< Embodiment >> The present invention will be described in detail with reference to the illustrated embodiment. As shown in FIG.
A main body opening 2a of the heat insulating tank main body 2 is provided so that it can be closed.

Here, the opening / closing door 1 in the figure has a double structure, and even if the outer door 1a is opened, the inner transparent door 1b is closed, and the inside of the heat insulating tank main body 2 can be visually seen through it. When the inner see-through door 1b is opened, the main body 2 is opened.

The inside of this heat-insulating tank main body 2 is a chamber CH for the heat exchanger on the depth side.
1 and an adjacent chamber CH2 on the front side thereof, in the illustrated example, both chambers CH1 and CH2 have a ventilation guard panel having a height lower than the ceiling by forming a large number of through holes 3a. It is divided by three standings.

A ventilation guard panel 3 is provided in the heat exchanger chamber CH1.
A heat exchanger 4 for cooling, a heat exchanger 5 for heating, and a ventilation guard panel 3 are arranged so as to be vertically arranged along
The fan 7 rotated by the motor 6 is attached to the wall surface of the heat insulating tank main body 2 facing to the panel 3 facing the above, and the temperature sensor 8 is provided above the fan 7 on the above wall surface. The sensor cover plate 8a, which is internally provided but is immediately below the sensor cover plate 8a, is provided so as not to directly hit the sensor 8 with cold air.

Here, reference numeral 9 in the drawing denotes an electric controller to which the output signal from the temperature sensor 8 is inputted,
The outputs of the cooling heat exchanger 4 and the heating heat exchanger 5 are connected so as to be ON-OFF controlled.

Next, for the heat exchanger chamber CH1, as shown in FIG. 3, the tube fitting 10 arranged vertically on the left wall surface of the heat insulating tank body 2 and the filter fitting on the right wall surface.
11 are provided respectively, and in the illustrated example, the upper mounting plate 10
a and a lower mounting plate 10b are provided with a keyhole-shaped locking groove 10c at the lower edge and the upper edge, respectively, and the heat exchange tube 12 inserted from the insertion slit 10d is forcibly inserted. And this is the slit
It is adapted to be fitted into a large-diameter fitting port 10e communicating with 10d.

Further, reference numeral 13 in the drawing denotes a filter which can be freely attached to and detached from the filter mounting tool 11, and as the mounting tool 11, FIG.
The one indicated by is formed by a pair of sandwiching bullet pieces 11a and 11b protruding from the heat insulating tank main body 2.
The filter 13 pushed in from the small fitting inlet 11c between 1a and 11b
However, the large-diameter fitting space 11d formed by the two members 11a and 11b is detachably fitted and retained.

Further, as shown in the figure, in the heat insulating tank main body 2, the end surface 2b of the main body opening 2a, that is, the surface on which the opening / closing door 1 is pressed so as to be freely opened, is at a required position, The insertion / holding opening 14 for accommodating the heat exchange tube 12 is recessed by a required number, and in FIG. 3, 14a is fitted and fixed to the insertion / holding opening 14 to form the heat exchange tube 12. It shows a cushioning material that keeps the airtight through.

Therefore, in order to use the thermostatic chamber 2 for plasmapheresis and to use it, first, the outer door 1a as the opening / closing door 1 and the inner transparent door 1b are opened, and the filter fixture 11 is opened. , The filter 13 is fitted, and the heat exchange tube 12 is attached to the fitting hole 10c using the upper fitting plate 10a and the lower fitting plate 10b of the tube fitting 10, and the fitting slit 10d has a larger diameter fitting port. 10e is inserted and locked, and the heat exchange tube 12 is inserted into the body opening 2a through the cushion material 14a.
The opening and closing door 1 is closed by fitting it into the insertion and holding port 14 provided in the end face 2b of the above.

When the required temperature is set by the electric controller 9, the temperature sensor 8 detects the temperature inside the adiabatic tank main body 2 and inputs an output signal to the controller 9, thereby cooling by the output. The heat exchanger 4 for heating or the heat exchanger 5 for heating is ONN-OFF controlled, and the temperature inside the heat insulating tank main body 2 is made uniform by the operation of the fan 7, and the temperature is maintained at the set temperature.

