JPH06327772A - Plastic cannula and its production - Google Patents

Abstract

PURPOSE:To provide the plastic cannula which has a high strength and high modulus of bending and good surface characteristics, permits easy piercing of a rubber plug, etc., of a blood collecting tube, does not damage biotissues at the time of piercing the cannula into these tissues, has excellent moldability and is suitable for extrusion molding. CONSTITUTION:A blood collecting needle 1 has the plastic cannula 10, a hub fixed thereto and a cap 30 enclosing the rubber plug piercing part 12 of the cannula 10. The cannula 10 is composed of a synthetic resin mainly consisting of polyphenylene sulfide(PPS) and more particularly the high-molecular linear type PPS. Blade surfaces 13, 14 are respectively formed on the blade edges at both ends of the cannula 10.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a plastic canula used for injection needles, blood collection needles, indwelling needles and the like, and a method for producing the same.

[0002]

2. Description of the Related Art Conventionally, a blood collecting unit has been used for quick and efficient blood sampling when conducting a clinical test. This blood collection unit is, for example, as shown in FIG. 2, a stainless steel canula (needle tube) 120 provided at each end of a plastic hub 110,
A blood collection needle 100 including 130, a tubular blood collection tube holder 200 into which the blood collection needle 100 is screwed, and a decompression blood collection tube 300 mounted inside the blood collection tube holder 200 and having a negative pressure inside. It is configured. Also, canula 1
30 is attached so as to surround the canula 130.
1 composed of a film of elastic material pierceable by
35 are provided.

When collecting blood using this blood collecting unit, first, the holder 200 and the blood collecting needle 100 are preassembled and integrated, and then the canula 120 side is punctured into the venous blood vessel to secure the venous blood vessel. After that, the holder 200
The reduced pressure blood collection tube 300 is pushed into the inside of the container and the rubber plug 310 is penetrated by the canula 130 (at this time, the canula
Pierces the cap 135, the cap 135 is the hub 11
0 side). As a result, the inside of the venous blood vessel and the inside of the blood collection tube 130 are communicated with each other via the lumens of the canulas 120, 130, and the negative pressure inside the blood collection tube 130 causes the venous blood to be collected.
It is sucked into 0 and blood is collected.

After the start of blood collection, blood collection is completed in a state where the pressure inside the reduced pressure blood collection tube 300 and the venous pressure are balanced.
After the blood collection is completed, the reduced pressure blood collection tube 300 containing the blood is removed from the holder 200 and subjected to a predetermined test.

If the operator accidentally touches the used blood collection needle 100 with his / her hand or the like by mistake, pathogenic bacteria may be transmitted, so that it must be quickly processed after use. Therefore, the blood collection needle 100 using the stainless steel canula which is an incombustible material is, for example, from the holder 200 to the collection container or the like described in Japanese Utility Model Publication No. 2-6056 so that the operator does not directly touch it. Remove, collect, sterilize, and then discard, plastic holder 2
00 was separately collected and incinerated.

[0006] However, it is very troublesome to separately dispose of the metal canula and the plastic material portion in this way, and in addition, in the disposal after use, the metal canula is incinerated. There are many problems due to the inability to do so, for example, the problem of reuse and the risk of infection due to the waste collector accidentally puncturing his or her hand.

For this reason, the development of a canula made of plastic that can be incinerated has been an issue, but since plastic has a lower strength than stainless steel, when injecting a drug into the body, piercing muscle tissue is pierced. When doing, the needle tip may be broken and the broken needle tip may remain in the body. Further, when it is used as a blood collection needle, there is a problem that it is not strong enough to pierce a lid member such as the rubber stopper 310 of the reduced pressure blood collection tube 300 described above and is broken.

As a solution to such a problem, Japanese Unexamined Patent Publication (Kokai) No. 63-260571 discloses a syringe using a plastic canula. After use, the syringe using this plastic canula is heated on the spot by the operator, the needle tip is rounded and sterilized, and then the holder can be incinerated. Compared to a syringe using a stainless steel canula, which must be collected and processed separately, there is an advantage that the time and effort for disposal after use is reduced.

The material used for the plastic canula is polycarbonate (PC), polyester, acrylate, polyaramid, polyamide (P
A), polyetheretherketone (PEEK), modified phenylene oxide, polyetherimide (PEI),
Polymethylpentene and polysulfone are mentioned.

However, since these plastic materials are easily broken due to lack of strength and have a low bending elastic modulus, for example, the rubber stopper 310 of the reduced pressure blood collection tube 300 described above is used.
When piercing such a lid member, there is a drawback that it is bent or bent. Therefore, for example, the application of the canula is restricted, the tip shape of the canula is limited, it is necessary to shorten the length or to make a large difference between the inner diameter and the outer diameter, which significantly restricts the design of the canula. However, it could not be put to practical use.

Further, among the above plastic materials,
Some have poor chemical resistance and heat resistance, and depending on the composition of the drug solution, the surface of the canula may change due to contact with it, or elution may occur due to contact with the organic solvent. There is also a problem that the eluate is mixed.

[0012] Further, sterilization treatment such as wet heat sterilization (autoclave sterilization), gas (EOG) sterilization, radiation (gamma ray) sterilization, etc. is usually applied to the canula. In some cases, sterilization causes deterioration or strength reduction.

Further, although extrusion molding is a molding method advantageous for molding a tubular body, since each of the above-mentioned plastic materials has too high fluidity, it is not suitable for extrusion molding, and canula is mass-produced. It was disadvantageous to do.

The flexural modulus of the plastic material is
It can be increased by adding a filler to the plastic material, and the fluidity can also be adjusted by adding an additive (filler) to the plastic material, but the addition amount of the filler is large. The more it becomes, the lower the strength of the plastic material is, and further, the surface after the canula molding becomes rough, so that the piercing resistance increases when piercing the rubber plug or the like, and the risk of breaking increases.
Further, when piercing muscle tissue, there is a risk of damaging the muscle tissue. For this reason, there are significant restrictions on the type and amount of filler added.

[0015]

DISCLOSURE OF THE INVENTION The present invention provides a plastic canula having a high strength, a high flexural modulus, an excellent moldability and a good surface property, and an easy production of such a plastic canula. An object of the present invention is to provide a method for producing a plastic canula capable of

[0016]

Such an object is achieved by the present invention described in (1) to (19) below.

(1) Polyphenylene sulfide (P
A plastic canula made of a synthetic resin containing PS as a main material.

(2) A plastic canula comprising a synthetic resin containing high molecular weight linear polyphenylene sulfide as a main material.

(3) The linear polyphenylene sulfide is thermally oxidized and crosslinked to give a molecular weight of 50,000 to 15
A plastic canula composed of a synthetic resin whose main material is a high-molecular-weight linear polyphenylene sulfide of 10,000.

