JPH05505333A - Rubber gloves, their manufacturing method and uses - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed description of the invention] Rubber gloves, their manufacturing method and uses Background of the invention Medical personnel such as doctors, nurses, paratroopers, and especially surgeons should protect patients and themselves from bacterial infections. Natural rubber gloves are often used to protect against viral infections. this This type of glove may be conveniently referred to as a "medical glove."

A long-standing problem with medical gloves is that they are difficult to wear.

To reduce this, powder the gloves so that they slip easily into the hands or gloves. This has been done for many years. However, many medical professionals and many glove wearers do not Not satisfied with the use of powder as a medical aid. This will remove excess powder after wearing. practical difficulties, such as the need to remove the powder, and in some cases the powder may be rough on the surface. This is because it raises concerns that the situation will worsen.

In order to provide medical gloves that are easy to wear without relying on powder, we and very different types of solutions. The first solution is that medical gloves It uses natural rubber that has been treated with chlorine to make it easier to wear. Another solution is A synthetic polymer layer is glued to the inside of the medical glove (the contact surface of the patient), thereby This makes it easier to use.

An example of a chlorinated medical glove is in U.S. Pat. No. 4,304,008, which Examples of providing a polymeric layer include U.S. Pat. No. 77, No. 4499154, No. 4548844, No. 4575476, No. 3 No. 856561, No. 3919442, No. 3967014, No. 4027060 No. 4082862, No. 3286011 and No. 3411982.

Uses a synthetic polymer layer that adheres well to natural rubber and is sufficient to eliminate the need for powder Making medical gloves that are slippery is difficult and expensive. To provide such a layer They also tend to require the use of complicated organic solvents.

Chlorinated medical gloves can be manufactured without the use of organic solvents and are widely used. It is used. However, such gloves are only easy to wear when hands are dry. However, many users (especially many surgeons) recommend wearing gloves. (e.g., a surgeon's hands should remain moist after cleaning with an antimicrobial agent. cormorant). This severely limits the use of chlorinated medical gloves.

One object of this invention is to avoid the need to use an inner layer of synthetic polymer on top of natural rubber. Easy to wear on dry or damp hands without requiring the use of powder. Our goal is to provide medical gloves.

Summary of the invention This invention allows for drying or dampening without the need for synthetic polymer inner layers or powders. To provide medical gloves that can be easily worn on wet hands. Medical treatment according to this invention Medical gloves have microscopic skin with one or both of surfactants and silicone on the inner surface. Consists of microtex tured medical gloves. The fine used here Fine texture refers to the surface of the glove that has been roughened, for example by treatment with halogens or acids. means that it is surfaced (e.g. J, Nat, Rubb, Res 4 (1), A, D, Roberts and C, A, Brac in 1-21 “5surface Treatment of Rubber” by k ley to Reduce Fr1ction+).

Detailed description of the invention In this invention, one of surfactants or silicone is added to the inner surface of medical gloves with a fine texture. To provide medical gloves that can be worn on dry or wet hands, or both. .

Microtextured gloves have microtextured surfaces (microtextured) only on the inside or on both the inside and outside. (kissture).

The fine-grained medical gloves used in this invention have a surface that is halogenated or may be obtained by treatment with acids, especially oxidizing acids. Fine skin weight The most suitable medical gloves are halogenated medical gloves. Fine-grained medical gloves are Chlorinated medical gloves are preferred.

One advantage of using chlorinated medical gloves is that there are many excellent commercially available chlorinated gloves or Unsales powder-free Sensochiku (5en) from CLRC available in sotech) G204, Pristin from Fuji Latex Co., Ltd. e) Berry Style CPerr from Smith & Neffney Berry Co. It is familiar to many users because it is Y5 style)47). Ru.

(These commercially available gloves have good wearability on dry hands, but the gloves of this invention Of course, it lacks the desired wearability against wet hands).

The gloves of this invention are most suitable as surgeon's gloves.

