JPH06199697A - Antiviral, antibacterial and fungicidal agent - Google Patents
Antiviral, antibacterial and fungicidal agentInfo
- Publication number
- JPH06199697A JPH06199697A JP4084861A JP8486192A JPH06199697A JP H06199697 A JPH06199697 A JP H06199697A JP 4084861 A JP4084861 A JP 4084861A JP 8486192 A JP8486192 A JP 8486192A JP H06199697 A JPH06199697 A JP H06199697A
- Authority
- JP
- Japan
- Prior art keywords
- antibacterial
- antiviral
- activity
- substance
- sod
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、抗ウイルス剤、抗菌・
殺菌剤に関する。The present invention relates to an antiviral agent, an antibacterial agent,
Regarding fungicides.
【０００２】[0002]
【従来の技術】従来より、抗菌剤、殺菌剤は数多く知ら
れている。2. Description of the Related Art Many antibacterial agents and bactericides have been known.
【０００３】[0003]
【発明が解決しようとする課題】しかし、これらのもの
は、ほとんどがバクテリアに作用するもので、ウイルス
あるいはカビ類に効くものはあまり知られておらず、ま
た効力も弱く、さらに副作用があり、人体に危険なもの
が多い。However, most of these act on bacteria, little are known to be effective against viruses or molds, their efficacy is weak, and they also have side effects. Many are dangerous to the human body.
【０００４】また、ウイルス性疾患にはインフルエン
ザ、肝炎、麻疹、日本脳炎、成人Ｔ細胞白血病、あるい
はエイズなど多くの疾患があるが、このようなウイルス
に対して有効な薬剤は多くなく、またその効果が明確で
なく、特に成人Ｔ細胞白血病あるいはエイズウイルスの
ようなレトロウイルスに効果のあるものは余り知られて
いない。In addition, there are many viral diseases such as influenza, hepatitis, measles, Japanese encephalitis, adult T-cell leukemia, and AIDS, but there are not many drugs effective against such viruses, and The effect is not clear, and there is little known that it is particularly effective against retroviruses such as adult T-cell leukemia or AIDS virus.
【０００５】さらに、人体に害がなく日常飲食も可能で
予防効果を有するような抗ウイルス、抗菌・殺菌剤は知
られていない。Further, there is no known antiviral, antibacterial or bactericidal agent which is harmless to the human body, can be eaten and eaten daily and has a preventive effect.
【０００６】本発明は、前記課題を解決し、レトロウイ
ルスに効果があり、また、副作用がなく、予防効果を有
する抗ウイルス、抗菌・殺菌剤を提供することを目的と
する。It is an object of the present invention to provide an antivirus, antibacterial and bactericidal agent which solves the above problems, is effective against retroviruses, has no side effects and has a preventive effect.
【０００７】[0007]
【課題を解決するための手段】そこで、本発明者らは、
前記目的を解決するために鋭意研究を重ねた結果、スー
パーオキシドジスムターゼ（ＳＯＤ）様活性および／ま
たは抗酸化能（スカベンジャー機能を含む）を有する物
質、フェノール化合物、及び、糖蛋白質、糖化フラボノ
イド等の糖化合物を含有してなる組成物が、抗ウイル
ス、抗菌・殺菌作用が強く、かつ人体、家畜などに対し
て副作用がなく安全な抗ウイルス、抗菌・殺菌剤である
との知見を得て本発明を完成した。Therefore, the present inventors have
As a result of intensive studies to solve the above-mentioned object, a substance having a superoxide dismutase (SOD) -like activity and / or an antioxidant ability (including a scavenger function), a phenol compound, and a glycoprotein, a glycated flavonoid, etc. Based on the finding that a composition containing a sugar compound is a safe antivirus, antibacterial / bactericidal agent that has strong antiviral, antibacterial / bactericidal activity and has no side effect on humans, livestock, etc. Completed the invention.
