JPH0654633A - Inserting material for teat canal - Google Patents

Abstract

PURPOSE:To carry out the treatment of a teat canal constriction by simple treatment such as inserting of a rodlike inserting material into the teat canal. CONSTITUTION:The objective teat canal inserting material is obtained by forming chitin or a derivative thereof or coating or impregnating a support with the chitin or the derivative thereof.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a teat canal insert.

[0002]

2. Description of the Related Art Thickening or stenosis of the mouth of the teat or the inner wall of the teat and damage to the sphincter of the teat due to trauma of the hoof of a dairy cow, improper use of the duct, incorrect use of a milker, stimulation of the Tate cup liner, etc. May cause milking disorders such as milk leaks.

Conventionally, in such a case, for example, a diameter of about 3 m
It is a threaded rod with a length of about 7 cm and a length of about 7 cm.The tip of the threaded rod is cut obliquely, and the back end of the threaded rod is about 5 mm wide. Then, a so-called rod-shaped twisted rod (TatePlug-B: manufactured by Denka Pharmaceutical Co., Ltd., Tatorpoint: manufactured by Nihon Kenken Co., Ltd.) etc., which is solidified with a binder, is inserted into the teat canal to prevent expansion and milk leakage of the teat canal. Etc. are taken.

[0004]

Even when these screw rods are used as a therapeutic material for the teat canal, there are almost no cases of healing of the teat canal stenosis except for the initial mastitis. In the case of nipple stenosis, even a single milking cannot be improved, and a milking duct must be used in combination at the time of milking, which causes further damage to the nipple. In such a case, the teat canal is highly thickened and milking becomes impossible. As a result, incision and dilatation of the nipple mouth are required. In addition, papillitis, which is transmitted after incision, cannot be prevented by conventional therapeutic materials, and in most cases, the progress from papillitis to mastitis is observed.

Further, although these conventional teat canal therapeutic materials are coated with antibiotics at the portion where the teat canal is inserted, they are continuously inserted between milking steps, so that the antibiotics are diluted with milk. As a result, the bactericidal power is lost and the milk is contaminated with antibiotics. Conversely, the capillary phenomenon of the base material itself promotes the entry of foreign bacteria from the outside world, and the emergence of resistant bacteria to this drug due to long-term use, etc. As a result, it has been regarded as a problem as a cause of iatrogenic mastitis.

[0006] That is, the conventionally used rod-shaped twisted rods or ducts have the drawback that they are not effective for the treatment of nipple stenosis and wounds, the prevention of mastitis or the treatment of mastitis. There is. It is an object of the present invention to treat a teat canal stenosis by a simple process of inserting a rod-shaped insertion material into a teat canal.

[0007]

Means for Solving the Problems The present invention provides a teat canal insert obtained by molding chitin or a chitin derivative, or a teat canal insert obtained by coating or impregnating a support with chitin or a chitin derivative. It is a summary.

As chitin used in the present invention, N-acetyl-D-glucosamine contained in shellfish such as shrimp and crab, insects such as grasshopper and beetle, shell of squid and the like is β.
Polysaccharides that have been polycondensed with (1 → 4) bonds, and include those obtained by purifying from natural products.

As the chitin derivative, various deacetylated chitins obtained by partially deacetylating the above chitin, chitosan (particularly chitin having a deacetylation degree of 80% or more), carboxymethylated chitin, hydroxyethylated chitin. And chemically modified chitin derivatives such as sulfonated chitin.

Examples of the support include threads, sponges, cloths, etc. made of a flexible material which is harmless to living organisms, such as silk, collagen, cellulose, nylon, polyethylene, polypropylene, polyester and Teflon. it can.

A teat canal insert obtained by molding chitin or a chitin derivative (hereinafter referred to as chitin) of the present invention, or a teat canal insert obtained by coating or impregnating a support with chitin or the like is required. Accordingly, hardness can be imparted by coating starch, polyvinyl alcohol, sodium carboxymethyl cellulose salt, alginic acid, or a salt thereof as a binder.

