JPH0572891B2 - - Google Patents
Info
- Publication number
- JPH0572891B2 JPH0572891B2 JP27559685A JP27559685A JPH0572891B2 JP H0572891 B2 JPH0572891 B2 JP H0572891B2 JP 27559685 A JP27559685 A JP 27559685A JP 27559685 A JP27559685 A JP 27559685A JP H0572891 B2 JPH0572891 B2 JP H0572891B2
- Authority
- JP
- Japan
- Prior art keywords
- ester
- parts
- prepared
- acid
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 17
- 125000004432 carbon atom Chemical group C* 0.000 claims description 12
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical class OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 claims description 6
- 125000001931 aliphatic group Chemical group 0.000 claims description 6
- 239000003960 organic solvent Substances 0.000 claims description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- -1 n-octyl Chemical group 0.000 description 72
- 229940079593 drug Drugs 0.000 description 64
- 239000003814 drug Substances 0.000 description 64
- 239000002253 acid Substances 0.000 description 31
- 230000000052 comparative effect Effects 0.000 description 24
- 239000012153 distilled water Substances 0.000 description 19
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 18
- ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 description 18
- 229960004025 sodium salicylate Drugs 0.000 description 13
- 238000000034 method Methods 0.000 description 11
- 125000000217 alkyl group Chemical group 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 7
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 6
- 235000019441 ethanol Nutrition 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 5
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 4
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 4
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 4
- 229940079889 pyrrolidonecarboxylic acid Drugs 0.000 description 4
- 229920006395 saturated elastomer Polymers 0.000 description 4
- 230000009885 systemic effect Effects 0.000 description 4
- ZNIFSRGNXRYGHF-UHFFFAOYSA-N Clonidine hydrochloride Chemical compound Cl.ClC1=CC=CC(Cl)=C1NC1=NCCN1 ZNIFSRGNXRYGHF-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 3
- 210000001015 abdomen Anatomy 0.000 description 3
- 150000001298 alcohols Chemical class 0.000 description 3
- 229960002925 clonidine hydrochloride Drugs 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- IRQVJPHZDYMXNW-UHFFFAOYSA-N metoclopramide dihydrochloride monohydrate Chemical compound O.[Cl-].[Cl-].CC[NH+](CC)CCNC(=O)C1=CC(Cl)=C([NH3+])C=C1OC IRQVJPHZDYMXNW-UHFFFAOYSA-N 0.000 description 3
- 229960000923 metoclopramide hydrochloride Drugs 0.000 description 3
- 239000004745 nonwoven fabric Substances 0.000 description 3
- 235000013772 propylene glycol Nutrition 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- KFVSLSTULZVNPG-UHFFFAOYSA-N terbutaline sulfate Chemical compound [O-]S([O-])(=O)=O.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1.CC(C)(C)[NH2+]CC(O)C1=CC(O)=CC(O)=C1 KFVSLSTULZVNPG-UHFFFAOYSA-N 0.000 description 3
- 229960005105 terbutaline sulfate Drugs 0.000 description 3
- CYSGHNMQYZDMIA-UHFFFAOYSA-N 1,3-Dimethyl-2-imidazolidinon Chemical compound CN1CCN(C)C1=O CYSGHNMQYZDMIA-UHFFFAOYSA-N 0.000 description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- ZMGMDXCADSRNCX-UHFFFAOYSA-N 5,6-dihydroxy-1,3-diazepan-2-one Chemical compound OC1CNC(=O)NCC1O ZMGMDXCADSRNCX-UHFFFAOYSA-N 0.000 description 2
- AMQJEAYHLZJPGS-UHFFFAOYSA-N N-Pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000002390 adhesive tape Substances 0.000 description 2