【０００８】ＳＯＤ様活性とは、スーパーオキシドラジ
カルを過酸化水素に変換するＳＯＤ活性に類似の活性
（生理機能）を有するものを示し、ＳＯＤ様活性を有す
る物質として、アミノ酸やペプチドの銅（ＩＩ）錯体、
マンガン錯体、脂溶性アスコルビン酸、ポリフィリン金
属錯体、ポリアミン金属錯体等の低分子化合物が挙げら
れ、また抗酸化能を有するものとしてビタミンＣ、ビタ
ミンＥ、尿酸、グルタチオン、βカロチン、カラター
ゼ、グルタチオンパーオキシンダーゼ等が挙げられる。[0008] The SOD-like activity refers to a substance having an activity (physiological function) similar to the SOD activity for converting superoxide radicals into hydrogen peroxide. As a substance having an SOD-like activity, copper (II ) Complex,
Low molecular weight compounds such as manganese complex, fat-soluble ascorbic acid, porphyrin metal complex, polyamine metal complex, etc. are mentioned, and those having antioxidant ability are vitamin C, vitamin E, uric acid, glutathione, β-carotene, calatase, glutathione peroxin. Examples include dase.
【０００９】フェノール化合物としては、グアイアコー
ル、フェノール、オイゲノール、フェニルエタノール等
の群より選ばれた１種またはこれらの混合物が上げられ
る。Examples of the phenol compound include one selected from the group consisting of guaiacol, phenol, eugenol, phenylethanol and the like or a mixture thereof.
【００１０】糖蛋白質、糖化フラボノイド等の糖化合物
としては、アスパラチン、オリエンチン（ルテキシ
ン）、シスオリエンチン（ルトナレチン）、イソクエル
シチン、ルチン等の群より選ばれた１種またはこれらの
混合物が挙げられる。Examples of sugar compounds such as glycoproteins and glycated flavonoids include one selected from the group consisting of aspalathin, orientin (lutexin), cis-orientin (lutonaretin), isoquercitin, rutin and mixtures thereof.
【００１１】また、本発明は、リン、鉄、カルシウム、
ナトリウム、カリウム、マグネシウム、銅、亜鉛、マン
ガン、ケルセチン、セレン等の１種またはこれらの混合
物であるミネラルを混合すればより効果が優れる。The present invention also provides phosphorus, iron, calcium,
The effect is more excellent if one or more kinds of minerals such as sodium, potassium, magnesium, copper, zinc, manganese, quercetin, selenium, etc. or a mixture thereof is mixed.
【００１２】本発明の構成物質はいずれも無毒性のもの
で薬理基準にも合致したもので、ラットに対する急性毒
性試験で死亡例は皆無であり、生化学血液検査および病
理組織学的検査においても異常が認められなかった。All of the constituents of the present invention are non-toxic and meet the pharmacological criteria. There are no deaths in the acute toxicity test on rats, and no biochemical blood tests or histopathological tests are conducted. No abnormality was found.
【００１３】本発明は、ＳＯＤ様活性および／または抗
酸化能を有する物質、糖化フラボノイド及びフェノール
化合物、また必要に応じて添加されるミネラルを含有す
ることによって初めて優れた効果を示すのであり、その
構成は、ＳＯＤ様活性および／または抗酸化能の力価が
１０，０００〜１００，０００単位／ｇ、糖化合物２〜
２０ｍｇ／ｇ、蛋白性物質１〜３０ｍｇ／ｇ、及びフェ
ノール化合物を１〜２０％、またミネラルを添加すると
きは、１０〜５００ｍｇ／ｇ含有することが必要であ
る。The present invention exhibits an excellent effect for the first time by containing a substance having SOD-like activity and / or antioxidant ability, a glycated flavonoid and a phenol compound, and a mineral added as necessary. The composition has a titer of SOD-like activity and / or antioxidant ability of 10,000 to 100,000 units / g, sugar compound 2 to
20 mg / g, 1 to 30 mg / g of a proteinaceous substance, 1 to 20% of a phenol compound, and when adding minerals, it is necessary to contain 10 to 500 mg / g.
【００１４】本発明に用いる、ＳＯＤ様活性及び／また
は抗酸化能を有する物質、糖成分、フェノール化合物
は、混合してそのまま溶液、粉末顆粒、錠剤、乳剤、ゼ
リー状など任意の形態で単独投与、または、他の飲食物
に混合して飲食することもできる。The substance having SOD-like activity and / or antioxidant ability, the sugar component and the phenol compound used in the present invention are mixed and directly administered in any form such as solution, powder granule, tablet, emulsion, jelly form. Alternatively, it can be mixed with other foods and drinks.
