JPH0562157B2 - - Google Patents
Info
- Publication number
- JPH0562157B2 JPH0562157B2 JP84200702A JP20070284A JPH0562157B2 JP H0562157 B2 JPH0562157 B2 JP H0562157B2 JP 84200702 A JP84200702 A JP 84200702A JP 20070284 A JP20070284 A JP 20070284A JP H0562157 B2 JPH0562157 B2 JP H0562157B2
- Authority
- JP
- Japan
- Prior art keywords
- organic acid
- calcium carbonate
- foaming agent
- reaction
- crystals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 100
- 239000013078 crystal Substances 0.000 claims description 69
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 50
- 150000007524 organic acids Chemical class 0.000 claims description 46
- 239000004088 foaming agent Substances 0.000 claims description 39
- 238000006243 chemical reaction Methods 0.000 claims description 35
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 25
- 239000010410 layer Substances 0.000 claims description 23
- 239000011248 coating agent Substances 0.000 claims description 22
- 238000000576 coating method Methods 0.000 claims description 22
- 239000011736 potassium bicarbonate Substances 0.000 claims description 20
- 229910000028 potassium bicarbonate Inorganic materials 0.000 claims description 20
- 235000015497 potassium bicarbonate Nutrition 0.000 claims description 20
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 claims description 20
- 239000002245 particle Substances 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 13
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 12
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 10
- 239000001530 fumaric acid Substances 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 6
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 6
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 6
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 5
- 239000007789 gas Substances 0.000 claims description 5
- 159000000007 calcium salts Chemical class 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- -1 organic acid salt Chemical class 0.000 claims description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- 239000011591 potassium Substances 0.000 claims description 2
- 159000000000 sodium salts Chemical class 0.000 claims description 2
- 239000002344 surface layer Substances 0.000 claims description 2
- 229940086066 potassium hydrogencarbonate Drugs 0.000 claims 3
- 239000004615 ingredient Substances 0.000 claims 1
- 229960003975 potassium Drugs 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 75
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 12
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 11
- 229910001415 sodium ion Inorganic materials 0.000 description 7
- 238000005187 foaming Methods 0.000 description 6
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Substances [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 6
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 6
- 229960005070 ascorbic acid Drugs 0.000 description 5
- 235000010323 ascorbic acid Nutrition 0.000 description 5
- 239000011668 ascorbic acid Substances 0.000 description 5
- 239000011230 binding agent Substances 0.000 description 5
- 235000011087 fumaric acid Nutrition 0.000 description 5
- 229910000029 sodium carbonate Inorganic materials 0.000 description 5
- 235000017550 sodium carbonate Nutrition 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 4
- 229960001138 acetylsalicylic acid Drugs 0.000 description 4
- 229910052500 inorganic mineral Inorganic materials 0.000 description 4
- 235000010755 mineral Nutrition 0.000 description 4
- 239000011707 mineral Substances 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 235000014214 soft drink Nutrition 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 239000007938 effervescent tablet Substances 0.000 description 3
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 3
- 229910000027 potassium carbonate Inorganic materials 0.000 description 3
- 235000011181 potassium carbonates Nutrition 0.000 description 3
- 229960004889 salicylic acid Drugs 0.000 description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 2
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 230000033558 biomineral tissue development Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- PFKGDYCESFRMAP-UHFFFAOYSA-L dicalcium citrate Chemical compound [Ca+2].[O-]C(=O)CC(O)(C(=O)O)CC([O-])=O PFKGDYCESFRMAP-UHFFFAOYSA-L 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000174 gluconic acid Substances 0.000 description 2
- 235000012208 gluconic acid Nutrition 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 159000000001 potassium salts Chemical class 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000006557 surface reaction Methods 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 239000011975 tartaric acid Substances 0.000 description 2
- 235000002906 tartaric acid Nutrition 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- 239000004604 Blowing Agent Substances 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 239000004278 EU approved seasoning Substances 0.000 description 1
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229910000288 alkali metal carbonate Inorganic materials 0.000 description 1
- 150000008041 alkali metal carbonates Chemical class 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 230000008275 binding mechanism Effects 0.000 description 1
- 239000007767 bonding agent Substances 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 229940093915 gynecological organic acid Drugs 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 229910001425 magnesium ion Inorganic materials 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 238000002161 passivation Methods 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- ABBQHOQBGMUPJH-UHFFFAOYSA-N sodium;2-hydroxybenzoic acid Chemical compound [Na+].OC(=O)C1=CC=CC=C1O ABBQHOQBGMUPJH-UHFFFAOYSA-N 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/40—Effervescence-generating compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Description
【発明の詳細な説明】
本発明は少なくとも一種の有機酸結晶と少なく
とも一種の該有機酸結晶との反応に際してCO2を
析出する炭酸塩とを含有する起泡剤、ならびに該
起泡剤の製造方法に関する。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a foaming agent containing at least one type of organic acid crystal and a carbonate that precipitates CO 2 upon reaction with the at least one type of organic acid crystal, and a method for producing the foaming agent. Regarding the method.
起泡剤が、例えばクエン酸、酒石酸のような有
機酸と炭酸水素ナトリウム、炭酸ナトリウム、炭
酸水素カリウムまたは炭酸カリウムのようなCO2
析出性物質との反応を基礎とする系の上に成り立
つていることは知られている。しかしこのような
系が非常に高い割合でナトリウムイオンを包含し
ていることが屡々批判され、より少いナトリウム
イオンを包含するか、あるいは可能な限りナトリ
ウムイオンを含まない起泡系を確立することが望
まれてきた。炭酸水素カリウムや炭酸カリウムの
みを使用することは、先ず第一にこれらの物質が
不快な石鹸様の味をもたらすことと、その上カリ
ウム塩の添加によつて湿気感受性が大きな技術上
の問題となることのために適当ではない。 The foaming agent is an organic acid such as citric acid, tartaric acid and CO 2 such as sodium bicarbonate, sodium carbonate, potassium bicarbonate or potassium carbonate.
It is known that it is based on a system based on reactions with precipitable substances. However, such systems are often criticized for containing very high proportions of sodium ions, and it is important to establish foaming systems that contain fewer sodium ions or are as free from sodium ions as possible. has been desired. The use of potassium bicarbonate or potassium carbonate alone is due to the fact that, first of all, these substances give an unpleasant soapy taste and, moreover, moisture sensitivity due to the addition of potassium salts poses a major technical problem. Not suitable for becoming.
