JPH0587806A - Urine analyzing method - Google Patents
Urine analyzing methodInfo
- Publication number
- JPH0587806A JPH0587806A JP27681991A JP27681991A JPH0587806A JP H0587806 A JPH0587806 A JP H0587806A JP 27681991 A JP27681991 A JP 27681991A JP 27681991 A JP27681991 A JP 27681991A JP H0587806 A JPH0587806 A JP H0587806A
- Authority
- JP
- Japan
- Prior art keywords
- urine
- specific gravity
- conductivity
- electrolyte component
- measured
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、例えば人体から採取し
た尿を分析する方法に関する。FIELD OF THE INVENTION The present invention relates to a method for analyzing urine collected from a human body, for example.
【０００２】[0002]
【従来の技術】尿の検査項目の一つに尿比重がある。こ
の尿比重は尿中に含まれる溶質の質量を表しており、臨
床的には腎の濃縮力が正常か異常か、脱水状態か、水分
過剰摂取か、異常物質の排泄がないかなどを知る重要な
検査である。健康人に含まれる有形成分（溶質）の主た
るものは、ＮａＣｌ（10〜15ｇ／日）と尿酸（15〜30ｇ
／日）であるから、尿比重は主としてこの２成分によっ
て支配されていることになる。Urine specific gravity is one of the urine test items. This urine specific gravity represents the mass of solute contained in urine, and clinically it is possible to know whether the concentration of the kidney is normal or abnormal, dehydration, excessive water intake, excretion of abnormal substances, etc. This is an important inspection. The main components of solutes contained in healthy people are NaCl (10-15g / day) and uric acid (15-30g).
Therefore, the specific gravity of urine is mainly controlled by these two components.
【０００３】従来、尿比重を測定する手法として、 尿比重が尿の屈折率によく比例することを利用した
屈折計による方法や、 尿を蓄尿ビンなどに入れて行う浮遊法（浮きばかり
法）や、 尿中のＮａ+ を化学的に測定し、呈色反応から間接
的に比重を求める試験紙法、 などがある。Conventionally, as a method for measuring the specific gravity of urine, a method using a refractometer, which utilizes that the specific gravity of urine is well proportional to the refractive index of urine, and a floating method (floating method) in which urine is put in a urine storage bottle or the like Alternatively, there is a test paper method in which Na + in urine is chemically measured and the specific gravity is indirectly determined from the color reaction.
【０００４】[0004]
【発明が解決しようとする課題】しかしながら、前記従
来技術には次のような問題点があった。すなわち、前記
の方式のものにおいては、尿中に蛋白やブドウ糖が含
まれていると、その影響を受けやすく、その補正が必要
である。また、前記の方式のものでは、測定精度が悪
いと共に、温度補正を行う必要がある。そして、前記
の方式のものにおいては、温度補正は必要ではないが、
測定精度が悪く、また、尿のｐＨが変化すると、測定結
果を補正しなければならないといった欠点がある。However, the above-mentioned prior art has the following problems. That is, in the above-mentioned method, if protein or glucose is contained in urine, it is susceptible to the influence, and the correction is necessary. Further, in the above-mentioned method, the measurement accuracy is poor and it is necessary to correct the temperature. And in the above-mentioned system, temperature correction is not necessary,
There are drawbacks in that the measurement accuracy is poor and the measurement result must be corrected when the pH of urine changes.
【０００５】さらに、前記従来技術〜の何れにおい
ても、尿全体の比重、いわゆる全比重しか測定できず、
尿中の電解質成分と非電解質成分との比については求め
ることができなかった。Further, in any of the above-mentioned prior arts, only the specific gravity of the whole urine, so-called total specific gravity, can be measured,
The ratio of the electrolyte component to the non-electrolyte component in urine could not be determined.
【０００６】ところで、近年、成人病などの疾患の治療
においては、疾患を早期に発見し、これに見合った治療
を行うことが望まれている。その場合、尿検査において
もできるだけ多くのデータ（情報）を精度よく集め、こ
れを医師の判定情報に供することが好ましい。By the way, in recent years, in the treatment of diseases such as adult diseases, it has been desired to detect the diseases at an early stage and to carry out a treatment commensurate with this. In that case, it is preferable to collect as much data (information) as possible in the urinalysis with high accuracy and use this as the judgment information of the doctor.
【０００７】ところで、ＮａＣｌ溶液やＫＣｌ溶液など
の溶液は、図２に示すように、溶液の濃度が希薄な場
合、濃度と導電率は比例している。そして、特に、Ｎａ
Ｃｌ溶液は、図３に示すように、濃度が大きくなっても
濃度と導電率との間に直線関係がある。By the way, in a solution such as a NaCl solution or a KCl solution, as shown in FIG. 2, when the concentration of the solution is low, the concentration and the conductivity are proportional. And especially Na
As shown in FIG. 3, the Cl solution has a linear relationship between the concentration and the conductivity even when the concentration is high.