From the above, according to a preferred aspect, the present invention provides a surfactant or a silicone on the inner surface. Dry or wet hands consisting of chlorinated medical gloves with one or both It will be appreciated that medical gloves are provided that can be worn on the wrist.

The surfactant used is a surfactant suitable for use on the skin, i.e. a skin-compatible surfactant. Any surfactant may be used. These surfactants can be ionic or nonionic. It can also be gender. Mixtures of one or more surfactants, e.g. two surfactants, can be used as desired. You may use it as well.

Suitable ionic surfactants include cationic, anionic, and amphoteric surfactants. be caught.

Suitable cationic surfactants include at least one hydrophobic molecule, e.g. 18 carbon atoms) and chlorinated nitrogen atoms (e.g. chlorinated nitrogen atoms) Alkylamino group, piperidium group, etc.) Includes surfactants containing ralkyl and aryl groups.

The counterions present, such as halides e.g. chloride, are skin compatible. Probably. Particularly suitable cationic surfactants include alkyl, alkenylpyridinyl compounds, such as those in which the hydrophobic molecule has 12 to 18 carbon atoms. . Preferred cationic surfactants include cetylpyridinium chloride (hex decylpyridinium chloride).

Suitable anionic surfactants include alkyl, alkenyl, aralkyl, ary surfactants containing at least one hydrophobic molecule (e.g. 8 to 18 carbon atoms) atomic groups) and chlorinated acidic groups (e.g. carboxylic acid, sulfuric acid, phosphoric acid) , acid groups such as phosphonic acid). For example, sodium and potassium counters present such as ions of alkali metals (preferably sodium) -ions will be skin compatible.

Particularly suitable anionic surfactants include alkyl and alkenyl sulfates (e.g. Examples include those in which the hydrophobic molecule contains 12 to 18 carbon atoms. Preferred a The ionic surfactant is sodium lauryl sulfate.

Suitable amphoteric surfactants include those containing cationic and anionic groups as described above. Ru.

Suitable nonionic surfactants include those containing residues of ethylene oxide, e.g. For example, polyethoxylated aliphatic alcohols, ethylene oxide polymers and and copolymers of ethylene oxide and propylene oxide.

Suitable polyethoxylated fatty acids include alkyls of 8 to 18 carbon atoms, alkali metals, or sorbitan or polyoxyethylene residues of about 15 to 80 Consisting of 1 to 10, usually 2 to 8, polyoxyethylene residues with cyethylene groups Includes those with similar groups. Such materials include TWEEN, Bridge (BRIJ), Span (SPAN), Genero (GENERO) L) and TERG [TOL], Merge (MYRJ), Anne Trade names such as ANTAROX and TR[TON] It is commercially available at.

Tweens (fatty acids like laurate, palmitate, sterate, oleate) (polyoxyethylene sorbitan esters) and antalox (nonilf) phenol ethoxylates) are particularly important.

Suitable polymers of ethylene oxide and propylene oxide are generally For example, PLURONIC, tar It is commercially available under trade names such as Ditol, Bridge and Dienerol.

List of usable surfactants that are ionic and also contain polyethylene oxide. The type consists of an ionic molecule joined to a hydrophobic molecule by a polyoxyethylene molecule. There are some.

A preferred surfactant is hexadecylpyridinium chloride. Surface activity A preferred mixture of sex agents is hexadecylpyridinium chloride and lauryl sulfate. Contains sodium.

The silicone used may be polysiloxane or similar skin-compatible silicone. But that's fine. Preferably, the silicon is liquid silicon. Suitable silicones include , polydimethylsiloxane and some of the methyl residues are alkyl, allyl, alkyl, Substituted by other functional groups like ralkyl, alkenyl, alkoxy etc. Similar compounds include polysiloxanes. Also, polysiloxane The terminal is polyethylene oxide dimethylsilyl, aminoethyldimethylsilyl , hydroxyethyldimethylsilyl, hydroxyethyldimethylsilyl, etc. It may also be a non-siloxane molecule.