(4) The plastic canula according to any of (1) to (3) above, wherein a filler for improving physical properties is added to the synthetic resin.

(5) The plastic canula according to (4) above, wherein the filler is whiskers (needle-shaped crystals) or fibers.

(6) The plastic canula according to (4) above, wherein the filler is long fibers oriented along the longitudinal direction of the canula.

(7) The amount of the filler added is 5 to 90.
The plastic canula according to any one of (1) to (3) above, which has a Wt%.

(8) The synthetic resin has a flexural modulus of 0.5 × 10 ⁵ kgf / cm ² or more (1) to (7).
The plastic canula according to any one of 1.

(9) Polyphenylene sulfide (P
Manufacture of a plastic canula, which comprises a step of forming a tubular body by extrusion molding using a synthetic resin containing PS) as a main material, a step of heat-treating the tubular body, and a step of forming a cutting edge. Method.

(10) Polyphenylene sulfide (P
PS) as a main material, a synthetic resin obtained by adding a filler for improving physical properties to the main material, to form a tubular body by extrusion molding, and a step of heat-treating the tubular body, And a step of forming a cutting edge.

(11) The method for producing a plastic canula according to the above (10), wherein the filler is whiskers (needle-shaped crystals) or fibers.

(12) The method for producing a plastic canula according to the above (10), wherein the filler is long fibers oriented along the extrusion direction of the synthetic resin.

(13) The amount of the filler added is 5 to 90.
The method for producing a plastic canula according to any one of the above (10) to (12), wherein Wt%.

(14) Polyphenylene sulfide (P
Using a synthetic resin containing PS as a main material, a step of forming a tubular body by extrusion molding, a step of heat-treating the tubular body, a step of stretching the tubular body, and a step of forming a cutting edge. A method for producing a plastic canula, which comprises:

(15) The method for producing a plastic canula according to any one of (9) to (14), wherein the heat treatment adjusts the crystallinity of polyphenylene sulfide (PPS) to improve the flexural modulus.

(16) The method for producing a plastic canula according to any of (9) to (15) above, wherein the heat treatment is performed in an oxygen-containing atmosphere.

(17) In the step of forming the tubular body, the synthetic resin containing the polyphenylene sulfide (PPS) as a main material and the synthetic resin having a different composition from that of the synthetic resin are subjected to multicolor extrusion molding. The method for producing a plastic canula according to any one of 16).

(18) The method for producing a plastic canula according to any one of (9) to (17) above, wherein the polyphenylene sulfide (PPS) is a high molecular weight linear polyphenylene sulfide.

(19) The polyphenylene sulfide (PPS) has a molecular weight of 50,000 to 150,000 by thermally oxidatively crosslinking linear polyphenylene sulfide.
The method for producing a plastic canula according to any one of (9) to (17) above, which is a high molecular weight linear polyphenylene sulfide having 0.

[0036]

BEST MODE FOR CARRYING OUT THE INVENTION The plastic canula of the present invention and the method for producing the same will now be described in detail with reference to the preferred embodiments shown in the accompanying drawings.

FIG. 1 is a vertical cross-sectional view showing a structural example in which the plastic canula of the present invention is applied to a blood collecting needle.
The blood collection needle 1 shown in the same figure is a so-called multi-type blood collection needle that collects blood from several blood collection tubes by performing a single vein puncture, and includes a plastic canula (hereinafter simply referred to as "canula") 10 of the present invention. The hub 20 and the cap 30 are provided.

The canula 10 is made of a synthetic resin containing polyphenylene sulfide (PPS) as a main material, which will be described later, and has an internal passage (lumen) 15 communicating with it axially and open at both ends. Have Further, both ends of the canula 10 have sharp shapes. That is, it has blade surfaces 13 and 14 cut obliquely with respect to the axis of the canula 10. The forming directions of the both blade surfaces 13 and 14 and the angle (blade angle) with respect to the axis may be the same or different.

The hub 20 has a substantially cylindrical shape, and has a communication hole 21 penetrating therethrough in the central axis direction, and the canula 10 is inserted into the communication hole 21. In this case, the canula 10 extends to both ends in the axial direction of the hub 20, one end of the canula 10 is a site 11 for puncturing a blood vessel (vein), and the other end thereof is the rubber stopper 31 of the reduced pressure blood collection tube 300 described above.
It is a part 12 that pierces 0.

The communication hole 21 is provided in the canula 10 as described above.
Is a hole that is fixed by an adhesive 25 such as an acrylic type, an epoxy type, or a cyanoacrylate type in a state in which is inserted, and has an inner diameter slightly larger than the outer diameter of the canula 10. The diameter difference between the inner diameter of the communication hole 21 and the outer diameter of the canula 10 is not particularly limited, but is usually about 0 to 0.3 mm.

A cap 30, which is made of a soft material, in particular, an elastic material that can be deformed and restored, that surrounds the rubber plug piercing portion 12 is liquid-tightly attached to the rear locking portion of the hub 20. Has been done. The cap 30 has a cylindrical shape having a bottom portion 31 and has an inner cavity portion 35 as a space surrounding the rubber plug piercing portion 12.

As a constituent material of the cap 30, for example, a soft rubber material having sufficient flexibility and resilience such as polyisoprene can be cited. The film thickness thereof is relatively thin, and the outer diameter thereof is, for example. It is about 1.0 to 3.0 mm.

The presence of such a cap 30 prevents blood from being ejected from the tip of the rubber plug puncture site 12 on the opposite side when the blood vessel puncture site 11 of the canula 10 is punctured into a vein. . Further, when the rubber plug 310 is pierced at the rubber plug piercing portion 12 of the canula 10, the cap 30 is also pierced by the rubber plug piercing portion 12,
It is pushed by the rubber plug 310, and is deformed and brought closer to the hub 20 side. Then, the rubber stopper piercing portion 12 is attached to the rubber stopper 31.
When removed from 0, the cap 30 re-encapsulates the rubber plug piercing part 12 by its restoring force, and
To prevent leakage from the tip of the.

Further, the hub 20 is generally provided with a spiral screw portion 22 on the outer periphery of the central portion of the main body of the main body. The screw portion 22 is provided in the holder 200 which is one unit of the blood collecting unit. It is adapted to be screwed (engaged) with the mouth portion 210.

At the rear end of the hub 20, the cap 3
A lock portion 23 is formed to lock and lock 0 in a liquid-tight manner. The locking portion 23 is not particularly limited as long as it has a shape such that the cap 30 cannot be easily removed, and in the case of the configuration shown in the figure, as an example thereof, a locking projection 23a protruding like a jaw is provided. ing.

Such a hub 20 is usually formed by injection molding, for example, having an outer diameter of 10 to 20 mm and an inner diameter of 0.5 to.
It is molded to have a length of about 3.0 mm and a length of about 10 to 50 mm, and its specific constituent material is polypropylene (PP),
Polyethylene (PE), polycarbonate (PC), polystyrene, polyethylene terephthalate (PET),
Resin materials such as polymethylpentene, polyacrylonitrile, and ABS resin can be used.

