JPH062662B2 - Whitening cosmetics - Google Patents
Whitening cosmeticsInfo
- Publication number
- JPH062662B2 JPH062662B2 JP1574187A JP1574187A JPH062662B2 JP H062662 B2 JPH062662 B2 JP H062662B2 JP 1574187 A JP1574187 A JP 1574187A JP 1574187 A JP1574187 A JP 1574187A JP H062662 B2 JPH062662 B2 JP H062662B2
- Authority
- JP
- Japan
- Prior art keywords
- ascorbic acid
- skin
- whitening
- calcium
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Description
【発明の詳細な説明】 （技術分野） 本発明は、ホパンテン酸カルシウムと、Ｌ−アスコルビ
ン酸、Ｌ−アスコルビン酸誘導体及びその塩の少なくと
も１種とを併用配合してなる、皮膚安全性に優れ、白黒
の皮膚を予防する効果と、色黒の皮膚を速やかに淡色化
する効果を有する美白化粧料に関する。TECHNICAL FIELD The present invention has excellent skin safety, which is obtained by combining calcium fopanthenate with at least one of L-ascorbic acid, L-ascorbic acid derivatives and salts thereof. The present invention relates to a whitening cosmetic having an effect of preventing black-and-white skin and an effect of promptly lightening black-black skin.
（従来技術） 日焼による色黒の皮膚は、皮膚内に存在するチロシンが
チロジナーゼの作用により酸化されてメラニン色素とな
り、このメラニンが過剰に生成することに起因するとさ
れている。この色素沈着を予防或いは治療すべく、従来
よりＬ−アスコルビン酸及びその誘導体、コロイド状硫
黄、過酸化水素、ハイドロキノン等を配合してなる美白
化粧料が提案されている。しかし、これらの美白化粧料
は、保存安定性が不充分であるか、或いは美白効果が充
分に認められないものであったり、または、色黒の皮膚
を淡色化する効果が認められるが、皮膚安全性上に問題
が生じるものであって、積極的に美白効果を期待する程
度に優れた美白化粧料を得ることは困難であった。(Prior Art) It is said that the dark skin due to sunburn is caused by tyrosine existing in the skin being oxidized by the action of tyrosinase to become a melanin pigment, and this melanin is excessively produced. In order to prevent or treat this pigmentation, whitening cosmetics containing L-ascorbic acid and its derivatives, colloidal sulfur, hydrogen peroxide, hydroquinone, etc. have been proposed. However, these whitening cosmetics have insufficient storage stability, or have insufficient whitening effect, or have the effect of lightening dark skin, There is a problem in safety, and it has been difficult to obtain a whitening cosmetic that is excellent enough to positively expect a whitening effect.
（発明の開示） そこで、本発明者は、表皮に過剰に存在するメラニン
を速やかに排除すること、新たに皮膚内にメラニンが
生成することを抑制すること、しかも、皮膚安全性上
に問題がないこと等を満足する美白化粧料を得ることを
目的として、鋭意研究した結果、ホパンテン酸カルシウ
ムとＬ−アスコルビン酸、Ｌ−アスコルビン酸の誘導体
及びその塩の群から選ばれた少なくとも１種とを配合し
てなる美白化粧料は、上記の目的を達成することを見出
し、本発明を完成するに至った。DISCLOSURE OF THE INVENTION Therefore, the present inventor has a problem of promptly eliminating melanin excessively present in the epidermis, suppressing new generation of melanin in the skin, and having a problem in skin safety. As a result of earnest research for the purpose of obtaining a whitening cosmetic satisfying the above-mentioned problems, calcium hopanthenate and at least one selected from the group consisting of L-ascorbic acid, L-ascorbic acid derivatives and salts thereof. It has been found that the whitening cosmetic compounded therein achieves the above object, and has completed the present invention.
（発明の目的） 即ち、本発明の目的は、皮膚刺激がなく、メラニン色素
形成抑制効果と色黒の皮膚を速やかに淡色化する効果を
有する優れた美白化粧料を提供することにある。(Object of the invention) That is, an object of the present invention is to provide an excellent whitening cosmetic composition which has no dermal irritation, an effect of suppressing melanin pigment formation, and an effect of rapidly lightening dark skin.