Preferably, the polysiloxane used is polydimethylsiloxane.

Surfactant and silicone can be used separately, but it is best to use a surfactant or not. is also appropriate, and it is preferable to use both.

From the above, according to a particularly preferable aspect, the present invention has cetylpyridinium coating on the inner surface. Drying consisting of chlorinated surgical gloves with loride and sodium lauryl sulfate It will be appreciated that the present invention provides a surgical glove that can be worn on wet hands.

The amount of surfactant and/or silicone on the inner surface of the glove may compensate for wet hand wearing. Any amount sufficient to help can be used, but is typically very low, e.g. (although this may be done if it is desired to leave an amount that is easily visible to the naked eye). It is not necessary to have readily visible deposits on the surface.

The amount of surfactant and/or silicone on the surface of the glove is at least 0.1% A heavy weight amount of surfactant and/or a weight amount of at least 0.05% silica. The amount that can be deposited from an aqueous solution and/or emulsion containing the compound is suitable.

Generally, aqueous systems are heated for at least 1 minute at non-extreme temperatures (e.g. 5-50°C). (usually 10 to 35°C, preferably 15 to 30°C, e.g. 20°C), or Approximately 10% or more surfactant by weight and/or 2.5% or more silica It will not contain any contaminants. Generally, the deposition takes at most 30 minutes, e.g. 5-20 minutes. completed in between. An example of a suitable aqueous system is approximately 0.1-10% w/w surfactant. agent and 0. Contains siloxane in an amount of 1 to 2.5% by weight.

Particularly suitable methods of applying surfactants and/or silicones are shown in the examples. It is.

It is best to apply the surfactant and/or silicone to both sides of the medical glove. It's urgent.

The glove of this invention has an inner surface treated with a surfactant and/or silicone. Therefore, it will be manufactured. If desired, the treatment can be applied to the outer surface of the glove. good.

Surfactants and/or silicones are typically used in aqueous solutions and/or emulsions. will be used.

Concentrations, temperatures and times will be as above.

A suitable method for simultaneously treating the inside and/or outside of fine-textured gloves is Tumble the skin-grained gloves in the paint liquid and then dry the gloves, for example in a tumble dryer. It is to dry it.

Treatment with surfactants and/or silicones after microtexturing or further It can be done directly on the gloves later. Therefore, for example, gloves can be placed in a chlorine bath in a conventional manner. Chlorinate, optionally rinse with water, then soak in a surfactant and/or silicone bath. It can be soaked and then dried.

It will be microtextured by physical or chemical means.

Suitable physical means include, for example, depositing rubber latex on an embossed molding machine. This is to mold the rubber surface. Appropriate chemical means include This includes treatment with chemicals, halogenating agents, acids, etc.

Microtextures are not visible to the naked eye as individual floating areas or depressions. death However, in some cases, it can be seen as a cloud. Between adjacent floating areas Suitable spacing is 100 microns or less, most suitable is 00 microns or less, and 30 microns. The following would be preferable. Is the distance between adjacent floating areas 0.5 microns or more? 1 micron or more would be most suitable, with 1.5 micron or more preferred.

The spacing between adjacent flying areas should be 1-10 microns, most suitably 2-6 microns. A particularly preferred method of producing a certain fine-grain surface is treatment with a chlorinating agent.

The spacing between adjacent flying areas should be 1-1o microns, most suitably 2-6 microns. A particularly preferred method of producing a certain fine-grain surface is treatment with a chlorinating agent.

The spacing between adjacent flying areas is between 10 and 100 microns, most suitably between 15 and 50 microns. Particularly preferred for producing a fine-grained surface of 20 to 30 microns, preferably 20 to 30 microns. The preferred method is to mold the rubber on a molding machine that has a mirror image of the desired fine texture. That is.