Next, the constituent materials of the canula 10 will be described. The canula 10 is made of a synthetic resin whose main material is polyphenylene sulfide (hereinafter referred to as "PPS"). This material has high strength and high flexural modulus, and when used as the canula 10, it is unlikely to be bent or bent. In addition, PPS has excellent biocompatibility,
It is extremely stable against alkalis and various organic solvents, and hardly elutes. Therefore, it is suitable for administration of drug solutions, blood transfusion, and blood collection. Furthermore, since PPS has an appropriate fluidity in a softened and molten state and is suitable for injection molding and extrusion molding, it is advantageous for mass production of the canula 10 and has high dimensional accuracy. PPSs are roughly classified into linear type, semi-linear type and cross-linked type. In the present invention, any of these may be used, and among them, linear PPS is particularly preferable. The linear PPS itself has high strength and high toughness (impact resistance), and is particularly excellent. And it also has sufficient abrasion resistance. Hereinafter, the linear type PPS will be mainly described, but the same applies to the crosslinked type.

The molecular weight of the linear PPS is not particularly limited, but in the present invention, the molecular weight is preferably 30,000.
The above high molecular weight linear PPS is preferable. PPS is
As the molecular weight increases, the strength and toughness (flexural modulus) are improved, but especially when the molecular weight is 30,000 or more, the improvement is remarkable.

Further, the linear type PPS is thermally oxidized and crosslinked (slightly crosslinked) to obtain a high molecular weight linear type PPS (hereinafter,
"Slightly crosslinked high molecular weight linear PPS") is preferred. In this case, the molecular weight of the slightly crosslinked high molecular weight linear PPS is preferably 50,000 to 150,000, and more preferably 60,000 to 100,000. The high molecular weight PPS increases the toughness but tends to decrease the rigidity. However, such a slightly crosslinked high molecular weight linear PPS provides high rigidity while maintaining high strength and high toughness. In particular, it is extremely effective in preventing breakage and bending of the cutting edge, and the effect is remarkable when the molecular weight is in the above range.

Furthermore, a slightly crosslinked high molecular weight linear PPS
Has an appropriate shear rate dependency when melted, and thus is particularly suitable for production by extrusion molding described later. In addition, the high molecular weight linear PPS, particularly the slightly crosslinked high molecular weight linear PPS, also has an excellent affinity with the filler described below.

In the present invention, the synthetic resin containing PPS as a main material means a polymer alloy of PPS and another polymer, a copolymer of PPS and another polymer,
Further, it is a concept including PPS, the polymer alloy or the copolymer to which a predetermined filler (additive) is added (composite resin).

Since PPS has excellent compatibility with other polymers, various polymer alloys are possible. Examples of the polymer to be alloyed include polyethylene, polyamide (PA), polyimide (PI), polyamideimide, polyester, polystyrene, polycarbonate (PC), polyacetal (POM), ABS resin, polymethylpentene, polyphenylene oxide, and poly. Ether ketone (PEK), polyether ether ketone (PEEK), fluororesin, epoxy resin, polyketone sulfide (PKS), polyether sulfone (PE
S), polyarylene sulfide sulfones, sulfur-containing aromatic polymers other than PPS such as polyarylene sulfide ketones, and one or two of them.
More than one species can be used.

Among the above-mentioned alloyed polymers, for example, polyethylene is blended to improve moldability, fluororesin is blended to improve slidability, and epoxy resin is used to increase melt viscosity or other factors. Formulated to improve compatibility with seed polymer, polyketone sulfide (PK
S) is added to improve heat resistance.

The content (total amount) of each polymer in such a polymer alloy varies depending on various conditions such as the purpose of blending, the type of polymer, the composition of PPS to be combined, and is not particularly limited.

The filler (additive) is manufactured in order to improve various physical properties (mechanical properties) such as strength, rigidity, flexural elasticity, toughness, creep resistance and fatigue resistance in the finished product. Added to adjust material properties such as flowability, dimensional stability, or to improve chemical properties such as heat resistance, chemical resistance, biocompatibility, etc.
Stabilizers, curing agents, softening point regulators, pigments (colorants) and the like can be added according to various purposes.

Inorganic or organic fillers are preferred as such fillers, especially as fillers for improving the physical properties of the material. The filler may be in any form such as granular (powdered), plate-shaped, needle-shaped (whiskers) and fibrous. Examples of fillers are shown in Table 1.

[0057]

[Table 1]

Such fillers are particularly preferably added as whiskers (needle-shaped crystals), and also glass fibers, carbon fibers, silicon carbide fibers, boron fibers, alumina fibers, polyethylene fibers, polyvinyl alcohol fibers, It is preferably added as a fibrous material (short fiber or long fiber) such as polyarylate fiber, aromatic or aliphatic polyamide fiber, polyimide fiber, polyamideimide fiber, aramid fiber and polyester fiber. In this case, the filler may be added singly or in combination of two or more, and in the latter case, it may have the same form or different forms (whiskers and fibers).

Examples of the substance constituting the whiskers include various oxides, hydroxides, carbonates, sulfates, sulfites, silicates, carbon and other metal compounds shown in Table 1. Among others, alumina, titanium oxide, graphite, silicon carbide, potassium titanate, lead zirconate titanate, aluminum borate, calcium borate, sodium borate, barium metaborate, aluminum hydroxide, calcium carbonate, magnesium carbonate, etc. Is preferred.

By adding a filler made of such a filler, the above-mentioned physical properties, especially the flexural modulus are further improved. Other physical properties are also improved depending on the type of filler. For example, the addition of the various whiskers (particularly, ceramic whiskers), carbon fiber, aramid fiber, polyester fiber or the like improves the rigidity, and addition of glass fiber, carbon fiber, aramid fiber or the like improves the strength. Therefore, high toughness (flexural modulus) can be obtained by mixing various whiskers and fibrous fillers in a well-balanced manner with high molecular weight linear PPS (particularly, finely crosslinked high molecular weight linear PPS) that is particularly excellent in toughness among PPS. ,
A canula material having high strength and high rigidity can be obtained.

In the present invention, it is also preferable to orient the long fibers made of various fibers as described above along the longitudinal direction of the canula. In this case, it is more preferable to embed continuous filaments in the range from one end to the other end of the canula.
With such a structure, the rigidity and the flexural modulus are dramatically improved.

As the long fibers, for example, reinforced long fibers (high-tensile long fibers) such as carbon fibers, glass fibers, aramid fibers, and wholly aromatic polyester fibers are preferable. From the viewpoint of incineration, aramid fibers and wholly aromatic fibers are preferable. Group polyester fibers are particularly preferred. Further, such a reinforced long fiber preferably has an elastic modulus of 5 × 10 ⁵ kgf / cm ² or more.

