JPH0616052B2 - Reagent dispenser - Google Patents

Description

TECHNICAL FIELD The present invention relates to a dispensing device, and particularly to a reagent dispensing device suitable for use in an automatic chemical analysis device.

(Prior Art) Generally, in an automatic chemical analyzer, many kinds of reagents are used to perform an analysis of porous cells. As a conventional reagent dispensing device that dispenses such various types of reagents, (1)
Dispensing syringe and dispensing nozzle are provided for each reagent, (2) One common dispensing syringe and dispensing nozzle are provided for multiple reagents, and the dispensing nozzle is moved to move multiple reagents. (3) that allows for selective dispensing of
As known from Japanese Patent Laid-Open No. 58-76764, there is a rotary type flow path switching valve provided to select a plurality of reagent discharge flow paths.

However, the dispensing device in (1) above requires a number of dispensing syringes equal to the number of reagents, which causes the entire analyzer to become bulky, and the dispensing nozzle moving type in (2) However, there is a problem that the moving mechanism becomes complicated and the reagents are easily contaminated with each other. Also, (3)
In the case of using the rotary type flow path switching valve of (1), when the reagent is quantitatively diluted with the cleaning solution that also serves as the diluting solution, the reagent is pushed out by the cleaning solution, so the flow path switching valve causes contamination between the reagents. However, if you try to dispense only the reagent, the cleaning liquid will remain between the flow path switching valve and the reagent discharge port in this case as well, and this will cause contamination between the reagents. There is a problem that it is practically impossible to order.

On the other hand, in the automatic analyzer, the number of channels, that is, the number of analysis items may increase. However, above (1)
In the case of using the dispensing device of (1), a dispensing syringe must be added as the number of dispensing reagents increases, and the work is extremely troublesome and the structure is complicated. Also,
In the case of using the dispensing device of (2), if the reagent is set on the turntable and aspirated by the dispensing nozzle at a predetermined position, it is possible to easily deal with the increase of the dispensing reagent. Even in some cases, there is a problem of contamination between reagents. Further, in the case of using the dispensing device of (3), the flow path switching valve may be replaced, but the replacement is extremely troublesome and not easy, and there is a problem that the structure is complicated.

(Object of the invention) An object of the present invention is to solve the above-mentioned various problems, and to dispense only a plurality of reagents selectively without causing contamination between them. It is an object of the present invention to provide a reagent dispensing apparatus that is appropriately configured so as to easily deal with an increase.

(Summary of the Invention) A reagent dispensing apparatus according to the present invention is configured such that one end of a first common channel is selectively connected to a reagent dispensing nozzle and a reagent container.
And a second switching valve that selectively connects the other end of the first common flow path to one end of the second common flow path and the drainage flow path. Means integrally provided, a common suction / discharge means connected to the other end of each of the plurality of second common channels connected to the rotary valve, and a cleaning liquid supply means connected to the suction / discharge means The cleaning liquid supply means is configured to wash the second common flow path by flowing the cleaning liquid through the suction / discharge means, the second common flow path and the drainage flow path. It is a thing.

FIG. 1 shows the principle of the present invention. In the present invention, a plurality of, in the illustrated example, two flow path switching means 1 are connected to a dispensing cylinder 2 serving as a common suction / discharge means, and a cleaning liquid supply means 3 is connected to this dispensing syringe 2. Each channel switching means 1 is a first switching for selectively connecting a dispensing nozzle 5 for dispensing a reagent into a container 4 and a reagent tank 6 containing a reagent to one end of a first common channel 7. The valve 8, the other end of the first common channel 7 and one end of the drainage channel 9 are connected to the second common channel 10
And a second switching valve 11 for selectively connecting to one end of the second common flow path 10 and the other end of the second common flow path 10 is connected to the dispensing syringe 2 via a manifold block 12. Also,
The cleaning liquid supply means 3 is a cleaning liquid tank 13 containing a cleaning liquid,
It comprises a pump 14 and an opening / closing valve 15, and the inlet side of the pump 14 is connected to the washing tank 13 and the outlet side thereof is connected to the dispensing syringe 2 via the opening / closing valve 15.