【０００８】一方、尿に含まれる２つの主成分のうち、
ＮａＣｌは、イオン化してＮａ+ とＣｌ- といった電解
質成分となるが、尿酸はイオン化しないので、従って、
尿の導電率はＮａＣｌの量に依存していると考えられ
る。On the other hand, of the two main components contained in urine,
NaCl ionizes into electrolyte components such as Na + and Cl −, but uric acid does not ionize, and therefore,
The conductivity of urine is considered to depend on the amount of NaCl.
【０００９】本発明は、上述の知見に基づいてなされた
もので、その目的とするところは、尿の全比重を、補正
を行ったりすることなく、精度よく測定することができ
ると共に、尿中の電解質成分と非電解質成分との比をも
精度よく求めることができる尿分析方法を提供すること
にある。The present invention has been made on the basis of the above-mentioned findings. The purpose of the present invention is that the total specific gravity of urine can be accurately measured without correction, and It is an object of the present invention to provide a urine analysis method capable of accurately obtaining the ratio between the electrolyte component and the non-electrolyte component.
【００１０】[0010]
【課題を解決するための手段】上記目的を達成するた
め、本発明に係る尿分析方法は、尿の全比重を振動式密
度測定装置を用いて測定すると共に、尿の導電率を導電
率測定装置を用いて測定し、測定された導電率に基づい
て尿中に含まれる電解質成分の濃度を求め、この濃度と
前記全比重とに基づいて尿中の電解質成分と非電解質成
分との比を求めるようにしている。In order to achieve the above-mentioned object, the urine analysis method according to the present invention measures the total specific gravity of urine by using a vibrating density measuring device and the conductivity of urine by measuring the conductivity. Measured using the device, determine the concentration of the electrolyte component contained in urine based on the measured conductivity, the ratio of the electrolyte component and the non-electrolyte component in urine based on this concentration and the total specific gravity. I try to ask.
【００１１】[0011]
【作用】本発明の尿分析方法においては、尿の全比重
は、振動式密度測定装置によって測定される。一方、尿
に含まれる２つの主成分のうち、ＮａＣｌは、イオン化
してＮａ+ とＣｌ- といった電解質成分となるが、尿酸
はイオン化しないので、導電率測定装置によって測定さ
れた導電率の大きさから電解質成分の濃度が得られる。
この濃度と前記全比重とに基づいて尿中の電解質成分と
非電解質成分との比を求めることができる。In the urine analysis method of the present invention, the total specific gravity of urine is measured by a vibration type density measuring device. On the other hand, of the two main components contained in urine, NaCl ionizes into electrolyte components such as Na + and Cl −, but uric acid does not ionize, so the conductivity measured by the conductivity measuring device is large. To obtain the concentration of the electrolyte component.
Based on this concentration and the total specific gravity, the ratio between the electrolyte component and the non-electrolyte component in urine can be obtained.
【００１２】[0012]
【実施例】以下、本発明の実施例を、図面を参照しなが
ら説明する。Embodiments of the present invention will be described below with reference to the drawings.
【００１３】図１は、本発明に係る尿分析方法を実施す
るための装置の構成例を示し、この図において、１は尿
タンクで、その底部に接続された配管２には、２つの電
磁弁３，４が互いに直列に介装されている。下方の電磁
弁４の他端側は図外の洗浄水タンクに接続されている。
そして、配管２の電磁弁３，４間にはガラス管よりなる
測定管５の一端が接続され、この測定管５には導電率測
定装置６の検出部７と振動式密度測定装置８の検出部９
とが適宜の間隔をおいて互いに直列に介装されると共
に、測定管５の他端は図外の排出管に接続されている。
10は演算制御を行うＣＰＵである。FIG. 1 shows a structural example of an apparatus for carrying out the urine analysis method according to the present invention. In this figure, 1 is a urine tank, and a pipe 2 connected to the bottom of the urine tank has two electromagnetic fields. The valves 3 and 4 are interposed in series with each other. The other end of the lower solenoid valve 4 is connected to a wash water tank (not shown).
Then, one end of a measuring tube 5 made of a glass tube is connected between the electromagnetic valves 3 and 4 of the pipe 2, and the detecting section 7 of the conductivity measuring device 6 and the detection of the vibration type density measuring device 8 are connected to the measuring pipe 5. Part 9
Are inserted in series at appropriate intervals, and the other end of the measuring pipe 5 is connected to a discharge pipe (not shown).
Reference numeral 10 is a CPU that performs arithmetic control.