【００１５】投与量は、対象となる疾患の種類、程度に
より異なるが、２〜４０ｍｇ／ｋｇ／日の範囲で用いる
のが好ましく、飲料として常用する場合には、０．１〜
３．０％溶液を１００ｍｌ〜５００ｍｌ／日飲食するの
が好ましい。Although the dose varies depending on the type and degree of the target disease, it is preferably used in the range of 2 to 40 mg / kg / day, and when used as a beverage, 0.1 to
It is preferable to eat and drink the 3.0% solution at 100 ml to 500 ml / day.
【００１６】[0016]
【作用】ウイルスの発症要因は複雑で不明な点が多い
が、体内の活性酸素が深く関わっている可能性がある。
本発明は、スーパーオキシドラジカルなどの活性酸素の
除去作用を有するスーパーオキシドジスムターゼ（ＳＯ
Ｄ）様活性を有する物質および糖化合物などの抗酸化作
用を有する物質が、組み合わさって作用していると考え
られる。[Function] Although the causative factors of the virus are complex and unclear, there is a possibility that active oxygen in the body is deeply involved.
The present invention is directed to superoxide dismutase (SO 2) having an action of removing active oxygen such as superoxide radical.
It is considered that a substance having D) -like activity and a substance having an antioxidant action such as a sugar compound act in combination.
【００１７】[0017]
【効果】本発明は、ウイルス、細菌、カビなど各種微生
物の成育を抑え、また殺菌し、レトロウイルスに効果が
あり、また、副作用がなく、予防効果を有する抗ウイル
ス、抗菌・殺菌剤することができる。[Effects] The present invention is an antiviral, antibacterial / bactericidal agent which suppresses the growth of various microorganisms such as viruses, bacteria and fungi, and sterilizes them, is effective against retroviruses, has no side effects, and has a preventive effect. You can
【００１８】[0018]
製造例 糖化合物として糖化フラボノイド１〜５０ｍｇ／ｇ、蛋
白質２〜２０％、フェノール３〜１５％を溶液状のまま
混合し、ＳＯＤ様活性及び／または抗酸化能として力価
２０，０００単位／ｇ以上となるように調製した。得ら
れた組成物に蒸留水を添加し、組成物が０．２５％含有
する溶液を得た。Production Example Glycated flavonoids 1 to 50 mg / g, protein 2 to 20%, and phenol 3 to 15% as a sugar compound are mixed in a solution state, and a titer of 20,000 units / g as SOD-like activity and / or antioxidant ability is mixed. It was prepared as described above. Distilled water was added to the obtained composition to obtain a solution containing 0.25% of the composition.
【００１９】実施例１ 製造例で得た溶液を、減菌後寒天培養地に加え通常のコ
ントロール群と微生物の生育状況を調べた。その結果を
表１に示す。Example 1 The solution obtained in Production Example was added to the agar culture medium after sterilization, and the normal control group and the growth state of microorganisms were examined. The results are shown in Table 1.
【表１】 [Table 1]
【００２０】実施例２ 製造例で得た溶液を、滅菌後ニワトリの卵にインフルエ
ンザウィルスを感染させてウィルスの増殖の程度を調べ
た。その結果を表２に示す。Example 2 After sterilizing the solution obtained in Production Example, chicken eggs were infected with influenza virus to examine the extent of virus growth. The results are shown in Table 2.
【表２】 [Table 2]
【００２１】実施例３ 製造例で得た溶液を減菌後、各種希釈濃度になるように
培地に添加し、表３に示した細菌の育成状況を調べ、各
種育成阻害の最低濃度を表３に示した。Example 3 The solution obtained in the production example was sterilized and then added to the medium at various dilution concentrations, and the growth conditions of the bacteria shown in Table 3 were examined. It was shown to.
