JPH058024B2 - - Google Patents
Info
- Publication number
- JPH058024B2 JPH058024B2 JP60186968A JP18696885A JPH058024B2 JP H058024 B2 JPH058024 B2 JP H058024B2 JP 60186968 A JP60186968 A JP 60186968A JP 18696885 A JP18696885 A JP 18696885A JP H058024 B2 JPH058024 B2 JP H058024B2
- Authority
- JP
- Japan
- Prior art keywords
- blood
- hollow fiber
- fiber membrane
- membrane
- processing device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000008280 blood Substances 0.000 claims description 116
- 210000004369 blood Anatomy 0.000 claims description 116
- 239000012528 membrane Substances 0.000 claims description 63
- 239000012510 hollow fiber Substances 0.000 claims description 51
- 229910052760 oxygen Inorganic materials 0.000 claims description 18
- 239000001301 oxygen Substances 0.000 claims description 18
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 17
- 239000007789 gas Substances 0.000 claims description 16
- 238000005192 partition Methods 0.000 claims description 12
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 229920002492 poly(sulfone) Polymers 0.000 claims description 5
- 239000000835 fiber Substances 0.000 claims description 3
- 230000000903 blocking effect Effects 0.000 claims description 2
- 229920000098 polyolefin Polymers 0.000 claims description 2
- 229920001296 polysiloxane Polymers 0.000 claims description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 20
- 239000007788 liquid Substances 0.000 description 15
- 229910002092 carbon dioxide Inorganic materials 0.000 description 10
- 239000001569 carbon dioxide Substances 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 210000001367 artery Anatomy 0.000 description 6
- 230000037452 priming Effects 0.000 description 5
- 206010018873 Haemoconcentration Diseases 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 210000003462 vein Anatomy 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 230000004199 lung function Effects 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 239000012466 permeate Substances 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 206010059484 Haemodilution Diseases 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 150000002926 oxygen Chemical class 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229920002239 polyacrylonitrile Polymers 0.000 description 1
- 229920006268 silicone film Polymers 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- External Artificial Organs (AREA)
Description
【発明の詳細な説明】
〔産業上の利用分野〕
この発明は、手術時に患者の生体外に連結して
血液に酸素を供給し二酸化炭素を除去しながら増
加した上記血液中の水分を除去して正常な水分量
の血液にするための血液処理装置に関するもので
ある。[Detailed Description of the Invention] [Field of Industrial Application] This invention is connected to a patient's body outside the body during surgery to supply oxygen to the blood, remove carbon dioxide, and remove increased water in the blood. The present invention relates to a blood processing device for converting blood to a normal water content.
従来のこの種装置としては第５図に示すものが
ある。この血液処理装置はその主体となる人工肺
４と血液濃縮器AXとが分離されていた。すなわ
ち一方側が血液ポンプ２、心内血貯血槽３、血液
フイルター１５を配置した第１の液回路５を介し
て生体の手術部出血部位１に連結され、またこの
側の液回路１１Ａを介して静脈Ｂに連結されてお
り、他方側がガスフイルター１６を配置した気体
回路１１Ｂを介して外部に連結され、またこの側
の血液ポンプ１７、血液フイルター１５を配置し
た第２の液回路１２を介して動脈Ｃに連結される
ことで、患者の血液に酸素を供給し二酸化炭素を
除去する人工肺４と、一方側の血液入口ポート６
ａは血液ポンプ１８を配置した液回路１３を介し
て人工肺４側に連結され、他方側の血液出口ポー
ト６ｂは液回路１９を介して前記の心内血貯血槽
３に連結されることで、患者の血液中の水分は透
過するがタンパク質は阻止する多数の中空繊維膜
を集束状に内蔵した血液濃縮器AXとが、上記に
よる血液処置装置の液回路に分離して並列ループ
状に配置されていた。なお第５図に示す血液濃縮
器AXの排水ポート６ｅは、圧力計２１付の吸引
ボトル２０を配置した液回路１４を介して陰圧源
Ｄに連結されている。
A conventional device of this type is shown in FIG. In this blood processing device, the oxygenator 4 and the hemoconcentrator AX, which are the main components thereof, are separated. That is, one side is connected to the surgical site bleeding site 1 of the living body via a first liquid circuit 5 in which a blood pump 2, an intracardiac blood reservoir 3, and a blood filter 15 are arranged, and also via a liquid circuit 11A on this side. It is connected to the vein B, and is connected to the outside via a gas circuit 11B in which a gas filter 16 is arranged on the other side, and via a second liquid circuit 12 in which a blood pump 17 and a blood filter 15 are arranged on this side. An artificial lung 4 that supplies oxygen to the patient's blood and removes carbon dioxide by being connected to the artery C, and a blood inlet port 6 on one side.
