JPH05317407A - Artificial intervertebral plate - Google Patents
Artificial intervertebral plateInfo
- Publication number
- JPH05317407A JPH05317407A JP4160377A JP16037792A JPH05317407A JP H05317407 A JPH05317407 A JP H05317407A JP 4160377 A JP4160377 A JP 4160377A JP 16037792 A JP16037792 A JP 16037792A JP H05317407 A JPH05317407 A JP H05317407A
- Authority
- JP
- Japan
- Prior art keywords
- substrate
- artificial intervertebral
- elastic member
- substrates
- intervertebral disc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
Landscapes
- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、椎間板ヘルニア等によ
る椎間板の変形や損傷を外科的に治療する際に使用され
る人工椎間板に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an artificial intervertebral disc used for surgically treating the deformation and damage of the intervertebral disc due to herniated intervertebral disc.
【０００２】[0002]
【従来の技術】椎間板ヘルニアや外傷による椎間板の変
形や損傷が起こると、神経の圧迫により腰痛や肢体の痺
れが発生する。軽度の症状の場合は患部の固定のみで治
癒するが、重度の場合は外科手術により椎間板を摘出し
なければならない。この場合、上下の椎体の間に自家骨
や、また最近ではアパタイト結晶を含有する生体活性結
晶化ガラスからなる椎間スペーサーを移植して固定する
ことが行われている。しかしながらこのような方法で
は、本来可動性がある椎体が完全に固定されてしまい、
機能障害が起こったり、或は治療部位に無理な荷重がか
かって再度損傷するというおそれがある。2. Description of the Related Art When an intervertebral disc is deformed or damaged due to a herniated disc or a trauma, back pain and numbness of the limbs occur due to pressure on nerves. In mild cases, only fixing the affected area can heal, but in severe cases, the intervertebral disc must be removed by surgery. In this case, autologous bone or an intervertebral spacer made of bioactive crystallized glass containing apatite crystals is transplanted and fixed between the upper and lower vertebral bodies. However, in such a method, the originally movable vertebral body is completely fixed,
There is a risk of functional damage or excessive load on the treatment site, resulting in damage again.
【０００３】このような事情から、椎体に可動性をもた
せることが可能な人工椎間板が種々提案されている。例
えば特公平３−６３８９８号には、外側表面にアパタイ
ト層が形成されたチタンからなる一対の基板が結合部材
を介して医療高分子からなる弾性部材の上面及び下面に
結合されてなる人工椎間板が開示されている。また特開
平３−２７５０５５号には、生体活性を有するガラス又
は結晶化ガラスからなる一対の基板が医療高分子からな
る弾性部材の上面及び下面に接着されてなる人工椎間板
が開示されている。Under such circumstances, various artificial intervertebral discs capable of making the vertebral body movable have been proposed. For example, Japanese Examined Patent Publication No. 3-63898 discloses an artificial intervertebral disc in which a pair of substrates made of titanium having an apatite layer formed on the outer surface are bonded to the upper and lower surfaces of an elastic member made of a medical polymer through a bonding member. It is disclosed. Further, JP-A-3-275055 discloses an artificial intervertebral disc in which a pair of substrates made of bioactive glass or crystallized glass are bonded to the upper and lower surfaces of an elastic member made of a medical polymer.
【０００４】[0004]
【発明が解決しようとする課題】しかしながら上記特公
平３−６３８９８号の人工椎間板は、アパタイト層が基
板から剥がれ易く、骨との間に緩みが生じてしまう。ま
た基板と弾性部材とが結合部材によって結合しているた
めに応力が部分的に集中し易く、長期に亙って荷重がか
かると弾性部材が損傷するなど長期安定性に問題があ
る。However, in the artificial intervertebral disc of Japanese Patent Publication No. 3-63898, the apatite layer is easily peeled off from the substrate, resulting in looseness between the apatite layer and the bone. Further, since the substrate and the elastic member are connected by the connecting member, stress is likely to be partially concentrated, and there is a problem in long-term stability such that the elastic member is damaged when a load is applied for a long period of time.
