JPH06103295B2 - Analysis instruction device of analysis device - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention relates to an analyzer such as a gas chromatograph or a liquid chromatograph, which is capable of continuously and automatically analyzing samples having different measurement conditions. In the device,
The present invention relates to an analysis instruction device capable of automatically setting the measurement conditions of each sample and the measurement order of samples.

(Prior Art) Taking a gas chromatograph as an example, a conventional gas chromatograph cannot continuously and automatically analyze samples with different measurement conditions. Even if it is possible, there are a few types of samples. Is limited to.

The measurement conditions of the gas chromatograph include carrier gas flow rate, column type, column temperature, etc., but considerable experience is required to set the optimum measurement conditions for each sample.

In addition, when measuring a plurality of samples, it is necessary for the operator to specify the measurement order. Depending on how to specify the measurement order, the total measurement time may become longer or shorter.

Such a situation exists not only in the gas chromatograph but also in the liquid chromatograph.

(Problems to be Solved by the Invention) The present invention is an analyzer capable of continuously measuring a plurality of types of samples, and when the information of the sample is input, the optimum measurement conditions for the sample are automatically determined, In addition, the measurement sequence is also automatically determined so that the total measurement time is the shortest, so that even those unskilled in analysis operation can easily complete the measurement in the shortest time under the optimum analysis conditions. The purpose is to

(Means for Solving the Problems) The present invention will be described with reference to FIG.

2 is an analytical instrument such as a gas chromatograph, 6 is a sample introduction device for introducing a sample selected from a plurality of samples arranged in the sample bottle rack 4 into the analytical instrument 2, 8 is the analytical instrument 2
A control device for controlling the analysis conditions and the operation of the sample introduction device 6, and 18 is an analysis instruction device. The analysis instruction device 18 determines the optimum measurement conditions for the sample from the measurement condition database 10 that stores the optimum measurement conditions for the sample and the measurement condition database 10 when the sample information is input, and then to the sample information table 12. Along with storing, an inference unit 14 for determining the sample measurement order from the current measurement conditions in the order of less change at the start of measurement, and a sample information table 12 for storing the measurement conditions of each sample determined by the inference unit 14, The controller 8 is instructed on the measurement sample and the analysis conditions.

In the measurement condition database 10, a combination of components contained in the sample and an analysis condition at that time are extracted from an input / output device 16 such as a keyboard and stored as a knowledge database by extracting from the knowledge of an expert. The contents of the measurement condition database 10 can be added or changed.

(Operation) The operation will be described with reference to FIGS. 2 and 3.

FIG. 2 shows a procedure in which the inference unit 14 determines the measurement condition of the sample when the information of the sample is input.

When the information of the sample to be measured (type of component contained in the sample) is input from the measurer (step S1),
The inference unit 14 selects the optimum measurement condition from the measurement condition database 10 (step S2). The selected measurement condition is registered in the sample information table 12 (step S3). When the information on the next sample is input (step S5), the measurement condition of the sample is determined in the same manner and registered in the sample information table 12 (steps S2, S3). After the operator inputs the required sample information and all the measurement conditions are registered in the sample information table 12, when the operator inputs a measurement start instruction (step S4), The procedure moves to the measurement flow shown in FIG.

FIG. 3 shows a measurement flow after the start of measurement is instructed.

By the time the measurement conditions of the sample to be measured are determined, the measurer has already set the sample at a predetermined position such as a sample bottle rack, a turntable or the like.

When the measurement person gives an instruction to start the measurement, the inference unit 14 selects a sample that can shift from the current measurement condition to the target condition in the shortest time among the unmeasured samples (step S12). Then, the control device 8 is instructed of information indicating the type of the sample and the measurement conditions, and the control device 8 controls the sample introduction device 6 to introduce the instructed sample into the analytical instrument 2 and the measurement conditions of the analytical instrument 2. Is changed (step S13). The measurement is started when the measurement condition reaches the target condition (steps S14, S1
Five).

When the measurement is completed (step S16), the inference unit 14 sets the state of the sample in the sample information table 12 to the measured sample, and selects the sample that can be moved in the shortest time from the current measurement conditions from the remaining samples ( Step S12). The same measurement is performed thereafter, and the measurement is repeated until there are no unmeasured samples registered in the sample information table 12 (step
S11).

(Example) FIG. 4 shows an example in which the present invention is applied to a gas chromatograph.