a is connected to the artificial lung 4 side via a liquid circuit 13 in which a blood pump 18 is disposed, and the blood outlet port 6b on the other side is connected to the intracardiac blood reservoir 3 via a liquid circuit 19. The hemoconcentrator AX, which has a bundle of multiple hollow fiber membranes that allow water to pass through but block protein in the patient's blood, is separated into the liquid circuit of the blood treatment device described above and placed in a parallel loop. It had been. The drain port 6e of the hemoconcentrator AX shown in FIG. 5 is connected to a negative pressure source D via a liquid circuit 14 in which a suction bottle 20 with a pressure gauge 21 is disposed.
上記の構成により、従来の血液処理装置には次
のような問題点があつた。
Due to the above configuration, the conventional blood processing apparatus has the following problems.
(1) 人工肺４と血液濃縮器AXとが別回路に分離
して配置されているため、回路の構成が複雑に
なるうえ、それぞれの側の回路に血液ポンプが
必要になり、これによつて血液処理操作が繁雑
になつた。(1) Since the oxygenator 4 and the hemoconcentrator AX are placed separately in separate circuits, the circuit configuration becomes complicated, and a blood pump is required for each side of the circuit. As a result, blood processing operations became complicated.
(2) 人工肺４と血液濃縮回路が別回路でしかも並
列状に配置されているので、総体的にプライミ
ング量（血液充填量）が多くなり、患者の血液
希釈量が多くなつた。(2) Since the artificial lung 4 and the hemoconcentration circuit are separate circuits and are arranged in parallel, the overall priming amount (blood filling amount) is increased and the patient's hemodilution amount is increased.
この発明は、上記した従来技術の問題点を解決
するものであり、人工肺機能と血液濃縮機能とが
同一ハウジング内に収納されて回路構成が簡単に
なりポンプも１台で済んで血液処理操作が容易に
でき、かつプライミング量（血液充填量）を少な
くできる血液処理装置を提供することにある。 This invention solves the above-mentioned problems of the prior art.The artificial lung function and the blood concentration function are housed in the same housing, simplifying the circuit configuration and requiring only one pump for blood processing operations. It is an object of the present invention to provide a blood processing device that can easily perform priming and reduce the amount of priming (blood filling amount).
本発明における上記問題点の解決手段は、ガス
交換能を有する第１の中空繊維膜と水分は透過す
るがタンパク質は阻止する第２の中空繊維膜とが
同一ハウジング内に並列状に収納されてなり、上
記第１の中空繊維膜と第２の中空繊維膜とは隔壁
により仕切られているうえ、上記ハウジングには
第１、第２の中空繊維膜内面と連通する血液の入
口、出口および第１の中空繊維膜外面と連通する
酸素または酸素含有ガスの入口、出口並びに第２
の中空繊維膜外面と連通する排水口がそれぞれ設
けられたことにある。
A means for solving the above problems in the present invention is that a first hollow fiber membrane having gas exchange ability and a second hollow fiber membrane that allows moisture to permeate but blocks protein are housed in parallel in the same housing. The first hollow fiber membrane and the second hollow fiber membrane are separated by a partition wall, and the housing has a blood inlet and an outlet communicating with the inner surfaces of the first and second hollow fiber membranes. an oxygen or oxygen-containing gas inlet and an outlet communicating with the outer surface of the hollow fiber membrane of 1;
A drain port communicating with the outer surface of the hollow fiber membrane is provided in each case.
