JPH06178925A - Dialyzer inspecting device - Google Patents

Abstract

PURPOSE:To facilitate handling and to automate the inspection of a dialyzer by maintaining the atmosphere temp. in the dialyzer at an approximately physio logical temp. and providing a thermostatic chamber for passing fluid into the dialyzer. CONSTITUTION:A case 1 is provided with the thermostatic chamber 12 which is internally maintained in an approximately hermetic state and in which the internal atm. temp. is maintained at about the physiological temp. Hot air is supplied from a hot air supplying device 2 to the chamber. The dialyzer is transported to an inspection chamber 16 of the thermostatic chamber 12 by a dialyzer transporting device 3. A dialyzer connecting device 4 is connected through the blood passage and dyalyzate passage of the dialyzer in the inspection chamber 16. Gas and liquid are passed to the blood passage and the dialyzate passage and the outflow of the gas and liquid from the blood passage and the dialyzate passage is detected.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a dialyzer inspection device.

[0002]

2. Description of the Related Art A dialyzer used for hemodialysis is sampled every suitable number to check whether its performance is satisfactory. At the time of the above inspection, gas or liquid is passed through the dialyzer to inspect the dialyzer. By the way, at the time of the above inspection, it is necessary to place the dialyzer under physiological temperature, but in the past, the dialyzer was placed in water at physiological temperature.

[0003]

As described above, since water is used to put the dialyzer under physiological temperature, it is troublesome to handle and the use of this water automates the inspection of the dialyzer. It was a bottleneck to that. An object of the present invention is to provide a dialyzer inspection device that can solve the above problems.

[0004]

In order to solve the above-mentioned problems, the feature of the present invention resides in that when a dialyzer is inspected by circulating a fluid in the dialyzer, the internal ambient temperature is substantially physiological. The point is that a temperature-controlled room is provided, which is maintained at a temperature and internally allows fluid to flow in the dialyzer.

[0005]

[Function] When inspecting the dialyzer, the dialyzer is put in a thermostatic chamber, and a fluid is circulated in the dialyzer to inspect the dialyzer.

[0006]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS An embodiment of the present invention will be described below with reference to the drawings. 1 to 3 show a dialyzer inspection device for measuring the performance of a dialyzer, which is a case 1
A hot air supply device 2, a dialyzer transfer device 3,
It has a dialyzer connection device 4, a dialyzer inspection circuit, a control device, and the like. The case 1 is hermetically or substantially hermetically sealed, and includes a case body 8 and a removable cover 9.

The case body 8 is formed by the left and right partition plates 10.
Divided in the left-right direction, the left side constant temperature room 11 and the right side constant temperature room 12 on the left side of the left and right partition plates 10 are the right constant temperature room 12, and the left and right constant temperature rooms 11, 12 are physiological temperature, that is,
Maintained at about 37 ° C. The left and right temperature-controlled chambers 11 and 12 have a temperature sensor T for measuring the internal ambient temperature.
Is provided. Also, the right temperature chamber 12 is the upper and lower partition plate 1
The upper part of the upper and lower partition plates 13 is defined as an upper constant temperature area 14 and the lower part of the upper and lower partition plates 13 is defined as a lower constant temperature area 15 by being substantially divided by 3 in the vertical direction. The upper constant temperature zone 14 is on the left side of the lower constant temperature zone 15, and the central part of the upper constant temperature zone 14 in the front-rear direction projects to the right as shown in FIG.
It is supposed to be 6. The inspection chamber 16 receives one dialyzer 17 from the dialyzer transport device 3 and has openings in the front, rear, and right sides.

The cover 9 has a substantially right-hand side of the upper constant temperature zone 14 and an upper side of the lower constant temperature zone 15 in a substantially sealed state. The hot air supply device 2 is arranged in the lower temperature-controlled zone 15 of the right temperature-controlled room 12, and supplies warm air to the left and right temperature-controlled rooms 11 and 12,
The ambient temperature inside each of the chambers 11 and 12 is maintained at the physiological temperature. As shown in FIGS. 4 to 7, the dialyzer transfer device 3 sequentially supplies the dialyzer 17 to the inspection position in the inspection chamber 16 and carries out the dialyzer 17 at the inspection position after the inspection is completed. A sample table 19 equipped with an appropriate number of
The sample table 19 is composed of a table rotating motor 20 for rotating the sample table 19 at a predetermined angle.

First, the dialyzer 17 will be described before the description of the dialyzer transport device 3. As shown in FIG. 8, the dialyzer 17 is composed of a cylindrical body 22 having both open ends and a large number of hollow fibers. Cylindrical body 22
It consists of a hollow fiber bundle 23 filled inside, and upper and lower headers 24, 25 that cover the openings at both ends of the cylindrical body 22, and the hollow fiber bundle 23 and the insides of both headers 24, 25 constitute a blood passage, A portion inside the cylindrical body 22 excluding the hollow fiber constitutes a dialysate passage. A blood inlet port 26 for introducing blood into the blood passage is formed in a protruding shape at the upper end of the upper header 24, and a blood outlet port 27 for discharging blood from the blood passage is provided at the lower end of the lower header 25. Are formed so as to project downward. Further, a dialysate inlet port 28 for introducing the dialysate into the dialysate passage is formed on the side surface of the lower end of the cylinder 22 so as to project laterally, and
A dialysate outlet port 29 for discharging the dialysate from the dialysate passage is formed on the side surface of the upper end portion of the so as to project laterally.

