JPH0566558U - Simple automatic analyzer - Google Patents

Abstract

(57) [Summary] [Purpose] To provide a simple automatic analyzer for increasing the treatments per unit time. [Structure] Several disposable chips can be loaded into and discharged from a cassette tray, and sample dispensing, first reagent dispensing, second reagent dispensing, and optical measurement are performed with intermittent movement of the tray. It is a method of processing several chips at the same time by multi-systems for chip feeding and discharging. [Effect] Several samples including standard samples and general samples can be processed simultaneously.

Description

[Detailed description of the device]

[0001]

[Industrial applications]

 The present invention relates to a simple automatic analyzer which uses a disposable chip for biochemical and clinical chemistry analysis and simply improves the reliability of measurement results.

[0002]

[Prior Art]

 Conventionally, the system used in this kind of simple automatic analyzer has adopted a method of dispensing one by one to a chip, and also a method of sequentially performing one by one such as optical measurement and reagent dispensing. It was

[0003]

[Problems to be solved by the device]

 In these conventional techniques, dispensing of a large number of specimens, movement, an optical device are complicated, and a large amount of processing time is required. Therefore, even if a disposable tip is used, the rationalization of them is not performed. The present invention aims to shorten the processing time and simplify the device, which are the problems of the conventional technology.

[0004]

[Means to be solved by the device]

 The present invention considers these drawbacks, performs steps of sample reception, pipetting, first reagent pipetting, second reagent pipetting, optical measurement, and sample reception by carrying out intermittent movement using a cassette. Disposable tip is used for the reaction tube of the above, the tip is discarded after the optical measurement, and the disposable tip is loaded using the multi-handle robot before receiving the specimen. For the reagent dispensing and the second reagent dispensing, the dispensing of the entire one cassette is completed at the same time using a multi-pipette, and the optical measurement also measures a large number of samples for each cassette tray. Since disposable chips are used, there is an advantage that the washing and drying steps which are complicated in the processing steps of the conventional automatic analyzer can be omitted. A computer was used to facilitate work such as sample dispensing, reagent dispensing, optical measurement, chip loading, and disposal of this device.

[0005]

【Example】

 The simple automatic analyzer according to the present invention, as shown in FIG. 2, transfers a sample cassette 10 holding a plurality of sample cups 1 containing samples in a cassette tray 2 in parallel to a predetermined suction position by a feeding device (not shown). To do. As shown in FIGS. 1 and 2, the cassette 11 that has undergone the predetermined sample processing is in an empty state in which chips are not loaded. When the empty cassette 11 moves in the direction of the downward arrow and reaches the position A, six disposable chips 14 in the chip stocker 12 are simultaneously inserted into the cassette 11 which is stopped at A by the handle movement by the robot 13 of the multi-handle mechanism. Be carried.

When the cassette further advances in the direction of the arrow F and reaches the position B, the sample dispensing mechanism 15 in the sample cassette 10 dilutes the specimen with a syringe by a known method using dilution water, By the injection mechanism, six diluted samples are simultaneously lowered and dispensed into each chip 14 in the cassette. The cassette tray 11 further advances in the direction of the arrow by using a feeding device (not shown). When it reaches the lower end, it laterally moves in the direction of the left arrow, and when it reaches the left end, it advances in the direction of the upper arrow. Done. As the above-mentioned feeding device, for example, the one having the mechanism disclosed in JP-A-57-37263 is used. Further, in order to keep the reaction liquid in the chip 14 receiving these specimens at a constant temperature, a heater device is arranged on one side of the transfer path.

The manner of using the sample of the cassette tray 11 in this device may be increased or decreased as necessary. For example, in the case of 6 chips, the first to fifth samples are general samples, and the samples stored in the sixth sample are It may be carried out by charging quality control substances, preliminarily inserting substances having clear numerical values as standard values, and arranging them every few pieces.

When the cassette is moved to the position C, the corresponding reagent in the reagent container 16 is selected according to the measurement items stored in the computer in advance by using the multi-pipe by the first reagent dispensing mechanism 17, and the cassette is lowered 6 At the same time, the first reagent is dispensed to the diluted sample width in the cassette 11.