この発明による血液処理装置を使用する際は、
患者の静脈内を液回路を介して血液処理装置の血
液入口に導入させ、また手術部出血部位は従来例
と同様に、第１の液回路に配置されている血液ポ
ンプ、心内血貯血槽、血液フイルターを経てこれ
も同じ血液入口に流入させるように連結し、さら
に上記装置の血液出口は従来図で示す血液ポンプ
と血液フイルターを配置した第２の液回路を介し
て処理済み血液を動脈に戻すように連結するとと
もに、上記装置の排水口は従来図で示した吸引ボ
トル付の液回路を介して陰圧源に連結することに
より、上記の装置に内蔵されている第１の中空繊
維膜は人工肺機能を発揮して血液に酸素を供給し
二酸化炭素を除去するうえ、第２の中空繊維膜は
血液濃縮機能を発揮して上記血液中の水分は透過
するがタンパク質は阻止するので、従来のような
複雑な回路を要しないで簡単で短かい回路構成で
済むことから、血液処理操作が容易になり、かつ
プライミング量（血液充填量）も少なくすること
ができる。
When using the blood processing device according to the present invention,
The patient's veins are introduced into the blood inlet of the blood processing device via a fluid circuit, and the bleeding site at the surgical site is handled by a blood pump and an intracardiac blood reservoir located in the first fluid circuit, as in the conventional example. , through a blood filter, which is also connected to the same blood inlet, and the blood outlet of the device also connects the treated blood to the arterial artery via a second fluid circuit in which a blood pump and a blood filter are arranged, as shown in the conventional diagram. The drain port of the device is connected to a negative pressure source via a liquid circuit with a suction bottle as shown in the conventional diagram, so that the first hollow fiber built in the device is The membrane functions as an artificial lung, supplying oxygen to the blood and removing carbon dioxide, and the second hollow fiber membrane functions as a hemoconcentrator, allowing water in the blood to pass through but blocking proteins. Since a simple and short circuit configuration is sufficient without requiring a complicated circuit like the conventional one, blood processing operation becomes easy and the priming amount (blood filling amount) can be reduced.
以下、この発明の実施例を添付図面に基づいて
説明する。なお従来技術のものと同一または相当
する部分には同一の符号を用いる。
Embodiments of the present invention will be described below with reference to the accompanying drawings. Note that the same reference numerals are used for parts that are the same as or correspond to those in the prior art.
第１図はこの発明による血液処理装置Ａの一実
施例を示すものである。上記の血液処理装置Ａは
次のように構成されている。すなわちこの血液処
理装置Ａは、合成樹脂材等をもつてその外郭が長
手方向の前後端を閉塞した筒状体によるハウジン
グ６に形成されている。このハウジング６には、
長手方向の初端側中心位置に未処理血液F1の導
入口となる血液入口ポート６ａが、また終端側中
心位置には処理済血液F2の排出口となる血液出
口ポート６ｂがそれぞれ軸方向に突設されてい
る。そしてこのハウジング６の人工肺機能が収納
される位置の外周面の一端側で、上記血液出口ポ
ート６ｂに近傍する位置には酸素O2の給気口と
なるガス入口ポート６ｄが、また血液入口ポート
６ａに近傍する位置には二酸化炭素CO2の排気口
となるガス出口ポート６ｃがそれぞれ径方向に突
設されている。さらにこのハウジング６の血液濃
縮機能が収納される位置の外周面の他端側で、上
記血液入口ポート６ａに近傍する位置には濾過液
Ｅの除水口となる排水ポート６ｅが径方向に突設
されている。なお、これらポートの位置、形態は
上記に限定されるわけではなく、それらが機能す
る位置及び形態であれば良い。 FIG. 1 shows an embodiment of a blood processing apparatus A according to the present invention. The blood processing apparatus A described above is configured as follows. That is, this blood processing apparatus A is formed in a housing 6 made of synthetic resin or the like and having a cylindrical outer shell whose front and rear ends are closed in the longitudinal direction. This housing 6 has