The inner surface of the glove may be modified, for example (i) by physical means such as molding, and (ii) 2 produced by chemical means such as treatment with halogenating agents, e.g. chlorination. Different types of fine grains may be used. Generally, only one type of micrograin is used. Because the results of wearing gloves while wet are excellent, we use two kinds of fine grains. Is it preferable to do so?

The glove may have giant grains on its inner surface. Such giant skin eyes often easily visible to the naked eye. A suitable spacing between floating areas is 100 microns or more, and 20 microns or more. 0 micron or more is more suitable, 450 micron or more, for example around 500-100 0 micron would be most suitable. A spacing of approximately 800 microns is particularly suitable. It has been thought that The giant grain is produced on a molding machine with a mirror image of the required giant grain. may be produced by physical means such as molding.

The depth of the giant grain (the "highest point relative to the average tough depth") is generally around 1~ It would be approximately 100 microns. The depth of the giant grain is suitable for 2 microns or more, 4 microns. Microns or larger would be more suitable, and 10 microns or larger would be most suitable. deep skin The diameter is preferably 70 microns or less, more preferably 50 microns or less, and 35 microns or less. would be most suitable. The depth of the macroscopic grains is approximately 20-30 microns, e.g. Approximately 25 microns is preferred.

The results of damp wear are especially enhanced in these cases, so if you have large skin Preferably, fine grains are used. give the type of texture mentioned in this Until now, such molding machines have not produced roughened surfaces on gloves. It is known as it has been used to make external surfaces. In this invention, Traditionally, the outside surface of the glove becomes the inside surface when in use (turn the glove inside out so that the outside surface is usually leather). (facing the skin). The mold is sandblasted with a porcelain molding machine, and glazed with a molding machine. sputtering or just suitable unglazed porcelain forming machine It can be manufactured by using unglazed porcelain forming machine (has the typical texture of unglazed porcelain), the use of chlorine The gloves of this invention are particularly suitable when can.

U.S. Patent Nos. 4,597,108, 4,851,266, 3,992,221, 3 No. 740262, No. 3637411 and European Patent Application No. 881198 No. 75 describes a method for halogenating gloves.

The gloves may be chlorinated by immersing them in a chlorination bath. This applies to both sides Alternatively, this can be done by chlorinating only the surfaces that come into contact with hands. If both sides are chlorinated If the gloves are to be removed, the gloves can be kept open in the bath. If it comes into contact with your hand If only the face needs to be chlorinated, place the gloves on the molding machine and then turn them over. Alternatively, you can close the opening or hold the glove flat and then turn it over.

Keep the gloves in the chlorination bath for a convenient time, e.g. approximately 15 seconds to 2 hours. However, 1 minute to 1 hour in the chlorination bath is more usual, and more than 1 minute is more suitable. 5 minutes or more is most appropriate, 8 minutes or more is preferable, and 20 minutes or less is more appropriate. suitable, most suitably 15 minutes or less, preferably 12 minutes or less.

Although chlorination may be carried out by any conventional method, one particularly suitable method is to and 6 volumes by weight of sodium hypochlorite solution (5% chlorine content). immersion in a water tank. Gloves, e.g. I, 5.1O120 and 30 minutes It will be immersed in a chlorination bath for a time range such as between on the outside of the gloves in the chlorine bath. This side will be the inside of the glove (when in use). After chlorination, gloves should be kept at 70°C for 30 minutes. or may be dried in an oven at any other convenient temperature and time.

The inside of the glove (when in use) may be treated with a mixture of surfactant and silicone in water.

The mixture consists of 2% (by weight) cetylpyridinium chloride (CPC) and 0.5 % DC365.

Keep the glove open and then fill it with the surfactant/silicone mixture. , then may be processed by emptying them again. then gloves , 70°C for 30 minutes or other convenient temperature and time. .

Gloves produced in this manner may be worn using damp hands.

These gloves, which are not CPC/silicone treated, can be worn while still wet. CPC/ The use of siliconization improves the performance of such gloves. i.e. optimal chlorination The time appears to be 10-30 minutes.

