JPH031451Y2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a novel container for a skin-permeating therapeutic agent, which is easy to administer to a particularly affected area, and is less likely to cause the main drug to volatilize during administration.

A poultice is a paste-like or slurry-like medicine that originally contains a large amount of powdered medicine, and is spread thickly on a cloth and applied to the affected area for the purpose of extinguishing inflammation and absorbing secretions. Kaolin buds, a pharmacopoeial product, have long been well-known. Disposable products for this purpose are also available. It is also well known that a product called 〇〇Pass, which is a bandage containing anti-inflammatory and analgesic drugs, is widely available as a treatment for stiff shoulders and the like.

However, in recent years, transcutaneous therapy (TTS), which attempts to transdermally administer drugs that permeate the skin, has emerged.
The effectiveness of skin permeation therapy has been recognized, and skin permeation therapy agents including nitroglycerin, scopolamine, estradiol, clonidine, indomethazine, nicardipine, etc. are already on the market or are in the stage of clinical research or animal experiments.

By the way, there are skin permeation therapy agents (hereinafter abbreviated as "TTS agents") that are currently in practical use or are in the research stage.
Generally, the drug is stored inside a dish-shaped container with a shallow flange made of thick aluminum foil, and the opening surface of the container is directly passed through a drug permeation control layer such as EVA or further through an aluminum foil and adhesive layer. It is covered with a lid made of elastic material. In use, the lid part excluding the container is attached to the skin surface of the application site using the adhesive layer of the part so that the drug part comes into contact with the skin.

However, although conventional products of this type pose no problems when stored, the container is removed when applied, so the key drug may evaporate during use or may be used as a vehicle. It is not uncommon for the solvent in the solution to evaporate and become useless. These drawbacks cannot be ignored since the main purpose of this type of drug is continuous administration over a long period of time (24 hours or more). Furthermore, when the gas is a harmful drug such as nitroglycerin, the volatilized gas may have harmful effects such as headaches and weakness on sensitive people nearby.

(Purpose of the invention) The present invention effectively suppresses the volatilization of the base agent and vehicle in existing TTS agents, thereby making the agent effective over a planned long period of time, and
The purpose of the present invention is to provide a new TTS agent that eliminates the harmful effects of vaporized drugs or solvent gases.

(Means for achieving the object) In order to achieve the above object, the TTS agent according to the present invention is made of a gas-impermeable plastic material such as a metal foil or a thin hard plastic sheet.
a shallow dish-shaped body having a flange on the periphery; a transdermal drug housed in the dish-shaped body in close contact with each other;
A control film that covers the opening surface of the dish-shaped body, an annular gasket that covers a flange portion at the periphery of the control membrane and whose back surface is adhered to the flange portion, and an adhesive applied to the periphery of the gasket. A configuration is adopted that includes a gas-impermeable cover layer that covers the surface of the control membrane and the packing via a material layer.

In the above configuration, the main body of the flanged plate is made of a gas-impermeable plastic material such as a metal foil or a thin hard plastic sheet, but practically it is preferably made of a thick aluminum foil. However, in this case, the inner surface is coated with a corrosion-resistant resin if necessary.

The base agent is stored inside the upper dish-shaped body in a plastic or gel state. Chemicals such as various polysaccharides, lactose, silicone resins, ethanol, acetone, dimethyl sulfoxide, ethylene glycol, and polyethylene glycol are used to matrix the substrate and solubilize the drug. In addition,
For purposes of this invention, the drug must be in intimate contact with the interior surface of the container.

The control film is attached to the inner surface of the collar so as to cover the opening of the container containing the drug. It can be made from a variety of porous membrane materials or non-porous permeable materials such as ethylene vinyl acetate copolymer (EVA) or ethylene vinyl alcohol copolymer to control the rate of exudation of the drug therein. Therefore, the seepage rate can be freely controlled depending on the type of material, the size and density of the micropores, etc. Therefore, the drug inside does not need to be strictly in a composition state or a gel state, but may be in a viscous fluid state.

An annular gasket made of a sealant such as urethane foam or soft rubber is attached to the outside of the flange of the container. This material is located between the cover and the flange, which will be described later, to prevent volatilization of the drug, solvent, or dispersion medium during storage and use, and at the same time provides a soft feel when applied to the skin.