（発明の構成） 本発明は、ホパンテン酸カルシウムと、Ｌ−アスコルビ
ン酸、Ｌ−アスコルビン酸の誘導体及びその塩の群から
選ばれた少なくとも１種とを配合してなる美白化粧料で
ある。(Structure of the Invention) The present invention is a whitening cosmetic composition containing calcium fopanthenate and at least one selected from the group consisting of L-ascorbic acid, L-ascorbic acid derivatives and salts thereof.
（構成の具体的な説明） 本発明に用いるＬ−アスコルビン酸及びその誘導体は公
知の物質であって、例えば、アスコルビン酸モノステア
レート、アスコルビン酸モノパルミテート、アスコルビ
ン酸モノオレート等のアスコルビン酸モノアルキルエス
テル類、アスコルビン酸モノ燐酸エステル及びそのマグ
ネシウム塩のようなアスコルビン酸モノエステル誘導体
とその塩、アスコルビン酸ジステアレート、アスコルビ
ン酸ジパルミテート、アスコルビン酸ジオレート等のア
スコルビン酸ジアルキルエステル類、アスコルビン酸ジ
燐酸エステルとその塩のようなアスコルビン酸ジエステ
ル誘導体、アスコルビン酸トリステアレート、アスコル
ビン酸トリパルミテート、アスコルビン酸トリオレート
等のトリアルキルエステル類等、アスコルビン酸トリ燐
酸エステル等のアスコルビン酸トリエステル誘導体等を
挙げることができる。(Specific Description of Structure) L-Ascorbic acid and its derivative used in the present invention are known substances, and examples thereof include monoalkyl ascorbic acid such as ascorbic acid monostearate, ascorbic acid monopalmitate and ascorbic acid monooleate. Ascorbic acid monoester derivatives such as esters, ascorbic acid monophosphoric acid ester and its magnesium salt and its salts, ascorbic acid dialkyl esters such as ascorbic acid distearate, ascorbic acid dipalmitate, ascorbic acid dioleate, ascorbic acid diphosphoric acid ester and its Ascorbic acid diester derivatives such as salts, trialkyl esters such as ascorbic acid tristearate, ascorbic acid tripalmitate, and ascorbic acid trioleate, ascorbic acid Examples thereof include ascorbic acid triester derivatives such as triphosphate.
また、３−Ｏ−エチル，６−アシルＬ−アスコルビン酸
は、例えば、３−Ｏ−エチル，６−アセチルＬ−アスコ
ルビン酸、３−Ｏ−エチル，６−ブチルＬ−アスコルビ
ン酸、３−Ｏ−エチル，６−ラウロイルＬ−アスコルビ
ン酸、３−Ｏ−エチル，６−パトイルＬ−アスコルビン
酸、３−Ｏ−エチル，６−オレオイルＬ−アスコルビン
酸、３−Ｏ−エチル，６−ステアロイルＬ−アスコルビ
ン酸、３−Ｏ−エチル，６−ベヘルミノイルＬ−アスコ
ルビン酸等を挙げることが出来る。これらアスコルビン
酸及びその誘導体は単独或いは２種以上併用して、ホパ
ンテン酸カルシウムと共に配合しても良い。Moreover, 3-O-ethyl, 6-acyl L-ascorbic acid is, for example, 3-O-ethyl, 6-acetyl L-ascorbic acid, 3-O-ethyl, 6-butyl L-ascorbic acid, 3-O. -Ethyl, 6-lauroyl L-ascorbic acid, 3-O-ethyl, 6-patoyl L-ascorbic acid, 3-O-ethyl, 6-oleoyl L-ascorbic acid, 3-O-ethyl, 6-stearoyl L -Ascorbic acid, 3-O-ethyl, 6-behelminoyl L-ascorbic acid and the like can be mentioned. These ascorbic acids and their derivatives may be used alone or in combination of two or more, and may be blended with calcium fopanthenate.