A gas chromatograph is shown as an analytical instrument, and the carrier gas passes through the pressure regulating valve 20, the liquid sample introducing port 22, and the column 26.
Guided to a or 26b. Sample inlet 22 and columns 26a, 26
A switching valve 24 is provided between b to connect either of the columns 26a and 26b to the carrier gas flow path. A switching valve 28 is also provided at the column outlet so that the column outlet is connected to any of the plurality of detectors 30a and 30b. The detector is not limited to the case where a plurality of detectors are connected in parallel as shown in the figure, but the detectors are connected in series such as the detector 30a and the detector 30c shown by a broken line. The output of the detector may be selected and captured.

The temperatures of the columns 26a and 26b and the detectors 30a and 30b are controlled by the oven 32. The oven 32 is provided with a temperature control device 34.

In order to automatically introduce a plurality of samples into the sample inlet 22,
A sample bottle rack 38 in which a plurality of sample bottles 36 are arranged, and a sampling needle 40 by selecting the sample bottle 36 of the sample bottle rack 38
A sample introducing device 42 for introducing the sample into the sample introducing port 22 is provided. The sampling needle 40 can be moved in any three-dimensional direction by the XYZ arm, sucks the sample from any selected sample bottle 36, and introduces the sample inlet 22.
To introduce.

In response to the instruction from the analysis instruction device 18, the control device 8 introduces one of the samples into the sample introduction port 22, adjusts the carrier gas flow rate through the pressure regulating valve 20, switches the switching valves 24 and 28, and controls the temperature. The control unit 34 controls each part such that the column temperature is controlled.

CPU44, RAM46, ROM4 to realize the analysis instruction device 18.
Equipped with a floppy disk device 50, a keyboard 52, a CRT 54, etc. The inference unit 14 in FIG. 1 is a CPU 44, a RAM 4
6 、 ROM48, sample information table 12 RAM46
The measurement condition database 10 is realized by the floppy disk device 50. The input / output device 16 corresponds to the keyboard 52.

In order to introduce the designated sample into the gas chromatograph, in addition to the one using the sample bottle rack 38 as shown in FIG.
It is also possible to use a device used as a sample introduction mechanism of a liquid chromatograph, such as a device in which sample bottles are arranged along the circumference of a turntable.

When measuring a gas sample with a gas chromatograph, a plurality of solenoid valves are provided at the gas sample introduction port of the gas chromatograph, and the solenoid valves are selected via the control device 8 to switch between any gas samples to switch the gas chromatograph. It should be introduced in the Tograph.

The number of columns and the number of detectors may be set arbitrarily.

The present invention can be applied not only to a gas chromatograph but also to a liquid chromatograph.

(Effects of the Invention) In the present invention, by setting a plurality of samples in the sample introduction mechanism and inputting the information of these samples, the optimum measurement conditions of each sample are automatically determined, and the total measurement time is minimized. Since the measurement order is also determined, it becomes possible for a person who is unfamiliar with the handling of the analytical instrument to easily perform the measurement under the optimum analysis conditions and in the optimum analysis order.

[Brief description of drawings]

FIG. 1 is a block diagram showing an outline when the present invention is applied to a gas chromatograph, FIG. 2 is a flowchart diagram showing a measurement condition determining operation, FIG. 3 is a flowchart diagram showing a measuring operation, and FIG. 4 is the present invention. It is a block diagram which shows one Example which applied this to a gas chromatograph. 2 ... Analytical instrument, 6 ... Sample introduction device, 8 ... Control device, 10 ... Measurement condition database, 12 ... Sample information table, 14 ... Inference unit, 16 ... Input / output unit, 18 ... Analysis Pointing device.

Claims (1)

[Claims] 1. An analyzer provided with an analytical instrument, a sample introduction device for introducing a sample selected from a plurality of samples into the analytical instrument, and a control device for controlling the analytical conditions of the analytical instrument and the operation of the sample introduction device. And a measurement condition database storing the optimum measurement conditions for the sample, and when the sample information is input, the optimum measurement conditions for the sample are determined from the measurement condition database and stored in the sample information table described later, and the measurement is performed. At the start, an inference unit that determines the sample measurement order from the current measurement condition in the order of least change, and a sample information table that stores the measurement conditions of each sample determined by the inference unit are provided to the control device of the analyzer. An analysis instruction device for instructing measurement samples and analysis conditions.