JPH057477A - Ginkgo leaf extract-containing chlorella preparation - Google Patents
Ginkgo leaf extract-containing chlorella preparationInfo
- Publication number
- JPH057477A JPH057477A JP3185903A JP18590391A JPH057477A JP H057477 A JPH057477 A JP H057477A JP 3185903 A JP3185903 A JP 3185903A JP 18590391 A JP18590391 A JP 18590391A JP H057477 A JPH057477 A JP H057477A
- Authority
- JP
- Japan
- Prior art keywords
- chlorella
- weight
- ginkgo biloba
- extract
- biloba extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Seeds, Soups, And Other Foods (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は健康食品及び循環障害治
療剤として使用されるイチョウ葉エキスを含むクロレラ
製剤に関するものである。FIELD OF THE INVENTION The present invention relates to a chlorella preparation containing a ginkgo biloba extract used as a health food and a therapeutic agent for circulatory disorders.
【０００２】[0002]
【従来の技術及び発明が解決しようとする課題】イチョ
ウは古くから去痰、鎮咳、解毒、治淋、瀕尿抑制、滋養
等の効があるとして民間薬として用いられており、ガ
ン、肺結核、タコ、ウオノ目等の治療にも使用されてい
る。一方、イチョウ葉より抽出したイチョウ葉エキスに
は、血流増大、血管拡張、血管老化防止、特に高齢者の
脳及び皮膚抹消血流の改善、精神的症候の改善等の効果
があり、動脈硬化、糖尿病性血管障害、皮膚血行障害、
老人ボケ、精神障害等の循環障害及び精神障害の治療薬
として使用されている。またイチョウ葉エキスのこのよ
うな薬理効果並びに滋養効果に着目して、イチョウ葉エ
キス製剤を健康食品として使用することも行われてい
る。BACKGROUND OF THE INVENTION Ginkgo biloba has long been used as a folk medicine for its effects such as expectoration, antitussive, detoxification, healing, suppressing excretion, and nourishment. Cancer, pulmonary tuberculosis, octopus, etc. It is also used for the treatment of the blue eye, etc. On the other hand, ginkgo biloba extract extracted from ginkgo biloba has effects such as increased blood flow, vasodilation, prevention of vascular aging, improvement of brain and skin peripheral blood flow in elderly people, improvement of mental symptoms, etc. , Diabetic angiopathy, cutaneous circulation disorder,
It is used as a remedy for circulatory disorders and mental disorders such as senility blur and mental disorders. Further, focusing on such pharmacological and nourishing effects of ginkgo biloba extract, ginkgo biloba extract preparations have been used as health foods.
【０００３】しかしながら、従来のイチョウ葉エキス製
剤からなる健康食品や治療薬には、イチョウ葉エキスに
由来する独特の苦みと臭みがあると言う欠点があった。
したがって、このような苦みや臭みのないイチョウ葉エ
キス製剤の開発が求められていた。本発明は、循環障害
治療や滋養に優れた効果を有するイチョウ葉エキスを含
み、該エキスに由来する独特の苦みと臭みを抑え、子
供、老人を含む何人も容易に服用飲食することができる
イチョウ葉エキス製剤を開発することを目的とするもの
である。[0003] However, conventional health foods and therapeutic agents comprising ginkgo biloba extract preparations have the drawback that they have peculiar bitterness and odor derived from gingko biloba extract.
Therefore, there has been a demand for the development of a ginkgo biloba extract extract that does not have such bitterness and odor. INDUSTRIAL APPLICABILITY The present invention includes a ginkgo biloba extract that has excellent effects on treating circulatory disorders and nourishment, suppresses the unique bitterness and odor derived from the extract, and can be easily taken and eaten by anyone including children and the elderly. The purpose is to develop a leaf extract formulation.