- BNPSSFBOAGDEEL-UHFFFAOYSA-N albuterol sulfate Chemical compound OS(O)(=O)=O.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 BNPSSFBOAGDEEL-UHFFFAOYSA-N 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- 229960001193 diclofenac sodium Drugs 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- ZSIAUFGUXNUGDI-UHFFFAOYSA-N hexan-1-ol Chemical compound CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical compound CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 description 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 description 2
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 description 1
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 1
- RWLALWYNXFYRGW-UHFFFAOYSA-N 2-Ethyl-1,3-hexanediol Chemical compound CCCC(O)C(CC)CO RWLALWYNXFYRGW-UHFFFAOYSA-N 0.000 description 1
- RRLZLFQAQXYARF-UHFFFAOYSA-N 2-cyclohexylethyl 2-oxopyrrolidine-1-carboxylate Chemical compound C1CCC(=O)N1C(=O)OCCC1CCCCC1 RRLZLFQAQXYARF-UHFFFAOYSA-N 0.000 description 1
- XDPIUTURIJYSNO-UHFFFAOYSA-N 2-ethylhexyl 2-oxopyrrolidine-1-carboxylate Chemical compound CCCCC(CC)COC(=O)N1CCCC1=O XDPIUTURIJYSNO-UHFFFAOYSA-N 0.000 description 1
- NPSJHQMIVNJLNN-UHFFFAOYSA-N 2-ethylhexyl 4-nitrobenzoate Chemical compound CCCCC(CC)COC(=O)C1=CC=C([N+]([O-])=O)C=C1 NPSJHQMIVNJLNN-UHFFFAOYSA-N 0.000 description 1
- 239000004808 2-ethylhexylester Substances 0.000 description 1
- ANJAJFJAKLZICO-UHFFFAOYSA-N 2-methylhexyl 2-oxopyrrolidine-1-carboxylate Chemical compound CCCCC(C)COC(=O)N1CCCC1=O ANJAJFJAKLZICO-UHFFFAOYSA-N 0.000 description 1
- HQGWGLASHJVQSJ-UHFFFAOYSA-N 3-cyclopentylpropyl 2-oxopyrrolidine-1-carboxylate Chemical compound C1CCC(=O)N1C(=O)OCCCC1CCCC1 HQGWGLASHJVQSJ-UHFFFAOYSA-N 0.000 description 1
- VQSJXSHSUKUYOJ-UHFFFAOYSA-N 4-cyclohexylbutyl 2-oxopyrrolidine-1-carboxylate Chemical compound C1CCC(=O)N1C(=O)OCCCCC1CCCCC1 VQSJXSHSUKUYOJ-UHFFFAOYSA-N 0.000 description 1
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 230000004872 arterial blood pressure Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
- ZAILDIWLVUILSE-UHFFFAOYSA-N butyl 2-oxopyrrolidine-1-carboxylate Chemical compound CCCCOC(=O)N1CCCC1=O ZAILDIWLVUILSE-UHFFFAOYSA-N 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- ATKBLOKVJJZAMM-UHFFFAOYSA-N cycloheptyl 2-oxopyrrolidine-1-carboxylate Chemical compound C1CCC(=O)N1C(=O)OC1CCCCCC1 ATKBLOKVJJZAMM-UHFFFAOYSA-N 0.000 description 1
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- JZPSPVYZFXNNRK-UHFFFAOYSA-N cyclohexylmethyl 2-oxopyrrolidine-1-carboxylate Chemical compound C1CCC(=O)N1C(=O)OCC1CCCCC1 JZPSPVYZFXNNRK-UHFFFAOYSA-N 0.000 description 1
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- AUTNUBIPSVJOIK-UHFFFAOYSA-N cyclooctyl 2-oxopyrrolidine-1-carboxylate Chemical compound C1CCC(=O)N1C(=O)OC1CCCCCCC1 AUTNUBIPSVJOIK-UHFFFAOYSA-N 0.000 description 1
- 125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- SSUXCXWKHBHFEH-UHFFFAOYSA-N decyl 2-oxopyrrolidine-1-carboxylate Chemical compound CCCCCCCCCCOC(=O)N1CCCC1=O SSUXCXWKHBHFEH-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- OPUNQOCLIVUKMO-UHFFFAOYSA-N dodecyl 2-oxopyrrolidine-1-carboxylate Chemical compound CCCCCCCCCCCCOC(=O)N1CCCC1=O OPUNQOCLIVUKMO-UHFFFAOYSA-N 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- ZSUZUJSDKZPWHH-UHFFFAOYSA-N ethyl 2-oxopyrrolidine-1-carboxylate Chemical compound CCOC(=O)N1CCCC1=O ZSUZUJSDKZPWHH-UHFFFAOYSA-N 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- IFGPXDKTPZGTSC-UHFFFAOYSA-N heptyl 2-oxopyrrolidine-1-carboxylate Chemical compound CCCCCCCOC(=O)N1CCCC1=O IFGPXDKTPZGTSC-UHFFFAOYSA-N 0.000 description 1
- VROJYRWXSALTFL-UHFFFAOYSA-N hexadecyl 2-oxopyrrolidine-1-carboxylate Chemical compound CCCCCCCCCCCCCCCCOC(=O)N1CCCC1=O VROJYRWXSALTFL-UHFFFAOYSA-N 0.000 description 1