【００１４】前記電磁弁３，４は、ＣＰＵ10からの開閉
制御信号によって開閉制御される。そして、導電率測定
装置６の検出部７および振動式密度測定装置８の検出部
９は、詳細な図示は省略しているが、例えば次のように
構成されている。導電率測定装置６の検出部７は、流通
型セル内に白金黒電極またはステンレス鋼電極などを設
けてなり、また、振動式密度測定装置８の検出部９は、
ガラス管よりなる振動部分にセンサとしての振動片を設
けたものであり、これらはいずれも公知のものである。
なお、前記検出部７は、３％以下のＮａＣｌ溶液で構成
を行っておくのが好ましい。The solenoid valves 3 and 4 are opened / closed by an opening / closing control signal from the CPU 10. Although detailed illustration is omitted, the detection unit 7 of the conductivity measuring device 6 and the detection unit 9 of the vibration type density measuring device 8 are configured as follows, for example. The detection part 7 of the conductivity measuring device 6 is provided with a platinum black electrode or a stainless steel electrode or the like in the flow-through type cell, and the detection part 9 of the vibration type density measuring device 8 is
A vibrating piece serving as a sensor is provided on a vibrating portion made of a glass tube, and all of these are known.
In addition, it is preferable that the detection unit 7 is configured with a NaCl solution of 3% or less.
【００１５】次に、上記構成の尿分析方法を用いて、尿
の分析を行う手順について説明する。尿タンク１内に人
体から排泄された尿を収容した状態で、電磁弁４を閉、
電磁弁３を開にすると、測定管５に尿が流れる。この測
定管５を流れる尿は、導電率測定装置６、振動式密度測
定装置８によって導電率Ａ、比重Ｂがそれぞれ測定さ
れ、これらの測定値Ａ，Ｂは、ＣＰＵ10に入力される。
前記測定の終了後は、電磁弁４を開、電磁弁３を閉にし
て、洗浄水を測定管５に流して洗浄を行い、次の測定に
備える。Next, a procedure for analyzing urine by using the urine analysis method having the above-mentioned structure will be described. With the urine tank 1 containing urine excreted from the human body, the solenoid valve 4 is closed,
When the solenoid valve 3 is opened, urine flows into the measuring tube 5. The conductivity A and the specific gravity B of the urine flowing through the measuring tube 5 are measured by the conductivity measuring device 6 and the vibration type density measuring device 8, respectively, and these measured values A and B are input to the CPU 10.
After completion of the measurement, the electromagnetic valve 4 is opened and the electromagnetic valve 3 is closed.
【００１６】ここで、振動式密度測定装置８によって測
定された比重値は、尿の全比重である。一方、尿に含ま
れる２つの主成分のうち、ＮａＣｌは、イオン化してＮ
ａ+ とＣｌ- といった電解質成分となるが、尿酸はイオ
ン化しないので、導電率測定装置６によって測定された
導電率は、尿中に含まれるＮａＣｌの量に比例すると考
えられる。Here, the specific gravity value measured by the vibration type density measuring device 8 is the total specific gravity of urine. On the other hand, of the two main components contained in urine, NaCl is ionized and
Although it becomes an electrolyte component such as a + and Cl − , uric acid is not ionized. Therefore, it is considered that the conductivity measured by the conductivity measuring device 6 is proportional to the amount of NaCl contained in urine.
【００１７】そこで、ＣＰＵ10のメモリ内に、導電率と
ＮａＣｌの濃度との対照表または検量線をストックして
おき、この対照表または検量線に基づいて尿のＮａＣｌ
に起因する比重を求めることができ、この比重と前記全
比重とに基づいて尿中の電解質成分と非電解質成分との
比を求めることができる。Therefore, a reference table or a calibration curve between the conductivity and the concentration of NaCl is stocked in the memory of the CPU 10, and urine NaCl is stored based on the reference table or the calibration curve.
It is possible to obtain the specific gravity caused by the above, and the ratio between the electrolyte component and the non-electrolyte component in urine can be obtained based on this specific gravity and the total specific gravity.
【００１８】例えば振動式密度測定装置８から得られた
比重値（全比重値）が1.020とし、導電率測定装置によ
って測定された導電率値に基づいて得られた尿のＮａＣ
ｌに起因する比重値が 1.018であるとする。これらの数
値は、純水にＮａＣｌと尿酸あるいはＮａＣｌが溶けた
ためと考えられるから、（ 1.018−１）は、尿中のＮａ
Ｃｌの量に比例し、（ 1.020−１）は、ＮａＣｌと尿酸
との総量に比例すると考えられる。そこで、（1.018−
１）を（ 1.020−１）で除することにより、尿中のＮａ
Ｃｌ（電解質成分）の比率を求めることができ、この実
施例では、90％となる。For example, the specific gravity value (total specific gravity value) obtained from the vibration type density measuring device 8 is 1.020, and NaC of urine obtained based on the conductivity value measured by the conductivity measuring device.
