JPH05506142A - Ｈｉｖ蛋白質の非免疫支配エピトープに特異的なモノクローナル抗体 - Google Patents
Ｈｉｖ蛋白質の非免疫支配エピトープに特異的なモノクローナル抗体Info
- Publication number
- JPH05506142A JPH05506142A JP91503590A JP50359091A JPH05506142A JP H05506142 A JPH05506142 A JP H05506142A JP 91503590 A JP91503590 A JP 91503590A JP 50359091 A JP50359091 A JP 50359091A JP H05506142 A JPH05506142 A JP H05506142A
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- antibodies
- hiv
- cells
- conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- VYMHBQQZUYHXSS-UHFFFAOYSA-N 2-(3h-dithiol-3-yl)pyridine Chemical compound C1=CSSC1C1=CC=CC=N1 VYMHBQQZUYHXSS-UHFFFAOYSA-N 0.000 description 1
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- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
- C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6839—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting material from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- AIDS & HIV (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Photometry And Measurement Of Optical Pulse Characteristics (AREA)
- Radiation Pyrometers (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46503590A | 1990-01-16 | 1990-01-16 | |
| US465,035 | 1990-01-16 | ||
| PCT/US1991/000319 WO1991010742A1 (fr) | 1990-01-16 | 1991-01-16 | Anticorps monoclonal specifique de l'epitope non-immunodominant de l'enveloppe proteinique du vih |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH05506142A true JPH05506142A (ja) | 1993-09-16 |
Family
ID=23846250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP91503590A Pending JPH05506142A (ja) | 1990-01-16 | 1991-01-16 | Ｈｉｖ蛋白質の非免疫支配エピトープに特異的なモノクローナル抗体 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0511300A4 (fr) |
| JP (1) | JPH05506142A (fr) |
| CA (1) | CA2073060A1 (fr) |
| WO (1) | WO1991010742A1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009538284A (ja) * | 2006-05-15 | 2009-11-05 | イムノメディックス，インク． | 合成抗体または抗体断片による、ヒト免疫不全ウイルス感染の治療のための方法および組成物 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06502539A (ja) * | 1990-10-26 | 1994-03-24 | ザ・パブリック・ヘルス・リサーチ・インスティチュート・オブ・ザ・シティ・オブ・ニューヨーク・インコーポレーテッド | Ｈｉｖ−１ ｇｐ１２０のｖ３ループおよびｃｄ−４結合部位に特異的な中和ヒトモノクローナル抗体 |
| US6797492B2 (en) | 1991-05-17 | 2004-09-28 | Merck & Co., Inc. | Method for reducing the immunogenicity of antibody variable domains |
| DE19809785C2 (de) * | 1998-03-08 | 2000-02-10 | Wolfgang Bergter | Radioimmunpharmakon zur Behandlung der HIV-1-Infektion |
| US8481041B2 (en) | 2005-04-06 | 2013-07-09 | Ibc Pharmaceuticals, Inc. | Dock-and-lock (DNL) constructs for human immunodeficiency virus (HIV) therapy |
| US20100266620A1 (en) * | 2006-01-20 | 2010-10-21 | Le Sun | Immunoconjugates for treatment of infectious diseases |
| CA2982376A1 (fr) | 2015-05-28 | 2016-12-01 | Immunomedics, Inc. | Produits de construction t20 pour therapie et/ou vaccins anti-vih (virus de l'immunodeficience humaine) |
| WO2017093985A1 (fr) | 2015-12-05 | 2017-06-08 | Centre Hospitalier Universitaire Vaudois | Agents de liaison au vih |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2437213A1 (fr) * | 1978-09-28 | 1980-04-25 | Cm Ind | Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation |
| US4861707A (en) * | 1987-02-02 | 1989-08-29 | E. I. Du Pont De Nemours And Company | Human immunodeficiency virus antigen |
| WO1988005824A1 (fr) * | 1987-02-02 | 1988-08-11 | E.I. Du Pont De Nemours And Company | Selection d'anticorps monoclonaux contre des glycoproteines virales |
-
1991
- 1991-01-16 EP EP19910903736 patent/EP0511300A4/en not_active Withdrawn
- 1991-01-16 WO PCT/US1991/000319 patent/WO1991010742A1/fr not_active Application Discontinuation
- 1991-01-16 JP JP91503590A patent/JPH05506142A/ja active Pending
- 1991-01-16 CA CA002073060A patent/CA2073060A1/fr not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009538284A (ja) * | 2006-05-15 | 2009-11-05 | イムノメディックス，インク． | 合成抗体または抗体断片による、ヒト免疫不全ウイルス感染の治療のための方法および組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1991010742A1 (fr) | 1991-07-25 |
| EP0511300A4 (en) | 1993-05-26 |
| EP0511300A1 (fr) | 1992-11-04 |
| CA2073060A1 (fr) | 1991-07-17 |
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