本発明に用いるホパンテン酸カルシウムは公知の物質で
あって、その薬理効果としてはブドウ糖の脳内取り込み
及びその代謝を促進させる作用があり、脳炎後遺症や脳
性麻痺などに随伴する多動、注意力低下、言語障害の治
療に有効であり、副作用も少ない薬剤であることが知ら
れている。Calcium hopantenate used in the present invention is a known substance, and its pharmacological effect has an action of promoting glucose uptake into the brain and its metabolism, and hyperactivity associated with encephalitis sequelae, cerebral palsy, etc. It is known that the drug is effective in treating speech disorders and has few side effects.
ホパンテン酸カルシウムに関する化学的性格等は下記の
通りである。The chemical properties and the like of calcium hopantenate are as follows.
(１)構造 （上記構造式のＲ１はＨＯＣＨ２基を、Ｒ２はＮＨＣＨ
２ＣＨ２ＣＨ２ＣＯＯ基を表わす。） (２)化学名 カルシウムＤ−（＋）−４−（２，４−ジヒドロキシ−
３，３−ジメチル ブチロアマイド）ブチレイト ヘミ
ハイドレイト Ｃａｌｃｉｕｍ Ｄ−（＋）−４−（２，４−ｄｉｈｙ
ｄｒｏｘｙ−３，３−ｄｉｍｅｔｈｙｌ ｂｕｔｙｒａ
ｔｅ ｈｅｍｉｈｙｄｒａｔ (３) 一般名：ホパンテン酸カルシウム （Ｃａｌｃｉｕｍ ｈｏｐａｎｔｅｎａｔｅ） (４) 分子式：Ｃ20Ｈ36ＣａＮＯ５・1/2Ｈ２Ｏ (５)分子量：５１３．６０ (６)融点 ：１５５−１６５℃ 本発明の美白化粧料に配合せるホパンテン酸カルシウム
は、メタノール４０mlに金属ナトリウム４００mgを加
え、加温して懸濁溶液とし、これにγ−アミノ酪酸１．
２ｇを加えて溶解した。次いてパントラクトン１．３ｇ
を加えて２時間攪拌の後、一夜放置、溶媒を留去し析出
せる白色結晶に水を加え不溶物を遠沈除去してから、水
を蒸散させ、乾燥後白色結晶状のホパンテン酸カルシウ
ムを得た。(1) Structure (In the above structural formula, R 1 is a HOCH 2 group, and R 2 is NHCH.
2 represents a CH 2 CH 2 COO group. ) (2) Chemical name Calcium D-(+)-4- (2,4-dihydroxy-)
3,3-Dimethyl butyroamide) Butyrate Hemihydrate Calcium D-(+)-4- (2,4-dihy)
droxy-3,3-dimethylbutyra
te hemihydrat (3) General name: Hopanten calcium (Calcium hopantenate) (4) Molecular formula: C 20 H 36 CaNO 5 · 1 / 2H 2 O (5) Molecular weight: 513.60 (6) mp: 155-165 ° C. present The calcium hopanthenate to be blended in the whitening cosmetic composition of the present invention is prepared by adding 400 mg of metallic sodium to 40 ml of methanol and heating to obtain a suspension solution, and γ-aminobutyric acid 1.
2 g was added and dissolved. Next, pantolactone 1.3g
After stirring for 2 hours, the mixture is allowed to stand overnight, the solvent is distilled off, water is added to the precipitated white crystals to remove the insoluble matter by centrifugation, the water is evaporated, and the white crystalline calcium hopanthenate is dried. Obtained.
上記合成法によって得られたホパンテン酸カルシウムを
本発明の諸試験に用いた。The calcium fopanthenate obtained by the above synthetic method was used in the tests of the present invention.