従つて、例えば炭酸カルシウムや炭酸マグネシ
ウムのような他の炭酸析出性担体を見出すことが
望まれていた。しかし、先ず選ばれるであろう炭
酸カルシウムは有機酸との反応が非常に遅く、し
たがつて溶解に長い時間を必要とする起泡系が生
ずるであろうから、全くあるいは殆んど考慮され
ていない。 It was therefore desirable to find other carbonate precipitating carriers, such as calcium carbonate and magnesium carbonate. However, calcium carbonate, which would be the first choice, reacts very slowly with organic acids and would therefore result in a foaming system that requires a long time to dissolve, so it has not been given any or little consideration. do not have.
本発明の課題は、例えばクエン酸のような有機
酸と炭酸カルシウムとの間の起泡反応を促進する
ことによつて実用不可能なような長い溶解時間を
解消し、安定にして貯蔵可能な起泡剤および該起
泡剤の製造方法を提供することにある。 The object of the present invention is to solve the impractically long dissolution time by promoting the foaming reaction between an organic acid such as citric acid and calcium carbonate, and to make it stable and storable. An object of the present invention is to provide a foaming agent and a method for producing the foaming agent.
本発明によれば、前記種類の起泡剤におけるこ
の課題は、有機酸結晶に該結晶の表面に炭酸カル
シウム含有被覆材料と各有機酸結晶の表面層との
反応によつて形成された結合層によつて付着して
いる炭酸カルシウム含有被覆を施すことによつて
解決される。 According to the invention, this problem in foaming agents of the above type is solved by providing organic acid crystals with a bonding layer formed on the surface of the crystals by reaction of a calcium carbonate-containing coating material with the surface layer of each organic acid crystal. The solution is to apply a coating containing calcium carbonate, which is deposited by
被覆材料は炭酸塩として炭酸カルシウムのみを
含有しているのが好ましい。被覆材料は炭酸水素
カリウムを含有していることができる。また本発
明によれば、被覆材料は炭酸水素ナトリウムをも
含有していることができる。 Preferably, the coating material contains only calcium carbonate as carbonate. The coating material may contain potassium bicarbonate. According to the invention, the coating material can also contain sodium bicarbonate.
また本発明によれば、被覆が多層形成されてい
ることができる。 Further, according to the present invention, the coating can be formed in multiple layers.
さらに本発明によれば、被覆は有機酸結晶の表
面に結合層を介して結合している反応済みの炭酸
カルシウム層とその上に付着した炭酸水素カリウ
ム層とを有していてもよい。 Furthermore, according to the invention, the coating may have a layer of reacted calcium carbonate bonded to the surface of the organic acid crystal via a bonding layer and a layer of potassium bicarbonate deposited thereon.
また、有機酸結晶の少なくとも一部がクエン酸
結晶であつてもよい。また、本発明によれば、有
機酸結晶の一部がアスコルビン酸結晶であつても
よい。 Furthermore, at least a portion of the organic acid crystals may be citric acid crystals. Further, according to the present invention, a part of the organic acid crystals may be ascorbic acid crystals.
結合層は有機酸結晶表面の少なくとも80％、特
に少なくとも95％被覆しているのが好ましい。こ
のような充分な被覆および前記表面での炭酸カル
シウムの捕捉によつて、有機酸結晶、例えばクエ
ン酸結晶と炭酸カルシウムとの、そうでなければ
極めて長くかかるであろう反応が、意外にも急速
に行われる。更に、このように充分な有機酸結晶
の被覆により、その周囲の湿分に対する確実な耐
性が得られる。このような特徴事項によつて得ら
れる特別な効果は、系の構成に対して決して他の
結合剤を使用しないこと、すなわち、前記結合層
により成分だけでの接着が行われることによるも
のである。 Preferably, the bonding layer covers at least 80%, especially at least 95%, of the organic acid crystal surface. Due to this sufficient coverage and entrapment of calcium carbonate at the surface, the reaction of organic acid crystals, such as citric acid crystals, with calcium carbonate, which would otherwise take a very long time, is surprisingly rapid. It will be held on. Furthermore, such a sufficient coating of organic acid crystals provides reliable resistance to the surrounding moisture. The special effect obtained with these features is that no other bonding agents are used for the construction of the system, i.e. the bonding layer provides a bonding of the components alone. .
炭酸カルシウムの粒径は、できるだけ凝集した
被覆が有機酸結晶上に存在するように、有機酸結
晶の粒径よりも約１オーダーだけ小さい。 The particle size of the calcium carbonate is about an order of magnitude smaller than the particle size of the organic acid crystals so that as much as possible agglomerated coating is present on the organic acid crystals.
結合層は、できるだけ多くの炭酸カルシウムを
起泡反応に供給するために、酸塩の形の炭酸カル
シウムの最大５重量％、特に最大２重量％からな
ることが好ましい。 The bonding layer preferably consists of at most 5% by weight, in particular at most 2% by weight, of calcium carbonate in the form of an acid salt in order to supply as much calcium carbonate as possible to the foaming reaction.
起泡剤の炭酸カルシウム成分は、最大20マイク
ロメーターの粒径を有するのが好ましい。何故な
らば、それにより炭酸カルシウムの反応面積が非
常に大きくなり、炭酸ナトリウムに匹敵する反応
速度が得られるからである。 Preferably, the calcium carbonate component of the foaming agent has a particle size of up to 20 micrometers. This is because the reaction area of calcium carbonate becomes very large and a reaction rate comparable to that of sodium carbonate can be obtained.
被覆材料が好ましくは専ら炭酸カルシウムから
成るときにも、該材料は更に炭酸水素ナトリウム
および／または炭酸水素カリウムを含有すること
ができ、ここで本発明の他の特徴事項によれば、
１つの層は本質的にカリウム塩および／またはナ
トリウム塩を含有し、他の層は本質的にカルシウ
ム塩を含有する。 Even when the coating material preferably consists exclusively of calcium carbonate, it can additionally contain sodium bicarbonate and/or potassium bicarbonate, wherein according to another feature of the invention:
One layer contains essentially potassium and/or sodium salts, the other layer essentially contains calcium salts.
本発明によれば、更に、被覆は有機酸結晶の表
面に結合層を介して結合している反応済みの炭酸
カルシウム層とその上に付着している炭酸水素カ
リウム層とを有している。 According to the invention, the coating further comprises a layer of reacted calcium carbonate bonded to the surface of the organic acid crystal via a bonding layer and a layer of potassium bicarbonate deposited thereon.