SEM test showed changes in latex texture according to time present in chlorine bath . A fine texture resembling that of a cauliflower flower was visible throughout. 1 to 10 minutes During chlorination, grooves are gradually carved into the latex and fine cracks appear on the surface. You can see many things. On the other hand, the area without - retains the state of cauliflower flower. There is a tendency to

A smooth latex surface is placed on the inside of the glove (when in use) as a donning aid. desirable. However, on the outside of the glove, the extremely smooth surface makes it difficult to hold tools in your hand. This is undesirable as it makes it difficult to use. As the degree of chlorination increases, the surface The differential chlorination between the inner and outer surfaces (in use) becomes more accommodating as the surface becomes smoother. .

The gloves may be manufactured on an unglazed porcelain molding machine.

The gloves are then placed in the chlorine bath for 1 to 30 minutes, e.g. 10 minutes. May be chlorinated by turning the side (when in use) outward. then remove the gloves If you want to chlorinate both sides, dry the back side before returning it to the chlorine bath for an additional 1 minute. Just give it back.

After chlorination, dry the gloves at 70°C for 30 minutes or at any convenient temperature and time. be able to.

The gloves are then prepared by filling the gloves with a two-part solution of CPC/silicone. It may be applied only to the inner (when in use) surface.

The most accommodating gloves of this invention are sterile surgical gloves.

These gloves must be placed in bacteria-resistant packaging to keep them sterile. is the most appropriate. Paper or plastic film packaging is most suitable.

Packaging in the form of individual containers such as sachets is preferred.

Accordingly, in a highly preferred aspect, the invention provides Surgical gloves of the present invention as described above are sterile gloves packaged in sachets. provide

The sterile gloves of this invention can be prepared using conventional methods such as ethylene oxide or gamma irradiation. Can be sterilized by treatment with ionizing radiation such as Methods of sterilizing gloves are known .

The invention is illustrated by the following examples.

Example 1 Size 7.5 "Ansell No Pawd" er)'' gloves (chlorinated on both sides) were placed in a bath having the following composition:

Distilled water 960.5 Hexadecylpyridinium chloride 20 = 2% Dow Corning (Do w Corning) 365 19.5 = 0.5% medical grade silicone milk The suspension (35%) gloves were left at room temperature for 15 minutes. Then heat them at 70℃ for 30 minutes After 15 minutes, the container was turned over to dry completely on the inside.

Once dry, they were returned to their initial state.

Example 2 Example 1 was repeated except for hexadecylpyridinium chloride.

Example 3 Example 1 was repeated except for the silicone.

Example 4 Example I was repeated applying only the inner surface.

Example 5 The gloves of Example 1 were placed in individual pouches with separate closures and the pouches were closed.

The gloves and sachets were sterilized by treatment with ethylene oxide in a conventional manner. .

Example 6 (a) Manufacture of basic gloves Place the gloves on an unglazed porcelain molder and replace the molder with a calcium ion coagulant. and then dipped into wax-free natural rubber latex. , dried, extracted in water and shaped in the conventional manner by curing. Do not contact until after chlorination. Starch was sprinkled on the outside of the gloves to prevent wear.

(b) Chlorination Gloves manufactured as described in (a) were mixed with concentrated hydrochloric acid (5 g) and sodium hypochlorite. The sample was placed in a chlorine bath consisting of an aqueous solution (465 g) of 20 g (30 g, 5%). gloves and tumbled in a bath for 10 minutes at room temperature (approximately 20° C.). Remove gloves from solution , washed with water, and then dried at 70°C for 30 minutes. To ensure that both sides are dry, The gloves were turned over approximately 2.3 times during the drying procedure. To keep the roughened surface on the outside Then, he turned his gloves on again.

(C) Slip treatment The gloves were then treated with cetylpyridinium chloride (2g ) and silicone, Dow Corning 365 (35%, 1.42g) in water. (100 g).

