JPH06128132A - Anti-suntan cosmetic - Google Patents

Abstract

PURPOSE:To provide an anti-suntan cosmetic having excellent anti-suntan effect and safety and free from side effects such as skin stimulation. CONSTITUTION:The anti-suntan cosmetic contains (A) one or more kinds of ultraviolet absorbers selected from benzophenone compound, p-aminobenzoic acid compound, salicylic acid compound and cinnamic acid compound and (B) natural melanin easily soluble in alkali.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a sunscreen cosmetic having an excellent effect of blocking ultraviolet rays and a high safety.

[0002]

2. Description of the Related Art Conventionally, sunscreen cosmetics that protect the skin from ultraviolet rays have been compounded with ultraviolet absorbers such as benzophenone compounds and cinnamic acid compounds and ultraviolet scattering agents such as zinc oxide.

[0003]

However, since these conventional UV absorbers and UV scatterers do not have a sufficient UV blocking effect, they must be blended in a large amount.
However, sunscreen cosmetics containing a large amount of these components have problems such as skin irritation and poor feel. Therefore, it is an object of the present invention to provide a sunscreen cosmetic having an excellent UV blocking effect and having high safety for the skin and the like.

[0004]

Therefore, as a result of various investigations by the present inventors in order to search for a UV absorber from among highly safe natural ingredients, a readily soluble alkali-soluble natural melanin has an excellent UV absorbing ability. In addition, if used in combination with a conventionally known benzophenone compound, a paraaminobenzoic acid compound, an ultraviolet absorber selected from salicylic acid compounds and cinnamic acid compounds, it has a strong ultraviolet blocking effect, and skin irritation, etc. It has been found that a highly safe sunscreen cosmetic having no side effects can be obtained, and the present invention has been completed.

That is, the present invention contains one or more kinds of ultraviolet absorbers selected from benzophenone compounds, para-aminobenzoic acid compounds, salicylic acid compounds and cinnamic acid compounds and natural melanin which is easily soluble in alkali. It provides a sunscreen cosmetic.

The origin of the easily soluble natural melanin used in the present invention is not limited as long as it is easily dissolved in a weak alkaline aqueous solution, for example, an alkaline aqueous solution having a pH of 10 or less. preferable. Of these, alkali easily soluble natural melanin derived from microorganisms is particularly preferable. As a microorganism that produces the natural melanin, Aureobasidium (Aureobasid)
ium, Aspergillus
s) genus, Streptomyces
s) Microorganisms belonging to the genus. Melanin derived from these microorganisms is, for example, FMS Microbiology Letters (FEMSMicrob).
iology Letters), 9 , 237-240.
(1980), Transactions of the British Mythological Society (Trans.
Br. Mycol. Soc. ), 70 (3), 453-
455 (1978), Molecular and General Genetics (Mol. Gen. Gene).
t. ), 200 , 422-432 (1985) and the like.

The ultraviolet absorption spectrum and safety test results of melanin derived from microorganisms, which is a natural melanin that is easily soluble in alkali, are shown below.

(1) Ultraviolet absorption spectrum Molecular and General Genetics (Mol. Gen. Genet.) 200 , 422-4
32 (1985), the crude microorganism melanin 1.4 g was added with 50 ml of 6N hydrochloric acid and heated at 110 ° C. for 48 hours for hydrolysis. To this, 100 ml of 6N sodium hydroxide was added and dissolved. This solution was filtered through glass fiber filter paper, and 200 ml of 6N hydrochloric acid was added to the filtrate. The precipitate was separated by sedimentation, 1 liter of water was added to the precipitate, and sedimented again. By freeze-drying the precipitate, 1 g of purified melanin was obtained. This purified melanin (hereinafter,
An ultraviolet absorption spectrum of a 0.01% aqueous solution of “microbial melanin A” and synthetic melanin (manufactured by Sigma) is shown in FIG. From FIG. 1, the microorganism melanin A has an excellent ultraviolet absorbing action as compared with synthetic melanin.

(2) Safety test Regarding the safety of the microorganism melanin A, a human 48 hr closed patch test [Nippon Kaihatsu, 80 (5), 301-3
14 (1970)], single oral administration toxicity test [Ministry of Health, Labor and Welfare Drug Examination No. 118 (February 15, 1984), Guidelines for toxicity tests necessary for drug manufacturing (import) approval application (Part 1)] And skin photosensitization test (Seijin skin, 42
Vol. 5). As a result, as shown in Table 1, it was found that the microorganism melanin A is highly safe not only when it is orally administered but also when it is applied to the skin.