本発明により起泡剤においては、粉体技術にお
いて普通に使用される結合剤の代りに結合層があ
るので、この結合層はミネラル物質および／また
はビタミンの保持に役立つことができる。 Since in the foaming agent according to the invention there is a bonding layer instead of the binding agents commonly used in powder technology, this bonding layer can serve to retain mineral substances and/or vitamins.
本発明による起泡剤は生活に必要なミネラル物
質および／またはビタミンを更に含有することが
できる。本発明は、このような起泡剤をソフトド
リンクのミネラル化に使用することもできる。非
常に糖分が多く部分的に顕著にミネラル分の少な
いソフトドリンクそして同時に多量の食塩（塩化
ナトリウム）の使用により、生体の生活に必要な
ミネラルの欠乏が増大するので、本発明の起泡剤
をこのようなソフトドリンクのミネラル化に使用
することは非常に強調される。 The foaming agent according to the invention can further contain mineral substances and/or vitamins necessary for life. The invention also allows the use of such foaming agents in the mineralization of soft drinks. The foaming agent of the present invention is used because the use of soft drinks that have a very high sugar content and are partially low in minerals and at the same time a large amount of salt (sodium chloride) increases the deficiency of minerals necessary for living organisms. Its use in the mineralization of such soft drinks is highly emphasized.
従つて、本発明の起泡剤によれば、ナトリウム
イオンが無いかまたは極めて少ない含有量で多量
のカルシウムイオン、マグネシウムイオン、カリ
ウムイオンおよびその他の生活に必要なイオンを
ソフトドリンクを容易に導入することができる。 Therefore, according to the foaming agent of the present invention, large amounts of calcium ions, magnesium ions, potassium ions and other ions necessary for daily life can be easily introduced into soft drinks with no or very low content of sodium ions. be able to.
本発明による起泡剤の製造方法は、有機酸結晶
の一部ならびにエタノールと水の混合物の一部を
先ず60℃で0.1バールまたはそれ以下の圧力の下
で混合し、次いで炭酸カルシウムを吸い込ませそ
して少くとも第一反応段階として炭酸カルシウム
の有機酸結晶との反応を、その反応の際に発生す
るCO2ガスによつて圧力が0.9バールに上昇する
まで行うことを特徴とする、一種またはそれ以上
の有機酸結晶と一種またはそれ以上の炭酸塩とを
真空混合機中でエタノールと水との混合物の添加
の下に相互に混合し粒状化する方法である。 The process for producing the foaming agent according to the invention consists in first mixing a portion of the organic acid crystals and a portion of the ethanol and water mixture at 60° C. under a pressure of 0.1 bar or less, and then sucking in calcium carbonate. and one or more of them, characterized in that, at least as a first reaction step, calcium carbonate is reacted with organic acid crystals until the pressure rises to 0.9 bar due to the CO 2 gas generated during the reaction. In this method, the above organic acid crystals and one or more carbonates are mixed with each other in a vacuum mixer with the addition of a mixture of ethanol and water and granulated.
この方法においては、有機酸結晶の炭酸カルシ
ウム被覆が終結した後、有機酸結晶の残部ならび
に炭酸水素カリウムおよびアルコールと水の混合
物の残部を第一反応段階の温度および圧力条件の
下で添加して反応を更に行うことができる。 In this method, after the calcium carbonate coating of the organic acid crystals is completed, the remainder of the organic acid crystals and the remainder of the potassium bicarbonate and alcohol-water mixture are added under the temperature and pressure conditions of the first reaction stage. Further reactions can be carried out.
また、本発明によれば、有機酸結晶の炭酸カル
シウム被覆が終結した後、炭酸水素カリウムなら
びに残りの成分を添加して第二の反応を行い、次
いで0.9バールで乾燥した後、そうして得られた
粒子を微粒子状のフマール酸で被覆することがで
きる。この方法はサリチル酸含有起泡剤を製造す
るのに役立つ。 Also according to the invention, after the calcium carbonate coating of the organic acid crystals has been completed, a second reaction is carried out by adding potassium bicarbonate as well as the remaining components, and then after drying at 0.9 bar, the resulting The particles can be coated with finely divided fumaric acid. This method is useful for producing salicylic acid-containing foaming agents.
本発明は、有機酸結晶例えばクエン酸結晶と炭
酸カルシウムとの間の起泡反応は該有機酸結晶を
炭酸カルシウムで被覆して炭酸カルシウムとクエ
ン酸とを有機酸結晶の表面で緊密に接触させるこ
とによつて促進することができるという意外な認
識に基づくものである。そうすることによつて酸
と炭酸カルシウムとの間の反応をアルカリ金属炭
酸塩またはアルカリ金属重炭酸塩との反応に匹敵
するものにすることができる。 In the present invention, the foaming reaction between an organic acid crystal, such as a citric acid crystal, and calcium carbonate is performed by coating the organic acid crystal with calcium carbonate and bringing the calcium carbonate and citric acid into close contact on the surface of the organic acid crystal. This is based on the surprising realization that it can be promoted by By doing so, the reaction between the acid and calcium carbonate can be made comparable to the reaction with alkali metal carbonates or alkali metal bicarbonates.
その際結合剤を考慮する必要があるが、この場
合の、結合剤は炭酸カルシウムの約５〜10％が有
機酸結晶の表面で反応して該有機酸結晶に対応す
るカルシウム塩を生成するその反応生成物であ
る。炭酸カルシウムと有機酸結晶、例えばクエン
酸結晶との間の表面反応は炭酸カルシウムを有機
酸結晶の表面に、後に混合した場合にもその構造
の分離が起こらぬようにしつかり固着させるのに
役立つ。 In this case, it is necessary to consider the binder, and in this case, the binder is a binder that reacts with about 5 to 10% of calcium carbonate on the surface of the organic acid crystal to form a calcium salt corresponding to the organic acid crystal. It is a reaction product. The surface reaction between the calcium carbonate and the organic acid crystals, such as citric acid crystals, serves to firmly fix the calcium carbonate to the surface of the organic acid crystals so that their structure does not separate when mixed later.