本発明の上記ホパンテン酸カルシウムと、アスコルビン
酸、Ｌ−アスコルビン酸の誘導体及びその塩より選ばれ
た少なくとも１種とを併用配合してなる本発明の美白化
粧料は、太陽光に曝される前の皮膚或いは曝された後の
色黒になった皮膚を対象として、特に日焼け後の皮膚生
理学に不安定状態にある皮膚に塗布しても皮膚刺激を生
ずることなく、ビタミンＣのメラニン色素生成阻害作
用、メラニン色素の還元脱色作用により、皮膚の淡色化
を促進すると共に、ホパンテン酸カルシウムの皮膚の血
行促進作用並びに皮膚機能亢進作用により、色素細胞の
新陳代謝を促進し、それらの物質が備えている作用が相
乗的に働きあって、皮膚が本来備えている機能を修復或
いは改善して皮膚を健常な状態に保持し、新たに色黒の
皮膚になることを予防する効果を発現すると言う、優れ
た効果を有することが認められたのである。Before the whitening cosmetic composition of the present invention, which is obtained by combining the above-mentioned calcium hopanthenate of the present invention with at least one selected from ascorbic acid, L-ascorbic acid derivatives and salts thereof, before being exposed to sunlight. Inhibition of melanin pigment production of vitamin C without causing skin irritation, especially when applied to skin that has been darkened after exposure to sunburn, or skin that is unstable to skin physiology after sunburn The action, the reduction and decolorization action of melanin pigment, promotes the lightening of the skin, and the action of calcium fopanthenate to promote the blood circulation and skin function of the skin, promotes the metabolism of pigment cells, and these substances are provided. The actions work synergistically to restore or improve the functions originally possessed by the skin, maintain the skin in a healthy state, and predict that it will become a new dark skin. It refers to express the effect of is the were found to have an excellent effect.
Ｌ−アスコルビン酸及びその誘導体の配合量は、単独ま
たは組合せの合計量が、当該化粧量の総量を基準とし
て、0.5〜10.0重量％（以下、ｗｔ％と略記する）あれ
ば良い。また、ホパンテン酸カルシウムの配合量は、0.
05〜2.0ｗｔ％重量％であればよく、好ましくは0.1〜1.
5ｗｔ％である。各々の配合量が上述の配合範囲の下限
未満では、本発明の目的とする効果に充分でなく、また
一方、上限を超えてもその増加分に見合った効果の向上
は望めないものである。The compounding amount of L-ascorbic acid and its derivative may be 0.5 to 10.0% by weight (hereinafter abbreviated as wt%) based on the total amount of the cosmetic amount, alone or in combination. In addition, the compounding amount of calcium hopanthenate is 0.
It may be 05 to 2.0 wt% by weight, preferably 0.1 to 1.
It is 5 wt%. If the amount of each compound is less than the lower limit of the above-mentioned compounding range, the effect aimed at by the present invention is not sufficient. On the other hand, if it exceeds the upper limit, the effect commensurate with the increase cannot be expected.
本発明の美白化粧料は、例えば、ローション類、乳液
類、クリーム類、パック類等に適用することができる。The whitening cosmetic composition of the present invention can be applied to, for example, lotions, emulsions, creams, packs and the like.
尚、本発明の皮膚化粧料には上記の他に色素、香料、防
腐剤、界面活性剤、顔料、抗酸化剤等を本発明の目的を
達成する範囲内で適宜配合することができる。In addition to the above, a colorant, a fragrance, an antiseptic, a surfactant, a pigment, an antioxidant and the like can be appropriately added to the skin cosmetic of the present invention within the range where the object of the present invention is achieved.
（実施例） 以下、実施例及び比較例に基づいて本発明を詳細に説明
する。(Example) Hereinafter, the present invention will be described in detail based on Examples and Comparative Examples.
尚、実施例に記載の皮膚刺激試験、角質層のターン
オーバー速度測定試験、皮膚色明度回復試験、美白
実用試験を下記に示す。The skin irritation test, the stratum corneum turnover speed measurement test, the skin color brightness recovery test, and the whitening practical test described in Examples are shown below.
皮膚刺激試験 夏期の太陽光に６時間（１日３時間で２日間）曝された
被験者２５名の前腕屈側部皮膚に、試料0.05ｇを直径1.
0cmの円形のリンネル布のついたパッチテスト用絆創膏
を用いて２４時間閉塞貼布した後、下記の判定基準に従
い、各試験について被験者２５名の皮膚の状態を評価判
定した。判定結果は、絆創膏除去１時間後及び２４時間
後のうち反応の強い方を採用し、評価が（±）以上の人
の数で示した。Skin Irritation Test A sample of 0.05 g was applied to the forearm flexor lateral skin of 25 subjects exposed to sunlight in summer for 6 hours (3 hours a day for 2 days).