Generally, in extrusion molding, the shearing stress at the time of molding is smaller than that in injection molding, so that the filler is likely to appear on the surface, and therefore the surface smoothness tends to be lowered. Among the fillers, the above-mentioned various whiskers, carbon fibers, and the like have small shapes, so that even if the addition amount is relatively large, the surface smoothness of the canula can be favorably maintained. In particular, whisker fillers themselves have good surface properties, and are the main materials of canula materials (hereinafter simply referred to as "materials").
It also has excellent affinity with PPS and the like.

In the case of the whiskers, the diameter thereof is preferably about 0.01 to 2.0 μm, more preferably
It is about 0.05 to 1.0 μm. In the case of the fibrous filler or long fiber, the diameter thereof is preferably about 5.0 to 30 μm, more preferably 7.0 to 20 μm.
It is about m.

Such filler may be added in a state of being surface-treated. As a result, the properties of the filler surface are further modified and the affinity with the material such as PPS is improved, and as a result, the effect of the filler blending is increased.

The surface treatment method of the filler includes, for example, application of a coupling agent such as a silane coupling agent and a titanium coupling agent, and coating with a substance having an affinity with the filler and the material. To be

The addition amount of the filler represented by the filler as described above varies depending on various conditions such as the type of the filler, the purpose of blending it, the degree of characteristics to be improved, the composition of PPS as a raw material and the like. , But not particularly limited, usually 5 to 9
About 0 Wt% is preferable, and about 30 to 80 Wt% is more preferable. If the amount of the filler added is less than this range, the effect of adding the filler may not be sufficiently exerted depending on the type of the filler, and if it exceeds the range, PPS may not be achieved depending on the type of the filler. This is because the properties of the canula may be impaired and the surface smoothness of the canula decreases. Since PPS has a lower viscosity when melted than other resins, extrusion molding is possible even if a relatively large amount of filler is added.

The above-mentioned synthetic resin containing PPS as a main material (in the case of containing a filler, the synthetic resin containing the same) has a flexural modulus of 0.5 × 10 ⁵ kgf / cm ² or more. It is preferably about 0.5 to 7.0 × 10 ⁵ kgf / cm ^{2, and} more preferably about 0.5 to 7.0 × 10 ⁵ kgf / cm ² .

The canula 10 is usually sterilized by wet heat sterilization (autoclave sterilization), gas (EOG) sterilization, radiation (gamma ray) sterilization and the like. The above-mentioned PPS, especially the synthetic resin mainly composed of linear type PPS, has excellent heat resistance, and since it does not come into contact with a sterilizing gas or deteriorate due to irradiation of radiation or decrease in strength, it can be used for sterilizing the canula 10. Is also suitable.

Further, since PPS, particularly linear PPS, has excellent chemical resistance and does not elute with various solvents, the eluate is not mixed in the blood collected via the canula 10, and If the canula comes into contact with the drug solution,
For example, even when the drug solution is administered via canula, the eluate is not mixed in the drug solution regardless of the composition of the drug solution. Further, deterioration or deterioration with time does not occur.

The constituent material of the canula 10 is excellent in moldability, that is, it has appropriate fluidity (low viscosity) in order to facilitate injection molding or extrusion molding. It is preferable. As an index of this fluidity, the melt index (MI) of the synthetic resin at a pressure of 5 kgf / cm ² and a temperature of 316 ° C. (near the melting point)
Is about 1 to 80 g / 10 min, preferably about 5 to 50 g / 10 min.

As described above, if the moldability is excellent, a canula having a smaller inner diameter and a smaller outer diameter can be manufactured, thin-wall molding becomes easy, and burrs are greatly suppressed. The above-mentioned PPS, particularly the linear PPS, has extremely good moldability in itself.

In the present invention, the shape of the canula is
As shown in FIG. 3, for example, as shown in FIG. 3, the tip portion 40 has a conical shape or a shell shape, and a side hole 42 communicating with the canula lumen 41 is formed. It may be configured as described above.

Next, the method for producing the plastic canula of the present invention will be described. The canula 10 as described above is manufactured by the following steps [1] to [4]. [1] Formation of tubular body A tubular body is formed by extrusion using the above-mentioned synthetic resin containing PPS as a main material (hereinafter referred to as "canula material"). An example of extrusion molding using PPS with a filler added as a canula material will be described.

For example, a linear PPS or a crosslinked PPS such as the high molecular weight linear PPS or the slightly crosslinked high molecular weight linear PPS, aluminum borate whiskers,
Titanium oxide whiskers, potassium titanate whiskers,
5 to 9 of at least one filler such as graphite whiskers, glass fibers, carbon fibers and aramid fibers
Add about 0 Wt%, preferably about 30 to 80 Wt%, more preferably about 20 to 40 Wt%, and knead.

The flexural modulus is 0.5 to 5.0 × 10 ⁵ kgf / cm ²
(Test method: ASTM D-790), temperature 300 ° C
At a shear rate of 1.0 × 10 ² / sec and a viscosity of 60000
After adjusting to less than poise, this resin is extruded by an extrusion molding machine to have an outer diameter of about 0.8 to 5.0 mm and an inner diameter of about 0.5 to 4.8 mm (thickness of 0.1 to 1.5 mm). To form a tubular body. In this case, the cross-sectional shape of the tubular body is
The shape is not limited to a circle, and may be, for example, an ellipse, a triangle, a quadrangle, a pentagon, a hexagon, an octagon, or another polygon. Note that injection molding may be performed instead of extrusion molding.

[2] Heat treatment of tubular body The tubular body obtained in the above step [1] is heat treated. The main purpose of the heat treatment is to adjust the crystallinity of PPS to improve the flexural modulus. Suitable conditions for the heat treatment are suitable crystallization temperature of the canula material, that is, preferably about 80 to 250 ° C., more preferably 100 to 200.
C., more preferably about 120 to 160.degree. C., preferably about 10 minutes to 24 hours, more preferably about 60 minutes to 240 minutes.

The heat treatment is preferably performed in an oxygen-containing atmosphere. PPS has the property of hardening when heat-treated in the presence of oxygen, but this is because molecular chain extension reaction, oxidative coupling reaction, thermosetting reaction, SO ₂ elimination reaction, etc. occur in parallel. Presumed to be. Examples of the oxygen-containing atmosphere include air and oxygen-rich gas.

[3] Stretching treatment of tubular body If the canula material does not contain a filler for improving its physical properties or its content is low (for example, 10 Wt% or less), it may be necessary. The tubular body can be stretched. This increases the rigidity and strength of the canula material (particularly linear PPS).

In this stretching treatment, the stretching ratio is usually preferably about 1.3 to 10.0 times, though it depends on the composition of the canula material and the degree of improvement of the target physical properties. It is more preferable to set it to about 1.5 to 5.0 times. The stretching treatment may be performed before the step [2] or may be omitted.