【表３】 [Table 3]
【００２２】実施例４ 製造例で得た溶液を用いて、試験管内における溶液の添
加量による活性酸素除去・消去作用を調べた。その結果
を図１に示す。図１によれば、試験管内におけるＥＳＲ
のシグナル（波形）の大きなものは活性酸素の存在を示
しており、溶液の添加量を増加することによって活性酸
素量が減少していくことがわかる。Example 4 Using the solution obtained in Production Example, the active oxygen removing / eliminating action depending on the addition amount of the solution in a test tube was examined. The result is shown in FIG. According to FIG. 1, ESR in a test tube
A large signal (waveform) indicates the presence of active oxygen, and it can be seen that the amount of active oxygen decreases as the amount of solution added increases.
【００２３】ついで、ラットに製造例で得た溶液を水の
代わりに８週間にわたり与えて脂肪組織における活性酸
素量を調べた。その結果を図２に示す。Then, the solution obtained in the production example was fed to rats for 8 weeks instead of water to examine the amount of active oxygen in adipose tissue. The result is shown in FIG.
【図１】試験管内における溶液の添加量による活性酸素
の変化を示す図。FIG. 1 is a diagram showing changes in active oxygen according to the amount of a solution added in a test tube.
【図２】腹腔内脂肪組織におけるＥＳＲシグナルの変動
を示す図。FIG. 2 is a view showing changes in ESR signal in abdominal adipose tissue.
【手続補正書】[Procedure amendment]
【提出日】平成５年２月５日[Submission date] February 5, 1993
【手続補正２】[Procedure Amendment 2]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】特許請求の範囲[Name of item to be amended] Claims
【補正方法】変更[Correction method] Change
【補正内容】[Correction content]
【特許請求の範囲】[Claims]
【手続補正３】[Procedure 3]
【補正対象書類名】明細書[Document name to be amended] Statement
【補正対象項目名】発明の詳細な説明[Name of item to be amended] Detailed explanation of the invention
【補正方法】変更[Correction method] Change
【補正内容】[Correction content]
【発明の詳細な説明】Detailed Description of the Invention
【０００１】[0001]
【産業上の利用分野】本発明は、抗ウイルス剤、抗菌・
殺菌剤に関する。The present invention relates to an antiviral agent, an antibacterial agent,
Regarding fungicides.
【０００２】[0002]
【従来の技術】従来より、抗菌剤、殺菌剤は数多く知ら
れている。2. Description of the Related Art Many antibacterial agents and bactericides have been known.
【０００３】[0003]
【発明が解決しようとする課題】しかし、これらのもの
は、ほとんどがバクテリアに作用するもので、ウイルス
あるいはカビ類に効くものはあまり知られておらず、ま
た効力も弱く、さらに副作用があり、人体に危険なもの
が多い。However, most of these act on bacteria, little are known to be effective against viruses or molds, their efficacy is weak, and they also have side effects. Many are dangerous to the human body.
【０００４】また、ウイルス性疾患にはインフルエン
ザ、肝炎、麻疹、日本脳炎、成人Ｔ細胞白血病、あるい
はエイズなど多くの疾患があるが、このようなウイルス
に対して有効な薬剤は多くなく、またその効果が明確で
なく、特に成人Ｔ細胞白血病あるいはエイズウイルスの
ようなレトロウイルスに効果のあるものは余り知られて
いない。In addition, there are many viral diseases such as influenza, hepatitis, measles, Japanese encephalitis, adult T-cell leukemia, and AIDS, but there are few drugs effective against such viruses, and The effect is not clear, and there is little known that it is particularly effective against retroviruses such as adult T-cell leukemia or AIDS virus.
【０００５】さらに、人に害がなく日常飲食も可能で予
防効果を有するような抗ウイルス、抗菌・殺菌剤は知ら
れていない。Further, there is no known antiviral, antibacterial or bactericidal agent which is harmless to human beings, can be eaten and eaten daily and has a preventive effect.
【０００６】本発明は、前記課題を解決し、レトロウイ
ルスに効果があり、また、副作用がなく、予防効果を有
する抗ウイルス、抗菌・殺菌剤を提供することを目的と
する。It is an object of the present invention to provide an antivirus, antibacterial and bactericidal agent which solves the above problems, is effective against retroviruses, has no side effects and has a preventive effect.