It is assumed that the specific gravity value due to l is 1.018. These values are considered to be due to dissolution of NaCl and uric acid or NaCl in pure water, so (1.018-1) is the value of Na in urine.
It is considered to be proportional to the amount of Cl, and (1.020-1) is proportional to the total amount of NaCl and uric acid. Therefore, (1.018-
By dividing 1) by (1.020-1), Na in urine
The ratio of Cl (electrolyte component) can be determined and is 90% in this example.
【００１９】このように、本発明に係る尿分析方法によ
れば、尿の全比重Ｂおよび尿中の電解質成分と非電解質
成分との比Ｒを同時に求めることができ、従来に比べ
て、尿検査からより多くのデータ（情報）を精度よく集
めることができ、これを医師の判定情報に供することが
できる。As described above, according to the urine analysis method of the present invention, the total specific gravity B of urine and the ratio R of the electrolyte component and the non-electrolyte component in urine can be determined at the same time. More data (information) can be collected from the examination with high accuracy, and this can be used as doctor's judgment information.
【００２０】上述の実施例においては、尿を自動分析し
ていたが、尿の全比重および導電率を個別に測定する所
謂手動によって分析してもよい。In the above-mentioned embodiment, urine is automatically analyzed, but it may be analyzed manually by individually measuring the total specific gravity and conductivity of urine.
【００２１】[0021]
【発明の効果】以上説明したように、本発明によれば、
尿の全比重を、補正を行ったりすることなく、精度よく
測定することができると共に、尿中の電解質成分と非電
解質成分との比をも精度よく求めることができる。As described above, according to the present invention,
The total specific gravity of urine can be accurately measured without correction, and the ratio of the electrolyte component to the non-electrolyte component in urine can also be accurately obtained.
【図１】本発明方法を実施するための装置の一例を示す
図である。1 is a diagram showing an example of an apparatus for carrying out the method of the present invention.
【図２】希薄溶液の導電率を示す図である。FIG. 2 is a diagram showing the conductivity of a dilute solution.
【図３】濃い溶液の導電率を示す図である。FIG. 3 is a diagram showing the conductivity of a concentrated solution.
６…導電率測定装置、８…振動式密度測定装置、Ａ…導
電率、Ｂ…全比重、Ｒ…尿中の電解質成分と非電解質成
分との比。6 ... Conductivity measuring device, 8 ... Vibration type density measuring device, A ... Conductivity, B ... Total specific gravity, R ... Ratio of electrolyte component and non-electrolyte component in urine.
Claims (1)
て測定すると共に、尿の導電率を導電率測定装置を用い
て測定し、測定された導電率に基づいて尿中に含まれる
電解質成分の濃度を求め、この濃度と前記全比重とに基
づいて尿中の電解質成分と非電解質成分との比を求める
ようにしたことを特徴とする尿分析方法。1. The total specific gravity of urine is measured using a vibration type density measuring device, and the conductivity of urine is measured using a conductivity measuring device, and the urine is contained in urine based on the measured conductivity. A urine analysis method, characterized in that a concentration of an electrolyte component is obtained, and a ratio of an electrolyte component and a non-electrolyte component in urine is obtained based on the concentration and the total specific gravity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP03276819A JP3098292B2 (en) | 1991-09-26 | 1991-09-26 | Urine automatic analysis method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP03276819A JP3098292B2 (en) | 1991-09-26 | 1991-09-26 | Urine automatic analysis method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0587806A true JPH0587806A (en) | 1993-04-06 |
| JP3098292B2 JP3098292B2 (en) | 2000-10-16 |
Family
ID=17574842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP03276819A Expired - Fee Related JP3098292B2 (en) | 1991-09-26 | 1991-09-26 | Urine automatic analysis method |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3098292B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7232241B2 (en) | 2002-08-30 | 2007-06-19 | Seiko Epson Corporation | Illumination system, projector, and method for manufacturing illumination system |
| CN109085090A (en) * | 2018-01-19 | 2018-12-25 | 上海荒岛科技有限公司 | Detect method, measuring instrument and the system of urine specific gravity of urine |
-
1991
- 1991-09-26 JP JP03276819A patent/JP3098292B2/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7232241B2 (en) | 2002-08-30 | 2007-06-19 | Seiko Epson Corporation | Illumination system, projector, and method for manufacturing illumination system |
| US7461954B2 (en) | 2002-08-30 | 2008-12-09 | Seiko Epson Corporation | Lighting system, projector, and method for assembling lighting system |
| CN109085090A (en) * | 2018-01-19 | 2018-12-25 | 上海荒岛科技有限公司 | Detect method, measuring instrument and the system of urine specific gravity of urine |
| CN109085090B (en) * | 2018-01-19 | 2021-06-29 | 上海荒岛科技有限公司 | Method, measuring instrument and system for detecting specific gravity of urine |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3098292B2 (en) | 2000-10-16 |
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