[4] Molding of Blade Edge The tubular body obtained as described above is cut into a desired length (for example, 6 to 100 mm), and a blade edge is formed at one or both ends thereof. The blade edge to be formed is a blade surface 1 as shown in FIG.
In the case of having 3 and 14, the following method can be given as a method of forming the same.

A mold corresponding to the shape of the blade surface is prepared, and while heating the mold to a temperature equal to or higher than the softening temperature of the canula material, the end portion of the tubular body is inserted into the mold for heat molding. A core rod for securing the inner cavity of the canula can be used simultaneously with the mold.

The end of the tubular body is cut diagonally. This cutting is, for example, a cutter (blade), heat, laser light,
It is performed by a cutting machine using high frequency, water jet, etc.

The end of the tubular body is ground or polished.
These are performed using a predetermined cutting tool or a grindstone.

Any combination of the above. When the tubular body is manufactured by injection molding, the blade edge can be molded simultaneously with the injection molding.

According to the above method for producing canula,
Canola with high strength and high flexural modulus can be easily manufactured, and it has excellent dimensional stability and high productivity, making it suitable for mass production, and tubular bodies and meat with small outer and inner diameters. Since it becomes possible to easily form a thin tubular body, the range of design is widened.

The canula of the present invention is not limited to the blood collecting needle as described in the constitution of the present invention, but may be, for example, a puncture needle, an injection needle, an intravenous injection needle, an indwelling needle, a winged needle, a bottle needle, an introduction needle. It can be used as a canula for all purposes and functions, such as sheaths and sheaths. Further, also in the blood sampling needle, the canula that penetrates the vein, such as the canula 10 (site 11).
And the canula that penetrates the rubber stopper of the blood collection tube (the part 12) are not limited to those that are integrated, and the canula that penetrates the vein,
The canula that communicates with the rubber stopper of the blood collection tube may be separately configured. As a method of fixing the canula to the hub, in addition to a method of using an adhesive, heat fusion, high frequency fusion, or the like can be used.

The canula 10 may be transparent, semi-transparent or opaque, and a desired color can be obtained by adding various coloring pigments to the canula material. It is also possible to integrally form the plastic canula and the hub by using the same material. Further, even when the hub is made of a material having a different composition from the canula, both materials can be integrally manufactured by injection molding or two-color molding. This applies not only to the hub but also to all resin molded parts such as attachment parts such as blades for fixing, connectors, chambers and tubes, and coating materials for the canula surface.

Further, the canula of the present invention can be formed into a linear shape in the longitudinal direction by, for example, another transparent material by two-color extrusion molding and has excellent adhesiveness. This is also the case with coextrusion. By doing so, the flow of blood or the like in the communication hole (canula lumen) of the canula can be visually recognized.

Further, since it is suitable for extrusion molding, not only a circular shape but also, for example, an oval shape or a polygonal shape can be selected by selecting a die.
A canula having any cross-sectional shape can be easily manufactured. Further, the outer diameter and inner diameter of the canula of the present invention are not limited to being the same over the entire length of the canula, and in all or part of the canula, the outer diameter and / or the inner diameter is continuous or stepwise along the longitudinal direction. (For example, a taper is formed).

[0091]

EXAMPLES Next, concrete examples of the plastic canula of the present invention will be described. First, the PPS resin was manufactured by the following method.

<PPS Production Method 1> Into a 150-liter autoclave, flaky sodium sulfide (61.2 Wt% Na) was added.
₂ S): 19.158 kg and N-methyl-2-pyrrolidone (hereinafter, NMP): 45.0 kg were charged. With stirring under a nitrogen stream, the temperature was raised to 204 ° C., and water was added to 3.995.
kg was distilled. Then, close the autoclave 1
After cooling to 80 ° C, paradichlorobenzene (hereinafter, p-
DCB): 21.388 kg and NMP: 18.0 kg were charged. Nitrogen gas was used at a liquid temperature of 150 ° C. to pressurize the pressure to 1 kg / cm ² G to start heating. The mixture was stirred at a liquid temperature of 260 ° C for 1.5 hours. Then, the polymerization solvent was filtered off from the slurry obtained by cooling, and the washing with warm water was repeated. Next, it was dried in a hot air circulation dryer at 120 ° C. for 6 hours to obtain white powdery PPS.

The obtained PPS was cooled by holding it for 48 hours in a dryer at 240 ° C. with occasional stirring. Thus, 15.6 kg of light brown crosslinked PPS was obtained. This cross-linked P
The PS resin is hereinafter referred to as PPS (S1).

<PPS Production Example 2> Into a 150 liter autoclave, flaky sodium sulfide (61.2 Wt% Na) was added.
₂ S): 19.158 kg and NMP: 45.0 kg were charged. The temperature was raised to 204 ° C. with stirring under a nitrogen stream, and 4.195 kg of water was distilled off. Then, the autoclave was sealed and cooled to 180 ° C., and p-DCB: 2
2.050 kg and NMP: 18.0 kg were charged. Nitrogen gas was used at a liquid temperature of 150 ° C. to pressurize the pressure to 1 kg / cm ² G to start heating. The mixture was stirred at a liquid temperature of 220 ° C for 2.5 hours. After that, the temperature was raised and the mixture was stirred at a liquid temperature of 255 ° C. for 1.5 hours. The polymerization solvent was filtered off from the slurry obtained by cooling, and further,
Washing with warm water and filtration were repeated. Then, it was dried in a hot air circulation dryer at 120 ° C. for 6 hours to obtain 15.7 kg of white powdery high molecular weight linear PPS (molecular weight of about 64,000). This high molecular weight linear PPS resin will be referred to as PPS
Call (S2).

<PPS Production Example 3> Into a 150-liter autoclave, flaky sodium sulfide (61.2 Wt% Na) was added.
₂ S): 19.158 kg and NMP: 45.0 kg were charged. The temperature was raised to 204 ° C. with stirring under a nitrogen stream, and 4.195 kg of water was distilled off. Then, the autoclave was sealed and cooled to 180 ° C., and p-DCB: 2
2.050 kg and NMP: 18.0 kg were charged. Nitrogen gas was used at a liquid temperature of 150 ° C. to pressurize the pressure to 1 kg / cm ² G to start heating. The mixture was stirred at a liquid temperature of 215 ° C for 4.0 hours. Then, the temperature was raised and the mixture was stirred at a liquid temperature of 255 ° C. for 2.0 hours. The polymerization solvent was filtered off from the slurry obtained by cooling, and then washing with warm water and filtration were repeated. Next, it was dried in a hot air circulation dryer at 120 ° C. for 2 hours.

