JPH0544928B2 - - Google Patents

Description

[Detailed description of the invention]

[Industrial Application Field] The present invention relates to a novel animal parasiticide egg preparation. More specifically, the present invention relates to an animal parasiticide egg preparation containing (A) o-dichlorobenzene and (B) chinomethionate as essential components. [Prior art and problems] The parasitic egg preparation in the present invention includes, for example,
In addition to livestock such as horses, cows, pigs, chickens, goats, and sheep, poultry, as well as various pet animals such as birds, dogs, and cats, roundworms, worms, flukes, stomach worms, lungworms, liver flukes, etc. A drug that kills parasite eggs. When raising these animals, they are often infected with various parasites at each stage of their development, which can cause diarrhea, bleeding, anemia, etc., resulting in poor growth and death due to malnutrition. This is a big problem for pet owners and pet owners. Currently, orthodichlorobenzene is used as a drug to kill these parasitic eggs, but its parasitic egg-killing effect is weak, and an effective drug is needed. [Means for solving the problem] Therefore, the present inventors have been conducting research for many years on parasitic egg preparations that are more effective than conventional ortho preparations, but surprisingly, o-dichlorobenzene The present invention was completed based on the discovery that it is effective to use the essential components of methane and chinomethionate. Therefore, the present invention provides a novel parasiticide egg preparation. The chinomethionate according to the present invention is S,S-6-methylquinoxaline-2,3-dyl dithiocarbonate having the following structural formula (). When carrying out the present invention, it is usually sprayed on animals, such as poultry houses. This makes it possible to kill eggs of various parasites such as roundworms, tubeworms, flukes, stomach worms, lungworms, liver flukes, etc. contained in the excrement of animals in the poultry house. When carrying out the present invention, various dosage forms may be used, such as powders, granules, wettable powders, emulsions, oils, and smoking agents. Of these, emulsions provide the best effect. Emulsions are the most preferred dosage form because of their high performance. Although there is no particular restriction on the mixing ratio of o-dichlorobenzene and chinomethionate, a ratio of about 0.1 to 15% (by weight) of chinomethionate to about 40 to 95% (by weight) of o-dichlorobenzene usually gives preferable results. When this is made into an emulsion, a surfactant suitable for achieving stable emulsification in water is added, and if necessary, a co-solvent, a penetration aid, a stabilizer, etc.
Ultraviolet absorbers, fixing agents, etc. can be added. Substituted phenol compounds such as phenol, cresol, and xylenol can also be used in combination as the main solvent for chinomethionate. As the surfactant, one is selected that has good emulsion stability, does not reduce the parasitic egg effect, and has high adhesiveness. Examples include anionic salts such as carboxylates, sulfonates, sulfate ester salts, phosphate ester salts, and cationic salts such as quaternary ammonium salts, pyrimidium salts, imidazolium salts, etc. Examples of amphoteric ion type include aminocarboxylate, imidazolium betaine type, and carboxybetaine type. However, using only the above-mentioned ionic surfactant may sometimes lack emulsion stability in water. Specifically, metal ions such as alkali metal ions in animal feces and soil, or mixed organic substances destroy the emulsification and not only prevent the desired effect, but also o-dichlorobenzene, chinomethionate, etc. Causes local coalescence and concentration in the material to be sprayed.
In particular, when the object to be sprayed is animal excrement such as chicken manure, and when this is applied to crops as fertilizer, there is also concern about secondary chemical damage to the crops. In order to avoid this, such a phenomenon can be prevented by selecting an optimal nonionic surfactant and using it in combination with the above-mentioned ionic surfactant. Examples of nonionic surfactants include polyoxyethylene alkyl ether, polyoxyethylene alkylaryl ether, formalin condensates thereof, ether ester type nonionic surfactants such as polyoxyethylene glycerin fatty acid ester, and polyoxyethylene. Examples include nitrogen-containing nonionic surfactants such as fatty acid ester type nonionic surfactants and polyoxyethylene fatty acid amide. Examples of co-solvents include ketones such as cyclohexanone and isophorone, ethers such as ethylene glycol monophenyl ether, sulfolane ethylene carbonate, tetrahydrofuran,