【０００７】[0007]
【課題を解決するための手段】そこで、本発明者らは、
前記目的を解決するために鋭意研究を重ねた結果、スー
パーオキシドジスムターゼ（ＳＯＤ）様活性および／ま
たは抗酸化能（スカベンジャー機能を含む）を有する物
質、フェノール化合物、及び、糖蛋白質、糖化フラボノ
イド等の糖化合物を含有してなる組成物が、抗ウイル
ス、抗菌・殺菌作用が強く、かつ人体、家畜などに対し
て副作用がなく安全な抗ウイルス、抗菌・殺菌剤である
との知見を得て本発明を完成した。Therefore, the present inventors have
As a result of intensive studies to solve the above-mentioned object, a substance having a superoxide dismutase (SOD) -like activity and / or an antioxidant ability (including a scavenger function), a phenol compound, and a glycoprotein, a glycated flavonoid, etc. Based on the finding that a composition containing a sugar compound is a safe antivirus, antibacterial and bactericidal agent that has strong antiviral and antibacterial and bactericidal effects and has no side effects on humans, livestock, etc. Completed the invention.
【０００８】ＳＯＤ様活性とは、スーパーオキシドラジ
カルを過酸化水素に変換するＳＯＤ活性に類似の活性
（生理機能）を有するものを示し、ＳＯＤ様活性を有す
る物質として、アミノ酸やペプチドの銅（ＩＩ）錯体、
マンガン錯体、脂溶性アスコルビン酸、ポリフィリン金
属錯体、ポリアミン金属錯体等の低分子化合物が挙げら
れ、また抗酸化能を有するものとしてビタミンＣ、ビタ
ミンＥ、尿酸、グルタチオン、βカロチン、カラター
ゼ、グルタチオンパーオキシンダーゼ等が挙げられる。[0008] The SOD-like activity is one having an activity (physiological function) similar to the SOD activity of converting superoxide radicals into hydrogen peroxide, and as a substance having the SOD-like activity, copper (II) of amino acids or peptides is used. ) Complex,
Low molecular weight compounds such as manganese complex, fat-soluble ascorbic acid, porphyrin metal complex, polyamine metal complex, etc. are mentioned, and those having antioxidant ability are vitamin C, vitamin E, uric acid, glutathione, β-carotene, calatase, glutathione peroxin. Examples include dase.
【０００９】フェノール化合物としては、グアイアコー
ル、フェノール、オイゲノール、フェニルエタノール等
の群より選ばれた１種またはこれらの混合物が上げられ
る。Examples of the phenol compound include one selected from the group consisting of guaiacol, phenol, eugenol, phenylethanol and the like or a mixture thereof.
【００１０】糖蛋白質、糖化フラボノイド等の糖化合物
としては、アスパラチン、オリエンチン（ルテキシ
ン）、シスオリエンチン（ルトナレチン）、イソクエル
シチン、ルチン等の群より選ばれた１種またはこれらの
混合物が挙げられる。Examples of sugar compounds such as glycoproteins and glycated flavonoids include one selected from the group consisting of aspalathin, orientin (lutexin), cis-orientin (rutonaretin), isoquercitin, rutin and the like or a mixture thereof.
【００１１】また、本発明は、リン、鉄、カルシウム、
ナトリウム、カリウム、マグネシウム、銅、亜鉛、マン
ガン、ケルセチン、セレン等の１種またはこれらの混合
物であるミネラルを混合すればより効果が優れる。The present invention also provides phosphorus, iron, calcium,
The effect is more excellent if one or more kinds of minerals such as sodium, potassium, magnesium, copper, zinc, manganese, quercetin, selenium, etc. or a mixture thereof is mixed.
【００１２】本発明の構成物質はいずれも無毒性のもの
で薬理基準にも合致したもので、ラットに対する急性毒
性試験で死亡例は皆無であり、生化学血液検査および病
理組織学的検査においても異常が認められなかった。All of the constituents of the present invention are non-toxic and meet the pharmacological criteria. There are no deaths in the acute toxicity test on rats, and no biochemical blood tests or histopathological tests are conducted. No abnormality was found.