The sample table 19 is rotatably provided on the upper and lower partition plates 13, and a portion of the sample table above the upper and lower partition plates 13 is covered with a cover 9 of the case 1. The sample table 19 has a drive shaft 31.
, The upper and lower discs 32 and 33, the mounting plate 34, and the partition plate 3
5 and a mounting mechanism 36 and the like.

The drive shaft 31 is rotatably provided vertically on the upper and lower partition plates 13, and its lower portion is interlocked with the table rotation motor 20 via a chain transmission mechanism 37. Both discs 32 and 33 are fixed to the upper side of the drive shaft 31,
It is located above the upper and lower partition plates 13. The mounting plate 34 is
The discs 32 and 33 are fixed to the outer peripheral edges of the discs 32 and 33 at equal intervals in the circumferential direction, and have a planar shape in the radial direction. Partition plate 35
Are fixed to the outer peripheral edges of both discs 32 and 33 in a standing manner at equal intervals in the circumferential direction, have a planar shape in the circumferential direction, and project radially outward from both discs 32 and 33. The partition plates 35 are located between the mounting plates 34. In addition, each mounting plate 34
Also, each partition plate 35 is slidable with respect to the upper and lower partition plates 13 or faces each other with a small gap in between. GS is an origin sensor for detecting the origin position of the sample table 19, I
S is a positioning sensor for rotating the sample table 19 to a predetermined angle.

The mounting mechanism 36 is provided on each mounting plate 34 to detachably mount the dialyzer 17 on each mounting plate 34. The guide shaft 39 and the upper and lower fitting members 4 are provided.
0, 41, upper / lower biasing springs 42, 43, and holding spring 4
It has 4 mag.

The guide shaft 39 is vertically provided on the outer surface of the mounting plate 34, and a pair of upper and lower fitting members 40, 4 are attached to the guide shaft 39.
1 is slidably fitted in the vertical direction, and the lock bolt 4
It can be fixed by 5. Both fitting members 40, 41
Is externally fitted to each header 24, 25 of the dialyzer 17 and each end of the cylindrical body 22 to sandwich the dialyzer 17 from above and below, and as shown in FIG. In addition, the inside is stepped so that it can accommodate a plurality of types of dialyzer 17 having different outer diameters. Further, each fitting member 40, 41 has a blood inlet port 26 and a blood outlet port 27 therein, and exposes the dialysate inlet port 28 or the dialysate outlet port 29 laterally from the notch 46. . The upper and lower urging springs 42 and 43 are provided at the upper and lower ends of the guide shaft 39 to urge the vertical fitting members 40 and 41 downward or upward, and the holding spring 44 moves in the vertical direction of the guide shaft 39. It is elastically provided in the middle portion to prevent the fitting members 40, 41 from approaching each other more than a predetermined amount, and thus, the fitting members 40, 4
1 is maintained at a predetermined position.

When the dialyzer 17 is received in the inspection chamber 16, the openings in the front and rear of the inspection chamber 16 are separated by the partition plate 3.
5, the right side opening of the examination room 16 is attached by the mounting plate 34,
Each has a substantially closed shape, but an elastically deformable rubber cover 47 projects from the opening edge of the inspection chamber 16 in order to complete the above-mentioned closure. This makes it difficult for the air in the inspection chamber 16 to escape, and prevents the temperature in the inspection chamber 16 from decreasing. When the sample table 19 rotates, the partition plate 35 elastically deforms the rubber cover 47.

The dialyzer connecting device 3 is connected to the blood ports 26 and 27 and the dialysate ports 28 and 29 of the dialyzer 17 at the inspection position, respectively. A guide plate 49, which is arranged in the left side portion of the area 15 and has an upright shape.
And upper / lower coupler units 50, 51 and the like. A pair of left and right guide portions 52 are vertically provided on the front surface of the guide plate 49. Each coupler unit 50, 51 is provided in each guide portion 52 so as to be movable in the vertical direction, and includes lifting members 54, 55, lifting motors 56, 57, movable members 58, 59, and movable member cylinders. 60, 61, a blood inlet coupler 62, a blood outlet coupler 63, a dialysate inlet coupler 64, a dialysate outlet coupler 65 and the like.

The elevating members 54 and 55 are provided on the guide portions 52 so as to be able to move up and down, and the elevating members 54 and 55 are provided on the upper and lower portions of the guide plate 49, respectively.
6, 57 are screwed together via screw shafts 66, 67, and each coupler unit 5 is driven by driving the lifting motors 56, 57.
0, 51 goes up and down. Each elevating member 54, 55 has a pair of upper and lower guide portions 68, 69 in the left-right direction, and movable members 58, 59 are provided in the guide portions 68, 69 so as to be movable in the left-right direction. , 59 and lifting member 5
Movable member cylinders 60 and 61 for moving the movable members 58 and 59 in the left and right direction are interposed between the four and 55. A blood inlet coupler 62 or a blood outlet coupler 63, which is detachably connected to the blood inlet port 26 or the blood outlet port 27, is attached to each movable member 58, 59.
It is provided so as to be movable in the vertical direction by means of the fitting / removing cylinders 72, 73 via 0, 71. In addition, each movable member 5
At 8, 59, a dialysate inlet coupler 64 that is separably connected to the dialysate inlet port 28 or dialysate outlet port 29.
Alternatively, the dialysate outlet coupler 65 has elastic cushioning mechanisms 74, 75.
It is provided so as to be movable in the left-right direction by means of the fitting / removing cylinders 76, 77 via.