As a method for producing a teat tube insertion material formed by molding chitin or the like of the present invention, a thread, sponge, cloth or the like prepared from chitin or the like is formed into a rope or a rod having a diameter of 1-5 mm, preferably 2-3 mm. After molding, 1-50 w / v%, preferably 1-10 w / v% of a binder solution is applied and dried to prepare a rod having a diameter of about 3 mm, which has a length of 1-10 cm, preferably 3-7 cm. The method of manufacturing can be exemplified by molding into a rod shape and further cutting the tip at a right angle (direct cutting) or obliquely (oblique cutting).

Further, as a method for producing a teat tube inserting material obtained by coating or impregnating a support with chitin or the like, a rod, thread, sponge, cloth or the like which is a support has a diameter of 1-5 mm, preferably 2
After molding into a 3 mm rope or rod, a 1-50 w / v% solution or dispersion of chitin and / or chitin derivative, preferably 1-
10 w / v% is applied or impregnated, further 1-50 w / v%, preferably 10-30 w / v% binder solution is applied thereon and dried to prepare a rod having a diameter of 3 mm, or After coating the support with chitin or the like, it is molded into a rope or rod shape, coated with a binder solution and dried to form a rod, and the rod is directly cut to a length of 1-10 cm, preferably 3-7 cm or A method of manufacturing by oblique cutting can be mentioned. The chitin or the like used in the present invention may be a single or a mixture of two or more kinds such as chitin, and in the production of the support, the above-mentioned silk, collagen, cellulose, nylon, polyethylene, polypropylene. It is also possible to use a mixture of a thread, a sponge, cloth or the like made of a material which is harmless to a living body and is flexible, such as polyester or Teflon, and a thread, sponge, cloth or the like prepared from chitin or the like.

[0014]

By using the teat canal insert of the present invention,
The reason for healing papillary canal stenosis and preventing mastitis is not known in detail so far, but various factors involved in wound healing by inserting the papillary canal insert of the present invention into the papillary canal. Migrate cells, do not induce tissue reaction, have extremely excellent angiogenesis, granulation tissue hyperproliferative action, and also have antibacterial properties, showing a direct promoting effect on healing of papillary canal stenosis, It is considered to prevent the entry of various bacteria.

[0015]

EXAMPLES The present invention will be described in more detail with reference to the following examples.
The present invention is not limited to such embodiments.

Example 1 Chitosan (Flownac C: manufactured by Kyowa Technos Co., Ltd.,
(Trade name) 200 g was dissolved in 1800 ml of 4.2 v / v% acetic acid aqueous solution, and pressure filtration (1-2 kg / cm ² ) was performed, and the mixture was left for 20 hours. This stock solution was mixed with 10 liters of ethylene glycol, 1.5 kg of ice and 1.8 kg of potassium hydroxide in a 1.5 m long first coagulation bath with 0.1 mm × 500
Spins by extruding from the nozzle of the hall, 50v /
A second coagulation bath of vm methanol aqueous solution with a length of 0.9 m is applied at a speed of 12 m /
It was passed through at s for further coagulation, stretched 1.17 times in air and wound on a bobbin. The bobbin wound with the thread was washed with running water for 12 hours, further immersed in hot water at 70-80 ° C. for 4 hours, immersed in ethanol for 24 hours, wound on a skein machine and naturally dried. The yarn was moistened with water, and the 18 yarns were twisted and twisted into a yarn having a diameter of 5 mm. Concentration of polyvinyl alcohol (Wako Pure Chemical Industries, Ltd., degree of polymerization about 1500) in this twist
It was dipped in a 7 w / v% aqueous solution to produce a twisted yarn in which 1 ml / 10 cm of polyvinyl alcohol was applied, and then dried under reduced pressure.
The obtained twisted rod having a diameter of 3 mm was 6.5 cm in length, and the tip was obliquely cut or directly cut at about 45 degrees in the longitudinal direction, and the obtained twisted rod had a diameter of 5 mm and a width at the rear end thereof. A teat tube insert (A) of the present invention was prepared by filling a 5 mm silicone tube.

Example 2 In place of polyvinyl alcohol in Example 1, it was immersed in a 2 w / v% aqueous solution of sodium salt of carboxymethyl cellulose (manufactured by Nacalai Tesque, Inc., first-class reagent),
The diameter was 3 m in the same manner as in Example 1 except that 0.5 ml / 10 cm of the sodium salt of carboxymethyl cellulose was applied.
A teat tube insertion material (B) having a length of m and a length of 6.5 cm was prepared.

Example 3 Chitosan (Flownac C: manufactured by Kyowa Technos Co., Ltd.)
15 g was dissolved in 300 ml of a 5 v / v% acetic acid aqueous solution and filtered under reduced pressure to prepare a uniform chitosan solution. Non-woven fabric made of rayon (Benlyse JF601 manufactured by Asahi Kasei, weight 60g / m ² , width 9
cm, length 30 cm) was immersed for 30 minutes. Lightly squeeze so that the drops do not drop, soak in an 8w / v% sodium hydroxide aqueous solution for 1 hour, wash with running water for 1 hour, then soak in hot water at 70-80 ° C for 30 minutes, and let it air dry. A chitosan-impregnated Benlyse impregnated with 0.2 g chitosan per gram fabric was prepared. Wet this chitosan-impregnated Benlyse in water and apply 4
It was folded and twisted in the longitudinal direction, and a 2 w / v% aqueous solution of sodium salt of carboxymethyl cellulose (manufactured by Nacalai Tesque, Inc., first-class reagent) was applied at 2.0 ml / 10 cm, and then dried under reduced pressure. The obtained rod with a diameter of 3 mm is 6.5 cm in length, the tip is obliquely cut (about 45 degrees in the length direction) or directly cut, and the rear end of the obtained twisted rod has a diameter of 5 mm and a width of 5 mm. A teat tube insert (C) of the present invention was prepared by filling a silicone tube.

The teat canal insert of the present invention produced as described above was inserted into the teat canal of a milking cow (Holstein breed) with teat canal stenosis. Milking was performed twice a day, and a new teat tube insert of the present invention was inserted each time after milking, and changes in the teat were observed daily. The outcome and mastitis status are shown in Table 1.

[0020]

[Table 1]

[0021]

EFFECTS OF THE INVENTION The use of the teat canal insert of the present invention improved the nipple stenosis in 4 out of 5 cases. No. 2 showed signs of improvement in nipple stenosis, but the number of treatment days was short, so
I could not see the effect after that. However, mastitis was cured by using this material for 7 days. No effect on other cells (change of milk in normal cells in the same sample) was observed at all. Furthermore, no transition to mastitis was observed with the use of teat canal inserts.

With the use of the teat canal insert (A), swelling and pain of the teat were mild, but there was no effect on the treatment procedure or milking.

No adverse effects such as swelling of the teat and pain were observed when the teat tube insert (B) was used.

As for the shape of the tip, the directly cut object was slightly more difficult to insert than the obliquely cut object, but there was less irritation to the teat canal and no particular inconvenience was felt in cases of mild stenosis. It was

For comparison, a commercially available therapeutic agent for teat canal (Teter Point), which has been commercially available, was used for cattle with teat canal stenosis not infected with mastitis (Table 1, No. 6). After 7 days of use, mastitis developed and papillary stenosis did not improve, so the experiment was stopped.

Claims (1)

[Claims] 1. A teat canal insert obtained by molding chitin or a chitin derivative, or a teat canal insert obtained by coating or impregnating a support with chitin or a chitin derivative.