JPH06285135A - Plastic container for medical liquid - Google Patents

Abstract

PURPOSE:To provide a plastic container for medical liquid excellent in heat resistance and rigidity, and having a high transparency even if it is subjected to sterilization treatment at a high temp. CONSTITUTION:This container has a lamination structure of basic material layer 7, outer surface layer 8 and inner surface layer 9. The basic material layer 7 occupies at least 50% in thickness while the outer and inner layers 8, 9 at least 5%. The layer 7 is composed of a resin obtained by blending linear polyethylene in which the number of short chain branches of alpha-olefin is 1 to 20 while the density is 0.920 to 0.970g/cm<3>, with 10-50wt.% of polyethylene of low density by high pressure method. The layers 8, 9 are composed of propylene-ethylene copolymer in which the percentage content of propylene is 95-85mol.% while the percentage content of ethylene is 5-15mol%.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liquid medicine for intravenous injection such as sugar infusion, electrolyte infusion, plasma expander, osmotic diuretic, amino acid infusion, fat emulsion, high calorie infusion, and enteral. Contains an oral drug solution such as a nutritional supplement, a high protein nutritional supplement, a component nutritional supplement, an enteral high calorie nutritional supplement such as liquid food,
The present invention relates to a plastic container for chemical liquid having a laminated structure having excellent heat resistance, transparency and flexibility.

[0002]

2. Description of the Related Art Conventionally, this type of plastic container for chemical liquid has a heat resistance at sterilization of 105 ° C. or more, has flexibility suitable for natural dropping at the time of administration of the chemical liquid, It is required to have transparency so that the liquid medicine for liquid food can be observed well from the outside. Currently, as a material satisfying such physical properties, the content of propylene is 95 to 85 mol% and the content of ethylene is 5 to 5.
There is a propylene / ethylene copolymer consisting of 15 mol%. An infusion bag made of a propylene / ethylene copolymer is a liquid medicine made of a blend of polypropylene, a propylene / ethylene copolymer and an ethylene / propylene copolymer in JP-A-60-63059. The plastic containers for use are described in JP-A-2-208339.

[0003]

The infusion bag described in Japanese Patent Laid-Open No. 63059/1985 is excellent in heat resistance but inferior in flexibility, so that it is a plastic container for chemical liquid by natural dropping. Is unsuitable as On the other hand, the plastic container for chemical liquid described in Japanese Patent Application Laid-Open No. 2-208339 is excellent in flexibility, but has a defect that transparency is remarkably lowered when sterilization is performed in a high temperature atmosphere.

In view of the above-mentioned drawbacks of the conventional ones, the present invention has an object to provide a plastic container for chemicals which has high heat resistance, is highly flexible, and retains high transparency even when sterilized at high temperature. It is what

[0005]

[Means for Solving the Problems] In order to achieve the above object, the present invention provides a plastic container for a chemical solution with a base material layer having a wall thickness of at least 50% and a surface layer having a wall thickness of at least 5%. Of a resin having a laminated structure of 1), the base material layer has 1 to 20 short-chain branched α-olefins per 1000 carbons in the main chain ethylene, and a density of 0.920 to 0.970 g / cm ³ linear polyethylene (hereinafter, referred to as H-LL) is composed of a resin in which 10 to 50% by weight of high-pressure low density polyethylene (hereinafter, referred to as LDPE) is blended, and the surface layer is made of propylene. Content of 95 to 85 mol% and ethylene content of 5 to 15
Propylene / ethylene copolymer consisting of mol% (hereinafter,
P-E resin).

[0006]

The plastic container for chemicals according to the present invention has a base layer of H-LL having excellent heat resistance and LDPE having excellent flexibility.
In addition, since the surface layer is made of PE resin which is particularly excellent in heat resistance, it has excellent heat resistance capable of withstanding high temperatures as a whole. Further, since the thickness of the base material layer is at least 50% and the thickness of the surface layer is at least 5%, even if the PE resin constituting the surface layer is poor in flexibility, it is flexible as a whole. It is possible to obtain a plastic for a chemical liquid which is excellent in heat resistance without impairing its properties and whose transparency is not impaired even when sterilized at high temperature.