Incidentally, each elastic cushioning mechanism 70, 71, 74, 7
5 is a telescopic double shaft 70A, 71A, 74A, 75
A and compression springs 70B, 71B, 74B, 75B for urging the double shafts 70A, 71A, 74A, 75A in the extension direction.
And has a shock absorber when connecting the couplers 62, 63, 64, 65 and the ports 26 to 29. Also, KS1, K
S2 is dialysate inlet port 28 or dialysate outlet port 2
The detection sensor for detecting 9, LS1 to LS4,
This is a limit switch for detecting the rising and falling limits of each coupler unit 50, 51. FIG. 9 shows an inspection circuit. The inspection circuit supplies air and liquid to the dialyzer 17 to inspect the dialyzer 17. The entire inspection circuit is provided in the left and right constant temperature chambers 11 and 12 of the case except for a large tank described later.

In FIG. 9, DT1 is a large RO water tank in which RO water (water treated with a reverse osmosis membrane) is stored, DT2 is a large creatine tank in which an aqueous creatine solution is stored, and D
T3 is a large urea tank in which the aqueous urea solution is stored, DT4 is a large vitamin B ₁₂ tank in which the aqueous vitamin B ₁₂ solution is stored, DT5 is a large dialysate tank in which the dialysate is stored, and each large tank DT1 to DT5 is RO water can be supplied through the valves 101 and the like. Each large tank DT1-D
The T5 is provided outside the case 1, but may be provided in the left constant temperature chamber 11 of the case 1 and the like. In addition, each of the large tanks DT1 to DT5 has a RO water constant temperature tank KT1,
Creatine constant temperature tank KT2, urea constant temperature tank KT3,
Vitamin B ₁₂ constant temperature tank KT4, dialysate constant temperature tank KT
Connected to 5.

Each of the constant temperature tanks KT1 to KT5 is a left constant temperature chamber 1
In addition to the above, the constant temperature tanks KT1 to KT5 store the same type of liquid as the corresponding large tanks DT1 to DT5. Each constant temperature tank KT1 to KT5
A heater H for maintaining the liquid in the constant temperature tanks KT1 to KT5 at a constant physiological temperature and a temperature measuring sensor T are provided.

The RO water constant temperature tank KT1 includes a pipe K1 and
Adjusting pump P via valves 102, 103, 107
The dialysate constant temperature tank KT5 is connected to U1 and is connected to the adjustment pump PU3 via the pipe K2 and the valve 109. The valves 102 and 103 of the pipe K1 and the valve 109 of the pipe K2 and the adjustment pump PU3 are connected by a pipe K3 and a valve 110. A creatine constant temperature tank K is provided between the valves 103 and 107 of the pipe K1.
T2, urea thermostatic tank KT3, vitamin B ₁₂ thermostatic tank KT4 is connected via a pipe K4~K6 and valve 104-106.

The adjusting pump PU1 supplies a liquid through a pipe K7 and valves 113 and 116, and the supplied liquid is exemplified as a liquid container through a valve 124 at the end of the pipe K7. Is discharged into the beaker 79, and the pipe K7 communicates with the outside through the valve 125. The liquid weight in the beaker 79 is measured by an electronic balance 80 exemplified as a measuring device. Pipe K
A part between the adjusting pump PU1 of No. 7 and the valve 113 passes through the heat exchanger 81 for bringing the liquid passing through the pipe K7 to the physiological temperature. In the heat exchanger 81, a heater H for bringing the heat retaining liquid stored therein to a physiological temperature,
A sensor T for measuring the temperature of the heat retaining liquid is provided.
A pipe K9 having a valve 111 is connected between the heat exchanger 81 and the valve 113 of the pipe K7.

The pipe K9 is connected to an air supply source AIR via a valve 121. The air supply source AIR is
It has an adjusting mechanism that can adjust the pressure of the supplied air. Between the valve 111 and both valves 121 of the pipe K9, the pipe K1
0, the blood inlet coupler 62 is connected to the blood inlet port 26 of the dialyzer 17 at the examination position, and the blood inlet pressure sensor PS1 and the blood inlet temperature sensor TS1 are provided at the end of the pipe K10 on the blood inlet coupler 62 side. Are connected. Between the valve 111 of the pipe K9 and the pipe K10,
The valve 112 communicates with the outside. Between the valves 113 and 116 of the pipe K7, the pipe K11 and the valve 11 are provided.
4. The blood outlet coupler 63 is connected to the blood outlet port 27 of the dialyzer 17 at the examination position, and the blood outlet pressure sensor PS2 is connected to the end of the pipe K11 on the blood outlet coupler 63 side.

Between the valves 113 and 116 of the pipe K7,
Adjusting pump P via pipe K12 and valve 115
It is connected to U2, and this adjustment pump PU2 and piping K7
Between the valve 116 and the valves 124 and 125 of the pipe K1
3 and the valve 117. The adjusting pump PU3 is connected to the dialysate inlet port 28 of the dialyzer 17 via the pipe K14, the valve 118 and the dialysate inlet coupler 64, and the dialysate inlet is provided at the end of the pipe K14 on the dialysate inlet coupler 64 side. A pressure sensor PS3 and a dialysate inlet temperature sensor TS2 are connected. Piping K1
A part between the adjusting pump PU3 of No. 4 and the valve 118 passes through the heat exchanger 81, and the end of the pipe K14 on the dialysate inlet coupler 64 side communicates with the outside through the valve 119.