In the present invention, the common dispensing syringe 2 is used to operate each of the flow path switching means 1 to dispense the reagent. Since the flow path reaching the reagent tank 6 is filled with the reagent and the other flow paths are filled with the cleaning liquid, the reagent is dispensed by the suction operation of the dispensing syringe 2 in the first common flow path 7 when dispensing the reagent. Will be sucked into. However, when the reagent infiltrates into the first common channel 7 in this way, this may gradually diffuse into the second common channel 10 to cause contamination with the reagent in the other channel switching means 1. Maru Further, when the reagent tank 6 connected to any one of the flow path switching means 1 becomes empty and the air enters the first common flow path 10, the fixed amount of the reagent in the other flow path switching means 1 is dispensed. Can not be done accurately.

Therefore, in the present invention, for example, each time a reagent is dispensed, after the reagent is aspirated or discharged, the washing liquid is supplied by the washing liquid supply means 3 through the dispensing syringe 2, the second common channel 10 and the drainage channel 9. To flush. If you do this,
The second common flow channel 10 is washed with the cleaning liquid and the second common flow channel 10 of the flow channel switching means 1 of the empty reagent tank 6 is washed.
Will also be filled with cleaning solution. Therefore, the reagent can be dispensed accurately and always without causing contamination.

Also, in a preferred embodiment of the present invention, a rotary valve,
With multiple sets of dispensing syringes connected to this,
Each set of rotary valves is unitized with a common drive means for driving them simultaneously. In this way, by preparing a large number of units having the number of flow path switching means corresponding to the predetermined number of dispensing syringes and connecting the necessary number of units to the dispensing syringes, various channel configurations are provided. An automatic chemical analyzer can be easily realized, and an increase in the dispensing reagent can be easily dealt with without adding a dispensing syringe. Therefore, it is possible to quickly and easily respond to the user's request, and it is possible to easily perform inspection and repair. Also,
Since the unit configurations are exactly the same, the manufacturing cost of the entire apparatus can be reduced.

(Embodiment) FIG. 2 shows a structure of a main part of an embodiment of the present invention. In this example, four dispensing syringes 21-1 to 21-4 and two units 22-1 and 22-2 are provided. Units 22-1 and 22-2
Have the same structure and are driven independently of each other
23-1 and 23-2, and four rotary valves 25A-1 to 25D-1 and 25A-2 of the same configuration, which are simultaneously driven by the respective motors via drive mechanisms 24-1 and 24-2.
~ 25D-2. Each rotary valve corresponds to one analysis item, that is, one channel, and in this example, each of the rotary valves selectively dispenses the first and second types of reagents. Therefore, each rotary valve has two flow path switching means. That is, as shown in an enlarged view of one rotary valve 25 in FIG. 3, long grooves 26-1 and 26-2 as the first switching valve of each flow path switching means are formed along the same circumference. At the same time, elongated grooves 27-1a and 27-1b as second switching valves 27-2a and 27-2b are formed along the concentric circles inside the elongated grooves 26-1 on the outer circumference. Discharge ports 28-1; 28-2 connected to the dispensing nozzle so as to be selectively connected to 26-2, suction ports 29-1; 29-2 connected to the reagent tank, and these discharge ports 28-1; 28-2
And the suction ports 29-1; 29-2 so as to be selectively connected to the suction ports 29-1; 29-2 via the long grooves 26-1; 26-2.
-2 and form. Also, on the inner circumference, long grooves 27-1a, 2
7-1b; 27-2a; 27-2b and common ports 31-1; 31-2 connected to the second common flow path so as to be selectively connected to the second grooves, and long grooves 27-1b; 27-2b Drainage ports 32-1; 32-2 connected to the drainage flow path so as to be selectively connected to the common ports 31-1; 31-2 via
And the connecting ports 33-1; 33 of the first common flow channel so as to be selectively connected to the common ports 31-1; 31-2 via the long grooves 27-1a; 27-2a.
-2, and the inner connection ports 33-1; 33-2 and the outer connection ports 30-1; 30-2 are connected by the evacuation pipes 34-1; 34-2 to form a first common port. Configure the flow path.