After applying the patch test adhesive bandage with a 0 cm circular linen cloth for 24 hours, the skin condition of 25 test subjects was evaluated for each test according to the following criteria. As the determination result, the one with the strongest reaction was used after 1 hour and 24 hours after the removal of the adhesive bandage, and the evaluation was shown by the number of persons with (±) or more.
判 定 基 準 角質層のターンオーバー速度測定試験 蛍光色素のダンシルクロライドを白色ワセリン中に５ｗ
ｔ％配合した軟膏を作り、被験者２０名の前腕屈側部の
皮膚に２４時間閉塞貼布し、角質層にダンシルクロライ
ドを浸透結合させる。その後同じ部位に１日２回（朝、
夕）被検試料を塗布し、毎日ダンシルクロライドの蛍光
を調べ、その蛍光が消滅するまでの日数を皮膚角質層の
ターンオーバー速度とした。測定結果は各被検者の日数
の平均値で示した。Turnover Velocity Measurement Test of Standardized Stratum Corneum 5w of fluorescent dye dansyl chloride in white petrolatum
An ointment containing t% was prepared, and occluded and applied on the skin of the flexion side of the forearm of 20 subjects for 24 hours, and dansyl chloride was permeated and bonded to the stratum corneum. Then on the same site twice a day (morning,
Evening) The test sample was applied, the fluorescence of dansyl chloride was examined every day, and the number of days until the fluorescence disappeared was defined as the turnover speed of the stratum corneum of the skin. The measurement results are shown by the average value of the number of days of each subject.
尚、通常の皮膚角質層のターンオーバー速度は、１４〜
１６日である。The normal turnover speed of the stratum corneum is 14-
16th.
皮膚色明度回復試験 被試験者２０名の背部皮膚にＵＶ−Ｂ領域の紫外線を最
小紅斑量の２倍照射し、１週間後、その照射部に試料塗
布部位と非塗布部位とを設定して各々の皮膚の基準明度
（Ｖ０値、Ｖ０’値）を測定した。引き続いて塗布部位
には試料を１日１回ずつ３ヶ月間連続塗布し、３、８、
１３週間後の塗布部位及び非塗布部位の皮膚の明度（Ｖ
ｎ…値、Ｖｎ’…値）を測定して、下記の判定基準によ
り、皮膚色の回復評価を実施した。Skin Color Brightness Recovery Test The back skin of 20 test subjects was irradiated with UV rays in the UV-B region at twice the minimum erythema dose, and one week later, a sample application site and a non-application site were set on the irradiation site. The standard lightness (V 0 value, V 0 'value) of each skin was measured. Subsequently, the sample was continuously applied to the application site once a day for 3 months, 3, 8,
Lightness of skin (V
(n ... value, Vn '... value) were measured, and skin color recovery evaluation was carried out according to the following criteria.
尚、皮膚の明度（マンセル表色系Ｖ値）は高速分光色彩
計で測定して得られたＸ，Ｙ，Ｚ値より算出した。ま
た、評価は非試験者２名の１３週間後の評価点の平均値
で示した。The lightness of skin (V value of Munsell color system) was calculated from X, Y, and Z values obtained by measurement with a high-speed spectrocolorimeter. The evaluation was shown by the average value of the evaluation points of two non-testers after 13 weeks.
判 定 基 準 美白実用試験 夏期の太陽光に３時間（１日1.5時間で２日間）曝され
た被検者２０名の前腕屈側部皮膚を対象として、左前腕
屈側部には太陽光に曝された日の７日後より各々試料を
朝夕１回ずつ１３週間連続塗布した。Criteria Practical whitening test The left forearm flexion side was exposed to sunlight for the skin of the forearm flexion side of 20 subjects who were exposed to sunlight in the summer for 3 hours (1.5 hours a day for 2 days). From 7 days after the day, each sample was continuously applied once a morning and evening for 13 weeks.
評価は、試料を塗布した皮膚の部位が他の皮膚の部位よ
り色白（淡色日）となったと回答した被検者の数で示し
た。The evaluation was shown by the number of subjects who answered that the skin area to which the sample was applied became lighter (lighter day) than other skin areas.