To ensure dryness on both sides, place the treated gloves at 70°C for 30 minutes. I turned it upside down and dried it. At the end of this process, the roughened and slipped surface is Inside when in use.

Example 7 Gloves made as in Example 6(a) were treated with chlorine as described in Example 6(b). The mixture was tumbled in a bath for 10 minutes. The gloves were returned to the bath and tumbled for an additional minute. gloves was removed, washed with water, and then dried at 70°C for 30 minutes. Make sure both sides are dry To ensure this, the gloves were turned over approximately 2.3 times during the drying procedure.

For the inner roughened surface, only the inner side was treated with a solution as described in Example 6(C). Processed. Remove the solution from the gloves and thoroughly dry the gloves at 70°C for 30 minutes. The gloves were dried by turning them inside out twice during the procedure so that the roughened side was on the outside of the glove.

Example 8 Size 7.5 berries sold by Smith & Nephney Berry Co. Style 47 gloves (chlorinated on both sides) are coated with a solution having the following composition: The liquid was sprayed.

Distilled water 960- Hexadecylpyridinium chloride 20g = 2% sodium lauryl sulfate 20g = 2% Gloves were dried for 30 minutes. Once dry, start them again It returned to its state. When tested, the gloves of this invention can be worn with damp hands. was significantly easier.

Example 9 Example 5 was repeated except for hexadecylpyridinium chloride.

summary Micro-textured medical gloves with surfactant and/or silicone on their inner surface Medical gloves that can be worn on dry or damp hands. Fine textured gloves are made of poly Dimethylsiloxane, hexyldecylpyridinium or sodium lauryl sulfate Chlorinated medical gloves or preferably treated with stomach.

International investigation report Low T10 mouth. ri/nn’+71

Claims (17)

[Claims] 1. Micro skin doctor with one or both of surfactant and silicone on the inner surface Medical gloves that can be worn on dry or damp hands. 2. The glove according to claim 1, wherein the fine-textured medical glove is a chlorinated medical glove. 3. According to any one of claims 1 and 2, wherein the inner surface of the glove is provided with a surfactant. Gloves as described. 4. Claim 1 also characterized in that the inner surface of the glove is provided with a mixture containing one or more surfactants. or the glove according to any one of 2. 5. According to any one of claims 1 and 2, the inner surface of the glove is made of silicone. Gloves included. 6. Either of claims 1 or 2, wherein the inner surface of the glove comprises a surfactant and silicone. One of them has gloves with numbers on it. 7. Claims that the surfactant is a cationic surfactant containing a chlorinated nitrogen atom The glove according to any one of Items 1 to 4 or 6. 8. 8. The surfactant according to claim 7, wherein the surfactant is hexyldecylpyridinium chloride. gloves. 9. A claim in which the surfactant is an anionic surfactant containing a chlorinated acidic group. The glove according to any one of 1 to 4 or 6. 10. 9. The glove of claim 8, wherein the surfactant is sodium lauryl sulfate. 11. If the mixture contains hexyldecylpyridinium and sodium lauryl sulfate, 5. The glove according to claim 4. 12. Claim 1, 2, 5 or 6, wherein the siloxane is polydimethylsiloxane. Gloves according to any one of the above. 13. Silicone is polydimethylsiloxane and surfactant is hexyldecyl The glove according to claim 6, which is pyridinium chloride. 14. Any one of claims 1 to 13, wherein the fine texture is formed by means of a molding process. Gloves as described. 15. 15. A sterilizer according to any one of claims 1 to 14 in a bacteria-resistant sachet. germy gloves. 16. The inner surface of the fine-grained gloves is coated with one or both of surfactant and silicone. A method for manufacturing a glove according to any one of claims 1 to 14, which comprises: Law. 17. Gloves with hexyldecylpyridinium chloride and sodium lauryl sulfate 17. The method according to claim 16, comprising treating with an aqueous solution of the hydroxide.