A blood inlet port 6a, which serves as an inlet for unprocessed blood F1 , is located at the center position on the starting end in the longitudinal direction, and a blood outlet port 6b, which serves as an outlet for processed blood F2 , is located at the center position on the terminal end, in the axial direction. It is installed protrudingly. At one end of the outer peripheral surface of the housing 6 where the oxygenator function is housed, a gas inlet port 6d serving as an oxygen O 2 supply port is located near the blood outlet port 6b; Gas outlet ports 6c, which serve as exhaust ports for carbon dioxide CO2 , are provided protruding in the radial direction at positions near the ports 6a. Further, on the other end side of the outer circumferential surface of the housing 6 at the position where the blood concentration function is housed, a drainage port 6e serving as a water removal port for the filtrate E is provided protruding in the radial direction at a position near the blood inlet port 6a. has been done. Note that the positions and forms of these ports are not limited to those described above, and may be any position and form that allows them to function.
上記によるハウジング６の一側にあたる径方向
の半身部強内すなわち前記によりガス出口ポート
６ｃとガス入口ポート６ｄとを突設した側にあた
る半身部を若干上回る容域内にはシリコール膜よ
りなる多数の第１中空繊維膜７が、所定量に集束
された状態をもつてその両端に体するポリウレタ
ン等の硬化性樹脂１０により気密に固着されたの
ち、その両端面を径方向に切断することで中空糸
膜内を軸方向へ流通する血液に径方向から酸素
O2を供給し、この酸素O2と交換された上記血液
中の二酸化炭素CO2が径方向へ排出される人工肺
機能の発揮が可能となるように収納配置されてい
る。 Inside the radial half of the housing 6 on one side, that is, slightly beyond the half on the side from which the gas outlet port 6c and the gas inlet port 6d are protruded, there are a large number of holes made of silicone film. 1 Hollow fiber membranes 7 are bundled in a predetermined amount and are airtightly fixed to both ends by a curable resin 10 such as polyurethane, and then both end surfaces are cut in the radial direction to form hollow fibers. Oxygen is supplied from the radial direction to the blood flowing axially within the membrane.
It is housed and arranged so that it can perform an artificial lung function in which O 2 is supplied and the carbon dioxide CO 2 in the blood that has been exchanged with the oxygen O 2 is discharged in the radial direction.
また上記ハウジング６の他側にあたる径方向の
半身部弱内すなわち前記により排水ポート６ｅを
突設した側にあたる半身部を若干下回る容域内に
はポリスルホン膜よりなる多数の第２中空繊維膜
８が、所定量に集束された状態をもつてその両端
を上記と同様のポリウレタン等による硬化性樹脂
１０により気密に固着されたのち、その両端面を
径方向に切断することで中空糸膜内を軸方向へ流
通する血液中の水分は径方向へ透過されるがタン
パク質は阻止される血液濃縮機能の発揮が可能と
なるように収納配置されている。 Further, inside the half body in the radial direction on the other side of the housing 6, that is, in the area slightly below the half body on the side from which the drain port 6e is protruded, there are a number of second hollow fiber membranes 8 made of polysulfone membranes. After the fibers are bundled in a predetermined amount and both ends are airtightly fixed with a curable resin 10 made of polyurethane or the like as described above, both end surfaces are cut in the radial direction so that the inside of the hollow fiber membrane is axially fixed. It is housed and arranged in such a way that it can perform a hemoconcentration function in which water in blood flowing through the bloodstream is permeated in the radial direction, but proteins are blocked.