比較例１〜８、実施例１〜６ 〔二層型ローション〕 下記の組成に於いて、第１表に示す通りに各々二層型ロ
ーションを調製して諸試験を実施した。その結果を第１
表右欄に示した。Comparative Examples 1 to 8 and Examples 1 to 6 [Two-layer type lotion] Two-layer type lotions having the following compositions were prepared as shown in Table 1 and various tests were conducted. The result is first
It is shown in the right column of the table.
尚、ホパンテン酸カルシウムをPo-Ｃａ、Ｌ−アスコル
ビン酸をＡｓ、アスコルビン酸モノステアレートをAs-
ＭＳ、アスコルビン酸ジパルミテートをAs-ＤＰ、アス
コルビン酸トリオレートをAs-ＴＯ、アスコルビン酸燐
酸エステルをAs-Ｐ、３−Ｏ−エチル，６−アセチルＬ
−アスコルビン酸をＥＡ−Ａｓ、３−Ｏ−エチル，６−
ステアロイルＬ−アスコルビン酸をＥＳ−Ａｓと略記す
る。In addition, calcium fopanthenate is Po-Ca, L-ascorbic acid is As, and ascorbic acid monostearate is As-.
MS, Ascorbic acid dipalmitate As-DP, Ascorbic acid trioleate As-TO, Ascorbic acid phosphoric acid ester As-P, 3-O-ethyl, 6-acetyl L
-Ascorbic acid was converted to EA-As, 3-O-ethyl, 6-
Stearoyl L-ascorbic acid is abbreviated as ES-As.
(1) 組成 (2) 調 法 (B)成分中のＰｏ−Ｃａと、Ａｓ及び燐酸エステル塩、
ＥＡ−Ａｓ、ＥＳ−Ａｓ等の水溶性成分は、予め(C)成
分中に均一に溶解せしめ、また、モノ・ジ・トリアルキ
ルエステル等の油溶性成分は、予め(A)成分中に均一に
溶解した後、(A)成分と(C)成分を混合攪拌分散し、次い
て容器に充填する。使用時には内容物を均一に振盪分散
して使用する。(1) Composition (2) Method (B) Po-Ca in the component, As and phosphoric acid ester salt,
Water-soluble components such as EA-As and ES-As should be uniformly dissolved in the component (C) beforehand, and oil-soluble components such as mono-di-trialkyl esters should be homogeneously distributed in the component (A) beforehand. After being dissolved in, the components (A) and (C) are mixed and dispersed by stirring, and then filled in a container. At the time of use, the contents should be evenly dispersed by shaking.
尚、Ｌ−アスコルビン酸に関しては、不安定な物質であ
るため、書試験を実施する都度調製して使用した。Since L-ascorbic acid is an unstable substance, it was prepared and used each time a book test was conducted.
(3) 特性 第１表に示す如く、比較例１〜８の二層型ローション
基剤及びこの基剤にＡｓ、As-ＭＳ、ＥＳ−Ａｓ等を単
独で配合した美白化粧料と比較して、実施例１〜６のPo
-ＣａとＡｓ、同じくＡｓの誘導体とを併用配合した美
白化粧料は角質層のターンオーバー速度測定試験、皮膚
色明度回復試験、美白実用試験の全てに亘って、良好な
る評価が得られた。特に、太陽光に曝された日の翌日
で、未だ過剰のメラニンが皮膚内に形成されていない状
態のときから試料を塗布した左前腕部の皮膚は、右前腕
部の未塗布部位と比較して、色黒の皮膚を予防する効果
が明らかに認められた。(3) Properties As shown in Table 1, in comparison with the two-layer lotion bases of Comparative Examples 1 to 8 and the whitening cosmetics in which As, As-MS, ES-As and the like were blended alone , Po of Examples 1 to 6
-The whitening cosmetic composition in which Ca and As, and a derivative of As as well, were used in combination had good evaluations in all of the stratum corneum turnover speed measurement test, skin color lightness recovery test, and whitening practical test. In particular, the skin on the left forearm that had been applied with the sample from the day after the day when it was exposed to sunlight, when the excess melanin had not yet been formed in the skin, was compared to the uncoated area on the right forearm. Thus, the effect of preventing dark skin was clearly recognized.