One rotary valve 25A-1 in unit 22-1
The suction ports 29-1 and 29-2 are connected to the corresponding first and second reagent tanks 42-1 and 42-2 stored in the reagent cooler 41, and the discharge ports 28-1 and 28- 2 is connected to the dispensing nozzles 44-1 and 44-2 arranged at a predetermined position where the reaction container 43 containing the test liquid is transferred, and a common port 31-1
And 31-2 are connected to the manifold block 46 for four stations via the second common flow paths 45-1 and 45-2, respectively, and the drain ports 32-1 and 32-2 are connected to the drain flow channel 47. -1 and 47-2 are connected respectively. Manifold block 46 has four connecting channels 48
-1 to 48-4 and a common flow channel 49 connected to these connection flow channels, respectively, and the common ports 31-1 and 31 of the rotary valve 25A-1 are connected to the connection flow channels 48-1 and 48-2. The other ends of the second common channels 45-1 and 45-2, whose one ends are connected to -2, are connected to each other.

Similarly, one rotary valve 25 in unit 22-2
The suction ports 29-1 and 29-2 of A-2 are connected to the corresponding first and second reagent tanks 42-3 and 42-4 housed in the reagent cooler 41,
The discharge ports 28-1 and 28-2 are connected to the dispensing nozzles 44-3 and 44-4 arranged at predetermined positions where the reaction container 43 containing the test liquid is transferred, and the common ports 31-1 and 31 are connected. -2 is connected to the manifold block 46 via the second common flow paths 45-3, 45-4 to the connection flow paths 48-3, 48-4, and to the drain ports 32-1, 32-2. The drainage channels 47-3 and 47-4 are connected.

Manifold block 46 with one rotary valve 25A-1 and 25A-2 of units 22-1 and 22-2 respectively
The common flow path 49 is connected to the dispensing syringe 21-1, and this dispensing syringe 21-1 has an opening / closing valve 50, a branch block 51 and a pump.
It is connected via 52 to a cleaning liquid tank 53 containing a cleaning liquid. The branch block 51 includes a main channel 54 and four branch channels 55-1 to 55-4 connected to the main channel,
The main flow path 54 is a pump 52, and one branch flow path 55-1 is an opening / closing valve 50.
Connect to each.

Although the connection regarding the dispensing syringe 21-1 has been described above, the other rotary valves 25B-1 of the units 22-1 and 22-2 are also provided for the other dispensing syringes 21-2 to 21-4. ~ 25D-1
And 25B-2 to 25D-2, for example, a dispensing syringe 21-2
Rotary valves 25B-1 and 25B-2 to the dispensing syringe 21-3
Rotary valves 25C-1 and 25C-2 to the dispensing syringe 21-4
Corresponding rotary valves 25D-1 and 25D-2 to, and similarly connected using a 4-way manifold block, each dispensing syringe 21-2 to 21-4 is branched through an on-off valve. Connected to the branch channels 55-2 to 55-4.

Thus, in this example, each dispensing syringe 21-1-21
In -4, four kinds of reagents are selectively dispensed respectively, but when additional reagents are required, units are added and each of them has a manifold block or a corresponding connection port. Replace with a dispensing syringe 21-1 ~
Just connect it to 21-4.

4A to 4C show an example of the configuration of the unit. In this example, four rotary valves are provided, but these four rotary valves (one rotary valve is indicated by reference numeral 25 in the figure) are held on the base 61,
Each drive shaft 62 is connected to one end of a valve drive shaft 64-1 to 64-4 rotatably attached to a base 61 via a bearing 63 via a drive pin 65. The drive pins 65 are held by the drive pin receivers 66, respectively. One end of each of the levers 67-1 to 67-4 is fixed to each of the valve drive shafts 64-1 to 64-4, and the other end of each of these levers is connected to a connecting plate 69 via a bearing 68. One valve drive shaft, in the figure, the other end of the valve drive shaft 64-2 is coupled 70
Via the output shaft 71 of the motor 23 held by the base 61. In this way, one motor 23 drives the four valve drive shafts 64-1 to 64-4, and thus the drive shafts 62 of the four rotary valves via the levers 67-1 to 67-4 and the connecting plate 69. Drive at the same time. A peeling spring 72 is wound between each lever 67-1 to 67-4 and the drive pin receiver 66.