この結合機構は有利には、例えば種々の大き
さ、例えば50〜500μｍのクエン酸結晶をアルコ
ールと水との混合物で湿潤させ、次に例えば真空
混合機中で500ｍバールの減圧にし、炭酸カルシ
ウムを吸引添加しそして500ｍバールの減圧下に
有利な水平軸のまわりを振動し時には重力に抗し
て回転する撹拌機中で混合を開始することによつ
て達成される。三次元の混合によつて全ての予め
湿潤させたクエン酸結晶は炭酸カルシウムと接触
させられて、その際起つた反応は真空混合機につ
いている減圧メーターの低下によつて測定するこ
とができる。一定量のガス発生後完全に真空する
ことによつて反応を停止させる。生成したクエン
酸水素カルシウム層は湿気によつて表面に付着し
ている炭酸カルシウムの結合剤として役立つ。こ
の系はその時に起る湿気の除去によつて機械的に
も化学的にも安定なものとなる。 This binding mechanism is advantageously carried out by wetting citric acid crystals of various sizes, e.g. This is achieved by suction addition and starting mixing under a reduced pressure of 500 mbar in a stirrer which preferably vibrates around a horizontal axis and sometimes rotates against gravity. By three-dimensional mixing, all the pre-moistened citric acid crystals are brought into contact with the calcium carbonate, and the reaction that occurs can be measured by the drop in the vacuum meter attached to the vacuum mixer. After a certain amount of gas has been generated, the reaction is stopped by applying a complete vacuum. The calcium hydrogen citrate layer formed serves as a binder for the calcium carbonate that is attached to the surface by moisture. The system becomes mechanically and chemically stable due to the moisture removal that occurs at that time.
この方法によつて１モルの炭酸カルシウムに対
して１モルのクエン酸の化学量論量にほぼ相当す
る量の炭酸カルシウムを導入し、そのうち５〜10
％のみを反応させることができる。 By this method, calcium carbonate is introduced in an amount approximately equivalent to the stoichiometric amount of 1 mole of citric acid per 1 mole of calcium carbonate, of which 5 to 10
% can be reacted.
真空中での製法は最初に精密な制御を行い、そ
してそれぞれの時点で反応を正確に終了し、操作
の正しい再現性を実現させることができ、相当す
る遅いかきまぜ速度により、他の方法、例えば流
動床乾燥の場合のように系を破壊することがな
く、系の構成が妨げられることはない。真空中の
製法により、特に、前記のように、ナトリウムを
含有していないかまたはナトリウム分の少ない起
泡剤を、従来の炭酸水素ナトリウムを基材とする
錠剤と同様に急速に溶解させ、更にその湿分感度
を本質的に小さくすることができる。 The preparation method in vacuum allows precise control initially and precise termination of the reaction at each time point, achieving correct reproducibility of the operation, and the correspondingly slow stirring speed makes it easier for other methods, e.g. There is no destruction of the system, as in the case of fluidized bed drying, and there is no interference with system configuration. The process in vacuum allows, in particular, the sodium-free or low-sodium effervescent agent, as described above, to dissolve rapidly in a manner similar to conventional sodium bicarbonate-based tablets; Its moisture sensitivity can be substantially reduced.
この系は今や起泡剤として確立され、一定量の
炭酸水素カリウムまたは炭酸カリウムを添加する
ことができるし、また少量の炭酸ナトリウムを
“低ナトリウム”あるいは“極低ナトリウム”と
いう表示に要求される量にしたがつて添加するこ
ともできる。 This system is now well-established as a foaming agent, and certain amounts of potassium bicarbonate or potassium carbonate can be added, and small amounts of sodium carbonate are required for "low sodium" or "very low sodium" claims. It can also be added according to the amount.
有機酸を選ぶ際には不溶性のカルシウム塩を与
えるような酸、例えば酒石酸などを選ばないよう
に注意しなければならない。使用できるのはリン
ゴ酸、フマール酸、アジピン酸などである。 When choosing an organic acid, care must be taken to avoid choosing acids that give insoluble calcium salts, such as tartaric acid. Examples that can be used include malic acid, fumaric acid, and adipic acid.
本発明の起泡剤の製造に特に適した方法および
装置はオーストリア特許第376147号に記載されて
いる。 A particularly suitable method and apparatus for producing the foaming agent of the invention is described in Austrian Patent No. 376147.
本発明の他の特徴おろび利点は特許請求の範囲
およびそれに続く記載から明らかであり、以下の
実施例に於て個々に説明される。 Other features and advantages of the invention are apparent from the claims and the following description and are explained individually in the examples below.
実施例 １
粒度0.4〜0.6mmのクエン酸結晶22部と粒度0.1mm
のクエン酸43部とを混合し、40℃に加熱しそして
50％のエタノール10部を加える。５分間振動混合
した後500ｍバールに減圧し、微粉状にした炭酸
カルシウム20部を添加する。撹拌することなく再
度減圧にし、500ｍバールに達した時に振動混合
しそして真空ポンプに通じるバルブを閉じる。反
応が起り真空度が徐々に低下する。200ｍバール
に達した時に完全に真空にする。圧力差を計算に
入れた残留空間の差は対応する炭酸カルシウム量
の約４％でクエン酸水素カルシウムに変化したこ
とを示す。Example 1 22 parts of citric acid crystals with a particle size of 0.4 to 0.6 mm and a particle size of 0.1 mm
and 43 parts of citric acid, heated to 40℃ and
Add 10 parts of 50% ethanol. After 5 minutes of vibratory mixing, the pressure is reduced to 500 mbar and 20 parts of pulverized calcium carbonate are added. Depressurize again without stirring, vibratory mix when 500 mbar is reached and close the valve leading to the vacuum pump. A reaction occurs and the degree of vacuum gradually decreases. Completely evacuate when the pressure reaches 200mbar. The difference in residual space, taking into account the pressure difference, indicates that about 4% of the corresponding amount of calcium carbonate was converted to calcium hydrogen citrate.
800ｍバールに到達した後、撹拌を停止し、撹
拌／停止を繰り返し乍ら10ｍバールまで乾燥させ
起泡剤が得られる。 After reaching 800 mbar, the stirring is stopped and the foaming agent is obtained by drying to 10 mbar while repeating stirring/stopping.
この起泡剤には80部までの炭酸水素カリウムお
よび30部までの炭酸ナトリウムを混合することが
でき、更に錠剤化することができる。 This foaming agent can be mixed with up to 80 parts of potassium bicarbonate and up to 30 parts of sodium carbonate and can be further tabletted.