【００１３】本発明は、ＳＯＤ様活性および／または抗
酸化能を有する物質、糖化フラボノイド及びフェノール
化合物、また必要に応じて添加されるミネラルを含有す
ることによって初めて優れた効果を示すのであり、その
構成は、ＳＯＤ様活性および／または抗酸化能の力価が
１０，０００〜１００，００単位／ｇ、糖化合物２〜２
０ｍｇ／ｇ、蛋白性物質１〜３０ｍｇ／ｇ、及びフェノ
ール化合物を１〜２０％、またミネラルを添加するとき
は、１０〜５００ｍｇ／ｇ含有することが必要である。The present invention exhibits an excellent effect for the first time by containing a substance having SOD-like activity and / or antioxidant ability, a glycated flavonoid and a phenol compound, and a mineral added as necessary. The composition is such that the titer of SOD-like activity and / or antioxidant capacity is 10,000 to 100,000 units / g, and the sugar compound is 2 to 2.
It is necessary to contain 0 mg / g, 1 to 30 mg / g of a proteinaceous substance, 1 to 20% of a phenol compound, and 10 to 500 mg / g when a mineral is added.
【００１４】本発明に用いる、ＳＯＤ様活性及び／また
は抗酸化能を有する物質、糖成分、フェノール化合物
は、混合してそのまま溶液、粉末顆粒、錠剤、乳剤、ゼ
リー状など任意の形態で単純投与、または、他の飲食物
に混合して飲食することもできる。The substance having SOD-like activity and / or antioxidant ability, the sugar component and the phenol compound used in the present invention are simply mixed in any form such as solution, powder granule, tablet, emulsion, jelly and the like. Alternatively, it can be mixed with other foods and drinks.
【００１５】投与量は、対象となる疾患の種類、程度に
より異なるが、２〜４０ｍｇ／ｋｇ／日の範囲で用いる
のが好ましく、飲料として常用する場合には、０．１〜
３．０％溶液を１００ｍｌ〜５００ｍｌ／日飲食するの
が好ましい。Although the dose varies depending on the type and degree of the target disease, it is preferably used in the range of 2 to 40 mg / kg / day, and when used as a beverage, 0.1 to
It is preferable to eat and drink the 3.0% solution at 100 ml to 500 ml / day.
【００１６】[0016]
【作用】ウイルスの発症要因は複雑で不明な点が多い
が、体内の活性酸素が深く関わっている可能性がある。
本発明は、スーパーオキシドラジカルなどの活性酸素の
除去作用を有するスーパーオキシドジスムターゼ（ＳＯ
Ｄ）様活性を有する物質および糖化合物などの抗酸化作
用を有する物質が、組み合わさって作用していると考え
られる。[Function] Although the causative factors of the virus are complex and unclear, there is a possibility that active oxygen in the body is deeply involved.
The present invention is directed to superoxide dismutase (SO 2) having an action of removing active oxygen such as superoxide radical.
It is considered that a substance having D) -like activity and a substance having an antioxidant action such as a sugar compound act in combination.
【００１７】[0017]
【効果】本発明は、ウイルス、細菌、カビなど各種微生
物の成育を抑え、また殺菌し、レトロウイルスに効果が
あり、また、副作用がなく、予防効果を有する抗ウイル
ス、抗菌・殺菌剤することができる。[Effects] The present invention is an antiviral, antibacterial / bactericidal agent which suppresses the growth of various microorganisms such as viruses, bacteria and fungi, and sterilizes them, is effective against retroviruses, has no side effects, and has a preventive effect. You can
【００１８】[0018]
【実施例】 製造例 糖化合物として糖化フラボノイド１〜５０ｍｇ／ｇ、蛋
白質２〜２０％、フェノール３〜１５％を溶液状のまま
混合し、ＳＯＤ様活性及び／または抗酸化能として力価
２０，０００単位／ｇ以上となるように調整した。得ら
れた組成物に蒸留水を添加し、組成物が０．２５％含有
する溶液を得た。EXAMPLES Production Example Glycated flavonoids 1 to 50 mg / g, proteins 2 to 20%, and phenol 3 to 15% were mixed as a solution as a sugar compound, and a titer of 20 as SOD-like activity and / or antioxidant ability was obtained. It was adjusted to be 000 units / g or more. Distilled water was added to the obtained composition to obtain a solution containing 0.25% of the composition.