By driving the motor 23, the four rotary valves simultaneously assume the same state, that is, the origin state, the second reagent suction state, the first reagent suction state, the washing state, the first reagent discharge state, and the second reagent discharge state. To set. In order to detect each of these states, a detection plate 73 is attached to the coupling 70, and two notches 74-1 and 74-2 are formed at predetermined positions of the detection plate 73, and these decisions are made in a predetermined positional relationship. So that the origin position sensor 75, the second suction sensor 76, the first suction sensor 77, the cleaning sensor 78, the first discharge sensor 79, and the second discharge sensor 80, which are formed of a host interpolator fixed to the base 61, detect Constitute.

Next, the operation of this embodiment will be described with reference to FIGS. 5A to 5F and FIG.

(1) Initialization of dispensing device First, the initial setting operation of the dispensing device will be described. In each unit 22-1, 22-2, four rotary valves 25A-
1 to 25D-1, 25A-2 to 25D-2 are in the same state at the same time,
The operation will be described focusing on one rotary valve 25A-1 of the unit 22-1. Unit 22 in steady state
-1 and 22-2 are in the origin state in which the origin position sensor 75 detects the decision 74-1 formed on the detection plate 73, and in that state, each of the rotary valves of each unit is shown in FIG. 5A. It is in the state shown. First, the motor 23-1 of the unit 22-1 is driven to rotate the detection plate 73 counterclockwise until the first discharge sensor 79 detects the decision 74-2 in FIG. 4B. As a result, as shown in FIG. 5E, the second common flow channel 45-1, the evacuation pipe 34-1, and the discharge port 28-1 are connected to each other via the long grooves 26-1 and 27-1b to be in the reagent discharge state. To do. In this state, start valve 50
Is opened and the pump 52 is operated, whereby the cleaning liquid is discharged from the dispensing nozzle 44-1 through the manifold block 46 and the rotary valve 25A-1.

Next, the motor 23-1 is driven to rotate the detection plate 73 in the clockwise direction until the first suction sensor 77 detects the notch 74-1 in FIG. 4B. Long groove as shown
The second common flow channel 45-1, the evacuation pipe 3 via 26-1 and 27-1a
4-1 and the suction port 29-1 are connected to obtain the first reagent suction state. In this state, the on-off valve 50 is closed and the dispensing syringe 21-1
By this suction operation, the reagent is sucked from the first reagent tank 42-1 into the retracting pipe 34-1 of the rotary valve 25A-1. Thereafter, the rotary valve 25A-1 is set to the first reagent discharge state shown in FIG. 5E, and the sucked reagent is pushed out to the dispensing nozzle 44-1 side by the discharging operation of the dispensing syringe 21-1. Perform the above operation once or multiple times to dispense pipette nozzle 44-1 from discharge port 28-1.
Fill up to the tip of the reagent with the long groove 26-1, evacuation tube 34
-1, Fill the long grooves 27-1a and 27-1b with the cleaning liquid.

Next, the motor 23-1 is driven to rotate the detection plate 73 counterclockwise from the origin position until the second discharge sensor 80 detects the cutout 74-2 in FIG. As shown in FIG. 5F, the second common flow channel 45-2, the evacuation tube 34-2, and the discharge port 28-2 are connected to each other via the long grooves 26-2 and 27-2b to be in the second reagent discharge state. . In this state, the same cleaning liquid supply operation as described above is performed to discharge the cleaning liquid from the dispensing nozzle 44-2.