この起泡剤は、度々の摂取に際して良く秤量さ
れた量のアルカリイオンおよびアルカリ土類イオ
ンを含有している高濃度処分のアセチルサリチル
酸含有起泡錠を製造するのに特に適している。従
来は大量のナトリウムイオンが起泡効果には必要
であつた。 This effervescent agent is particularly suitable for producing highly concentrated acetylsalicylic acid-containing effervescent tablets containing well-metered amounts of alkali and alkaline earth ions for repeated ingestion. Previously, large amounts of sodium ions were required for the foaming effect.
実施例 ２
粒度0.5mmのクエン酸結晶22部を粒度0.1mmのク
エン酸88部と混合し、エタノールと水の混合物20
部で湿潤させる。炭酸カルシウム22部を添加し、
乾燥後、炭酸水素カリウム60部および炭酸ナトリ
ウム10部を加えて起泡剤が得られる。Example 2 22 parts of citric acid crystals with a particle size of 0.5 mm were mixed with 88 parts of citric acid with a particle size of 0.1 mm, and a mixture of ethanol and water was mixed with 20 parts of citric acid crystals with a particle size of 0.5 mm.
Moisten with water. Add 22 parts of calcium carbonate,
After drying, 60 parts of potassium bicarbonate and 10 parts of sodium carbonate are added to obtain a foaming agent.
この起泡剤に所望量のアセチルサリチル酸結晶
を添加した後、40部までのラクトースをさらに添
加することもできる。その際は対応する起泡剤が
希釈されたアセチルサリチル酸の安定性が高くな
る。この組成に従つて、一回投与量として１ｇま
でのアセチルサリチル酸を含有することのできる
４ｇの起泡錠を製造することができる。 After adding the desired amount of acetylsalicylic acid crystals to the foaming agent, up to 40 parts of lactose can also be added. In this case, the stability of acetylsalicylic acid diluted with the corresponding foaming agent is increased. According to this composition, 4 g effervescent tablets can be produced which can contain up to 1 g of acetylsalicylic acid as a single dose.
実施例 ３
粒度0.7mmのクエン酸結晶40部をアスコルビン
酸結晶30部と混合し、さらに粉末状のクエン酸結
晶45部を加える。Example 3 40 parts of citric acid crystals with a particle size of 0.7 mm are mixed with 30 parts of ascorbic acid crystals, and further 45 parts of powdered citric acid crystals are added.
エタノール70％と水30％の混合物25部で再度湿
潤させそして炭酸カルシウム25部と実施例１にお
ける如く反応させる。10ｍバールで乾燥した後、
炭酸水素カリウム80部と粒度0.2mmのラクトース
60部を加え、打錠して錠剤にすることができる。 Rewet with 25 parts of a mixture of 70% ethanol and 30% water and react as in Example 1 with 25 parts of calcium carbonate. After drying at 10m bar,
80 parts of potassium bicarbonate and 0.2 mm particle size lactose
60 parts can be added and compressed into tablets.
実施例 ４
粒度0.4〜0.6mmのクエン酸結晶22重量部および
粒径0.1mmのクエン酸結晶30重量部を混合し、40
℃に加熱し、グルコン酸−δ−ラクトン13重量部
の水５重量部中の溶液を添加する。例１に従つて
反応させ、例１のように乾燥して起泡剤が得られ
る。Example 4 22 parts by weight of citric acid crystals with a particle size of 0.4 to 0.6 mm and 30 parts by weight of citric acid crystals with a particle size of 0.1 mm were mixed,
C. and a solution of 13 parts by weight of gluconic acid-delta-lactone in 5 parts by weight of water is added. Reacting according to Example 1 and drying as in Example 1 gives a blowing agent.
ラクトン１重量部がグルコン酸に変化したグル
コン酸−δ−ラクトンを添加すると、クエン酸お
よびグルコン酸のPHが異なり反応を遅延させる表
面緩衝作用が妨げられ、系の溶解速度が促進され
るので有利である。 Adding gluconic acid-δ-lactone, in which 1 part by weight of lactone is converted to gluconic acid, is advantageous because the pH of citric acid and gluconic acid is different, and the surface buffering effect that delays the reaction is hindered, accelerating the dissolution rate of the system. It is.
実施例 ５
クエン酸結晶200部を真空混合機中でエタノー
ル５部および水５部で湿潤させそして60℃に加熱
する。次に炭酸カルシウム30部を吸引添加し、混
合物を反応させる。その際先ず約100ｍバールに
減圧しそして真空混合機内の空間を反応で発生す
るCO2ガスで充たして900ｍバールに至らしめる。Example 5 200 parts of citric acid crystals are moistened with 5 parts of ethanol and 5 parts of water in a vacuum mixer and heated to 60°C. Then 30 parts of calcium carbonate are added by suction and the mixture is allowed to react. First, the pressure is reduced to approximately 100 mbar, and the space inside the vacuum mixer is filled with CO 2 gas generated in the reaction to a pressure of 900 mbar.
このガスの発生を二度繰り返し、次に真空にし
て停止させる。 This gas generation is repeated twice and then stopped by applying a vacuum.
次いで炭酸水素カリウム10部を加え、さらにク
エン酸結晶20部を加え、そしてエタノール２部と
水１部で不動態化を繰り返す。 Then 10 parts of potassium bicarbonate are added, a further 20 parts of citric acid crystals are added, and the passivation is repeated with 2 parts of ethanol and 1 part of water.
この方法によつて、反応済の炭酸カルシウムと
炭酸水素カリウムとから成つており、湿気に対し
注目に値する安定性をもつた不動態化された起泡
剤を得ることができた。 By this method it was possible to obtain a passivated foaming agent consisting of reacted calcium carbonate and potassium bicarbonate and having a remarkable stability against moisture.
この基本的な起泡剤にさらに差当り低ナトリウ
ムとして合法的に許されている量の炭酸水素ナト
リウムを加えることができる。この混合物は通常
の複合ビタミン混合物と一しよになつてナトリウ
ムイオンの含有量が極度に低く打錠し易い起泡錠
混合物を与える。 To this basic foaming agent may be further added sodium bicarbonate in amounts that are legally permitted as low sodium for the time being. This mixture, in combination with a conventional multivitamin mixture, provides an effervescent tablet mixture with an extremely low content of sodium ions that is easy to compress.