【０００４】[0004]
【課題を解決するための手段】本発明は前記課題を解決
するためになされたものであり、製剤中にイチョウ葉エ
キスにクロレラを混合させて調製したもので、イチョウ
葉エキス０．１〜１５重量％と共にクロレラ０．５〜７
５重量％を含有することを特徴とするイチョウ葉エキス
を含有するクロレラ製剤である。本発明で使用するイチ
ョウ葉エキスは、公知の方法（特開平１ー２５８６２６
号公報、特開平２ー３１６４８号公報等参照）により製
造されたものであり、例えば、乾燥イチョウ葉を含水低
級アルコールで抽出した後、得られた抽出物より肪溶性
有機溶剤を用いて低極性化合物を除くか、あるいは更に
水と混和しない有機溶剤により抽出することにより製造
される。この抽出物は通常有機溶剤を除去し粉末状態で
使用する。この公知の方法で得られるイチョウ葉エキス
は普通褐色であり、強い苦みと独特の臭みを有するが、
本発明者はこのイチョウ葉エキスにクロレラを加えるこ
とにより鮮やかな緑色を示し、上記苦みと臭みを抑えた
製剤とすることができることを発見し、本発明をなすに
至ったものである。本発明で使用するクロレラは、健康
食品等に使用される公知のクロレラ、例えばクロレラ・
ピレノイドーサ、クロレラ・ブルガリス、クロレラ・エ
リプソデアセネデスム等を挙げることができる。またク
ロレラの一部をクロレラエキスで置換することもでき
る。Means for Solving the Problems The present invention has been made to solve the above problems, and is prepared by mixing ginkgo biloba leaf extract with chlorella in the formulation. Chlorella 0.5-7 with wt%
It is a chlorella preparation containing Ginkgo biloba extract, which is characterized by containing 5% by weight. The ginkgo biloba extract used in the present invention can be obtained by a known method (JP-A-1-258626).
JP-A-2-31648, etc.), for example, dried ginkgo biloba leaves are extracted with hydrous lower alcohol, and then the extract obtained is of low polarity using a fat-soluble organic solvent. It is produced by removing the compound or further extracting with an organic solvent immiscible with water. This extract is usually used in powder form after removing the organic solvent. The ginkgo biloba extract obtained by this known method is usually brown and has a strong bitterness and a unique odor,
The present inventor discovered that it is possible to obtain a bright green color by adding chlorella to the ginkgo biloba extract, and to suppress the bitterness and odor described above, thereby completing the present invention. Chlorella used in the present invention is a known chlorella used in health foods, for example, chlorella
Pyrenoidosa, Chlorella vulgaris, Chlorella ellipso de acenedesm, etc. can be mentioned. It is also possible to replace part of chlorella with chlorella extract.
【０００５】本発明のクロレラ製剤は、通常固形剤の形
で製造されるが、溶液剤として製造することも可能であ
る。固形剤の場合には、粉末剤、顆粒剤、錠剤、トロー
チ剤、丸剤等の剤形とすることができるが、飲み易さ等
を考慮して錠剤とすることが有利である。またドロップ
やガムの形とすることも可能である。The chlorella preparation of the present invention is usually manufactured in the form of a solid preparation, but it may be manufactured as a solution preparation. In the case of a solid preparation, it may be in the form of powder, granules, tablets, troches, pills, etc. However, tablets are advantageous in view of ease of drinking and the like. It can also be in the form of drops or gum.
【０００６】イチョウ葉エキス、クロレラの含有量は、
目的とする医療効果によって異なるが、イチョウ葉エキ
ス製剤の全重量に対し、イチョウ葉エキスを０．１〜１
５重量％、好ましくは１〜１０重量％とし、クロレラを
０．５〜７５重量％、好ましくは５〜６０重量％とす
る。クロレラの含有量は、イチョウ葉エキスの苦みと臭
みを抑制する整味効果を考慮して調整するとよい。[0006] The content of ginkgo biloba extract and chlorella is
Depending on the intended medical effect, 0.1 to 1 ginkgo biloba extract is added to the total weight of the ginkgo biloba extract formulation.
5% by weight, preferably 1 to 10% by weight, and chlorella 0.5 to 75% by weight, preferably 5 to 60% by weight. The content of chlorella may be adjusted in consideration of the seasoning effect of suppressing the bitterness and odor of the ginkgo biloba extract.
【０００７】本発明のクロレラ製剤には、上記主成分の
外に製剤の製造において慣用されている種々の添加剤を
適宜含有させる。これらの添加剤には賦形剤、結合剤、
滑沢剤、帯電防止剤、離型剤などの成型性の向上を目的
としたものや、崩壊剤、着色剤、矯味剤、矯臭剤、成分
強化剤などの物性の改良や識別を目的としたものが挙げ
られるが、実際の使用にあたっては、例えば賦形剤、結
合剤、崩壊剤等として使用される澱粉のように、一つの
物質を複数の目的として使用さることが普通である。The chlorella preparation of the present invention appropriately contains, in addition to the above main components, various additives commonly used in the preparation of the preparation. These additives include excipients, binders,
For the purpose of improving the moldability of lubricants, antistatic agents, release agents, etc., and for improving and identifying the physical properties of disintegrating agents, coloring agents, flavoring agents, flavoring agents, component enhancers, etc. In the actual use, one substance is usually used for a plurality of purposes, such as starch used as an excipient, a binder, a disintegrant, etc.