【０００５】一方特開平３−２７５０５５号に記載の人
工椎間板は、基板が機械的強度の低い材料であるガラス
又は結晶化ガラスからなっているため、日常の動作時に
体重の２〜５倍の荷重が椎体にかかると、基板の肉厚が
薄い場合には破壊が生じてしまう。それゆえ充分な強度
を得るために基板の肉厚を厚くする必要があるが、基板
を厚くすると、その分弾性部材を薄くする必要があり、
椎体の可動性が損なわれるという不都合が生じる。On the other hand, in the artificial intervertebral disc described in JP-A-3-275055, since the substrate is made of glass or crystallized glass which is a material having low mechanical strength, the load is 2 to 5 times the weight of the body during daily operation. If it is applied to the vertebral body, it will be destroyed if the thickness of the substrate is small. Therefore, in order to obtain sufficient strength, it is necessary to increase the thickness of the substrate, but if the thickness of the substrate is increased, it is necessary to reduce the elastic member accordingly.
The disadvantage is that the mobility of the vertebral body is impaired.
【０００６】本発明の目的は、生体内で長期に亙り安定
で、且つ、可動性が良好であるために人体の運動に追従
可能な人工椎間板を提供することである。It is an object of the present invention to provide an artificial intervertebral disc which can follow the movement of the human body because it is stable in the body for a long period of time and has good mobility.
【０００７】[0007]
【課題を解決するための手段】本発明の人工椎間板は、
図１に示すように、一対の略板状の基板１ａ、１ｂが、
医療高分子からなる略板状の弾性部材２の上面及び下面
にそれぞれ接着されてなる人工椎間板であって、該基板
１ａ、１ｂがチタン又はチタン合金からなるとともに、
該基板１ａ、１ｂの外側表面に生体活性を有するガラス
層又は結晶化ガラス層３ａ、３ｂが融着されてなること
を特徴とする。The artificial intervertebral disc of the present invention comprises:
As shown in FIG. 1, a pair of substantially plate-shaped substrates 1a and 1b are
An artificial intervertebral disc bonded to the upper and lower surfaces of a substantially plate-shaped elastic member 2 made of a medical polymer, wherein the substrates 1a and 1b are made of titanium or a titanium alloy, and
It is characterized in that a glass layer or a crystallized glass layer 3a, 3b having bioactivity is fused to the outer surfaces of the substrates 1a, 1b.
【０００８】[0008]
【作用】本発明の人工椎間板は、基板が弾性部材に接着
されているため、椎体に荷重がかかった時に応力が一点
に集中することがない。なお基板と弾性部材とを接着す
るには熱圧着する方法や、生体適合性のある接着剤（例
えばシリコーン系カップリング剤、チタン系カップリン
グ剤、アルミニウム系カップリング剤等）を使用する方
法等がある。また人工椎間板の厚さは使用箇所や患者の
体格によっても異なるが、１０〜２０ｍｍが適当であ
る。In the artificial intervertebral disc of the present invention, since the substrate is bonded to the elastic member, stress is not concentrated at one point when a load is applied to the vertebral body. In addition, in order to bond the substrate and the elastic member, a method of thermocompression bonding, a method of using a biocompatible adhesive (for example, a silicone coupling agent, a titanium coupling agent, an aluminum coupling agent, etc.), etc. There is. The thickness of the artificial intervertebral disc varies depending on the place of use and the physique of the patient, but is preferably 10 to 20 mm.