実施例 ６
アスコルビン酸（ビタミンＣ）結晶105部とク
エン酸結晶130部をエタノール６部および水３部
とともに60℃に加熱し、そして炭酸カルシウム22
部で実施例１と同様に処理する。この場合アスコ
ルビン酸結晶もその表面を炭酸カルシウムと反応
させるが、それはそうすることによつて系の安定
性が非常に高くなるからである。アスコルビン酸
はその低いPHと易水溶性のため表面が既に不動態
化され従つて反応性が低くなる。Example 6 105 parts of ascorbic acid (vitamin C) crystals and 130 parts of citric acid crystals are heated to 60°C with 6 parts of ethanol and 3 parts of water, and 22 parts of calcium carbonate is heated to 60°C.
Section is processed in the same manner as in Example 1. In this case, the ascorbic acid crystals are also reacted on the surface with calcium carbonate, since this greatly increases the stability of the system. Due to its low pH and easy water solubility, ascorbic acid is already surface passivated and therefore less reactive.
次に炭酸水素カリウム10部およびクエン酸結晶
10部とさらに同様に反応させ、有機酸結晶の全て
の未反応の表面をカルシウム塩またはカリウム塩
で表面反応によつて不動態化する。この場合も最
後に少なくとも20ｍバールにして乾燥させて起泡
剤が得られる、この起泡剤に調味料や色素を公知
の方法で乾燥添加し打錠することができる。 Then 10 parts of potassium bicarbonate and citric acid crystals
10 parts, and all unreacted surfaces of the organic acid crystals are passivated by surface reaction with calcium or potassium salts. In this case too, a foaming agent is finally obtained by drying at a pressure of at least 20 mbar, to which seasonings and pigments can be dry added in a known manner and tableted.
実施例 ７
低ナトリウムのサリチル酸含有起泡剤の製造は
若干難かしい。すなわち次の通りである。Example 7 The production of low sodium salicylic acid-containing foaming agents is somewhat difficult. That is, as follows.
クエン酸結晶68部をエタノール２部と水１部で
湿潤させ、60℃に加熱し、そして炭酸カルシウム
20部と反応させる。 68 parts of citric acid crystals were moistened with 2 parts of ethanol and 1 part of water, heated to 60°C, and calcium carbonate
React with 20 parts.
引続いて炭酸水素カリウム40部を、有利には70
％のエタノール２部を反応開始のために加えるこ
とによつて、一回だけ反応させる。 Subsequently 40 parts of potassium bicarbonate, preferably 70 parts
The reaction is carried out only once by adding 2 parts of % ethanol to start the reaction.
部分的に乾燥した後、反応成分のおそらくなお
未反応で残つている部分をフマール酸で被覆する
ために微粉状のフマール酸結晶20部を添加しなけ
ればならない。これは先の反応を一定の真空度、
例えば90ｍバールまで乾燥させるにとどめて小量
の湿気を残留させることによつて非常に巧く達成
できる。残留した小量の湿気が微粉状のフマール
酸を表面に固定する。 After partial drying, 20 parts of pulverulent fumaric acid crystals must be added in order to coat the possibly still unreacted parts of the reaction components with fumaric acid. This allows the previous reaction to be carried out at a certain degree of vacuum,
This can be very successfully achieved, for example, by only drying to 90 mbar and leaving a small amount of moisture behind. The small amount of residual moisture fixes the finely divided fumaric acid on the surface.
こうして得られた混合物は２：１までの割合で
サリチル酸結晶と混合することができ、ナトリウ
ムイオンを全く含有せず、長く貯蔵した際にも遊
離のサリチル酸のほんの僅かなケン化しか起さな
いという特徴をもつた、固い即時崩壊性の起泡剤
を与える。 The resulting mixture can be mixed with salicylic acid crystals in a ratio of up to 2:1, does not contain any sodium ions, and only slightly saponifies free salicylic acid during long-term storage. Provides a hard, instantly disintegrating foaming agent with characteristics.
崩壊速度を改良するためには勿論適切な測定の
後に小量の炭酸水素ナトリウムを添加することが
できる。起泡剤を不活性物質、例えばマンニツト
で希釈することも可能であり、それによつて崩壊
時間を短かくし安定性を改良することができる。
マンニツトの起泡剤に対する割合をほぼ１：１に
すると常に即時崩壊性でしかも安定な起泡剤が得
られる。 To improve the disintegration rate, small amounts of sodium bicarbonate can of course be added after appropriate measurements. It is also possible to dilute the foaming agent with inert substances, such as mannitol, thereby shortening the disintegration time and improving stability.
A ratio of mannite to foaming agent of approximately 1:1 always results in an instantly disintegrating and stable foaming agent.