Dialysate outlet port 2 of dialyzer 17
9 is connected to the pipe K15 via the dialysate outlet coupler 65, and the terminal end of the pipe K15 opens into the beaker 79 of the electronic balance 80 via the valve 123, and also via the valve 126. , Also communicates with the outside. Piping K1
5, the dialysate outlet pressure sensor PS4 is connected to the dialysate outlet coupler 65 side end, and the air supply source AIR is connected to the middle of the pipe K15 via the pipe K16 and the valve 120. There is.

Between the valves 103 and 107 of the pipe K1, a pipe K17, a valve 130, a spectrophotometer 84 having a pump PU5, and an autosampler 85 for automatically sampling the liquid inspected by the spectrophotometer 84 into a test tube. Through the outside. The spectrophotometer 84 is exemplified as a concentration measuring device, and measures the spectrophotometric value of the inspection liquid to measure the concentration of the inspection liquid. A liquid chromatography or a biochemical analyzer may be used as the concentration measuring device.

Valve 130 of pipe K17 and pump PU5
Between the pipe K18 and the valve 127, the pipe K13
Is connected between the adjustment pump PU2 and the valve 117, and is also connected between the valve 130 and the pump PU5 of the pipe K17 through a pipe K19 and a valve 128 to an intermediate portion of the pipe K15. The pump PU4 is a pump for discharging the liquid in the beaker 79 of the electronic balance 80 to the outside.

A weighing device composed of the electronic balance 80 and the like is constructed as follows. That is, as shown in FIG. 10, the tip of the tube 86 connected to the valves 123 and 124 is cut off obliquely, a hole 87 is formed at the tip, and the thread 88 is connected to the hole 87. The liquid is hung down to the bottom surface inside the beaker 79, and the liquid discharged from the valves 123 and 124 travels along the thread 88 and enters the inside of the beaker 79.

By configuring the metering device as described above, the liquid discharged from the tube 86 does not fall into the beaker 79 at a high drop velocity, and therefore the liquid is discharged into the beaker 79 electronically. It does not greatly affect the display of the balance 80, and the thread 88 hung from the tube 86
Since it is thin, even if it is immersed in the liquid in the beaker 79, a large buoyancy does not occur. Therefore, the buoyancy of the thread 88 does not significantly affect the display of the electronic balance 80, and The liquid weight can be accurately measured by the electronic balance 80. FIG. 11 shows a control device, which controls the entire dialyzer inspection device to automatically inspect the dialyzer 17, and has a microcomputer 89, a personal computer 90 and the like.

In the microcomputer, the temperature of the liquid measured by the temperature measuring sensor T of each of the constant temperature tanks KT1 to KT5 and the temperature of the liquid measured by the temperature measuring sensor T of the heat exchanger 81 are measured via a parallel interface and a sequence control circuit. While the temperature is input, the origin sensor GS, the positioning sensor IS, the detection sensors KS1 and KS2, the limit switches LS1 to LS4, the operation switches and the like are input and the alarm / display is performed via the sequence control circuit. , Each valve 101 to 10 of the inspection circuit
7,109-121,123-128,130 opening and closing,
Pump PU4, PU5 control, table rotation motor 2
0, lifting motors 56 and 57, movable member cylinder 6
The control of 0, 61, the fitting / removing cylinders 72, 73, 76, 77 and the like are performed.

In the microcomputer, the temperature measured by the blood inlet temperature sensor TS1 near the blood inlet coupler 62, the temperature measured by the dialysate inlet temperature sensor TS2 near the dialysate inlet coupler 64, and the left / right constant temperature Temperature measured by temperature sensor T in chambers 11 and 12, blood inlet pressure sensor PS for liquid near blood inlet coupler 62
1, the pressure measured by the blood outlet pressure sensor PS2 of the liquid near the blood outlet coupler 63, the pressure measured by the blood outlet pressure sensor PS2 of the liquid near the dialysate inlet coupler 64, PS3
And the measured value from the dialysate outlet pressure sensor PS4 of the liquid in the vicinity of the dialysate outlet coupler 65, the measured value from the electronic balance 80, and the number of revolutions of the adjustment pumps PU1 to PU3 are controlled by the pulse number. Controlled by.

Further, a commercial AC power source is connected to the microcomputer and the personal computer 90 via an uninterruptible power source 94, and the personal computer 9 is used.
A spectrophotometer 84, an auto sampler 85, and a printer 96 are connected to 0 through an expansion board. An open / close switch controlled by a microcomputer is provided between the commercial AC power supply and the uninterruptible power supply 94.

According to the embodiment configured as described above, when the dialyzer 17 is inspected, the cover 9 is removed,
The sampled dialyzer 17 is sequentially set in advance on the mounting plate 34 of the sample table 19 via the mounting mechanism 36. In this case, the upper and lower fitting members 40, 41
The upper and lower biasing springs 42 and 43, the holding spring 44, etc.
After loosening the lock bolt 45 of the upper fitting member 40, raising the upper fitting member 40 to fit the dialyzer 17 to the lower fitting member 41, lowering the upper fitting member 40,
The upper fitting member 40 is fitted to the dialyzer 17 and fixed by the lock bolt 45.

In this way, after setting the dialyzer 17 on each mounting plate 34, the cover 9 is attached and the inspection is started. First, the sample table 19 is rotationally driven by the table rotation motor 20. hand,
The origin position is set, and as shown in FIGS. 5 and 7, a predetermined dialyzer 17 is housed in the inspection chamber 16 and positioned at the inspection position.