Next, the motor 23-1 is driven to rotate the detection plate 73 in the clockwise direction until the second suction sensor 76 detects the notch 74-1 in FIG. 4B. Long groove as shown
The second common flow channel 45-2 and the evacuation pipe 3 via 26-2 and 27-2a
4-2 and the suction port 29-2 are connected to obtain the second reagent suction state. In this state, the on-off valve 50 is closed and the dispensing syringe 21-1
By the suction operation of (2), the reagent is sucked from the second reagent tank 42-2 into the retreat tube 34-2 of the rotary valve 25A-1. Then, the rotary valve 25A-1 is sucked in the second reagent discharge state shown in FIG. 5F, and the reagent is pushed out to the dispensing nozzle 44-2 side by the discharging operation of the dispensing syringe 21-1. Perform this operation once or multiple times to dispense from the discharge port 28-2 to the dispensing nozzle 44-2.
Fill up to the tip of the sample with reagent, and insert the long groove 26-2
-2, fill the long groove 27-2b with the cleaning liquid.

Next, the motor 23-1 is driven to rotate the detection plate 73 counterclockwise from the origin position until the cleaning sensor 78 detects the notch 74-1 in FIG. 4B, and as a result, FIG. As shown in D, the second common flow channel 45-1 is connected to the drainage flow channel 47-1 via the long groove 27-1b, and the second common flow channel 45-is connected via the long groove 27-2b. 2 and the drainage channel 44-1 are connected to each other to be in a cleaning state. In this state, the on-off valve 50 is opened and the pump 52 is operated, whereby the cleaning liquid is supplied to the manifold block 46, the second common flow paths 45-1 and 45-2 and the drainage flow paths 47-1 and 47-2. Then wash away.

By the above operation, the dispensing nozzle
-1 to the flow path and the first reagent tank 42-1 to the suction port 29
-1 is filled with the first reagent, and the flow path from the tip of the dispensing nozzle 44-2 to the discharge port 28-2 and the second reagent tank 42-2 to the suction port 29-2 The flow channel is filled with the second reagent, and the other flow channels are filled with the cleaning liquid.

Although the initial setting operation has been described by focusing on the rotary valve 25A-1, the rotary valves 25A-1 to 25D-1 are in the same state at the same time, so that the other dispensing syringes 21-2 to 21-4 and By similarly operating the on-off valves connected to each, the same initialization can be performed at the same time.

After the initialization of the unit 22-1, the rotary valves 25A-1 to 25D-1 of the unit 22-1 are set to the origin state and the unit 22-2 is similarly initialized.

(2) Dispensing operation of reagent into reaction container After initialization, select units 22-1 and 22-2, and dispense syringe via the selected unit.
21-1 to 21-4 are used to simultaneously or selectively dispense reagents. The sequential dispensing operation of the two kinds of reagents by the rotary valve 25A-1 of the unit 22-1 will be described below. First, with the open / close valve 50 closed, set the rotary valve 25A-1 to the 5th position.
From the origin state shown in FIG. A to the right by one step, the second reagent suction state shown in FIG. 5B is obtained. In this state, the dispensing syringe 21-1 sucks the second reagent tank 42-1 from the second reagent tank 42-1. Aspirate a predetermined amount or a little larger amount of reagent. As a result, the aspirated amount of reagent passes through the long groove 26-2 and the evacuation tube 34-2.
It is sucked inside. Next, the rotary valve 25A-1 is further rotated rightward by one step to the first reagent suction state shown in FIG. 5C, and in this state, the dispensing syringe 21-1 is further sucked to perform the first suction operation. A predetermined amount or a slightly larger amount of reagent is sucked from the reagent tank 42-2 into the evacuation pipe 34-1 through the long groove 26-1.

After that, the rotary valve 25A-1 is rotated rightward by three steps to the washing state shown in FIG. 5D, and in this state, the opening / closing valve 50 is opened and the pump 52 is operated, whereby the washing liquid is dispensed. -1, the manifold block 46, the second common flow paths 45-1; 45-2 and the long grooves 27-1b; 27-2b to the drainage flow paths 47-1; 47-2 to flow those flow paths. To wash.