上記により第１中空繊維膜７と第２中空繊維膜
８とがハウジング６内に並列状にかつ前後に僅か
の貯血間隙６ｆを設けて収納配置されたのち、両
中空繊維膜７，８の境界域には平板状の隔壁９が
収装されて、上記両中空繊維膜７と８とは気密状
に仕切られ、全体として一括体の血液処理装置Ａ
に構成されている。 After the first hollow fiber membrane 7 and the second hollow fiber membrane 8 are housed in the housing 6 in parallel with a slight blood storage gap 6f in the front and rear as described above, the boundary between the two hollow fiber membranes 7 and 8 is A flat partition wall 9 is housed in the area, and the two hollow fiber membranes 7 and 8 are airtightly partitioned, and the entire blood processing apparatus A is integrated.
It is composed of
上記の構成による血液処理装置Ａを用いて手術
を行う場合は、第２図に示す様に患者の静脈Ｂ
を、この静脈Ｂにおける未処理血液F1を第２図
に示すこの側の液回路１１Ａを介して血液処理装
置Ａの血液入口ポート６ａに導入させるように連
結し、また上記患者の手術部出血部位１は、この
手術部において出血中の未処理血液F1′を第１の
液回路５に配置された血液ポンプ２、心内血貯血
槽３、血液フイルター１５の部材を経てもう一つ
設けた血液入口ポート６a′に流入させるように連
結するとともに、さらに血液処理装置Ａの血液出
口ポート６ｂは、血液ポンプ１７と血液フイルタ
ー１５を配置した第２の液回路１２と同様の液回
路を介して処理済の血液F2を動脈Ｃへ戻すよう
に連結し、かつ血液処理装置Ａのガス入口ポート
６ｄには酸素O2の供給管を、またガス出口ポー
ト６ｃには二酸化炭素CO2の排出管を、さらにま
た排水ポート６ｅには圧力計２１付の吸引ボトル
２０を配置した液回路１４をそれぞれ連結するこ
とにより、上記血液処理装置Ａの血液入口ポート
６ａ内へ導入された未処理血液F1，F1′の半量強
は、ハウジング６内の径方向の一側に収納配置さ
れている第１中空繊維膜７内へ流入してこの第１
中空繊維膜７における人工肺機能により、上記未
処理血液F1に酸素O2を供給し、この酸素O2と交
換されて上記血液中の二酸化炭素CO2を除去する
ことができる。そしてこの処理済血液F2は血液
出口ポート６ｂから前記液回路を経て患者の動脈
Ｃへ戻される。 When performing surgery using the blood processing device A with the above configuration, the patient's vein B is
is connected so that the unprocessed blood F1 in this vein B is introduced into the blood inlet port 6a of the blood processing apparatus A through the liquid circuit 11A on this side shown in FIG. In the surgical section 1, the untreated blood F 1 ' that is being bled is passed through a blood pump 2 disposed in a first liquid circuit 5, an intracardiac blood reservoir 3, and a blood filter 15, which is provided with another blood filter 15. In addition, the blood outlet port 6b of the blood processing apparatus A is connected to the blood inlet port 6a' of the blood processing apparatus A through a liquid circuit similar to the second liquid circuit 12 in which the blood pump 17 and the blood filter 15 are disposed. The processed blood F 2 is connected to be returned to the artery C, and the gas inlet port 6d of the blood processing device A is connected with an oxygen O 2 supply pipe, and the gas outlet port 6c is connected with a carbon dioxide CO 2 discharge pipe. The untreated blood F introduced into the blood inlet port 6a of the blood processing apparatus A is A little more than half of F 1 , F 1 ' flows into the first hollow fiber membrane 7 housed on one radial side of the housing 6 and
The artificial lung function in the hollow fiber membrane 7 can supply oxygen O 2 to the untreated blood F 1 and remove carbon dioxide CO 2 from the blood by being exchanged with the oxygen O 2 . The processed blood F2 is then returned to the patient's artery C from the blood outlet port 6b via the liquid circuit.