【０００８】このような添加剤を含有するクロレラ製剤
を例示すると、上記含有量のイチョウ葉エキス及びクロ
レラに加え、更に賦形剤、結合剤、崩壊剤等として使用
されるコーンスターチ１〜５０重量％、好ましくは２０
〜３５重量％、カルシウム強化成分として使用される乳
酸カルシウム１〜１５重量％、好ましくは６〜１０重量
％、矯臭剤として使用されるミント１〜６重量％、好ま
しくは３〜５重量％、離型剤として使用されるラブリー
ワックス０．５〜４重量％、好ましくは１〜３重量％を
含有するクロレラ錠剤が挙げられる。この錠剤は前記ク
ロレラの整味効果に加え、コーンスターチの作用により
表面につやのある鮮やかな緑色を呈し、かつ粉っぽさが
ないので服用し易いものとなる。As an example of a chlorella preparation containing such an additive, 1 to 50% by weight of corn starch used as an excipient, a binder, a disintegrating agent, etc. in addition to the above-mentioned contents of ginkgo biloba extract and chlorella. , Preferably 20
˜35 wt%, calcium lactate 1-15 wt%, preferably 6-10 wt%, used as a calcium enhancing component, mint 1-6 wt%, preferably 3-5 wt%, used as a flavoring agent, A chlorella tablet containing 0.5 to 4% by weight, preferably 1 to 3% by weight of a lovely wax used as a molding agent can be mentioned. In addition to the taste adjusting effect of chlorella, this tablet has a vivid green color with a glossy surface due to the action of cornstarch, and is not powdery, so that it is easy to take.
【０００９】[0009]
【実施例】クロレラ粉末５０重量％、イチョウ葉エキス
粉末８重量％、乳酸カルシウム７．５重量％、ミント４
重量％、ラブリーワックス２重量％、コーンスターチ２
８．５重量％を原料として乾式打錠法により２５ｍｇの
錠剤を製造した。この錠剤は鮮やかな緑色を示す。
（比較例）実施例におけるクロレラ粉末の代わりにコー
ンスターチを増量して実施例と同様に２５ｍｇの錠剤を
製造した。この錠剤はくすんだ褐色を示す。
（風味試験）実施例及び比較例で得られた錠剤に対し、
１０人のパネラーにより表１の判定項目について官能検
査を実施した。[Example] Chlorella powder 50% by weight, ginkgo biloba extract powder 8% by weight, calcium lactate 7.5% by weight, mint 4
% By weight, 2% by weight lovely wax, 2 cornstarch
A tablet of 25 mg was produced by a dry tableting method using 8.5% by weight as a raw material. The tablets show a bright green color. (Comparative Example) A tablet of 25 mg was produced in the same manner as in Example except that the amount of corn starch was increased instead of the chlorella powder in Example. The tablets have a dull brown color. (Flavor test) For tablets obtained in Examples and Comparative Examples,
A sensory test was conducted on the judgment items in Table 1 by 10 panelists.
【００１０】[0010]
【表１】 [Table 1]
【００１１】表１の結果から明らかなように、イチョウ
葉エキスを含む本発明のクロレラ製剤は比較品に比べて
風味が優れていることが分かる。また本発明の錠剤は光
沢と鮮やかな緑色を示すので、ほとんどのパネラーがく
すんだ褐色を示す比較例品に比べ服用に抵抗がないとの
判断を示した。As is clear from the results shown in Table 1, the chlorella preparation of the present invention containing the ginkgo biloba extract has an excellent flavor as compared with the comparative product. Further, since the tablet of the present invention exhibits gloss and bright green color, it was judged that most of the panelists have no resistance to taking the drug as compared with the comparative example product showing a dull brown color.