Next, the rotary valve 25A-1 is further rotated leftward by one step to the first reagent discharge state shown in FIG. 5E, and the open / close valve 50 is closed in this state to discharge the dispensing syringe 21-1. The first reagent that has been actuated and sucked is discharged from the dispensing nozzle 44-1 into the reaction container 43 that is being conveyed therebelow by a predetermined amount. Next, the rotary valve 25A-1 is further rotated leftward by one step to the second reagent discharge state shown in FIG. 5F,
In this state, the dispensing syringe 21-1 is further discharged and discharged, and the sucked second reagent is discharged from the dispensing nozzle 44-2 to the reaction container 43 which is being conveyed therebelow by a predetermined amount. After that, the rotary valve 25A-1 is rotated to the right by three steps and the fifth
It returns to the original state shown in FIG.

Dispensing syringe 21-1, rotary valve 25 in the sequential reagent dispensing process for the rotary valve 25A-1
A time chart showing the operations of A-1, the on-off valve 50 and the pump 52 is shown in FIG.

As described above, in this embodiment, after the reagent is aspirated, the cleaning liquid is dispensed through the silage 21-1, the manifold block 46, and the second common flow paths 45-1; 45-2, and the drainage flow paths 47-1; 47. Since it is made to flow from -2 to wash those flow paths, it is possible to effectively prevent the above-mentioned contamination due to the diffusion of the reagent into the second common flow path, Even if it becomes empty, the second common flow channel is filled with the cleaning liquid, so that it does not adversely affect the quantitative dispensing of other reagents.

7A to 7F show an example of the structure of an automatic chemical analysis device equipped with the reagent dispensing device of the present invention. FIG. 7A consists of one analysis unit 81 of 24 channels, and FIG. It consists of two analysis units 83-1 and 83-2 of 12 channels, and
FIG. C is composed of three 8-channel analysis units 85-1 to 85-3, each of which analyzes up to 24 items. Also, FIG. 7D shows four analysis units 87-1 with 8 channels.
~ 87-4 analyzes up to 32 items, and Fig. 7E and F show 6 analysis units 89-1 ~ 4 channels each ~
89-6 and eight analysis units 89-1 to 89-8 are used to analyze up to 24 items and 32 items, respectively. In each configuration example, a plurality of racks 92 each holding a plurality of sample cups 92 are set in the rack feeding section 91, and the sequential racks 93 are stored in the racks through a predetermined passage 95 under the control of the controller 94. While being stored in the section 96, the sample in each sample cup 92 is dispensed into a reaction container provided in the reaction line 97 of each analysis unit according to the number of channels of the analysis unit, and a predetermined analysis operation is performed. It is supposed to be.

Each analytical unit comprises four dispensing syringes each. For this reason, in the analysis unit 81 shown in FIG. 7A, as shown in FIG. 8A, six units 22-1 to 22 having the same structure as described above each having four rotary balls are provided. -6 using 4 dispensing syringes 21-1 to 21-4
2 manifold blocks 101-1 and 101 for 6 stations each
Corresponding to -2, each rotary valve of each unit is connected to each dispensing syringe via a manifold block, and is constructed in the same manner as in FIG. In this way, one dispensing syringe is assigned with six rotary valves to selectively dispense up to 12 kinds of reagents. Also, FIG. 7B
In the above, since each of the analysis units 83-1 and 83-2 is responsible for 12 channels, each analysis unit uses three units 22-1 to 22-3, as shown in FIG. 8B. Dispense each rotary valve of each unit into syringe 21-1
21-4 may be connected to each of the dispensing syringes 21-1 to 21-4 via one manifold block 101 for six stations corresponding to each of 21 to 21-4.

Since each analysis unit shown in FIGS. 7C and D is responsible for eight channels, each analysis unit uses two units 22-1, 22-2 as shown in FIG. 8C. The configuration may be similar to that shown in FIG. Further, in FIGS. 7E and 7F, since each analysis unit is responsible for four channels, as shown in FIG. 8D, each of the four rotary valves of one unit 22 is used as a manifold for two stations. Dispensing syringes 21-1 to 2 through block 102
It may be configured by connecting to each of 1-4.