The cassette is further transferred in the upward direction of the arrow, and when it reaches the position D, the second reagent is dispensed. In this system, the dispensing position D can be moved back and forth as appropriate according to the color of the reaction liquid. The second dispensing reagent is dropped from the reagent container 16 by the multi-pipette 18 according to the measurement item stored in the computer in advance according to the measurement item, and six reagents are simultaneously added to the reaction solution in the chip 14. Dispensing is performed.

When the cassette tray 11 reaches the upper left portion, it changes from vertical feed to horizontal feed and reaches the E position. The E position has an optical measuring device M, and this device uses a light source 19, a lens 20, a diffraction grating 21, and an optical fiber 22 to disperse light using several prisms 23 and passes them through the respective reaction tube chips. The light is received by the light receiving element 24, and the absorbance is sequentially measured. In the signal processing device S, the measurement result can automatically detect the accuracy at the time of measurement, correct the measurement value between the quality control substance and the general substance, examine the dispersion, and detect the reliability of the measurement site.

Further, the cassette tray 11 reaches the point F, and by the operation of the multi-gripping device 26 which is a robot, six chips 14 are simultaneously gripped and discarded in the disposal tank 27. The chip 14 drops on the screen 28, descends while tilting on the screen 28, and is separated into a liquid tank 29 and a waste chip tank 30. The cassette emptied at the F position is transferred in the downward direction and returned to the A position again. For the vertical and horizontal feed mechanism of the cassette tray 11, the method described in JP-A-57-37263 is used.

The acceptance of the sample is input to the storage device S of the computer CPU by collating the barcode with the blood collection tube. As a device interlocking with the memory device S, loading and unloading of chips with the chip gripping devices A and F, dispensing of the sample and diluted sample at point B, selection of the first reagent at point C, dispensing, D The second reagent dispensing position at the point, the reagent selection, the dispensing, and the accuracy, detection, correction, and reliability detection of the measurement result of the data in the optical measurement are performed.

[0013]

[Effect of the Invention] This simple automatic analyzer sequentially performs sample dispensing, first reagent dispensing, second reagent dispensing, and optical measurement by moving the cassette tray, and at that time, using a multi-pipette for each sample and reagent. Can be dispensed at one time, and optical measurement can also be performed by photometrically measuring, calculating and correcting the data in the cassette tray group at a time, and at the same time, it is disposable with a chip, so the washing and drying process performed by the conventional automatic analyzer can be performed. It becomes unnecessary. Since these are compact and work in conjunction with the computer, it is possible to obtain various data with extremely high accuracy.

[0014]

[Brief description of drawings]

FIG. 1 is an explanatory view of a simple automatic analyzer according to the present invention.

FIG. 2 is a plan view of a simple automatic analyzer according to the present invention.

[Explanation of symbols]

 1 sample cup 2 cassette tray 10 sample cassette 11 cassette tray 12 chip stocker 13 robot gripping device 14 chip 15 sample dispensing mechanism 16 reagent container 17 first reagent dispensing mechanism 18 second reagent dispensing mechanism 26 robot gripping device 27 waste tank M Optical measuring device S Storage device CPU computer

Claims (2)

[Scope of utility model registration request] 1. A sample specimen receiving mechanism stored in a cassette, a test solution dispensing mechanism, a disposable chip that is installed in and removed from the cassette tray, a reagent container, a first reagent dispensing mechanism, a second reagent dispensing mechanism, and a measurement. Optical measuring device for cell reaction solution, chip disposal mechanism, gripping movement mechanism, control of dispensing mechanism,
A simple automatic analyzer characterized by comprising an analysis mechanism of the measurement result of the measuring device. 2. The above-mentioned sample dispensing, reagent dispensing, and optical measurement are systematically performed by intermittent movement of a cassette, a disposable chip is used for a cell, and a multi-dispensing mechanism, a multi-gripping device, and an optical measurement are performed. A simple automatic analyzer characterized by being used in the device to process several samples in a cassette tray at the same time.