【００１２】[0012]
【発明の効果】前記のようにイチョウ葉エキスとクロレ
ラを含む本発明の製剤は、イチョウ葉エキス効果と共に
クロレラ効果を奏し、循環障害の予防・治療効果と共に
滋養効果が期待できる。また、クロレラを含むことによ
りイチョウ葉エキス独特の苦みと臭みを抑制する整味効
果をもち、子供、老人を含む何人も容易に服用飲食する
ことができるので健康食品若しくは循環障害治療薬とし
て極めて有用である。Industrial Applicability As described above, the preparation of the present invention containing ginkgo biloba extract and chlorella exerts a chlorella effect together with a ginkgo leaf extract effect, and is expected to have a nutritional effect as well as a preventive and therapeutic effect on circulatory disorders. In addition, since it has a seasoning effect of suppressing bitterness and odor peculiar to Ginkgo biloba extract by containing chlorella, it can be easily taken and eaten by anyone including children and the elderly, so it is extremely useful as a health food or a remedy for circulatory disorders. Is.
Claims (3)
及びクロレラ０．５〜７５重量％を含有することを特徴
とするイチョウ葉エキス含有クロレラ製剤。1. 0.1 to 15% by weight of ginkgo biloba extract,
And 0.5 to 75% by weight of chlorella, a chlorella preparation containing ginkgo biloba extract.
レラ４０〜６０重量％、乳酸カルシウム６〜１０重量
％、ミント３〜５重量％、ラブリーワックス１〜３重量
％、及びコーンスターチ２０〜３５重量％を含有するこ
とを特徴とするイチョウ葉エキス含有クロレラ製剤。2. Ginkgo biloba extract 1 to 10% by weight, chlorella 40 to 60% by weight, calcium lactate 6 to 10% by weight, mint 3 to 5% by weight, lovely wax 1 to 3% by weight, and corn starch 20 to 35% by weight. % Of ginkgo biloba leaf extract containing chlorella preparation.
エキス含有クロレラ製剤からなることを特徴とする健康
食品。3. A health food comprising the chlorella preparation containing the ginkgo biloba extract according to claim 1 or 2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP03185903A JP3106565B2 (en) | 1991-07-01 | 1991-07-01 | Chlorella preparation containing ginkgo biloba extract |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP03185903A JP3106565B2 (en) | 1991-07-01 | 1991-07-01 | Chlorella preparation containing ginkgo biloba extract |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH057477A true JPH057477A (en) | 1993-01-19 |
| JP3106565B2 JP3106565B2 (en) | 2000-11-06 |
Family
ID=16178901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP03185903A Expired - Lifetime JP3106565B2 (en) | 1991-07-01 | 1991-07-01 | Chlorella preparation containing ginkgo biloba extract |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP3106565B2 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999043219A1 (en) * | 1998-02-27 | 1999-09-02 | Nippon Shinyaku Co., Ltd. | Ginkgo leaf extract compositions and foods containing the same |
| JP2000050833A (en) * | 1998-08-05 | 2000-02-22 | Lotte Co Ltd | Material having function for improving flavor and taste, drink, food and composition for oral cavity, using the same |
| NL2003171C2 (en) * | 2009-07-09 | 2011-01-11 | Carel Christiaan Helsdingen | Composition for providing relief of undesired body odours. |
| CN104273530A (en) * | 2014-10-11 | 2015-01-14 | 中山百鸥医药科技有限公司 | Health plant food |
| CN110897056A (en) * | 2019-12-30 | 2020-03-24 | 内江师范学院 | Ginkgo leaf extract fish feed adhesive and preparation method and application thereof |
-
1991
- 1991-07-01 JP JP03185903A patent/JP3106565B2/en not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999043219A1 (en) * | 1998-02-27 | 1999-09-02 | Nippon Shinyaku Co., Ltd. | Ginkgo leaf extract compositions and foods containing the same |
| JP2000050833A (en) * | 1998-08-05 | 2000-02-22 | Lotte Co Ltd | Material having function for improving flavor and taste, drink, food and composition for oral cavity, using the same |
| NL2003171C2 (en) * | 2009-07-09 | 2011-01-11 | Carel Christiaan Helsdingen | Composition for providing relief of undesired body odours. |
| CN104273530A (en) * | 2014-10-11 | 2015-01-14 | 中山百鸥医药科技有限公司 | Health plant food |
| CN110897056A (en) * | 2019-12-30 | 2020-03-24 | 内江师范学院 | Ginkgo leaf extract fish feed adhesive and preparation method and application thereof |
| CN110897056B (en) * | 2019-12-30 | 2023-08-25 | 内江师范学院 | Ginkgo leaf extract fish feed adhesive and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3106565B2 (en) | 2000-11-06 |
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