The gas-impermeable cover covers the entire surface of the control membrane, including the gasket, and prevents the contents from volatilizing and drying until use. This cover is made using metal foil such as aluminum foil, but it is preferable that the cover be subjected to a release process using polyethylene film or silicone paint.

(Effect) The drug and solvent or dispersion medium inside the TTS agent of the present invention are protected by the container and cover until use, so they can be effectively stored for a long time. Furthermore, even during use, the drug and the like are protected by the gas-impermeable container (cover), so the drug's efficacy remains for a long time.

(Examples) Hereinafter, two examples of embodiments of the invention will be explained using examples, but the examples are, of course, for illustrative purposes and do not indicate the connotation or extension of the idea of the invention.

Example 1 Fig. 1 is a longitudinal cross-sectional view of the central part of an example of the TTS agent according to the present invention (however, the thickness of the material is exaggerated), Fig. 2 is a cross-sectional view showing the agent in Fig. 1 in an unsealed state, and Fig. 3 Similarly, FIG. 4 is a perspective view thereof, and FIG. 4 is an explanatory view showing its usage state.

The entire agent 1 is provided with a dish-shaped container 2 made of thick aluminum foil equipped with a flange 3 on the periphery, and a container filled in the container.
A TTS drug 4, an EVA control membrane 5 covering the opening surface of the container, an annular gasket 6 located on the flange 3 at the peripheral edge of the membrane 5, and the gasket 6 and the membrane 5.
The control film 5 and the packing 6 are attached to the upper surface of the collar 3 via an adhesive layer 7, and the cover 8 is
They are each adhered to the surface of the gasket 6 via an adhesive layer 9. In addition, in one corner of the outer surface of the cover 8,
A handle 10 for opening is added.

When the handle 10 is pulled during use, only the cover 8 will be separated as shown in Figures 2 and 3, so use the adhesive layer 9 and place it on a suitable area (left chest in the figure) as shown in Figure 4. Paste it on. At this time, the drug 4 is kept in a substantially airtight state by the container 2 and the gasket 6, so that its efficacy remains for a long time.

Embodiment 2 FIG. 5 is a sectional view similar to FIG. 1 showing another embodiment of the invention.

In this example, since the collar 3 is provided with the stepped portion 3a, the surfaces (lower surfaces in the figure) of the thin control film 5 and the thick gasket 6 can be aligned on the same plane. In this example, there is also a handle on the bottom of the container.
1 is attached, so it can be easily removed after use.

(Effects) As explained above, according to the present invention, it is possible to provide a skin permeation therapeutic agent that can withstand long-term storage and maintains its efficacy over a long period of time, so it can make a significant medical contribution.

[Brief explanation of drawings]

Figure 1 is a longitudinal cross-sectional view of the central part of an example of the TTS agent according to the present invention (however, the thickness of the material is exaggerated), Figure 2 is a cross-sectional view showing the agent in Figure 1 in an unsealed state, and Figure 3 is the same. FIG. 4 is a perspective view, FIG. 4 is an explanatory view showing the state of use thereof, and FIG. 5 is a sectional view similar to FIG. 1 showing another embodiment of the invention. The meanings of the symbols in the diagram are as follows: 1: whole drug, 2: 1 container, 3: 2
flange part, 11:2 handle part, 4:1 medicine, 5:
1 control film, 6:1 packing, 7:1 adhesive layer, 8:1 cover, 9:1 adhesive layer, 1
0:8 handle.

Claims (1)

[Scope of Claim for Utility Model Registration] (1) A shallow dish-shaped body made of a gas-impermeable plastic material such as a metal foil or a thin hard plastic sheet, and having a flange portion on the periphery, and an object inside the dish-shaped body. A transdermal drug housed in close contact with each other, a control membrane covering the opening surface of the dish-shaped body, and a flange portion at the periphery of the control membrane, the back surface of which is adhered to the flange portion. A skin permeation therapy agent comprising an annular patch and a gas-impermeable cover layer that covers the surface of the control membrane and the patch via an adhesive layer applied to the peripheral edge of the patch. (2) The agent according to claim 1, wherein the surface of the control membrane is covered with a gas-impermeable membrane, and the membrane is configured to be removable together with the removal of the cover layer. (3) The agent according to claim 1, wherein the dish-shaped body has a hook portion for opening the package on its flange portion.