比較例８〜１３、実施例７〜１１ 〔スキンクリーム〕 実施例１と同様に、下記の組成に於いて各々のスキンク
リームを調製して諸試験を実施し、その結果を第２表右
欄に示した。Comparative Examples 8 to 13 and Examples 7 to 11 [Skin Cream] Similar to Example 1, various skin creams having the following compositions were prepared and various tests were carried out. The results are shown in the right column of Table 2. It was shown to.
(1) 組成 （２） 調製法 (B)成分の内、ホパンテン酸カルシウムと燐酸エステル
等の水溶性成分は、予めか(C)成分中に均一に溶解せし
め８０℃に加熱し、また、モノ・ジ・トリアルキルエス
テル等の油溶性成分は、(A)分中に均一に加熱溶解して
温度を８０℃にした後、(C)分中に(A)分を注入攪拌混合
する。次いて、攪拌しながら温度３０℃迄冷却する。(1) Composition (2) Preparation method Of the component (B), the water-soluble components such as calcium hopanthenate and phosphoric acid ester are either dissolved in advance in the component (C) and then heated to 80 ° C. An oil-soluble component such as an alkyl ester is uniformly heated and dissolved in the component (A) to bring the temperature to 80 ° C., and then the component (A) is poured into the component (C) and mixed by stirring. Then, the temperature is cooled to 30 ° C. with stirring.
(3) 特性 第１表に示す如く、比較例８〜１３に対して本発明の美
白化粧料である実施例７〜１１は全ての諸試験に於いて
良好な結果を示した。また、前記実施例１〜６と同様
に、特に美白実用試験に於いても、前腕部の塗布部分の
皮膚は、過剰のメラニン色素の沈着を防ぎ、色黒となる
ことを予防する効果が向上していることが認められた。(3) Characteristics As shown in Table 1, Examples 7 to 11, which are the whitening cosmetics of the present invention, showed good results in all tests in comparison with Comparative Examples 8 to 13. In addition, as in Examples 1 to 6, particularly in the whitening practical test, the effect of preventing excessive melanin pigment deposition on the skin of the applied portion of the forearm and preventing it from becoming dark black is improved. It was recognized that
（発明の効果） 以上記載の如く、本発明の美白化粧料は、皮膚安全性が
高く、メラニン色素形成抑制効果と色黒の皮膚を速やか
に淡色化する効果を有することが明らかであり、特に太
陽光等に曝された後、速やかに使用することによって、
更に一段と美白効果が向上することが認められた。 (Effects of the Invention) As described above, the whitening cosmetic composition of the present invention has high skin safety, and it is clear that it has an effect of suppressing melanin pigment formation and an effect of promptly lightening dark skin. By being used immediately after being exposed to sunlight,
It was further confirmed that the whitening effect was further improved.
Claims (3)
ビン酸、Ｌ−アスコルビン酸誘導体及びその塩の群から
選ばれた少なくとも１種とを配合したことを特徴とせる
美白化粧料。1. A whitening cosmetic comprising a mixture of calcium hopanthenate and at least one selected from the group consisting of L-ascorbic acid, L-ascorbic acid derivatives and salts thereof.
が、アスコルビン酸エステルである特許請求の範囲第
(１)項記載の美白化粧料。2. The L-ascorbic acid derivative and its salt are ascorbic acid esters.
Whitening cosmetic composition according to item (1).
エチル，６−アシルＬ−アスコルビン酸である特許請求
の範囲第(１)項に記載の美白化粧料。3. A derivative of L-ascorbic acid is 3-O-
The whitening cosmetic composition according to claim (1), which is ethyl, 6-acyl L-ascorbic acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1574187A JPH062662B2 (en) | 1987-01-26 | 1987-01-26 | Whitening cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1574187A JPH062662B2 (en) | 1987-01-26 | 1987-01-26 | Whitening cosmetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS63185910A JPS63185910A (en) | 1988-08-01 |
| JPH062662B2 true JPH062662B2 (en) | 1994-01-12 |
Family
ID=11897186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1574187A Expired - Fee Related JPH062662B2 (en) | 1987-01-26 | 1987-01-26 | Whitening cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH062662B2 (en) |
-
1987
- 1987-01-26 JP JP1574187A patent/JPH062662B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPS63185910A (en) | 1988-08-01 |
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