The upper and lower coupler units 50 and 51
The ascending / descending motors 56, 57 are driven to rotate, and the ascending / descending members 54, 55 of the upper / lower coupler units 50, 51 are ascended / descended. When the 28 and the dialysate outlet port 29 are detected, the lifting motors 56 and 57 are stopped, and the dialysate inlet coupler 64 and the dialysate outlet coupler 65 of the upper and lower coupler units 50 and 51 are dialyzed by the dialyzer 17 at the inspection position. It corresponds to the liquid inlet port 28 and the dialysate outlet port 29 in the vertical direction. Next, the movable members 58 and 59 are brought closer to the dialyzer 17 side of the inspection position by the movable member cylinders 60 and 61, and the blood inlet coupler 62 is arranged above the blood inlet port of the dialyzer 17 and the blood outlet coupler 63. Is located below the blood outlet port 27 of the dialyzer 17.

Thereafter, as shown in FIG. 6, the blood inlet coupler 62 and the blood outlet coupler 63 are connected to each other by the fitting / removing cylinder 7
2, 73 is moved in the vertical direction to be connected to the blood inlet port 26 or the blood outlet port 27, and the dialysate inlet coupler 64 and the dialysate outlet coupler 65 are
By moving the fitting / removing cylinders 76 and 77, the cylinder moves to the right side and enters the dialysate inlet port 28 or the dialysate outlet port 29.
Connected to. After that, each test is conducted as follows.

[Air Leak Test] In the air leak test, first, each of the couplers 62 to 6 of the dialyzer inspection device is tested.
After confirming the connection between the No. 5 and each of the ports 26 to 29 of the dialyzer 17, the leakage of air from the hollow fiber of the dialyzer 17 is inspected. First, the valves 119 and 1
21 and 126 are opened and valves 111, 112 and 11 are opened.
4, 118 and 120 are closed.

Then, the air having the highest working pressure of the dialyzer is supplied from the air supply source AIR to the valve 121 and the pipe K.
9 and K10 to supply the blood passage of the dialyzer 17 to connect the blood inlet coupler 62 and the blood inlet port 26, and the blood outlet coupler 63 and the blood outlet port 27.
Check the connection with. And the blood inlet pressure sensor P
S1, when the air pressure detected by the blood outlet pressure sensor PS2 is equal to or lower than the specified pressure SP9, the blood inlet coupler 62 and the blood outlet coupler 63 are disconnected from the blood inlet port 26 and the blood outlet port 27, and then reconnected. And supply air again. Even if executed twice, the air pressure is SP9
In the following cases, the test is aborted due to poor connection.

When the air pressure is SP9 or higher, it is determined that the connection is good, and the process proceeds to the next step, the valve 120 is opened and the valves 111, 112, 114, 118, 11 are opened.
9, 121, 123, 126, 128 are closed. Then, from the air supply source AIR, the air having the maximum working pressure of the dialyzer is supplied to the dialysate passage of the dialyzer 17 through the valve 120 and the pipes K16 and K15 to connect the dialysate inlet coupler 64 and the dialysate inlet port 28. And the connection between the dialysate outlet coupler 65 and the dialysate outlet port 29.

The dialysate inlet pressure sensor PS3,
When the air pressure detected by the dialysate outlet pressure sensor PS4 is SP9 or less, the dialysate inlet coupler 64 and the dialysate outlet coupler 65 are disconnected from the dialysate inlet port 28 and the dialysate outlet port 29, and then reconnected. Then, the air is supplied again. Even if it is executed twice, if the air pressure is equal to or lower than SP9, the connection is defective and the test is stopped. or,
If the air pressure is SP9 or higher, it is determined that the connection is good, and the process proceeds to the next step, the valves 112, 119, 126 are opened, and the valves 111, 114, 118, 120, 121 are opened.
Closed, and the air inside the dialyzer 17 is replaced by the pipe K1.
0, K9, through the valve 112, or the pipe K14,
Via valve 119, or piping K15, valve 1
It is released to the outside via 26.

After that, the valves 119 and 126 are opened, the valves 111, 112, 114, 118 and 120 are closed, and the valve 121 is opened so that the air having the maximum dialyzer working pressure is passed through the pipes K9 and K10. ,
After the prescribed T1 time is applied to the blood passage of the dialyzer 17, air having a pressure of 80% of the maximum dialyzer operating pressure is applied to the blood passage of the dialyzer 17 through the pipes K9 and K10 for the prescribed T2 time.

After the lapse of T2, the valve 121 is closed to stop the application of air to the blood passage of the dialyzer 17, and at that time, the air pressure detected by the blood inlet pressure sensor PS1 and the blood outlet pressure sensor PS2 is changed to the initial pressure. When the air pressure is detected in the same manner as above after a lapse of the specified T3 time with IP, and if the expression of the specified pressure P3 ≧ IP-air pressure after the T3 time is satisfied, the air leak test is passed and the next test is performed. If the above equation is not satisfied, proceed to
Fail the air leak test and stop the test.

[Filling (Priming) Test] Next, after filling the blood passage and the dialysate passage of the dialyzer 17 with RO water, the valves 102, 103, 107 and 112 to
114 is opened and the valves 111, 115, 116 and 12 are opened.
1 is closed. Then, the adjustment pump PU1 is rotated at the specified flow rate QDT2 for the specified TDT2 time, and the RO water in the RO water constant temperature tank KT1 is supplied to the pipe K1 and the adjustment pump PU.
The blood passage is supplied from the blood outlet port 27 of the dialyzer 17 to the blood passage in the dialyzer 17 via the pipes K7 and K11, the blood outlet coupler 63, and the like, and the air is expelled from the bottom to the top of the blood passage. Fill with RO water.