Claims (1)
ており、該被覆は該有機酸結晶の表面に炭酸カル
シウム含有被覆材料とそれぞれの有機酸結晶の表
面層との反応によつて形成された結合層によつて
付着していることを特徴とする、少なくとも１種
の有機酸結晶と、少なくとも１種の有機酸結晶と
の反応に際してCO2を放出する炭酸塩とを含有す
る起泡剤。 ２ 結合層が有機酸結晶の少なくとも80％、好ま
しくは少なくとも95％を被覆している特許請求の
範囲第１項記載の起泡剤。 ３ 炭酸カルシウムの粒径が有機酸結晶の粒径よ
りも約１オーダー小さい特許請求の範囲第１項ま
たは第２項記載の起泡剤。 ４ 結合層が最大５重量％、好ましくは最大２重
量％の有機酸塩の形の炭酸カルシウムからなる特
許請求の範囲第１〜３項の何れか１項記載の起泡
剤。 ５ 被覆が多層形成されている特許請求の範囲第
１項〜４項の何れか１項記載の起泡剤。 ６ 被覆が特に炭酸水素ナトリウムおよび／また
は炭酸水素カリウムを含有している特許請求の範
囲第１項〜５項の何れか１項記載の起泡剤。 ７ １つの層が本質的にカリウム塩および／また
はナトリウム塩を含有し、他の層が本質的にカル
シウム塩を含有する特許請求の範囲第５項または
第６項記載の起泡剤。 ８ 被覆が有機酸結晶の表面に結合層を介して結
合している反応済みの炭酸カルシウム層とその上
に付着している炭酸水素カリウム層とを有してい
る特許請求の範囲第１〜７項の何れか１項記載の
起泡剤。 ９ 炭酸カルシウムが最大20マイクロメーターの
粒径を有する特許請求の範囲第１〜８項の何れか
１項記載の起泡剤。 １０ 有機酸結晶の一部ならびにエタノールと水
の混合物の一部を先ず60℃で0.1バールまたはそ
れ以下の圧力の下で混合し、次いで炭酸カルシウ
ムを吸い込ませ、そして少なくとも第一反応段階
として炭酸カルシウムの有機酸結晶との反応を、
その反応の際に発生するCO2ガスによつて圧力が
0.9バールに上昇するまで行うことを特徴とする、
１種またはそれ以上の有機酸結晶と１種またはそ
れ以上の炭酸塩とを真空混合機中でエタノールと
水との混合物の添加の下に相互に混合し粒状化す
る、少なくとも１種の有機酸結晶と、少なくとも
１種の有機酸結晶との反応に際してCO2を放出す
る炭酸塩とを含有する起泡剤の製造方法。 １１ 有機酸結晶の炭酸カルシウム被覆が終結し
た後、有機酸結晶の残部ならびに炭酸水素カリウ
ムおよびアルコールと水との混合物を残部を第一
反応段階の温度および圧力条件の下で添加して反
応を更に行う特許請求の範囲第１０項記載の方
法。 １２ 有機酸結晶の炭酸カルシウム被覆が終結し
た後、炭酸水素カリウムならびに残りの成分を添
加して第二の反応を行い、次いで0.9バールで乾
燥した後、こうして得られた粒子を微粒子状のフ
マール酸結晶で被覆する特許請求の範囲第１１項
記載の方法。[Scope of Claims] 1. An organic acid crystal has a calcium carbonate-containing coating, and the coating is formed on the surface of the organic acid crystal by a reaction between a calcium carbonate-containing coating material and a surface layer of each organic acid crystal. and a carbonate which releases CO 2 upon reaction with the at least one organic acid crystal, characterized in that it is attached by a bonding layer formed by Foaming agent. 2. A foaming agent according to claim 1, wherein the bonding layer covers at least 80%, preferably at least 95% of the organic acid crystals. 3. The foaming agent according to claim 1 or 2, wherein the particle size of the calcium carbonate is about one order of magnitude smaller than the particle size of the organic acid crystals. 4. A foaming agent according to any one of claims 1 to 3, in which the tie layer comprises at most 5% by weight, preferably at most 2% by weight of calcium carbonate in the form of an organic acid salt. 5. The foaming agent according to any one of claims 1 to 4, wherein the coating is formed in multiple layers. 6. A foaming agent according to any one of claims 1 to 5, wherein the coating contains in particular sodium hydrogen carbonate and/or potassium hydrogen carbonate. 7. A foaming agent according to claim 5 or 6, wherein one layer essentially contains potassium and/or sodium salts and the other layer essentially contains calcium salts. 8. Claims 1 to 7 in which the coating has a reacted calcium carbonate layer bonded to the surface of the organic acid crystal via a bonding layer and a potassium hydrogen carbonate layer attached thereon. The foaming agent according to any one of the items. 9. A foaming agent according to any one of claims 1 to 8, wherein the calcium carbonate has a particle size of at most 20 micrometers. 10 A portion of the organic acid crystals and a portion of the ethanol and water mixture are first mixed at 60° C. under a pressure of 0.1 bar or less, then the calcium carbonate is imbibed, and at least as a first reaction step the calcium carbonate reaction with organic acid crystals,
The pressure increases due to the CO 2 gas generated during the reaction.
characterized in that it is carried out until it rises to 0.9 bar,
at least one organic acid, in which one or more organic acid crystals and one or more carbonates are mixed with each other and granulated in a vacuum mixer with the addition of a mixture of ethanol and water; A method for producing a foaming agent comprising crystals and a carbonate that releases CO 2 upon reaction with at least one organic acid crystal. 11 After the calcium carbonate coating of the organic acid crystals is completed, the remainder of the organic acid crystals and the remainder of the mixture of potassium hydrogen carbonate and alcohol and water are added under the temperature and pressure conditions of the first reaction stage to further carry out the reaction. 11. The method according to claim 10, which is carried out. 12 After the calcium carbonate coating of the organic acid crystals has been completed, a second reaction is carried out by adding potassium bicarbonate as well as the remaining ingredients, and then, after drying at 0.9 bar, the particles thus obtained are coated with finely divided fumaric acid. 12. The method according to claim 11, wherein the method is coated with crystals.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT3450/83 | 1983-09-28 | ||
| AT345083A AT381451B (en) | 1983-09-28 | 1983-09-28 | SHOWER SYSTEM FOR SHOWER TABLETS |
| DE3434774.7 | 1984-09-21 | ||
| DE19843434774 DE3434774A1 (en) | 1983-09-28 | 1984-09-21 | Effervescent mixture, in particular for effervescent tablets, effervescent tablets made with the use thereof and process for the production thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6092378A JPS6092378A (en) | 1985-05-23 |
| JPH0562157B2 true JPH0562157B2 (en) | 1993-09-07 |
Family
ID=25600062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59200702A Granted JPS6092378A (en) | 1983-09-28 | 1984-09-27 | Foamable mixture, particularly for foaming tablet, foaming tablet manufactured thereby and manufacture |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS6092378A (en) |
| CH (1) | CH662926A5 (en) |
| ES (1) | ES536336A0 (en) |
| FR (1) | FR2552308B1 (en) |
| GB (1) | GB2148117B (en) |
| IT (1) | IT1178516B (en) |
| SE (1) | SE462014B (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3440288A1 (en) * | 1984-11-05 | 1986-05-07 | Gergely, Gerhard, Dr.-Ing., Wien | PHARMACEUTICAL PREPARATION WITH A CONTENT OF AT LEAST ONE Mucous-irritating SUBSTANCE OR THE LIKE, PARTICULARLY PROFESSIONALS, AND METHOD FOR THE PRODUCTION THEREOF |