[0010]

[Table 1]

From these results, it is understood that the easily soluble alkali natural melanin has an excellent ultraviolet absorbing action and is highly safe.

The blending amount of the easily soluble alkali natural melanin in the sunscreen cosmetic of the present invention is not particularly limited,
0.01 to 20% by weight, particularly 0.1 to 5% by weight is preferable.

Among the ultraviolet absorbers contained in the sunscreen cosmetics of the present invention, examples of benzophenone compounds include 2-hydroxy-4-methoxybenzophenone and 2-hydroxy-4-methoxybenzophenone.
Sodium 5-sulfonate and the like are benzoic acid compounds, for example, p-aminobenzoic acid, ethyl ethoxyaminobenzoate, octyl paradimethylaminobenzoate, and the like, and salicylic acid compounds are, for example, triethanolamine salicylate. , 2-ethylhexyl salicylate, trimethylcyclohexyl salicylate and the like, and examples of the cinnamic acid compound include p-methoxycinnamic acid diethanolamine and methoxycinnamic acid ethylhexyl.

These UV absorbers may be used alone or in combination of two or more, and the amount thereof is 0.01 to 15% by weight, particularly 1 to 10% by weight based on the total composition of the sunscreen cosmetic. Weight percent is preferred.

Further, in the sunscreen cosmetic of the present invention, organic / inorganic powders, alcohols (lower alcohols and polyhydric alcohols), oily substances, in addition to the above essential components, are used within the range that does not impair the effects of the present invention. Ingredients, surfactants, various cosmetic ingredients, moisturizers, thickeners, pigments, preservatives, fragrances and other ingredients commonly used in sunscreen cosmetics can be added.

Organic / inorganic powders include titanium dioxide, talc, sericite, mica, titanium mica, montmorillonite, kaolin, alumina, magnesium oxide, cesium oxide, silica, kaolin, muscovite, barium sulfate, aluminum silicate, and silica. Magnesium aluminum oxide,
Sodium magnesium silicate, calcium silicate, iron oxide, calcium carbonate, nylon 6, nylon 6,6,
Nylon powder, cellulose, crystalline cellulose, silk powder, pumice powder and the like can be mentioned. These powders are preferably added to the sunscreen cosmetic of the present invention in an amount of 0.01 to 90% by weight.

Alcohols (lower alcohols and polyhydric alcohols) include ethanol, glycerin and 1,3-
Examples include butylene glycol and propylene glycol. These alcohols are preferably added to the sunscreen cosmetic of the present invention in an amount of 0.01 to 60% by weight.

As the oil component, fats and oils, hydrocarbons,
Examples thereof include waxes, fatty acids, synthetic esters, and higher alcohols. Examples of the oils and fats include jojoba oil, castor oil, olive oil, soybean oil, coconut oil, palm oil, cocoa oil, mink oil, turtle oil, and fatty acid diethanolamide. Examples of the hydrocarbons include liquid paraffin, petrolatum, microcrystalline wax, squalane and the like. As waxes, beeswax,
Examples include lanolin, carnauba wax, and candelilla wax. Examples of the fatty acids include myristic acid, palmitic acid, stearic acid, oleic acid and isostearic acid. Synthetic esters include isopropyl myristate, isopropyl palmitate, butyl oleate, myristyl myristate, octyldecyl myristate, propylene glycol monostearate,
Examples include myristyl lactate, isostearyl malate, glyceryl monostearate, and distearyl dimethyl ammonium chloride. Examples of higher alcohols include lauryl alcohol, cetanol, stearyl alcohol, and oleyl alcohol. It is preferable to add 0.01 to 70% by weight of these oily components to the sunscreen cosmetic of the present invention.

As the surfactant, polyoxyethylene hydrogenated castor oil, sodium lauryl sulfate, polyoxyethylene glyceryl isostearate pyroglutamate,
Sodium alkylbenzenesulfonate, polyoxyethylene (10) stearyl ether, dialkylsulfosuccinic acid, cetylpyridinium bromide, n-octadecyltrimethylammonium chloride, monoalkylphosphoric acid, N-acylglutamic acid, sucrose fatty acid ester, polyoxyethylene (20) Examples thereof include sorbitan monostearate, sodium polyoxyethylene lauryl ether sulfate, and polyoxyethylene reduced lanolin. These surfactants are preferably added to the sunscreen cosmetic of the present invention in an amount of 0.01 to 40% by weight.