After the lapse of TDT2 hours, the valve 112 is closed, the adjusting pump PU1 is rotated at the specified flow rate QB3, and if the pressure detected by the blood inlet pressure sensor PS1 and the blood outlet pressure sensor PS2 reaches the specified pressure PB,
The valve 112 is opened. Then, again, the valve 112
Is closed and the same operation as described above is performed, and this operation is repeated once for the specified SP. After that, the adjustment pump PU1 is rotated at the flow rate QB3 for the specified time TB3,
The RO passage is filled with RO water in the dialyzer 17.
Next, after stopping the adjustment pump PU1, the valve 10
2, 103, 107, 112 to 114, 121 are opened, and the valves 111, 115, 116 are closed.

Then, the adjusting pump PU1 is stopped, and the maximum operating pressure of the dialyzer is set to 8 from the air supply source AIR.
The RO water in the upper part of the blood passage of the dialyzer 17 is discharged to the outside through the valve 121, the pipe K9, and the valve 112 for a specified SP time through the pipe K10. And discharge it to the outside. Next, the valves 102, 103, 107, 1
12 to 115, 117 are opened and the valves 111, 11 are opened.
Close 6,121.

Then, the adjusting pump PU2 is set to the specified flow rate Q.
In the blood passage of the dialyzer 17, the RO water in the blood passage of the dialyzer 17 is drawn to the adjustment pump PU2 side through the pipes K11, K12, the valves 114, 115, etc. by rotationally driving the TB2 for a prescribed time period at B2. Draw air into. At this time, if air is drawn into the adjustment pump PU2, the adjustment pump PU2 will be damaged. Therefore, pay sufficient attention to the flow rate QB2 of the adjustment pump PU2 and its drive time TB2. Next, the valves 102, 103, 107, 112
~ 114 open and valves 111, 115, 116, 1
21 is closed.

Then, the adjusting pump PU1 is set to the flow rate QB3.
The RO water in the RO water constant temperature tank KT1 is supplied from the blood outlet port 27 of the dialyzer 17 to the blood in the dialyzer 17 through the pipe K1, the adjustment pump PU1, the pipes K7 and K11, the blood outlet coupler 63, and the like. The RO is filled in the blood passage while supplying air to the passage to expel the air in the blood passage from the bottom to the top. Then, when the pressure detected by the blood inlet pressure sensor PS1 and the blood outlet pressure sensor PS2 reaches the specified pressure PB, the valve 112 is opened. Then, the valve 112 is closed again to perform the same operation as described above, and this operation is repeated SP1 times.

Thereafter, the adjusting pump PU1 is set to the flow rate QB.
Rotate at TB 3 for 3 hours and use RO water dialyzer 1
Fill the blood passage in 7. Next, the valves 102 and 11
0, 118, 126 are opened and valves 109, 119,
Close 120. Then, the adjustment pump PU3 is rotationally driven at the specified flow rate QD1 for the specified time TD1 to feed the RO water in the RO water constant temperature tank KT1 to the pipes K1, K3, K2, the adjustment pump PU3, the pipe K14, and the dialysate inlet coupler 64.
The dialysate passage of the dialyzer 17 is supplied through the dialyzer 17 and the like, and the RO water is discharged from the dialysate passage to the outside through the dialysate outlet coupler 65, the pipe K15, and the valve 126.

After that, the adjusting pump PU3 is set to the specified flow rate Q.
D2 rotates for TD2 hours. As described above, the blood passage and the dialysate passage of the dialyzer 17 are sufficiently filled with RO water. [Ultrafiltration rate (UFR) test]
A liquid that passes through the hollow fiber bundle 23 of the dialyzer 17, for example, RO water, is filtered from the hollow fiber bundle 23 into the dialysate passage of the dialyzer 17, and the amount of filtration is measured to calculate the ultrafiltration rate. .

(1) Measurement of filtration amount when TMP set pressure is P1 Valves 102, 103, 107, 111, 114, 11
5, 117, 125, 126 are opened, the valve 112,
113, 116, 118 to 121, 124 are closed.
The adjustment pump PU1 is rotationally driven at a flow rate QDT2, and R
RO water in the O water constant temperature tank KT1 is supplied from the blood inlet port 26 of the dialyzer 17 to the blood passage of the dialyzer 17 through the pipe K1, the adjustment pump PU1, the pipes K7, K9, K10, the blood inlet coupler 62, and the like. At the same time, the adjustment pump PU2 is rotationally driven to remove the RO water in the blood passage of the dialyzer 17 from the blood outlet port 2
7, the blood outlet coupler 63, the pipes K11 and K12, the adjusting pump PU2, the pipes K13 and K7, and the valve 125 to discharge the gas to the outside.

At this time, the rotation speed of the adjusting pump PU2 is controlled so that the pressure detected by the blood inlet pressure sensor PS1 and the blood outlet pressure sensor PS2 becomes the specified TMP set pressure P1. Also, the blood inlet pressure sensor PS1,
The RO water filtered into the dialysate passage of the dialyzer 17 is discharged to the outside through the pipe K15 and the valve 126 until the pressure detected by the blood outlet pressure sensor PS2 becomes stable. During the above period, the RO water in the beaker 79 of the electronic balance 80 is discharged to the outside by the pump PU4.