Therefore, in the above operating state, the filter 13 and the heat exchange tube 12 are held at the set temperature, and at this time, if only the outer door 1a of the opening / closing door 1 is opened,
Since the inside of the heat insulating tank main body 2 can be seen through the inner see-through door 1b, it is possible to confirm a situation where plasma is leaking from the heat exchange tube 12 or the like.

The temperature set by the cooling heat exchanger 4 is
The temperature is in the range of 2 ° C to 4 ° C, and the filtration substance varies depending on the temperature within this range. In the case of high temperature setting by the heat exchanger for heating, plasma sterilization and other (protein removal, low density lipolysis, etc. To remove the protein).

If you want to replace the filter 13 with a new one,
The opening / closing door 1 may be opened, the filter 13 may be removed from the filter fixture 11, and a new filter may be attached to the fixture 11 described above. When removing the heat exchange tube 12, after opening the door, the tube
Remove 12 from the tube fitting 10 and insert and
The same can be removed by pulling the above tube 12 toward the front side.

<< Effect of the Invention >> Since the present invention is configured as described above,
According to claim (1), the heat exchange tube can be cooled or heated to a predetermined temperature without the trouble of cooling it with ice, and the filter is also cooled or heated. Therefore, it is possible to efficiently remove the required undesired solute and selectively remove different filtration substances at each temperature, and it is possible to replace, attach and detach the heat exchange tube and the filter. Can be performed extremely easily and quickly.

Furthermore, in the case of claim (2), since the filter and the heat exchange tube can be confirmed through the inner see-through door,
It is possible to detect unintended leakage of plasma and the like while keeping the temperature inside the heat insulating tank body constant.

Also, in the constant temperature bath of claim (3), since the insertion and holding port is recessed in the end face of the main body opening, unlike the case of passing the heat exchange tube through the hole or removing it, ,
By opening the door, the mounting and removal thereof can be facilitated and can be performed quickly.

[Brief description of drawings]

FIG. 1 is a schematic vertical sectional side view of a constant temperature oven according to the present invention, FIG.
FIG. 4 is a schematic front view of a heat exchanger chamber portion in the same tank with the opening / closing door removed, FIG. 3 is a schematic front view of an adjacent chamber portion with the same opening / closing door removed as in FIG. 2, and FIG.
(a) (b) is the partial front view which shows the upper attaching plate in each tube attachment of the same tank, and the partial plan view which shows the filter attachment. 1 …… Opening / closing door 1a …… Outside door 1b …… Inside see-through door 2 …… Insulation tank body 2a …… Main body opening 2b …… End face 4 …… Cooling heat exchanger 5 …… Heating heat exchanger 7 ...... Fan 8 ...... Temperature sensor 9 ...... Electrical controller 10 ...... Tube fitting 11 ...... Filter fitting 12 ...... Heat exchange tube 13 ...... Filter 14 ...... Insertion pinch CH1 ...... Heat exchanger chamber CH2 ... Adjacent chamber

Claims (3)

[Scope of utility model registration request] 1. A heat exchanger chamber and an adjoining chamber are provided in an adiabatic tank body having an opening / closing door, and the heat exchanger chamber has a cooling heat exchanger, a heating heat exchanger, a fan, and A temperature sensor is provided, and the output side of the electric controller connected to the temperature sensor is connected to the cooling heat exchanger and the heating heat exchanger, and the adjacent chamber has a closed door state. And a constant temperature bath for plasmapheresis, comprising a filter attachment and a tube attachment, each of which has a filter and a heat exchange tube that can be attached and detached. 2. The thermostat for plasmapheresis according to claim 1, wherein the opening / closing door has a double structure of an outer door and an inner see-through door. 3. A heat exchanger chamber and an adjoining chamber are provided in an adiabatic tank body having an opening / closing door, and the heat exchanger chamber has a cooling heat exchanger, a heating heat exchanger, and a fan. And a temperature sensor are provided, and the output side of the electric controller connected to the temperature sensor is connected to the cooling heat exchanger and the heating heat exchanger, and an opening / closing door is closed in the adjacent chamber. In the state, a filter attachment and a tube attachment where the filter and the heat exchange tube can be attached and detached respectively are provided, and the opening and closing door of the heat insulation tank body is opened and closed on the end face of the opening. A constant temperature chamber for plasmapheresis, wherein the insertion and holding port of the heat exchange tube is recessed.