Examples include hexamethylphosphoric triamide, dimethylsulfoxide, dimethylformamide, and N-methylpyrrolidone. Examples of penetration aids include alkyl sulfosuccinates, and stabilizers include acidic substances such as alkyl acid phosphates and polyhydric phenols, epoxy compounds such as epichlorohydrin and butyl glycidyl ether, alkanolamines, alkyl amines, and alkyl anilines. Examples include alkali compounds such as. In addition, as a fixing agent, for example, various oil-soluble resins,
Higher fatty acids, high molecular weight hydrocarbons, etc., and examples of the ultraviolet inhibitor include benzophenone, salicylic acid such as ethylene glycol salicylate, and cyanoacrylic compounds. [Example] Next, experimental examples will be shown to explain the effects of the present invention in more detail, but it goes without saying that the present invention is not limited to these experimental examples. Note that all percentages (%) in the experimental examples are based on weight. Experimental Example 1 1) Test drug A drug consisting of an emulsion having the composition shown below was prepared. o-Dichlorobenzene 88.5% Chinomethionate 1.5% Emulsifier 10.0% For experiments, this drug was used at 50x (drug concentration 2%, the same applies hereafter), 100x (1%), 200x (0.5%), and 400x (0.25%). It was diluted and used. 2) Test insect eggs Pork roundworm eggs were collected directly from the uterus of female adult pig roundworms obtained from a slaughterhouse. In addition, hepatic fluke eggs were collected from the gallbladder of a hepatic fluke-infected cow obtained from a slaughterhouse. 3) Test drug sensitization and efficacy evaluation Add the stock solution of this drug to a predetermined concentration to a suspension of the two types of insect eggs tested, stir well, and sensitize at 28℃ for 24 hours. did. The control group was sensitized to tap water only. After 24 hours of sensitization in each experimental group, the insect eggs were centrifugally washed to remove the drug. After the drug was removed, the pig Ascaris eggs were deproteinized using antiformin, and then the eggs were cultured on a formalin-added agar medium. Hepatica fluke eggs were cultured in tap water. The incubation period is 15 to 16 days for roundworm eggs (Tables 1 and 2
Experiment No. 1, 2) to 27 days (Experiment No. 3 in Tables 1 and 2), and 14 days for liver fluke eggs. After culturing for a specified number of days, 100 eggs of each insect were examined under a microscope.
The presence or absence of growth of insect eggs was observed, and the growth rate and larva formation rate were determined to determine the effectiveness. This experiment was repeated three times. 4) Results and discussion (a) Effect on porcine roundworm eggs Table 1 shows the growth rate and Table 2 shows the larval formation rate as the effect of the direct action of this drug on porcine roundworm eggs. Furthermore, Table 3 shows the results of the egg development stage in Experiment No. 1 of Table 1. The 50-fold diluted solution showed a growth rate of 22.9%, but as shown in Table 3, the growth stage was mostly in the early stage of division, with only a few in the mulberry stage. Furthermore, the larva formation rate was 0%, indicating that this diluted solution almost completely killed roundworm eggs. The growth rate of the 100-fold diluted solution was 28.9%, which tended to be slightly higher than that of the 50-fold diluted solution. Furthermore, at this concentration, larval formation was observed, and the larval formation rate was 5.7%. The growth rate of the 200-fold dilution was almost the same as that of the 100-fold dilution, but the larval formation rate increased. Both the growth rate and the larval formation rate increased with the 400-fold dilution. The effect of this drug on pork roundworm eggs was such that the growth rate and larva formation rate increased with increasing dilution of the drug, and the effect of this drug was dose-dependent. When using this drug for the purpose of killing roundworm eggs,
A 50-fold diluted solution is most desirable, but even with a 200-fold diluted solution, the larva formation rate is as low as 9.2%, and it is considered that the roundworm egg-killing effect can be expected. (b) Effect on liver fluke eggs Table 4 shows the miracidium formation rate as the ovicidal effect of this drug on liver fluke eggs. As can be seen from Table 4, 50 times more than this drug
The inhibitory effect on miracidium formation was observed in all dilutions up to 400 times, demonstrating that this drug is a disinfectant capable of killing Hepatica fluke eggs.

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Claims (1)

[Claims] 1. An animal parasiticide egg preparation containing (A) o-dichlorobenzene and (B) chinomethionate as essential components.