JPH06178671A - Food containing chondroitin sulfate protein complex - Google Patents

Abstract

PURPOSE:To obtain a food containing chondroitin sulfate protein complex capable of effectively absorbing calcium by a user, useful for preventing and treating osteoporosis. CONSTITUTION:A food containing chondroitin sulfate protein complex is obtained by blending 20-80 chondroitin sulfate protein complex with 3 pts.wt. calcium or a calcium-containing material (in terms of content converted into calcium).

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a food containing chondroitin sulfate protein complex, and more specifically,
The present invention relates to a chondroitin sulfate protein complex-containing food that can effectively absorb calcium and that is effective for preventing or treating osteoporosis.

[0002]

2. Description of the Related Art The dietary habits of Japan in recent years have almost satisfied the nutritional requirements, but the intake of calcium alone is still insufficient. Moreover, it is expected that the aging will continue to progress, and there is concern that osteoporosis will increase as a result. Osteoporosis is more likely to occur in post-menopausal women, resulting in a decrease in bone mineral, fragile bones, and easy fracture.
In addition, a fracture requires a long time for treatment, which is one of the illnesses that imposes a heavy mental, physical and financial burden on the patient.

It is said that one of the causes of osteoporosis is disturbance of hormone balance in the body, and in particular, estrogen is deeply involved and it is said that the decrease in secretion due to menopause triggers the onset of the disease. In addition, processed foods have become widespread in recent years, and since phosphates are used as food additives for various purposes in these, the intake of phosphorus is gradually increasing, and the suppression of calcium absorption by phosphorus is also a factor. It is said that It is conventionally said that active intake of calcium through diet is effective in preventing or treating osteoporosis, and boiled milk, milk and the like are known as foods having an osteoporosis preventive and therapeutic effect.

[0004]

However, the absorption rate of calcium ingested from milk or the like which has been boiled as a conventional food having a preventive and therapeutic effect on osteoporosis is not good, and its effect is low. For this reason, there is a demand for foods having a higher therapeutic effect, especially foods in which ingested calcium is effectively absorbed in the body. Therefore,
An object of the present invention is to provide a chondroitin sulfate protein complex-containing food that can effectively absorb calcium and is useful for preventing or treating osteoporosis.

[0005]

[Means for Solving the Problems] In general, chondroitin sulfate is known in the fields of biochemistry or medicine to contribute to wound healing and fossil formation of connective tissues of animals,
As a medicine, it is mainly handled only for the purpose of treating wounds. Therefore, it has not been admitted that chondroitin sulfate, its salt, etc. are added orally or to foods. The present inventors, as a result of diligent research, surprisingly, even such a chondroitin sulfate complex bound to a protein, that is, a chondroitin sulfate protein complex effectively acts on calcium in food to effectively absorb calcium. It was discovered that it would take place. That is, the present invention has achieved the above-mentioned object based on the above-mentioned findings, and it is preferable to add 20 to 80 parts by weight of chondroitin sulfate protein complex per 3 parts by weight of calcium or its content converted to calcium. It is intended to provide a food containing a characteristic chondroitin sulfate protein complex which is suitable for absorbing calcium. Further, such foods suitable for absorption of calcium can be widely used for preventive and therapeutic treatment of osteoporosis, etc., and can be used as a meal food or an oral drug.

The present invention will be described in detail below. The chondroitin sulfate protein complex used in the present invention is a digestion product of cartilage-derived chondroitin sulfate proteoglycan with a protease. The chondroitin sulfate protein complex may be added to the food product as a powder, or the effect is not changed even if it is added in any form depending on the shape of the intended food product. Therefore, it can be applied to many foods. For example, bread, French bread, butter roll, milkshake, corn soup, potage soup, curry, stew, sugar-coated tablets, capsules and the like. By the way, conventionally, calcium carbonate has been widely used as a supplemental source of calcium in the prevention and treatment of osteoporosis. Calcium carbonate is inexpensive and can supply a large amount of calcium, but it is very unsatisfactory in terms of its effect. That is, the ingested calcium is not sufficiently absorbed in the body and is excreted outside the body.