The obtained PPS was cooled by holding it for 20 hours in a dryer at 200 ° C. with occasional stirring. In this way, a light white brown slightly crosslinked high molecular weight linear PPS (molecular weight of about 6
7,000) was obtained. This slightly crosslinked high molecular weight linear PPS resin is hereinafter referred to as PPS (S3).

(Example 1) As a synthetic resin material used for plastic canula, the above-mentioned PPS (S1): 3 kg and a commercially available aluminum borate whisker: 1.2 kg were uniformly dry-blended, and a twin screw having a screw diameter of 20 mm was used. Using an extruder (AS-20 type manufactured by Nakatani Machinery Co., Ltd.), pellets were obtained by melting and kneading at a preset barrel temperature of 320 ° C. and pelletizing.

Using this pellet, screw diameter 20 mm
Was extruded by a twin-screw extruder (2D25-S type manufactured by Toyo Seiki Seisaku-sho, Ltd.) to form a tubular body having an inner diameter of 0.7 mm and an outer diameter of 1.0 mm.

This molded product was cut into a length of 50 mm, heat-treated at a temperature of 150 ° C. for 60 minutes, air-cooled naturally, and then both ends were polished with grindstones to obtain a blade surface (blade surface) as shown in FIG. Angle with respect to the axis of 20 °) to form a plastic canula.

(Example 2) As a synthetic resin material used for plastic canula, the above PPS (S1): 3 kg and high-rigidity carbon fiber manufactured by Tonensha Co., Ltd. (fiber diameter: 7 μm, length: 3 mm)
(However, this length is the length at the time of pellets, and the extruded product has a length of about 1 mm.): 1.0 kg was dry blended uniformly, and a twin screw extruder with a screw diameter of 20 mm (AS manufactured by Nakatani Machinery Co., Ltd.) -20 type) and set barrel temperature 320
Pellets were obtained by melting and kneading at 0 ° C and pelletizing.
A plastic canula was produced by the same method and conditions as in Example 1 except that this pellet was used.

(Example 3) As a synthetic resin material used for plastic canula, the above-mentioned PPS (S1): 3 kg, the same high-rigidity carbon fiber as in Example 2, 1.0 kg, and commercially available potassium titanate whiskers: 1 .2 kg was uniformly dry blended, and the barrel temperature was set to 3 using a twin-screw extruder (AS-20 type manufactured by Nakatani Machinery Co., Ltd.) with a screw diameter of 20 mm.
Pellets were obtained by melting and kneading at 20 ° C. and pelletizing. A plastic canula was produced by the same method and conditions as in Example 1 except that this pellet was used.

(Example 4) As a synthetic resin material used for plastic canula, the above-mentioned PPS (S2): 3 kg was used, and a twin-screw extruder having a screw diameter of 20 mm (AS manufactured by Nakatani Machinery Co., Ltd.) was used.
-20 type), melt at a set barrel temperature of 300 ° C.,
The mixture was kneaded and pelletized to obtain pellets.

Using this pellet, screw diameter 20 mm
After being extruded by a twin-screw extruder (2D25-S type manufactured by Toyo Seiki Seisakusho Co., Ltd.) to form a tubular body, the tubular body is subjected to a stretching treatment at a stretching ratio of 3.0 times in the longitudinal direction, and an inner diameter: A tubular body having a diameter of 0.7 mm and an outer diameter of 1.0 mm was formed.

This molded product was cut into a length of 50 mm, heat-treated at a temperature of 150 ° C. for 60 minutes, naturally air-cooled, and then both ends were polished with grindstones to form a blade surface similar to that of the first embodiment. Then, a plastic canula was manufactured.

(Example 5) As a synthetic resin material used for plastic canula, 3 kg of the above PPS (S2) and 1.2 kg of commercially available aluminum borate whiskers were uniformly dry blended, and a twin screw having a screw diameter of 20 mm was used. Using an extruder (AS-20 type manufactured by Nakatani Machinery Co., Ltd.), pellets were obtained by melting and kneading at a preset barrel temperature of 320 ° C. and pelletizing. A plastic canula was produced by the same method and conditions as in Example 1 except that this pellet was used.

(Example 6) As a synthetic resin material used for plastic canula, 3 kg of the above PPS (S2) and 3.0 kg of the same high-rigidity carbon fiber as in Example 2 were uniformly dry-blended to obtain a screw diameter. Using a 20 mm twin-screw extruder (AS-20 type manufactured by Nakatani Machinery Co., Ltd.), the pellets were obtained by melting and kneading at a preset barrel temperature of 320 ° C. and pelletizing. A plastic canula was produced by the same method and conditions as in Example 1 except that this pellet was used.

(Example 7) As a synthetic resin material used for plastic canula, the above-mentioned PPS (S2): 3 kg, the same high-rigidity carbon fiber as in Example 2, 2.0 kg, and commercially available potassium titanate whiskers: 1 .2 kg was uniformly dry blended, and the barrel temperature was set to 3 using a twin-screw extruder (AS-20 type manufactured by Nakatani Machinery Co., Ltd.) with a screw diameter of 20 mm.
Pellets were obtained by melting and kneading at 20 ° C. and pelletizing. A plastic canula was produced by the same method and conditions as in Example 1 except that this pellet was used.

(Example 8) As a synthetic resin material used for a plastic canula, the above-mentioned PPS (S3): 3 kg, a twin-screw extruder having a screw diameter of 20 mm (AS manufactured by Nakatani Machinery Co., Ltd.) was used.
-20 type), melting at a preset barrel temperature of 305 ° C.,
The mixture was kneaded and pelletized to obtain pellets.

Using this pellet, screw diameter 20 mm
Extruded by a twin-screw extruder (2D25-S type manufactured by Toyo Seiki Seisakusho Co., Ltd.) to form a tubular body, and then subjected to a stretching treatment with a stretching ratio of 1.5 times in the longitudinal direction of the tubular body, and an inner diameter: A tubular body having a diameter of 0.7 mm and an outer diameter of 1.0 mm was formed.

This molded product was cut into a length of 50 mm, heat-treated at a temperature of 150 ° C. for 60 minutes, air-cooled naturally, and then both ends were polished with grindstones to form a blade surface similar to that of the first embodiment. Then, a plastic canula was manufactured.

(Example 9) As a synthetic resin material used for a plastic canula, 3 kg of the above-mentioned PPS (S3) and 1.2 kg of commercially available aluminum borate whiskers were uniformly dry-blended, and a twin screw having a screw diameter of 20 mm was used. Using an extruder (AS-20 type manufactured by Nakatani Machinery Co., Ltd.), pellets were obtained by melting and kneading at a preset barrel temperature of 320 ° C. and pelletizing. A plastic canula was produced by the same method and conditions as in Example 1 except that this pellet was used.

(Example 10) As a synthetic resin material used for plastic canula, the above PPS (S3): 3 kg,
Twin screw extruder with a screw diameter of 20 mm (N.
S-20 type) was melted and kneaded at a preset barrel temperature of 320 ° C. and pelletized to obtain pellets.