As shown in the above configuration example, by preparing a large number of units having four rotary valves corresponding to the four dispensing syringes and connecting a necessary number of units to the dispensing syringes, various channel configurations can be obtained. It is possible to easily realize an automatic chemical analyzer having the above. Therefore, it is possible to quickly and easily respond to the user's request, and it is possible to easily perform inspection and repair. Further, since the units have exactly the same configuration, the manufacturing cost of the entire apparatus can be reduced.

It should be noted that the present invention is not limited to the examples described above, and many variations and modifications are possible. For example, when the volume of the dispensing syringe is sufficiently large with respect to the amount of the reagent to be dispensed, it is also possible to sequentially aspirate a plurality of reagents to the rotary valves of a plurality of units connected thereto and sequentially discharge them. it can. Also, the rotary valve is 1
It can be configured to correspond to one reagent or three or more reagents, and other suction / discharging means such as a rotary pump can be used instead of the dispensing syringe. Further, the number of rotary valves to be unitized can be set according to the number of suction / exhaust means. Further, the cleaning of the second common channel can be performed after the reagent is discharged.

(Effects of the Invention) As described above, according to the present invention, quantitative dispensing of only a plurality of reagents can be carried out selectively and accurately without causing contamination between them, and The increase and decrease can be easily dealt with by adding the suction / exhaust means.

[Brief description of drawings]

FIG. 1 is a diagram for explaining the principle of the present invention, FIG. 2 is a diagram showing an essential part of an embodiment of the present invention, FIG. 3 is an enlarged view of the rotary valve shown in FIG. 2, and FIG. A to C are diagrams showing an example of the configuration of the unit shown in Fig. 2, Figs. 5 A to F and Fig. 6 are diagrams for explaining the operation, and Figs. 7 A to F are components for the reagent according to the present invention. FIG. 8 is a diagram showing an example of the configuration of an automatic chemical analysis device including an injection device, and FIGS. 8A to 8D are diagrams showing the configuration of the main part of the reagent dispensing device of the analysis unit shown in FIGS. 7A to 7F. DESCRIPTION OF SYMBOLS 1 ... Flow path switching means, 2 ... Dispensing syringe 3 ... Washing liquid supply means, 4 ... Container 5 ... Dispensing nozzle, 6 ... Reagent tank 7 ... 1st common flow path, 8 ... 1st switching valve 9 ... Drainage channel, 10 ... 2nd common channel 11 ... 2nd switching valve, 12 ... Manifold block 13 ... Cleaning solution tank, 14 ... Pump 15 ... Opening / closing Valve, 21-1 to 21-4 …… Dispensing syringe 22-1, 22-2 …… Unit, 23-1, 23-2 …… Motor 24-1, 24-2 …… Drive mechanism 25A-1 ~ 25D-1, 25A-2 to 25D-2 …… Rotary valve 34-1,34-2 …… Evacuation pipe, 42-1 to 42-4 …… Reagent tank 43 …… Reaction container, 44-1 to 44- 4 …… Dispensing nozzle 45-1 to 45-4 …… Second common channel 46 …… Manifold block 47-1 to 47-4 …… Drainage channel 50 …… Opening valve 51 …… Branching block, 52 ... Pump 53 ... Cleaning solution tank.

Claims (2)

[Claims] 1. A first switching valve for selectively connecting one end of each first common flow path to a reagent dispensing nozzle and a reagent container,
A plurality of flow path switching means integrally having a second switching valve for selectively connecting the other end of the first common flow path to one end of the second common flow path and the drainage flow path, respectively. A rotary valve provided, a common suction / discharge means connected to the other end of each of the plurality of second common flow paths connected to the rotary valve, and a cleaning liquid supply means connected to the suction / discharge means, This cleaning liquid supply means allows the suction and discharge means, the second
The reagent dispensing apparatus is configured to wash the second common channel by flowing a cleaning liquid through the common channel and the drain channel. 2. A plurality of sets of the rotary valve and the suction / discharge means connected to the rotary valve are provided, and the rotary valves of each set are unitized with common drive means for driving them simultaneously. The reagent dispensing apparatus according to claim 1.