Examples of the thickener include carboxyvinyl polymer, methylpolysiloxane, dextran, carboxymethylcellulose, carrageenan and hydroxymethylcellulose. As antiseptics, benzoic acid, salicylic acid, dehydroacetic acid or salts thereof,
Phenols such as paraoxybenzoic acid ester, 2,
4,4'-trichloro-2'-hydroxydiphenyl ether, 3-trifluoromethyl-4,4'-dichlorocarbanilide and the like can be mentioned.

The sunscreen cosmetics of the present invention can be produced by a conventional method and include basic cosmetics such as emulsions, creams and lotions; hair cosmetics such as hair liquids and hair treatments; foundations, lipsticks, blushers, It can be applied in various forms such as makeup cosmetics such as eyeliner.

[0022]

EXAMPLES Next, the present invention will be further described with reference to examples, but the present invention is not limited to these examples.

Example 1 A sunscreen cosmetic having the composition shown in Table 2 was produced and the degree of erythema due to ultraviolet rays was evaluated.

(Production Method) A: (1) to (9) are mixed by heating and kept at 70 ° C. B: (10) to (13) and (15) were heated and mixed, and 70
Keep at ℃. C: Add A to B, mix, cool to 30 ° C., (1
4) is added to obtain a cream. (Test method) 50 males aged 22 to 32 were used as a panel,
One product was applied to the upper bowl of 10 people, and the degree of erythema when irradiated with ultraviolet rays was observed by a solar simulator, and the score was calculated according to the following criteria. Erythema score: 3; erythema is clearly visible and the skin surface is slightly sore. 2; Erythema is observed. 1; slight erythema is observed. 0; no erythema

[0025]

[Table 2]

As is clear from the results shown in Table 2, Examples 1 and 2 in which a specific ultraviolet absorber and a readily soluble alkali melanin were blended together were used as Comparative Examples 1 and 2 in which the ultraviolet absorber alone was blended. In comparison with Comparative Example 3 containing no ultraviolet absorber, the erythema suppressing effect was more remarkable.

[0027]

Table 2 Example 2 Emulsion (% by weight) (1) Stearic acid 2.5 (2) Cetanol 1.6 (3) Beeswax 1.5 (4) Stearic acid monoglyceride 0.8 (5) Sorbitan sesquioleic acid Ester 0.3 (6) Polyoxyethylene oleyl ether (20E.O.) 0.6 (7) Liquid paraffin 10.0 (8) Trimethylcyclohexyl salicylate 5.0 (9) 1,3-Butylene glycol 6.0 (10) Preservative 1.0 (11) Triethanolamine 1.0 (12) Microbial melanin A 5.0 (13) Perfume 0.1 (14) Purified water Remaining amount

(Production Method) A: (1) to (8) are mixed and heated to 70 ° C. to dissolve. B: (9) to (12) and (14) were mixed by heating, and 70
Keep at ℃. C: A is added to B, and after mixing and cooling, (13) is added to obtain an emulsion. The obtained emulsion prevented erythema due to ultraviolet rays and was excellent as a sunscreen cosmetic.

[0029]

Table 3 Example 3 Lotion (% by weight) (1) Polyoxyethylene (20) Polyoxypropylene (8) Cetyl ether 0.2 (2) Concentrated glycerin 2.0 (3) 1,3-Butylene glycol 12.0 (4) Sodium carbonate 0.25 (5) Ethanol 1.0 (6) Sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate 5.0 (7) Microbial melanin A 5.0 (8) Fragrance 0.1 (9) Purified water Remaining amount

(Production Method) A: (1), (5) and (8) are mixed and dissolved. B: (2) to (4), (6), (7) and (9) are mixed and dissolved. C: A is added to B and mixed to obtain a lotion. The lotion obtained prevented erythema due to ultraviolet rays and was excellent as a sunscreen cosmetic.

[0031]

EFFECT OF THE INVENTION The sunscreen cosmetic composition of the present invention is excellent in sunscreen effect and highly safe without side effects such as skin irritation.

[Brief description of drawings]

FIG. 1 is a diagram showing ultraviolet absorption spectra of microbial melanin A and synthetic melanin.

Claims (1)

[Claims] 1. A sunscreen makeup containing one or more UV absorbers selected from a benzophenone compound, a paraaminobenzoic acid compound, a salicylic acid compound and a cinnamic acid compound and a natural melanin which is easily soluble in alkali. Fee.