Using this pellet, screw diameter 20 mm
Was extruded by a twin-screw extruder (2D25-S type manufactured by Toyo Seiki Seisaku-sho, Ltd.) to form a tubular body having an inner diameter of 0.7 mm and an outer diameter of 1.0 mm. At this time, along with the extrusion of the resin,
Commercially available aramid filaments (fiber diameter: 12 μm) were continuously fed in the extrusion direction. As a result, the aramid filaments oriented in the longitudinal direction were added at a ratio of 70 Wt% of the whole over the entire length of the tubular body.

The molded product thus obtained was cut into a length of 50 mm and heat-treated at a temperature of 150 ° C. for 60 minutes,
After air cooling naturally, both ends are polished with grindstones,
The same blade surface as in Example 1 was formed to manufacture a plastic canula.

(Example 11) As a synthetic resin material used for plastic canula, the above PPS (S3): 3 kg,
Commercially available aluminum borate whiskers: 1.2 kg were uniformly dry-blended, and were melted and kneaded at a preset barrel temperature of 320 ° C. using a twin-screw extruder with a screw diameter of 20 mm (AS-20 type manufactured by Nakatani Machinery Co., Ltd.). And pelletized to obtain pellets.

Using this pellet, screw diameter 20 mm
Was extruded by a twin-screw extruder (2D25-S type manufactured by Toyo Seiki Seisaku-sho, Ltd.) to form a tubular body having an inner diameter of 0.7 mm and an outer diameter of 1.0 mm. At this time, along with the extrusion of the resin,
The same aramid filament as in Example 10 was continuously fed in the extrusion direction. As a result, the aramid filaments oriented in the longitudinal direction of the tubular body are distributed over the entire length of the tubular body.
It was added at a rate of 0 Wt%.

The molded product thus obtained is cut into a length of 50 mm and heat-treated at a temperature of 150 ° C. for 60 minutes,
After air cooling naturally, both ends are polished with grindstones,
The same blade surface as in Example 1 was formed to manufacture a plastic canula.

(Example 12) As a synthetic resin material used for plastic canula, the above PPS (S3): 3 kg,
The same high-rigidity carbon fiber as in Example 2 (2.8 kg) was uniformly dry blended, and a twin-screw extruder (AS-20 type manufactured by Nakatani Machinery Co., Ltd.) having a screw diameter of 20 mm was used at a preset barrel temperature of 320 ° C. The pellets were obtained by melting and kneading and pelletizing. A plastic canula was produced by the same method and conditions as in Example 1 except that this pellet was used.

(Example 13) As a synthetic resin material used for plastic canula, the above PPS (S3): 3 kg,
The same high-rigidity carbon fiber as in Example 2 (1.8 kg) and a commercially available potassium titanate whisker (1.0 kg) were uniformly dry-blended to obtain a twin-screw extruder having a screw diameter of 20 mm (AS-20 manufactured by Nakatani Machinery Co., Ltd.). Mold) and melted and kneaded at a preset barrel temperature of 320 ° C. and pelletized to obtain pellets. A plastic canula was produced by the same method and conditions as in Example 1 except that this pellet was used.

Example 14 As a synthetic resin material used for plastic canula, the above PPS (S3): 3 kg,
The same high-rigidity carbon fiber as in Example 2 (1.8 kg) and a commercially available aluminum borate whisker (1.1 kg) were uniformly dry blended, and a twin-screw extruder having a screw diameter of 20 mm (AS-20 manufactured by Nakatani Machinery Co., Ltd.) was used. Mold) and melted and kneaded at a preset barrel temperature of 320 ° C. and pelletized to obtain pellets. A plastic canula was produced by the same method and conditions as in Example 1 except that this pellet was used.

(Comparative Example 1) Polycarbonate (PC) pellets were prepared as a synthetic resin material used for plastic canula, and the pellets were used for screw diameter 20.
mm twin screw extruder (2D25-S type manufactured by Toyo Seiki Seisakusho Co., Ltd.)
Was extruded to form a tubular body having an inner diameter of 0.7 mm and an outer diameter of 1.0 mm. This molded product was cut into a length of 50 mm, and both ends were polished with grindstones to form a blade surface similar to that in Example 1 to manufacture a plastic canula.

Comparative Example 2 As a synthetic resin material used for plastic canula, a commercially available aluminum borate whisker as a filler is used as a filler in polycarbonate (PC) at 30 Wt.
% Prepared pellets, and using this pellet, a twin-screw extruder with a screw diameter of 20 mm (manufactured by Toyo Seiki Seisakusho Co., Ltd. 2
D25-S type) and extruded to form a tubular body having an inner diameter of 0.7 mm and an outer diameter of 1.0 mm. This molded product is 20mm
Cut to length and polish both ends with grindstone,
A blade surface similar to that in Example 1 was formed to manufacture a plastic canula.

Comparative Example 3 As a synthetic resin material used for plastic canula, polyether ether ketone (P
EEK) except that pellets obtained by adding commercially available aluminum borate whiskers as a filler in an amount of 30 wt% were used.
A plastic canula was manufactured by the same method and conditions as in Comparative Example 1.

(Comparative Example 4) As Comparative Example 1 except that a pellet obtained by adding 30 Wt% of commercially available aluminum borate whiskers as a filler to polyamide (PA) was used as the synthetic resin material used for the plastic canula. The plastic canula was produced by the method and conditions described in 1.

Comparative Example 5 Polyacetal (POM) was used as a synthetic resin material used for plastic canula, and commercially available aluminum borate whiskers were used as a filler.
A plastic canula was produced by the same method and conditions as in Comparative Example 1 except that the pellet containing Wt% was used.

Comparative Example 6 Polyacetal (POM) was used as a synthetic resin material for plastic canula, and 40 Wt of commercially available potassium titanate whiskers was used as a filler.
% Plastic pellets were produced by the same method and conditions as in Comparative Example 1 except that the pellets added in% were used.

Comparative Example 7 A liquid crystal polymer (LCP) was used as a synthetic resin material used for plastic canula, and 30 Wt of commercially available aluminum borate whiskers was used as a filler.
% Plastic pellets were produced by the same method and conditions as in Comparative Example 1 except that the pellets added in% were used.

For each of the plastic canulas of Examples 1 to 14 and Comparative Examples 1 to 7, the extrusion moldability, the surface condition (surface smoothness) of the canula after molding and the use condition (rubber plug piercing property) were measured. The following 3 to 4 grades were used for the evaluation.
The results are shown in Tables 2 and 3 below. For evaluation of the rubber plug piercing property, a glass blood collection tube manufactured by Terumo (trade name:
A rubber stopper with a benoject and a blood collection amount of 5 ml) was used.