次に上記と同じ経路により血液処理装置Ａの血
液入口ポート６ａ内へ導入された未処理血液F1，
F1′の残りの半量弱は、ハウジング６内の径方向
の他側に収納配置されている第２中空繊維膜８内
へ流入してこの第２中空繊維膜８における血液濃
縮機能により、上記未処理血液F1中の余剰水分
を径方向に除水することができる。そして正常の
水分保有の状態になつた処理済血液F2は血液出
口ポート６ｂから前記の液回路を経て患者の動脈
Ｃへ戻される。その際この血液出口ポート６ｂか
ら前記によりハウジング６の一側で酸素O2を供
給し二酸化炭素CO2は除去された処理済血液F2も
同時に配出されるため、双方の正常な処理済血液
F2をこの位置から合流した状態で患者の動脈Ｃ
へ戻すことができるものである。なお第２中空繊
維膜８において除水された濾過液Ｅは、排水ポー
ト６ｅからこの位置に連結されている陰圧源Ｄ側
へ排出される。 Untreated blood F 1 is then introduced into the blood inlet port 6a of the blood processing device A through the same route as above.
The remaining half of F 1 ' flows into the second hollow fiber membrane 8 housed on the other side in the radial direction within the housing 6, and due to the hemoconcentration function of the second hollow fiber membrane 8, the above-mentioned Excess water in unprocessed blood F 1 can be removed in the radial direction. The processed blood F2 , now in a state of normal water retention, is returned to the patient's artery C from the blood outlet port 6b via the liquid circuit described above. At this time, processed blood F 2 from which oxygen O 2 is supplied and carbon dioxide CO 2 removed from one side of the housing 6 as described above is also delivered from this blood outlet port 6b, so both normal processed blood
With F 2 merging from this position, the patient's artery C
It is something that can be returned to. The filtrate E from which water has been removed in the second hollow fiber membrane 8 is discharged from the drain port 6e to the negative pressure source D connected to this position.
第１図の実施例ではハウジング６の初端側に１
つの血液入口ポート６ａを設け第２図では液回路
の接続が便利なように２つの入口ポートを６ａ，
６a′の２つに分離して設けたが、この発明は上記
の実施例に限定することなく、例えば第３図のよ
うにこの初端側に第１中空繊維膜７専用の血液入
口ポート６ａと第２中空繊維膜８専用の血液入口
ポート６a′との２つを並列状に設けても、上記実
施例と同様の作用効果が得られるものである。さ
らには出口ポート側も同様に２つ設けても良い。 In the embodiment shown in FIG.
In Fig. 2, two blood inlet ports 6a and 6a are provided for convenient connection of the liquid circuit.
6a', but the present invention is not limited to the above-described embodiment. For example, as shown in FIG. Even if the blood inlet port 6a' and the blood inlet port 6a' exclusively for the second hollow fiber membrane 8 are provided in parallel, the same effects as in the above embodiment can be obtained. Furthermore, two ports may be provided on the exit port side as well.
また上記の実施例では第１中空繊維膜７と第２
中空繊維膜８とを平らな隔壁９で仕切つたが、こ
の隔壁９も上記の平らな隔壁９に限定することな
く、例えば第４図のように第１中空繊維膜７を円
形の外周に配置し第２中空繊維膜８はその同心円
の軸心近くに配置して、双方の境界周面部分に円
筒形の隔壁９′を同心状に収納配置しても、上記
の実施例と同様の仕切作用ができるものである。 Further, in the above embodiment, the first hollow fiber membrane 7 and the second hollow fiber membrane
Although the hollow fiber membrane 8 is separated from the hollow fiber membrane 8 by a flat partition wall 9, the partition wall 9 is not limited to the flat partition wall 9 described above. However, even if the second hollow fiber membrane 8 is arranged near the axis of its concentric circles and a cylindrical partition wall 9' is concentrically housed on the boundary surface between the two, the same partition as in the above embodiment can be obtained. It is something that can act.