【００１９】実施例１ 製造例で得た溶液を、減菌後寒天培養地に加え通常のコ
ントロール群と微生物の生育状況を調べた。その結果を
表１に示す。Example 1 The solution obtained in Production Example was added to the agar culture medium after sterilization, and the normal control group and the growth state of microorganisms were examined. The results are shown in Table 1.
【表１】[Table 1]
【００２０】実施例２ 製造例で得た溶液を、滅菌後ニワトリの卵にインフルエ
ンザウィルスを感染させてウィルスの増殖の程度を調べ
た。その結果を表２に示す。Example 2 After sterilizing the solution obtained in Production Example, chicken eggs were infected with influenza virus to examine the extent of virus growth. The results are shown in Table 2.
【表２】[Table 2]
【００２１】実施例３ 製造例で得た溶液を減菌後、各種希釈濃度になるように
培地に添加し、表３に示した細菌の育成状況を調べ、各
種育成阻害の最低濃度を表３に示した。Example 3 The solution obtained in the production example was sterilized and then added to the medium at various dilution concentrations, and the growth conditions of the bacteria shown in Table 3 were examined. It was shown to.
【表３】[Table 3]
【００２２】実施例４ 製造例で得た溶液を用いて、試験管内における溶液の添
加量による活性酸素除去・消去作用を調べた。その結果
を図１に示す。図１によれば、試験管内におけるＥＳＲ
のシグナル（波形）の大きなものは活性酸素の存在を示
しており、溶液の添加量を増加することによって活性酸
素量が減少していくことがわかる。Example 4 Using the solution obtained in Production Example, the active oxygen removing / eliminating action depending on the addition amount of the solution in a test tube was examined. The result is shown in FIG. According to FIG. 1, ESR in a test tube
A large signal (waveform) indicates the presence of active oxygen, and it can be seen that the amount of active oxygen decreases as the amount of solution added increases.
【００２３】ついで、ラットに製造例で得た溶液を水の
代わりに８週間にわたり与えて脂肪組織における活性酸
素量を調べた。その結果を図２に示す。Then, the solution obtained in the production example was fed to rats for 8 weeks instead of water to examine the amount of active oxygen in adipose tissue. The result is shown in FIG.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.5 識別記号 庁内整理番号 ＦＩ 技術表示箇所 Ａ６１Ｋ 31/375 7431−4Ｃ 31/70 ＡＤＹ 8314−4Ｃ (72)発明者 中野 昌俊 愛知県知立市新林町茶野36−16─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. 5 Identification code Internal reference number FI Technical indication location A61K 31/375 7431-4C 31/70 ADY 8314-4C (72) Inventor Masatoshi Nakano Chiryu City, Aichi Prefecture 36-16 Chano, Shinbayashi
Claims (3)
Ｄ）様活性および／または抗酸化能（スカベンジャー機
能を含む）を有する物質、フェノール化合物、及び、糖
蛋白質、糖化フラボノイド等の糖化合物を含有してなる
抗ウイルス、抗菌・殺菌剤。1. Superoxide dismutase (SO
D) An antiviral or antibacterial / bactericidal agent comprising a substance having a similar activity and / or an antioxidant ability (including a scavenger function), a phenol compound, and a sugar compound such as glycoprotein and glycated flavonoid.
ェノール、オイゲノール、フェニルエタノール等の群よ
り選ばれた１種またはこれらの混合物であることを特徴
とする請求項１記載の抗ウイルス、抗菌・殺菌剤。2. The antiviral, antibacterial and bactericidal agent according to claim 1, wherein the phenol compound is one selected from the group consisting of guaiacol, phenol, eugenol, phenylethanol and the like or a mixture thereof.