The pressure detected by the blood inlet pressure sensor PS1 and the blood outlet pressure sensor PS2 is TMP.
When the set pressure P1 is reached, the valve 123 is opened, the valve 126 is closed, and the pump PU4 is stopped. Next, the RO water filtered into the dialysate passage of the dialyzer 17 is received in the beaker 79 of the electronic balance 80 via the pipe K15 and the valve 123. From this point, the blood inlet pressure sensor PS1 and the blood outlet pressure sensor PS2
Wait for the specified ΔT time until the pressure detected by is stable. After the lapse of ΔT time, the displayed value on the electronic balance 80 is read. Then, after the lapse of the prescribed ST1 hour, the display value of the electronic balance 80 is read, and the filtration amount within the ST1 hour is measured.

(2) The TMP set pressure is the specified pressure P2, P
When the TMP set pressure is P2, the filtration amount within the specified ST2 time and when the TMP set pressure is P3, the specified ST3 is measured by the same method as the above (1). The amount of filtration in the time,
taking measurement. (3) Calculation of ultrafiltration rate (UFR) The ultrafiltration rate is calculated by the least squares method from the respective filtration amounts when the TMP set pressures are P1, P2, and P3.

[Clearance Test] The clearance test is a test for measuring how much the solute of the aqueous solution passing through the blood passage of the dialyzer 17 permeates into the dialysate passage. For example, while passing the creatine aqueous solution through the blood passage of the dialyzer 17, , RO water is passed through the dialysate passage of the dialyzer 17 to measure how much creatine permeates from the blood passage to the dialysate passage.

First, either the valve 102 is opened or the valves 109 and 110 are opened (in the embodiment, the valve 102 is opened). Also, the valves 103, 107, 113, 115, 117, 125 are opened, and the valves 104 to 106, 111, 114, 11 are opened.
6,121,127,128,130 are closed. Adjusting pumps PU1 and PU2 with specified flow rate QBi at specified TA
The RO water in the RO water constant temperature tank KT1 is driven to rotate for a time, and the pipe K1, the adjustment pump PU1, the pipes K7 and K1 are supplied.
2, adjusting pump PU2, piping K13, K7, valve 1
It is discharged to the outside via 25.

After the lapse of TA time, the valve 130 is opened,
The RO water in the pipe K1 is guided to the spectrophotometer 84 (ABS) via the pipe K17, the absorbance of the RO water is measured, and the zero point of the spectrophotometer 84 is set by setting the measured value to zero. Next, any of the valves 104 to 106 (the valve 104 in the embodiment) is opened. Also, the valves 102, 1
It is selected whether the valve 10 is opened or the valve 109 is opened (in the embodiment, the valves 102 and 110 are opened).

Further, the valves 107, 111, 114, 11
5, 117, 118, 125, 126 are opened, and the valves 103, 112, 113, 116, 119 to 121, 1 are opened.
23, 124, 127 and 128 are closed. Then, while rotating the adjustment pump PU1 at the flow rate QBi,
The adjustment pump PU2 is also rotationally driven to supply the creatine aqueous solution from the creatine constant temperature tank KT2, and the pipe K
4, K1, adjustment pump PU1, pipes K7, K9, K1
0, blood inlet coupler 62, blood inlet port 26, blood passage of dialyzer 17, blood outlet port 27, blood outlet coupler 63, pipes K11, K12, adjustment pump PU
2. It is discharged to the outside through the pipes K13 and K7 and the valve 125.

In the case of pressure TMP control, blood inlet pressure sensor PS1 and blood outlet pressure sensor PS
2. The rotation of the adjusting pump PU2 is controlled so that the pressure detected by the dialysate inlet pressure sensor PS3 and the dialysate outlet pressure sensor PS4 becomes the set pressure, and the flow rate QF
In the case of control, set the adjustment pump PU2 to the specified flow rate QBo.
Drive to rotate with. Note that QF = QBi-QBo (where QBi ≧ QBo).

Further, the adjustment pump PU3 is set to the specified flow rate QDi.
Drive the RO water to supply the RO water from the RO water constant temperature tank KT1 to the pipes K1, K3, K2, the adjusting pump PU3, the pipe K14, the dialysate inlet coupler 64, the dialysate inlet port 2
8, dialysate passage of dialyzer 17, dialysate outlet port 29, dialysate outlet coupler 65, pipe K15, valve 1
It is discharged to the outside via 26. Then, the valve 130
Is opened, and the RO water in the pipe K1 is led to the spectrophotometer 84 (ABS) through the pipe K17, and the spectrophotometer of this RO water is measured as CBi.

After the prescribed TC2 hours have elapsed since the adjustment pumps PU1 to PU3 were rotationally driven, the valve 130
And the valve 127 is opened, and the pipe K1 is closed.
The creatine aqueous solution of No. 3 is led to a spectrophotometer 84 (ABS) via pipes K18 and K17, and the spectrophotometric value of this creatine aqueous solution is measured as CBo. After the measurement, the valve 127 is closed, the valve 128 is opened, and the pipe K
Liquid in 15 (RO water containing creatine solution)
To the spectrophotometer 84 (A
BS) and measure the spectrophotometric value of this liquid as CDo.

[Filling Volume (Priming Volume) Test] The filling volume test is performed by using the liquid of the dialyzer 17,
For example, it is a test for measuring the RO water discharged when air of a predetermined pressure is applied to the blood passage filled with RO water. This test assumes that the dialyzer 17 is filled with RO water. First, the RO water in the beaker 79 on the electronic balance 80 is pumped out by the pump PU4 to adjust the zero point of the electronic balance 80.