| WO1987001936A1 (en) * | 1985-09-25 | 1987-04-09 | Gerhard Gergely | Desintegration tablet and process for its manufacture |
| IT1209667B (en) * | 1985-11-12 | 1989-08-30 | Zambon Spa | EFFEVERSCENT COMPOSITION ANALGESIC ADAPTITY. |
| DE3635864A1 (en) * | 1986-06-26 | 1988-05-05 | Gerhard Gergely | Process for producing effervescent granules, effervescent granules produced thereby and use thereof |
| CA2023493C (en) * | 1989-08-31 | 2000-01-04 | Masami Moroi | Composition for foaming preparation |
| CA2021548A1 (en) * | 1989-09-01 | 1991-03-02 | Ronald Nash Duvall | Effervescent cold or sinus allergy medicine composition having reduced sodium content |
| US5254355A (en) * | 1992-05-29 | 1993-10-19 | Kraft General Foods, Inc. | Process for beverage tablets and products therefrom |
| US5503846A (en) * | 1993-03-17 | 1996-04-02 | Cima Labs, Inc. | Base coated acid particles and effervescent formulation incorporating same |
| ATE180164T1 (en) * | 1993-09-07 | 1999-06-15 | Gergely Gerhard | EFFORTABLE MIXTURE WITH ALKALINE SALTS OR LYSINATES OF ACIDIC, INSOLUBLE OR POORLY SOLUBLE ACTIVE INGREDIENTS |
| DE59407351D1 (en) * | 1993-09-09 | 1999-01-07 | Gerhard Gergely | SHOWER GRANULES AND METHOD FOR THE PRODUCTION THEREOF |
| DE59808063D1 (en) * | 1998-06-03 | 2003-05-28 | Gergely Dr & Co | Citric acid doped with alkali or alkaline earth ions |
| NL1019544C2 (en) | 2001-12-12 | 2003-06-13 | Sara Lee De Nv | Device for offering and dispensing mineral water suitable for consumption. |
| EP3248792B1 (en) * | 2011-03-31 | 2019-08-28 | Brother Kogyo Kabushiki Kaisha | Printing control apparatus |
| CA2876062C (en) | 2012-06-12 | 2017-09-12 | The Procter & Gamble Company | Effervescent dosage form |
| US20140371174A1 (en) | 2013-06-12 | 2014-12-18 | The Procter & Gamble Company | Effervescent Dosage Form |
| CH710361B1 (en) | 2014-11-12 | 2018-12-28 | Laboratoires Biofar Sarl | Sodium-ion-free effervescent tablet or effervescent powder with high calcium ion content (CaCO3). |
| WO2021131458A1 (en) * | 2019-12-23 | 2021-07-01 | 花王株式会社 | Foaming agent |
| CN113813240A (en) * | 2021-09-18 | 2021-12-21 | 博凯药业有限公司 | Sodium-free effervescent tablet, preparation method and application |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3495001A (en) * | 1968-05-27 | 1970-02-10 | Miles Lab | Effervescent compositions of acetylsalicylic acid |
| AT374348B (en) * | 1980-07-01 | 1984-04-10 | Gergely Gerhard | METHOD FOR PRODUCING THE DESIRED CASE FOR EFFECTABLE SHOWER TABLETS |
| EP0076340B1 (en) * | 1981-10-06 | 1984-08-15 | Gerhard Dr. Gergely | Process for manufacturing effervescent granules which may be transformed, when required, into effervescent tablets |
-
1984
- 1984-09-27 GB GB08424451A patent/GB2148117B/en not_active Expired
- 1984-09-27 FR FR848414851A patent/FR2552308B1/en not_active Expired - Lifetime
- 1984-09-27 JP JP59200702A patent/JPS6092378A/en active Granted
- 1984-09-27 SE SE8404841A patent/SE462014B/en not_active IP Right Cessation
- 1984-09-28 IT IT22908/84A patent/IT1178516B/en active
- 1984-09-28 CH CH4676/84A patent/CH662926A5/en not_active IP Right Cessation
- 1984-09-28 ES ES536336A patent/ES536336A0/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| CH662926A5 (en) | 1987-11-13 |
| ES8603552A1 (en) | 1985-12-16 |
| IT8422908A0 (en) | 1984-09-28 |
| FR2552308A1 (en) | 1985-03-29 |
| JPS6092378A (en) | 1985-05-23 |
| IT1178516B (en) | 1987-09-09 |
| SE462014B (en) | 1990-04-30 |
| SE8404841L (en) | 1985-03-29 |
| GB2148117B (en) | 1987-10-21 |
| SE8404841D0 (en) | 1984-09-27 |
| ES536336A0 (en) | 1985-12-16 |
| FR2552308B1 (en) | 1991-07-05 |
| GB2148117A (en) | 1985-05-30 |
| GB8424451D0 (en) | 1984-10-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPH0562157B2 (en) | ||
| US4678661A (en) | Effervescent composition and method of making same | |
| JP3372053B2 (en) | Chewable or sucking tablets | |
| US5415870A (en) | Effervescent systems using reaction doping agents | |
| US5064656A (en) | Uncoated pharmaceutical reaction tablet | |
| US3105792A (en) | Stable effervescent compositions and method of preparing same | |
| JP3357081B2 (en) | Excellent taste pharmaceutical composition with porous particles, and process for preparing such a pharmaceutical composition | |
| US5260304A (en) | Pharmaceutical preparation binding with gastric acid | |
| US3441417A (en) | Beverage product and process | |
| EP0688208B1 (en) | Sugar- and sodium-free effervescent tablets and granules and process for preparing same | |
| RU2153330C2 (en) | Carbonated granulate and method of its making | |
| EP0011489A1 (en) | An analgesic effervescent powder and process for its preparation | |
| JP2640108B2 (en) | Method for producing expandable granular material | |
| JP2001515019A5 (en) | ||
| EP0219337A2 (en) | Improvements in and relating to effervescent acetylsalicylic acid tablets | |
| CA1302148C (en) | Method for preparing an effervescent granulate, an effervescent granulate made accordingly, and its utilization | |
| US4985593A (en) | Magnesium potassium citrate | |
| US4895980A (en) | Method of manufacturing magnesium potassium citrate | |
| US3663271A (en) | Surface-modified acid crystals and process for their preparation | |
| JPS61152268A (en) | Powdery foamable, water-soluble and non-hygroscopic composition and its preparation | |
| EP0236771A2 (en) | Amino sugar carbonating agents and their preparation | |
| US3102075A (en) | Tableting process | |
| US10485754B2 (en) | Method for the production of a sodium ion-free effervescent tablet, powder or granulate having a high X ion content, where X can be a variety of substances | |
| US6497900B2 (en) | Effervescent base | |
| CA1219767A (en) | Tableted beverage composition containing dipeptide sweetener and process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |