JPH0650501Y2 - Medical adhesive tape - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial application] The present invention relates to a medical adhesive tape, and more particularly to a medical adhesive tape having a function of improving the transdermal absorption rate of a patch. .

[Prior Art] Conventionally, it has been used as a patch for local stiff shoulders, muscle aches, etc. Recently, instead of oral administration, drug administration by transdermal absorption has been studied, and it has been partially commercialized. Has been done.

Therefore, various drugs having various medicinal effects have been used, but all of them are limited to those whose effects are exhibited by transdermal absorption of a small amount of drug, and for many drugs, its transdermal absorbability is Low, need to increase drug absorption rate.

In recent years, in the patch, in order to increase the absorption rate of the applied drug, an absorption enhancer, for example, 2-pyrrolidone, methyldecyl sulfoxide, 1-dodecylazacycloheptan-2-one, etc., is compounded into the drug. Practical application is under study.

However, such chemical substances may cause allergies in some individuals, and, unlike the conventional patch which is merely for local efficacy, the drug for systemic action is The blood concentration of A must be increased to the effective therapeutic range, and drugs such as aspirin must significantly increase the absorption rate.

On the other hand, some findings have been published regarding the skin permeability of drugs. For example, regarding the permeability of aspirin to the skin, when the temperature rises from 10 ° C to 40 ° C, the permeability of aspirin is 88% relative humidity. It has been reported that it increases by 8 times and at a relative humidity of 50% by 15 times (Fishou, WC, Stoughton, RB, J. Invest. Dermatr. Vol. 41, p. 307, 1963).

The effect of such temperature is known empirically, and there is known a method in which an oxidative heating element is attached to the back surface of a warm poultice for local effect and used.
-69230 publication).

In this case, since the efficacy of the heating element is not reduced, it is necessary to shield the oxidation heating element from the air just before use.
Therefore, in the method of the above publication, one set of hot compress and heating element is stored in an airtight bag for each use.

This requires breaking the airtight bag after each use,
Not only is it time-consuming, but it also has the drawback of bulky packaging.

[Problems to be Solved by the Invention] An object of the present invention is to provide a medical pressure-sensitive adhesive tape in which the percutaneous absorption rate is increased due to an increase in skin temperature so that the packaging is not bulky and the use is simple.

[Means for Solving Problems] The inventors of the present invention focused on the fact that the skin temperature greatly affects the permeability of the drug on the skin, and directly warm the application site of the medical patch with an oxygen heating element. In view of the above, the present invention has been made by focusing on increasing the permeability of a drug and adopting a method of laminating a sealed oxidation heating element for each medical adhesive tape.

That is, the present invention is to fix a breathable bag containing an oxygen-reactive heat-generating composition on the heat-sealing resin layer surface of a laminated sheet of a material layer having an oxygen barrier performance and a resin layer having a heat-sealing performance, When a heat-sealing resin layer is placed on the inner surface of a laminated sheet of a material layer having the same oxygen barrier performance as that of the laminated sheet and a resin layer having heat-sealing performance, the periphery of the two laminated sheets is heat-sealed. Medical application in which a release agent is applied to the back surface of a structure that is sealed by applying heat seal after applying a fusion inhibitor to a part of the heat seal surface An adhesive tape is provided.

The present invention will be described in detail with reference to the drawings of the embodiments.

The material layer having an oxygen barrier property used in the present invention includes an outer barrier layer 1 and an inner barrier layer 2, both of which are a metal layer such as an aluminum foil layer, a polyvinylidene chloride resin layer, an ethylene-vinyl acetate copolymer layer. Combined saponified resin layer,
An oxygen barrier functional resin layer such as a polyamide resin layer or a polyester resin layer can be used.

Among these, the ethylene-vinyl acetate copolymer saponified resin is excellent in oxygen barrier performance, but when it is used because it has low water resistance, it is necessary to further laminate polyamide or polypropylene on the surface.

As the layer having an oxygen barrier property used in the present invention, two or more kinds of these materials can be combined to use a multilayered sheet.

Further, the oxygen barrier layer does not need to be the same layer as the outer barrier layer 1 and the inner barrier layer 2. Instead, the outer barrier layer is a resin layer due to printing, design, etc., and the inner barrier layer is a heat transfer layer. From the point of view, it is often preferable to use a metal layer.

The heat seal layer resin laminated inside the outer barrier layer 1 and the inner barrier layer 2 of the present invention is, for example, low density polyethylene, high density polyethylene, LLDPE (linear low density polyethylene), EVA, ionomer, modified polyolefin, etc. The thermoplastic resin layer having heat sealability can be used.

It is desirable to use the same heat seal resin layers 3 and 4 as much as possible from the viewpoint of heat sealability.

However, even if the heat-sealing resin layers are not the same, it is sufficiently possible to use the polyethylene resin in the present invention among similar resins. That is,
Even if two different resins are used for the heat seal resin layer from polyethylene, EVA, ionomer, modified polyolefin, etc., they can be preferably used in the present invention.

There is no particular limitation on the thickness of the upper and lower two laminated sheets used in the present invention, but they can be usually used in a thickness of about 10 to 200 μm. In this case, it is desirable to make the oxygen barrier resin layer as thick as possible.

As the heating element used in the present invention, any heating element can be used as long as it reacts moderately with oxygen to generate heat gently.

As such, various compositions containing iron or iron compounds can be preferably used in the present invention.

For example, a composition composed of iron powder, water, wood powder, zeolite, activated carbon, and salt can be preferably used. When this composition comes into contact with oxygen, it slowly reacts and generates heat.
Prepare the composition so that the temperature does not exceed 60 ° C.
It is desirable to generate such mild heat, and if this temperature is too high, low temperature burns may occur.

In the case of this composition, water is adsorbed on wood flour or zeolite and participates in the reaction during the reaction.

As the heating element composition used in the present invention, iron powder, iron sulfide,
Manganese dioxide, ferric oxide, compositions composed of ammonium chloride, compositions composed of sulfides and iron carbides of alkali metals, iron powder, iron sulfide, carbon substances, water, compositions composed of metal salts, etc. It is possible to use one that gently generates heat.

The breathable bag 5 for accommodating the heating element of the present invention has good breathability such as non-woven fabric, paper, micropore polyethylene, etc., so that the powder of the heating element composition does not spill out, and it is desirable that it is strong and does not break.

This breathable bag can be fixed on top of the underlying oxygen barrier laminate sheet.

The fixing method is usually an adhesive method, but when the breathable bag is a thermoplastic resin, it can be fixed by fusion bonding.

In the case of fixing with an adhesive, it is desirable that the bonded portion does not come off due to the heat of the heating element, and the double-sided pressure-sensitive adhesive tape 6 can also be preferably used.

In the pressure-sensitive adhesive tape of the present invention, the sealing of the heating element ventilation bag with the barrier layer is performed by sandwiching the two oxygen barrier layers and heat sealing the periphery thereof.

The heat sealing is performed by fusing the heat sealing resin layer with, for example, a hot iron or a high frequency sealing.

The drug used in the present invention is not particularly limited as long as it is dissolved in an adhesive and transferred and absorbed to the applied skin surface. Anti-inflammatory analgesics, corticosteroids, anesthetics, antibiotics, antihypertensive agents, vasodilators. Agents, hormone agents, etc. are used.

That is, since the present invention can efficiently administer a drug transdermally instead of orally administering the drug, it is more suitable for a drug having a systemic effect which is not limited to the place where the adhesive tape is applied. There is.

In the adhesive tape of the present invention, an adhesive 9 containing a predetermined medicine is applied to the back surface of the lower oxygen barrier layer.

An absorption promoter may be further added to this pressure-sensitive adhesive.

The adhesive may be directly applied to the barrier layer 2 or may be applied to the film 8 laminated on the back surface of the barrier layer 2.

In the present invention, a release paper is coated on the adhesive compounded with the medicine by a conventional method.
10 is attached.

In the present invention, the performance of the heating element is lost if the sealing property of the heating element composition is low. Therefore, in the present invention, high sealing performance is maintained by heat sealing.

Instead, it may be troublesome to peel off the laminated sheet of the cover of the heating element of the adhesive tape of the present invention.

In order to make it easy to peel off in such a case, in the embodiment of the present invention, at the corner position between the heat seal resin 3 and the heat seal resin 4 shown in FIG. Heat sealing is performed after applying the anti-fusion agent.

A printing ink or the like can be preferably used as a material having such an action.

When the portion of the fusion preventing portion 11 is rubbed and unraveled with a finger, the heat seal resin layer 3 and the heat seal resin layer 4 are loosened and the corner portions are peeled off. it can.

Alternatively, it is also effective to apply the anti-fusion agent to the center of the edge of the heat seal. In this way, for example, when a uniaxially stretched film is used for the outer barrier resin layer, when the fusion-coated portion is unraveled and separated, the outer barrier layer is pulled vertically and the outer barrier layer is formed as shown in FIG. An opening having a considerable width can be formed in the center of the. Sufficient air enters through this large opening to generate heat.

In this case, the external oxygen barrier layer remaining on both sides of the opening is
Since it functions to hold the heating element-holding breathable bag 5 from above, it is convenient because it does not come off during use.

On the other hand, when the same heat seal resin layer is used for both layers,
Complete fusing makes it difficult to peel off. In such a case, the fusion strength can be adjusted by lowering the temperature of heat sealing.

[Effects of the Invention] The present invention has the advantages of improving the absorption rate of a transdermal drug, achieving a drug effect quickly, and maintaining the effect of an oxidative heating element for a long period of time, and moreover, containing an oxygen-reactive composition. The fusible seal of the bag can be easily opened, and there is an advantage that the packaging is not bulky and is easy to use, which is useful.

[Brief description of drawings]

FIG. 1 is a cross-sectional view showing the structure of an adhesive tape for medical use according to an embodiment of the present invention, FIG. 2 is a plan view thereof, and FIG. 3 is a perspective view when a seal of another embodiment is opened. It is a figure. Reference numerals in the drawing are 1; external oxygen barrier resin layer, 2; internal oxygen barrier resin layer, 3; external heat seal resin layer, 4; internal heat seal resin layer, 5; heating element housing breathable bag, 6; both sides tape,
7: heat-sealed portion, 8: adhesive support layer, 9: pharmaceutical compounded adhesive layer, 10: release paper, 11: fusion preventing application portion.

Claims (2)

[Scope of utility model registration request] 1. A breathable bag containing an oxygen-reactive heat-generating composition is fixed to the heat-sealing resin layer surface of a laminated sheet of a material layer having an oxygen barrier performance and a resin layer having a heat-sealing performance, and the above-mentioned lamination is performed thereon. When a heat-sealing resin layer is placed on the inner surface of a laminated sheet of a material layer having the same oxygen barrier performance as that of the sheet and a resin layer having a heat-sealing performance, the heat-sealing of the two laminated sheets is performed. Adhesive containing a drug is applied to the back surface of the structure that is sealed by applying a fusion inhibitor to a part of the fusion surface and then heat-sealing. tape. 2. The medical adhesive tape according to claim 1, wherein the drug is a drug having a systemic medicinal effect.