物がアスパラチン、オリエンチン（ルテキシン）、シス
オリエンチン（ルトナレチン）、イソクエルシチン、ル
チン等の群より選ばれた１種またはこれらの混合物であ
ることを特徴とする請求項１記載の抗ウイルス、抗菌・
殺菌剤。3. The glyco compound such as glycoprotein and glycated flavonoid is one or a mixture thereof selected from the group consisting of aspalathin, orientin (lutexin), cis-orientin (lutonaretin), isoquercitin, rutin and the like. The antivirus and antibacterial agent according to claim 1,
Fungicide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4084861A JPH06199697A (en) | 1992-03-06 | 1992-03-06 | Antiviral, antibacterial and fungicidal agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4084861A JPH06199697A (en) | 1992-03-06 | 1992-03-06 | Antiviral, antibacterial and fungicidal agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH06199697A true JPH06199697A (en) | 1994-07-19 |
Family
ID=13842596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4084861A Pending JPH06199697A (en) | 1992-03-06 | 1992-03-06 | Antiviral, antibacterial and fungicidal agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH06199697A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999044578A1 (en) * | 1998-03-05 | 1999-09-10 | Merck Patent Gmbh | Formulations with an anti-viral effect |
| WO2000025795A1 (en) * | 1998-10-29 | 2000-05-11 | Merck Patent Gmbh | Compositions comprising a mixture of bioflavonols |
| JP2001511770A (en) * | 1997-01-13 | 2001-08-14 | エモリー ユニバーシティー | Compounds for treating influenza infection and combinations thereof |
| WO2001003681A3 (en) * | 1999-07-08 | 2002-05-10 | Patrick T Prendergast | Use of flavones, coumarins and related compounds to treat infections |
| US6514527B1 (en) | 1998-10-29 | 2003-02-04 | Merck Patentgesellschaft | Compositions comprising a mixture of bioflavonols |
| WO2004014413A1 (en) * | 2002-07-31 | 2004-02-19 | Procyte Corporation | Compositions containing peptide copper complexes and phytochemical compounds, and methods related thereto |
| EP1590357A4 (en) * | 2003-01-07 | 2009-12-30 | Kemin Pharma Europ Bvba | Bicyclic carbohydrate compounds useful in the treatment of infections caused by flaviviridae sp., such as hepatitis c and bovine viral diarrhea viruses |
| JP2020527536A (en) * | 2017-07-04 | 2020-09-10 | バイオノス バイオテック，エス．エル | Use of macroazapyridinophan metal complexes in the treatment of diseases |
| CN116076261A (en) * | 2022-11-14 | 2023-05-09 | 云南农业大学 | Application of phenethyl alcohol in aspect of inducing plant resistance |
-
1992
- 1992-03-06 JP JP4084861A patent/JPH06199697A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001511770A (en) * | 1997-01-13 | 2001-08-14 | エモリー ユニバーシティー | Compounds for treating influenza infection and combinations thereof |
| WO1999044578A1 (en) * | 1998-03-05 | 1999-09-10 | Merck Patent Gmbh | Formulations with an anti-viral effect |
| WO2000025795A1 (en) * | 1998-10-29 | 2000-05-11 | Merck Patent Gmbh | Compositions comprising a mixture of bioflavonols |
| US6514527B1 (en) | 1998-10-29 | 2003-02-04 | Merck Patentgesellschaft | Compositions comprising a mixture of bioflavonols |
| EP1319405A1 (en) * | 1998-10-29 | 2003-06-18 | MERCK PATENT GmbH | Composition comprising a mixture of bioflavonols |
| WO2001003681A3 (en) * | 1999-07-08 | 2002-05-10 | Patrick T Prendergast | Use of flavones, coumarins and related compounds to treat infections |
| US6555523B1 (en) | 1999-07-08 | 2003-04-29 | Patrick T. Prendergast | Use of cirsiliol and derivatives to treat infections |
| WO2004014413A1 (en) * | 2002-07-31 | 2004-02-19 | Procyte Corporation | Compositions containing peptide copper complexes and phytochemical compounds, and methods related thereto |
| EP1590357A4 (en) * | 2003-01-07 | 2009-12-30 | Kemin Pharma Europ Bvba | Bicyclic carbohydrate compounds useful in the treatment of infections caused by flaviviridae sp., such as hepatitis c and bovine viral diarrhea viruses |
| JP2020527536A (en) * | 2017-07-04 | 2020-09-10 | バイオノス バイオテック，エス．エル | Use of macroazapyridinophan metal complexes in the treatment of diseases |
| CN116076261A (en) * | 2022-11-14 | 2023-05-09 | 云南农业大学 | Application of phenethyl alcohol in aspect of inducing plant resistance |
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