- 125000001183 hydrocarbyl group Chemical group 0.000 description 1
- SMMMXPNNEVLBRH-UHFFFAOYSA-N icosyl 2-oxopyrrolidine-1-carboxylate Chemical compound CCCCCCCCCCCCCCCCCCCCOC(=O)N1CCCC1=O SMMMXPNNEVLBRH-UHFFFAOYSA-N 0.000 description 1
- YAMHXTCMCPHKLN-UHFFFAOYSA-N imidazolidin-2-one Chemical compound O=C1NCCN1 YAMHXTCMCPHKLN-UHFFFAOYSA-N 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229940035429 isobutyl alcohol Drugs 0.000 description 1
- 229960004592 isopropanol Drugs 0.000 description 1
- 125000005645 linoleyl group Chemical group 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- WFYCWAPHNCARGR-UHFFFAOYSA-N methyl 2-oxopyrrolidine-1-carboxylate Chemical compound COC(=O)N1CCCC1=O WFYCWAPHNCARGR-UHFFFAOYSA-N 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- ZCOGQSHZVSZAHH-UHFFFAOYSA-N n,n-dimethylaziridine-1-carboxamide Chemical compound CN(C)C(=O)N1CC1 ZCOGQSHZVSZAHH-UHFFFAOYSA-N 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- BNMGHTMPTXZOHA-UHFFFAOYSA-N nonan-2-yl 2-oxopyrrolidine-1-carboxylate Chemical class CCCCCCCC(C)OC(=O)N1CCCC1=O BNMGHTMPTXZOHA-UHFFFAOYSA-N 0.000 description 1
- GYEIHWMOVAIDAD-UHFFFAOYSA-N nonyl 2-oxopyrrolidine-1-carboxylate Chemical compound CCCCCCCCCOC(=O)N1CCCC1=O GYEIHWMOVAIDAD-UHFFFAOYSA-N 0.000 description 1
- QYVZEPLDLPYECM-XUTLUUPISA-N octadecyl (e)-3-(3,4-dihydroxyphenyl)prop-2-enoate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)\C=C\C1=CC=C(O)C(O)=C1 QYVZEPLDLPYECM-XUTLUUPISA-N 0.000 description 1
- NWKNKIKNQBSFGH-UHFFFAOYSA-N octadecyl 2-oxopyrrolidine-1-carboxylate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)N1CCCC1=O NWKNKIKNQBSFGH-UHFFFAOYSA-N 0.000 description 1
- WTJUYBSTYYKTGD-UHFFFAOYSA-N octyl 2-oxopyrrolidine-1-carboxylate Chemical compound CCCCCCCCOC(=O)N1CCCC1=O WTJUYBSTYYKTGD-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- YTLHAWKUXSUXIR-UHFFFAOYSA-N propyl 2-oxopyrrolidine-1-carboxylate Chemical compound CCCOC(=O)N1CCCC1=O YTLHAWKUXSUXIR-UHFFFAOYSA-N 0.000 description 1
- 229940071139 pyrrolidone carboxylate Drugs 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- KUKAXYLECOULLV-UHFFFAOYSA-N tetradecyl 2-oxopyrrolidine-1-carboxylate Chemical compound CCCCCCCCCCCCCCOC(=O)N1CCCC1=O KUKAXYLECOULLV-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- SAGFKEVKFWCOPZ-UHFFFAOYSA-N tridecyl 2-oxopyrrolidine-1-carboxylate Chemical compound CCCCCCCCCCCCCOC(=O)N1CCCC1=O SAGFKEVKFWCOPZ-UHFFFAOYSA-N 0.000 description 1
- FDDOEWMEOHASSD-UHFFFAOYSA-N undecyl 2-oxopyrrolidine-1-carboxylate Chemical compound CCCCCCCCCCCOC(=O)N1CCCC1=O FDDOEWMEOHASSD-UHFFFAOYSA-N 0.000 description 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27559685A JPS62135435A (ja) | 1985-12-06 | 1985-12-06 | イオントフオレ−ゼ生体電極用基剤組成物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27559685A JPS62135435A (ja) | 1985-12-06 | 1985-12-06 | イオントフオレ−ゼ生体電極用基剤組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62135435A JPS62135435A (ja) | 1987-06-18 |
| JPH0572891B2 true JPH0572891B2 (enrdf_load_stackoverflow) | 1993-10-13 |
Family
ID=17557647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP27559685A Granted JPS62135435A (ja) | 1985-12-06 | 1985-12-06 | イオントフオレ−ゼ生体電極用基剤組成物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62135435A (enrdf_load_stackoverflow) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2208336A1 (en) * | 1996-06-20 | 1997-12-20 | Hisamitsu Pharmaceuticals Co., Inc. | A device structure for iontophoresis |
-
1985
- 1985-12-06 JP JP27559685A patent/JPS62135435A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS62135435A (ja) | 1987-06-18 |
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