<Evaluation on Extrusion Molding> ⊚: Very good extrusion moldability ◯: Good extrusion moldability ×: Poor extrusion moldability XX: Extremely poor extrusion moldability and molding into a predetermined size

<Evaluation of Surface Condition of Cannula> ◎: Surface condition is extremely smooth ○: Surface condition is smooth ×: Surface condition is rough

<Evaluation of the usage status> Usage status when the rubber stopper of the blood collection tube is pierced ◎: The rubber stopper of the blood collection tube can be easily pierced ○: The rubber stopper of the blood collection tube can be pierced ×: The rubber stopper of the blood collection tube cannot be pierced, causing bending and bending −: Unable to evaluate because it cannot be molded to a predetermined size In addition, the bending elastic modulus was measured by the test method ASTM D-790. It was The results are shown in Tables 2 and 3 below together with the evaluation.

[0132]

[Table 2]

[0133]

[Table 3]

As shown in Tables 2 and 3, the plastic canulas of Examples 1 to 14 all have excellent results in terms of extrusion moldability, surface condition and use condition.

Among these, those containing linear PPS (S2 or S3) in the constituent material of the canula and those having the filler added tended to have a higher flexural modulus, and as a result, the canula was used. There is no breakage and the usage is good. In addition, those containing the slightly crosslinked high molecular weight linear PPS (S3) are particularly excellent in extrusion moldability. Further, as in Examples 4 and 8, even when the filler is not added, by performing the stretching treatment,
High rigidity and flexural modulus are obtained.

On the other hand, the canula of Comparative Example 2 using the polycarbonate with the addition of whiskers had a usable performance only when the length of the canula was short due to the effect of the addition of the whiskers. None of the example canulas were tolerable for use. Moreover, it was difficult or impossible to manufacture the canulas of Comparative Examples 3 to 7 by extrusion molding.

(Example 15) The same as Examples 1 to 14 except that pellets of a synthetic resin material blended with 8 wt% of a fluororesin were further used for the purpose of further reducing the sliding resistance of the canula surface. Similarly, a plastic canula was manufactured.

For each of these plastic canulas,
When the extrusion moldability, the surface state of the canula after molding and the use condition were evaluated, the same results as those in Tables 2 and 3 were obtained.

[0139]

As described above in detail, according to the plastic canula and the method for producing the same of the present invention, a canula having high strength, high rigidity, and high flexural modulus can be obtained. Easy to puncture,
At that time, no bending or bending occurs.

Furthermore, the surface quality of the canula is good,
In particular, even when a large amount of filler is added, the surface smoothness is maintained, so that the resistance to piercing a rubber plug or the like is low, the living tissue such as muscle tissue is not damaged, and the canula The flow resistance of the liquid is also reduced in the lumen.

Further, the canula material of the present invention has suitable fluidity and excellent moldability, and therefore is suitable for extrusion molding. As a result, for example, the canula can be designed in terms of outer diameter, inner diameter, wall thickness and the like. With a wider range of products, productivity can be improved, that is, mass production is possible. When manufactured by extrusion molding, the molding shrinkage rate is extremely small, so that dimensional stability is excellent, burrs do not occur, and it is safe even when used as a puncture needle for living tissue.

Further, since the canula material of the present invention has excellent chemical resistance and heat resistance and does not cause elution, for example, when a drug solution is administered via canula, or blood is transfused or blood is collected, the drug can be eluted into the drug solution or blood. Is not mixed in, and neither deterioration nor deterioration with time and deterioration or deterioration during sterilization treatment occur.

Furthermore, since the canula material of the present invention is excellent in biocompatibility (affinity with living body), it can be applied to a puncture needle for puncturing living tissue, an intravenous injection needle, an indwelling needle, or the like. It is advantageous.

The canula material of the present invention is excellent in affinity and adhesion with various coating compositions such as lubricants (water-soluble polymer materials) and antithrombotic agents. Is advantageous to.

Further, since the canula material in the present invention has excellent affinity and adhesion with other resins, for example, by coextrusion molding or two-color molding, it is possible to easily attach an accessory such as a hub to the canula. It can be manufactured integrally.

The canula material is a linear PPS, especially a high molecular weight linear PPS or a slightly crosslinked high molecular weight linear P.
When PS is used as a main material, or when a filler such as various whiskers or fibers is added, the above respective effects become more remarkable.

When the canula of the present invention is used by connecting it to a resin product such as a hub, syringe, tube, wing or connector, the canula and the resin product connected thereto are separated after use. Since it is not necessary to dispose them separately, they can be disposed of together, especially by incineration, so that the labor of disposal is greatly reduced. In this case, at the time of disposal, the needle tip of the canula can be heated and melted to be rolled or sterilized, so that the safety for the operator is improved and the risk of reuse can be prevented.

[Brief description of drawings]

FIG. 1 is a vertical cross-sectional view showing an embodiment in which the plastic canula of the present invention is applied to a blood sampling needle.

FIG. 2 is an exploded perspective view showing a configuration of a conventional blood collection needle.

FIG. 3 is a vertical sectional view showing another embodiment of the plastic canula of the present invention.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Blood collection needle 10 Canula 11 Venous puncture site 12 Rubber plug puncture site 13, 14 Blade surface 15 Internal passage 20 Hub 21 Communication hole 22 Screw part 23 Locking part 23a Locking projection part 25 Adhesive 30 Cap 31 Bottom part 35 Lumen Part 40 Tip part 41 Canula lumen 42 Side hole 100 Blood collection needle 110 Hub 120, 130 Canula 135 Cap 200 Blood collection tube holder 210 Mouth 300 Reduced pressure blood collection tube 310 Rubber stopper

 ─────────────────────────────────────────────────── ─── Continued Front Page (72) Inventor Yoichi Imai 4-1-1 Tsukiji, Chuo-ku, Tokyo Tonen Kagaku Co., Ltd. (72) Inventor Kazuhiro Ichikawa 4-1-1 Tsukiji, Chuo-ku, Tokyo Tonen Kagaku Co., Ltd.

Claims (5)

[Claims] 1. Polyphenylene sulfide (PPS)
A plastic canula made of a synthetic resin whose main material is. 2. A plastic canula comprising a synthetic resin containing high molecular weight linear polyphenylene sulfide as a main material. 3. A high molecular weight linear polyphenylene sulfide is thermally oxidatively crosslinked to give a molecular weight of 50,000 to 15.
A plastic canula composed of a synthetic resin whose main material is a high-molecular-weight linear polyphenylene sulfide of 10,000. 4. The plastic canula according to claim 1, wherein a filler for improving physical properties is added to the synthetic resin. 5. Polyphenylene sulfide (PPS)
A method for producing a plastic canula, comprising: a step of forming a tubular body by extrusion molding using a synthetic resin containing as a main material; a step of heat-treating the tubular body; and a step of forming a cutting edge.