[0007] The present inventor believes that when a chondroitin sulfate protein complex is ingested together with calcium carbonate, it has a strong effect. When the present invention was conducted under the following conditions, the chondroitin sulfate protein complex was added to the calcium carbonate. It has been found that the strongest effect is obtained when a feed adjusted to 0.3% by weight is fed, especially when a feed added with 4% by weight of chondroitin sulfate protein complex is fed. That is, 20-80 parts by weight of chondroitin sulfate protein complex per 3 parts by weight of calcium showed a calcium absorption promoting effect, and particularly 40 parts by weight of chondroitin sulfate protein complex was most effective. When the amount of chondroitin sulfate protein complex is 20 parts by weight or less, no increase in bone strength can be obtained, and when it is 80 parts by weight or more, the chondroitin sulfate protein complex contains 12.5% by weight of fibrous material, so that excretion function It is not preferable because it shows symptoms such as increased diarrhea. In addition, various vitamins can be added to such foods as long as the above-mentioned purpose is not impaired. Among various vitamins, vitamin D is particularly preferable for the above purpose.

[0008]

EXAMPLES Examples of chondroitin sulfate protein complex-containing foods according to the present invention will be shown below, but the present invention is not limited to the following examples. Example 1 Bread was produced using the following raw materials. Powerful flour 248.37 g Dry yeast 3.00 g Chondroitin sulfate protein complex 1.00 g Calcium carbonate 0.38 g Salt 5.00 g Sugar 10.00 g Skim milk 3.00 g Butter 10.00 g Calcium (Ca) and chondroitin sulfate in food above The weight ratio with the protein complex (SCP) is (Ca) :( S
CP) = 3: 20.

Example 2 A soup was produced using the following raw materials. Sweet corn 250.0 g Butter 30.0 g Onion 20.0 g Wheat flour 15.0 g Chondroitin sulfate protein complex 5.0 g Calcium carbonate 1.0 g Milk 200 ml Salt 1.5 g Pepper 0.1 g Sugar 1 0.0 g garlic 5.0 mg celery 5.0 mg laurel 1.0 mg sodium glutamate 0.1 g sodium inosinate 0.01 g The weight ratio between calcium (Ca) and chondroitin sulfate protein complex (SCP) in the food above is , (Ca): (S
CP) = 3: 40.

(Example 3) Using the following raw materials, curry was produced by a conventional method to produce a retort food. Carrot 100.0 g Potato 300.0 g Onion 200.0 g Beef 300.0 g Curry powder 5.0 g Wheat flour 30.0 g Chondroitin sulfate protein complex 12.5 g Calcium carbonate 1.2 g Salt 5.0 g Pepper 1.0 g Sugar 0.1 g The weight ratio of calcium (Ca) and chondroitin sulfate protein complex (SCP) in foods containing 1.0 g or more of sodium glutamate is (Ca) :( S
CP) = 3: 80.

Example 4 A tablet was produced using the following raw materials. Chondroitin sulfate protein complex 300 mg Calcium carbonate 50 mg Vitamin B ₂ 5 mg Vitamin C 100 mg Vitamin D 0.25 mg Vitamin K 0.50 mg Lactose 100 mg Corn starch 44.25 mg Total 600.00 mg The tablets were coated with sugar. Calcium in the above foods (C
The weight ratio of a) to the chondroitin sulfate protein complex (SCP) was (Ca) :( SCP) = 3: 40. (Example 5) Shape formulation 600 of untableted powder of Example 4
Hard capsules were filled with mg to obtain capsules. (Example 6) A rat feed simulating the composition ratio of calcium and chondroitin sulfate protein complex of Examples 1 to 5 was prepared, and the following measurement and evaluation were performed. The ovaries of SD female rats were excised and a low-calcium diet (0.01% by weight of calcium) was administered for 12 days to experimentally establish osteoporosis. Next, each diet and control diet are given 15
Reared for days. The experimental diets were the experimental feeds shown in Tables 1 to 4 below. In addition, Table 2 shows the mixed composition of vitamins used in the feed diet of Table 1, Table 3 shows the free mineral composition of Ca and P, and Table 4 shows the specifications and test results of the chondroitin sulfate protein complex. It is a thing.