[0007]

1 and 2 illustrate a plastic container for chemical liquid according to the present invention. This plastic container for chemical liquid 1 is formed by blow molding, and has a mouth portion 3 at an upper end of a body portion 2 and a hanging piece 5 at a bottom surface 4. A plug 6 is welded to the mouth 3. As shown in FIG. 3, the chemical liquid plastic container 1 includes a base material layer 7,
It has a three-layer structure of an outer surface layer 8 and an inner surface layer 9.
The base material layer 7 is composed of a blend of H-LL and LDPE, and the outer surface layer 8 and the inner surface layer 9 are PE.
It is made of resin.

The H-LL constituting the base material layer 7 is a copolymer of ethylene and butene-1, and the number of short chain branches of butene-1 per 1000 carbons in the main chain ethylene is 100 pieces with a density of 0.935 g / cm ³ , MFR =
5.0, flexural modulus: 5300 Kg / cm ² . The LDPE constituting the base material layer 7 is a high-pressure low density polyethylene having a density of 0.920 g / cm ³ which is radically polymerized with ethylene at a high pressure, and has an MFR of 0.3 and a flexural modulus of 21.
It is 00 Kg / cm ² . Outer surface layer 8 and inner surface layer 9
The P-E resin constituting the is a copolymer having a propylene content of 12 mol% and an ethylene content of 88 mol%, and has a density of 0.90 g / cm ³ and a bending elastic modulus of 5500.
It is Kg / cm ² . The thickness of the base material layer 7 is at least 50% of the total thickness, and the total thickness of the outer surface layer 8 and the inner surface layer 9 is at least 5% of the total thickness. Therefore, even if the PE resin constituting the surface layers 8 and 9 is poor in flexibility, it is excellent in heat resistance as a whole without impairing flexibility, and further, is transparent even if sterilized at high temperature. The plastic container 1 for chemical liquid which is not damaged is obtained.

Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples.

[Table 1] Table 1 shows that in the plastic container for chemical liquid 1 having the shape shown in FIGS. 1 to 3, A = 20 mm, B = 220 mm,
Examples 1 to 8 and comparative examples 1 to 4 having a width of 100 mm and a thickness of 40 mm are shown.

In Table 1, ⊚, ○, Δ and × indicate the following evaluation results. (Flexibility) A chemical solution was filled inside and judged by the dropping property. A: Good dripping property was obtained. ◯: There was some variation in the dropping rate, but no chemical solution remained. Δ: The dropping rate varied, and some residual chemical liquid was observed. X: There were variations in the dropping rate, and many chemical solutions remained. (Transparency) Sterilization was performed at 115 ° C. for 30 minutes, and the total light transmittance before and after the sterilization treatment was measured. JIS total light transmittance
It represents the ratio of the incident amount of visible light having a wavelength of 450 nm specified in K6714 to the total light transmission amount. Was measured and expressed as a percentage. ⊚: Maintains the same high transparency as before treatment. ◯: The transparency is slightly lowered, and the transparency is high. Δ: The transparency was considerably lowered. X: The transparency was remarkably reduced. As is clear from the evaluations of Examples and Comparative Examples, it is clear that the chemical liquid plastic container 1 according to the present invention is resistant to high-temperature sterilization treatment and is excellent in flexibility and transparency.

[0011]

EFFECTS OF THE INVENTION According to the present invention, it is possible to obtain a plastic container for chemical liquids which has high heat resistance, is highly flexible, and retains high transparency even when sterilized at high temperature.

[Brief description of drawings]

FIG. 1 is a front view of a plastic container for chemical liquid according to the present invention.

FIG. 2 is a side view of the chemical liquid plastic container according to the present invention.

FIG. 3 is a partially enlarged sectional view of FIG.

[Explanation of symbols]

 1 Plastic Container for Chemical Liquid 2 Body 3 Mouth 4 Bottom 4 Bottom 5 Suspension 6 Plug 7 Base Layer 8 Outer Surface Layer 9 Inner Surface Layer

Claims (1)

[Claims] 1. A resin having a laminated structure of a base material layer occupying a wall thickness of at least 50% and a surface layer occupying a wall thickness of at least 5%, wherein the base material layer is made of ethylene in the main chain. 10 to 50% by weight of high density low linear density in linear polyethylene having a number of short chain branches of α-olefin of 1 to 20 and a density of 0.920 to 0.970 g / cm ³ per 1000 carbons. The surface layer is composed of a resin blended with polyethylene, and the surface layer has a propylene content of 95 to 85 mol% and an ethylene content of 5 to 15 mol%.
A plastic container for a chemical liquid, which is made of an ethylene copolymer.