Next, the valves 114, 116 and 124 are opened and the valves 111 to 113, 115, 117 and 12 are opened.
Close 3,125. Then, the valve 121 is opened, and air having a pressure of about 0.5 kg / cm ² is applied from the air supply source AIR to the blood passage of the dialyzer 17 for a period of T1 through the pipes K9 and K10. The RO water in the blood passage is discharged into the beaker 79 on the electronic balance 80 via the pipes K11, K7 and the valve 124. Next, in the same manner as above, the air supply source AIR
From the above, air having a higher pressure than the above is applied to the blood passage of the dialyzer 17 through the pipes K9 and K10 for T2 time, and the RO water in the blood passage of the dialyzer 17 is passed through the pipes K11, K7 and the valve 124. Electronic balance 80
Discharge into the upper beaker 79.

After that, the displayed value of the electronic balance 80 is read and the capacity is measured. As described above, the reason why high pressure air is not applied to the blood passage of the dialyzer 17 from the beginning is to prevent the RO water from being drastically discharged and scattered in the beaker 79 of the electronic balance 80. is there.
Next, the valves 119 and 120 are opened and the valves 118 and
123 and 126 are closed. And the air supply source AIR
From the valve 120, the pipe K1
6, K15 to the dialysate passage of the dialyzer 17, and the RO water in the dialysate passage is discharged to the outside through the pipe K14 and the valve 119.

The purpose of this process is to drain the RO water in the dialysate passage of the dialyzer 17, regardless of the measurement. When each test is completed as described above, each fitting / removing cylinder 72, 73, 76, 77 is actuated, and each coupler 62-65 is connected to each port 26 of the dialyzer 17.
Separate from ~ 29. Next, the movable members 58 and 59 are separated from the dialyzer 17 at the inspection position by the movable member cylinders 60 and 61 and returned to the original position. afterwards,
Motor 56 for raising and lowering the upper and lower coupler units 50, 51,
57 is driven to rotate, and upper / lower coupler units 50, 5
The first elevating member 54, 55 moves up and down and returns to the original position.

Next, by the table rotation motor 20,
The sample table 19 is driven to rotate by a predetermined angle, the dialyzer 17 that has completed the inspection is transported from the inspection position, the next dialyzer 17 is transported to the inspection position, and each test is performed in the same manner as above. When all the dialyzer 17 on the sample table 19 have been inspected as described above, the dialyzer inspection device is stopped. Then, the cover 9 is removed and the dialyzer 17 is removed from the sample table 19.

[0065]

As described in detail above, according to the present invention,
Since the internal atmospheric temperature is maintained at a substantially physiological temperature and a constant temperature chamber for circulating a fluid is provided inside the dialyzer, it is easy to handle and the inspection of the dialyzer can be automated.

[Brief description of drawings]

FIG. 1 is a front sectional view showing an embodiment of the present invention.

FIG. 2 is a plan view showing an embodiment of the present invention.

FIG. 3 is a vertical side sectional view showing an embodiment of the present invention.

FIG. 4 is a front cross-sectional view of a dialyzer transfer device showing an embodiment of the present invention.

FIG. 5 is a partially sectional front view of a dialyzer connecting device and the like showing one embodiment of the present invention.

FIG. 6 is a partially sectional front view of a dialyzer connecting device and the like showing an embodiment of the present invention.

7 is a cross-sectional view taken along the line AA of FIG.

FIG. 8 is a front sectional view of a fitting member and the like showing an embodiment of the present invention.

FIG. 9 is a test circuit diagram showing an embodiment of the present invention.

FIG. 10 is a partial front cross-sectional view of the liquid detection device showing the embodiment of the present invention.

FIG. 11 is a control circuit diagram showing an embodiment of the present invention.

[Explanation of symbols]

1 ... Case, 2 ... Warm air supply device, 3 ... Dializer conveyance device, 4 ... Dializer connection device, 11, 12 ... Left / right constant temperature chamber, 16 ... Examination room, 17 ... Dializer, 1
9 ... Sample table, 20 ... Table rotation motor,
23 ... Hollow fiber bundle, 26 ... Blood inlet port, 27 ... Blood outlet port, 28 ... Dialysate inlet port, 29 ... Dialysate outlet port, 50, 51 ... Upper / lower coupler unit, 54, 5
5 ... Lifting member, 56, 57 ... Lifting motor, 58, 59
... Movable member, 60, 61 ... Cylinder for movable member, 62
... blood inlet coupler, 63 ... blood outlet coupler, 64 ... dialysate inlet coupler, 65 ... dialysate outlet coupler, 72, 73,
76, 77 ... Fitting / removing cylinder, 79 ... Beaker (container), 80 ... Electronic balance (measuring device), 84 ... Spectrophotometer (concentration inspection device), 86 ... Tube, 88 ... Thread, 90 ...
Personal computer 101-121, 123-1
28, 130 ... Valve, AIR ... Air supply source, KT1 ...
RO water constant temperature tank, KT2 ... Creatine constant temperature tank, K
T3 ... urea thermostatic tank, KT4 ... vitamin B ₁₂ thermostatic tank, KT5 ... dialysate thermostatic tank, PS1 ... Blood inlet pressure sensor, PS2 ... blood outlet pressure sensor, PS3 ... dialysate inlet pressure sensor, PS4 ... dialysate outlet pressure sensor , PU1 to PU3 ... Adjusting pumps, PU4, PU5 ...
Pump, TS1 ... Blood inlet temperature sensor, TS2 ... Dialysate inlet temperature sensor.

Claims (1)

[Claims] 1. A tester for inspecting a dialyzer by circulating a fluid in the dialyzer, wherein a temperature-controlled room is provided in which the internal ambient temperature is maintained at substantially physiological temperature and the fluid is internally flown in the dialyzer. A dialyzer inspection device characterized by.