さらに上記の実施例では第１中空繊維膜７をシ
リコーン膜により形成したが、これも上記の素材
に限定することなく、例えば多孔性ポリオレフイ
ン膜やポリスルホン膜を用いても、上記実施例と
同様に、未処理血液F1に酸素O2を供給し、この
酸素O2と交換して上記血液F1中の二酸化炭素
CO2を除去することができるものである。そして
第２中空繊維膜８もポリスルホン膜だけでなくセ
ルロースアセテートやポリアクリルニトリルなど
からなる膜も使用することができる。 Further, in the above embodiment, the first hollow fiber membrane 7 was formed of a silicone membrane, but this is not limited to the above materials, and for example, a porous polyolefin membrane or a polysulfone membrane may be used as well. , supplying oxygen O 2 to the untreated blood F 1 and exchanging this oxygen O 2 with carbon dioxide in the blood F 1 above.
It is capable of removing CO 2 . As the second hollow fiber membrane 8, not only a polysulfone membrane but also a membrane made of cellulose acetate, polyacrylonitrile, or the like can be used.
この発明は、ガス交換能を有する第１の中空繊
維膜と水分は透過するがタンパク質は阻止する第
２の中空繊維膜とが同一ハウジング内に並列状に
収納されてなり、上記第１の中空繊維膜と第２の
中空繊維膜とは隔壁により仕切られているうえ、
上記のハウジングには第１、第２の中空繊維膜内
面と連通する血液の入口ポート、出口ポートおよ
び第１の中空繊維膜外面と連通する酸素または酸
素含有ガスの入口ポート、出口ポート並びに第２
の中空繊維膜外面と連通する排水ポートがそれぞ
れ設けられたことを特徴とするものである。従つ
てこの血液処理装置は、患者の生体外に連結して
使用した場合、人工肺機能と血液濃縮機能の双方
が同一のハウジング内に収納されているため、従
来のような複雑な回路を要しないで簡単な回路構
成にでき、またポンプも出血吸引用を除き１台で
済むことから、血液処理操作が容易になる。さら
に簡単かつ短い回路構成であるからプライミング
量（血液充填量）も少なくすることができる等の
効果がある。
In this invention, a first hollow fiber membrane having a gas exchange ability and a second hollow fiber membrane that allows moisture to permeate but blocks protein are housed in the same housing in parallel, and the first hollow fiber membrane The fiber membrane and the second hollow fiber membrane are separated by a partition wall, and
The housing includes a blood inlet port and an outlet port that communicate with the inner surfaces of the first and second hollow fiber membranes, an oxygen or oxygen-containing gas inlet port and an outlet port that communicate with the outer surface of the first hollow fiber membrane, and a second
Each of the hollow fiber membranes is characterized by being provided with a drainage port communicating with the outer surface of the hollow fiber membrane. Therefore, when this blood processing device is connected to a patient's body outside the body, both the oxygenator function and the hemoconcentration function are housed in the same housing, which eliminates the need for complicated circuits as in the past. Since the circuit structure can be simplified without having to do anything, and only one pump is required except for the one for suctioning blood, blood processing operations become easier. Furthermore, since the circuit configuration is simple and short, the priming amount (blood filling amount) can also be reduced.
第１図はこの発明の一実施例による血液処理装
置を示す縦断面図、第２図は上記の血液処理装置
を使用した血液処理回路構成図、第３図および第
４図は他の実施例を示す縦断面図、第５図は従来
例を示す血液処理装置の回路構成図である。
６……ハウジング、６ａ，６a′……血液入口ポ
ート、６ｂ……血液出口ポート、６ｃ……ガス出
口ポート、６ｄ……ガス入口ポート、６ｅ……排
水ポート、７……第１中空繊維膜、８……第２中
空繊維膜、９，９′……隔壁、Ａ……血液処理装
置。
FIG. 1 is a longitudinal sectional view showing a blood processing device according to an embodiment of the present invention, FIG. 2 is a configuration diagram of a blood processing circuit using the above blood processing device, and FIGS. 3 and 4 are other embodiments. FIG. 5 is a circuit configuration diagram of a conventional blood processing apparatus. 6...Housing, 6a, 6a'...Blood inlet port, 6b...Blood outlet port, 6c...Gas outlet port, 6d...Gas inlet port, 6e...Drainage port, 7...First hollow fiber membrane , 8... Second hollow fiber membrane, 9,9'... Partition wall, A... Blood processing device.