In the rearing group, a low calcium diet was administered, followed by administration of a normal diet containing 0.3% by weight of calcium and 2% by weight of the chondroitin sulfate protein complex (S2 in FIGS. 1 and 2). , A food containing 4% by weight of chondroitin sulfate protein complex (S4 in FIGS. 1 and 2) and a food containing 8% by weight of chondroitin sulfate protein complex (see FIGS. 1 and 2) S8). In the comparative group, a low calcium diet was administered and then only a normal diet containing 0.3% by weight of calcium was administered (L in FIGS. 1 and 2). The fed control group was a normal diet containing 0.3% by weight of calcium shown in Table 1 during the breeding period (N in FIGS. 1 and 2).

Rats were placed in stainless cages one by one, and distilled water and feed were freely taken under the environment of room temperature 23 ± 2 ° C. and humidity 55 ± 10%. A metabolic test was conducted for 2 days before the end of breeding, feces and urine were collected, and the calcium content in each was measured to determine the balance of calcium components. After the end of the breeding period, the femur was dissected out to remove the femur, and the fracture of the femur was measured by a fracture characteristic measuring device (Toyo Seiki Seisakusho, Strograph R2). The calcium content was analyzed by ashing in an electric furnace at 590 ° C. for 24 hours and then measuring by atomic absorption method.

[0014]

[Table 1]

[0015]

[Table 2]

[0016]

[Table 3]

[0017]

[Table 4]

Evaluation Results The results of calcium balance of SD female rats fed with each feed are shown in FIG. In the group to which the chondroitin sulfate protein complex was added, the calcium absorption rate increased. Here, the absorption rate indicates the ratio of the amount of calcium absorbed in the body to the amount of calcium in the ingested feed, and the absorption amount is the amount of calcium ingested minus the amount of calcium excreted in the feces. . It can be seen that the absorption rate is increased by adding the chondroitin sulfate protein complex to the feed. Also, in the results of measuring the femoral fracture strength, as shown in FIG. 2, in the group to which the chondroitin sulfate protein complex was added, an increase in femoral fracture strength, that is, an increase in bone strength was found. Especially, when the feed containing 4% by weight of the chondroitin sulfate protein complex was fed, the strongest effect was exhibited. Therefore, such foods are useful for preventing osteoporosis,
It has a remarkable effect on treatment, and depending on taste and use, it can be used as a food for preventing or treating osteoporosis in the form of the food containing chondroitin sulfate protein complex as it is.

[0019]

INDUSTRIAL APPLICABILITY By ingesting the food of the present invention, absorption of calcium into the body is promoted, and osteoporosis can be prevented or treated.

[Brief description of drawings]

FIG. 1 is a bar graph showing the amount of calcium balance when each diet of this example and the diets of its control and comparative examples were fed to rats.

FIG. 2 is a bar graph showing the strength of the femur of each diet of this example and the diets of the control and comparative examples thereof, which were fed to rats.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Takashi Baba 16-2 Wadai, Tsukuba City, Ibaraki Prefecture Central Research Institute, Taiyo Fisheries Co., Ltd.

Claims (2)

[Claims] 1. A chondroitin sulfate-protein complex-containing food containing 20 to 80 parts by weight of chondroitin sulfate-protein complex per 3 parts by weight of calcium or its content converted to calcium. 2. A food containing chondroitin sulfate protein complex, wherein the food according to claim 1 is a medicinal food or an oral drug used for the prevention or treatment of osteoporosis.