Claims (1)
は透過するがタンパク質は阻止する第２の中空繊
維膜とがハウジング内に並列状に収納されてな
り、前記第１の中空繊維膜と第２の中空繊維膜と
は隔壁により仕切られているうえ、前記ハウジン
グには前記第１、第２の各中空繊維膜内面と連通
する血液の入口、出口および第１の中空繊維膜外
面と連通する酸素または酸素含有ガスの入口、出
口並びに第２の中空繊維膜の外面と連通する排水
口がそれぞれ設けられていることを特徴とする血
液処理装置。 ２ 前記血液の入口が１つ設けられている特許請
求の範囲第１項記載の血液処理装置。 ３ 前記血液の入口が２つ設けられている特許請
求の範囲第１項記載の血液処理装置。 ４ 前記２種類の中空繊維膜が平らな隔壁により
仕切られて収納されてなる特許請求の範囲第１項
記載の血液処理装置。 ５ 前記２種類の中空繊維膜が円筒状の隔壁によ
り仕切られて同心円状に収納されてなる特許請求
の範囲第１項記載の血液処理装置。 ６ 前記第１の中空繊維膜がシリコーン膜、多孔
性ポリオレフイン膜またはポリスルホルン膜より
なる特許請求の範囲第１項ないし第５項のいずれ
かの項に記載の血液処理装置。 ７ 前記第２の中空繊維膜がポリスルホン膜より
なる特許請求の範囲第１項ないし第６項のいずれ
かの項に記載の血液処理装置。[Scope of Claims] 1. A first hollow fiber membrane having gas exchange ability and a second hollow fiber membrane permeating moisture but blocking proteins are housed in a housing in parallel, The hollow fiber membrane and the second hollow fiber membrane are separated by a partition wall, and the housing has a blood inlet and an outlet communicating with the inner surfaces of the first and second hollow fiber membranes, and a first hollow. A blood processing device characterized in that an inlet and an outlet for oxygen or oxygen-containing gas communicate with the outer surface of the fiber membrane, and a drain port communicates with the outer surface of the second hollow fiber membrane. 2. The blood processing device according to claim 1, wherein one blood inlet is provided. 3. The blood processing device according to claim 1, wherein two blood inlets are provided. 4. The blood processing device according to claim 1, wherein the two types of hollow fiber membranes are housed separated by a flat partition wall. 5. The blood processing device according to claim 1, wherein the two types of hollow fiber membranes are partitioned by a cylindrical partition and housed concentrically. 6. The blood treatment device according to any one of claims 1 to 5, wherein the first hollow fiber membrane is a silicone membrane, a porous polyolefin membrane, or a polysulfone membrane. 7. The blood processing device according to any one of claims 1 to 6, wherein the second hollow fiber membrane is made of a polysulfone membrane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60186968A JPS6247368A (en) | 1985-08-26 | 1985-08-26 | Blood treatment apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60186968A JPS6247368A (en) | 1985-08-26 | 1985-08-26 | Blood treatment apparatus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6247368A JPS6247368A (en) | 1987-03-02 |
| JPH058024B2 true JPH058024B2 (en) | 1993-02-01 |
Family
ID=16197875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60186968A Granted JPS6247368A (en) | 1985-08-26 | 1985-08-26 | Blood treatment apparatus |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6247368A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5347602B2 (en) * | 2009-03-16 | 2013-11-20 | 株式会社ジェイ・エム・エス | Blood processing equipment |
-
1985
- 1985-08-26 JP JP60186968A patent/JPS6247368A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6247368A (en) | 1987-03-02 |
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