【０００９】本発明の人工椎間板において、基板には高
い機械的強度を有するチタン又はチタン合金を使用す
る。チタン合金としては、Ｔｉ−６Ａｌ−４ＶやＴｉ−
５Ｍｏ−５Ｚｒ−３Ａｌ等を使用することが好ましい。
なお基板は、弾性部材に十分な厚さをもたせ、良好な可
動性が得られるように厚さが４ｍｍ以下であることが望
ましい。In the artificial intervertebral disc of the present invention, titanium or titanium alloy having high mechanical strength is used for the substrate. Titanium alloys include Ti-6Al-4V and Ti-
It is preferable to use 5Mo-5Zr-3Al or the like.
The substrate preferably has a thickness of 4 mm or less so that the elastic member has a sufficient thickness and good movability can be obtained.
【００１０】また基板の外側表面には骨と結合すること
ができるように生体活性を有するガラス層又は結晶化ガ
ラス層が形成されている。このガラス層又は結晶化ガラ
ス層は基板と融着しているため、プラズマ溶射等の方法
で形成されるアパタイト層に比べ、基板との結合力が強
い。なお使用するガラス又は結晶化ガラスは、生体活性
を有し、骨と化学的に結合するものであれば特に制限は
なく、例えばアパタイトを含有するＣａＯ−Ｐ2 Ｏ5 −
ＭｇＯ−ＳｉＯ2 系結晶化ガラス等を用いることができ
る。Further, a glass layer or a crystallized glass layer having bioactivity is formed on the outer surface of the substrate so as to be able to bond with bone. Since this glass layer or crystallized glass layer is fused to the substrate, it has a stronger bonding force with the substrate than an apatite layer formed by a method such as plasma spraying. Incidentally glass or crystallized glass used has a biological activity is not particularly limited as long as it binds to bone chemically, for example CaO-P 2 O 5 containing apatite -
It may be used MgO-SiO 2 based crystallized glass.
【００１１】弾性部材には生体内で長期安定な医療高分
子、例えばシリコーンゴムやポリウレタンゴムを使用す
ることができる。なお高分子の弾性は、使用箇所や使用
状況に合わせて適宜調整すればよい。また弾性部材の厚
さは５〜１８ｍｍ程度であることが望ましい。As the elastic member, a medical polymer that is stable in the living body for a long period of time, such as silicone rubber or polyurethane rubber, can be used. The elasticity of the polymer may be appropriately adjusted according to the place of use and the situation of use. The thickness of the elastic member is preferably about 5-18 mm.
【００１２】なお本発明の人工椎間板において、基板や
弾性部材は略板状であればよく、例えば基板の場合、骨
との接着性を高めるために基板の外側となる面に凹凸を
形成したり、弾性部材との接着性を高めるために内側と
なる面にチタンやチタン合金からなるビーズ等を接着し
たものを用いることができる。また弾性部材は、外周面
を凹状にへこませて、屈曲し易くしてもよい。In the artificial intervertebral disc of the present invention, the substrate and the elastic member may be substantially plate-shaped. For example, in the case of the substrate, irregularities are formed on the outer surface of the substrate in order to enhance the adhesiveness with bone. In order to enhance the adhesiveness with the elastic member, it is possible to use one having beads or the like made of titanium or titanium alloy adhered to the inner surface thereof. Further, the elastic member may have a concave recessed outer peripheral surface to facilitate bending.
【００１３】また基板や弾性部材の形状は円形に限られ
るものではなく、楕円形や実際の脊椎を模して円の片側
が押し潰されたような形状であってもよい。The shape of the substrate and the elastic member is not limited to the circular shape, but may be an elliptical shape or a shape in which one side of a circle is crushed to imitate an actual spine.
【００１４】次に本発明の人工椎間板を製造する方法を
説明する。Next, a method for manufacturing the artificial intervertebral disc of the present invention will be described.
【００１５】まず略板状に成形された医療高分子からな
る弾性部材を用意する。First, an elastic member made of a medical polymer molded in a substantially plate shape is prepared.
【００１６】また、略板状に成形された一対のチタン又
はチタン合金からなる基板を用意する。次に各基板の一
方の表面に、生体活性を有するガラス粉末と有機バイン
ダーを含む溶液を混練して得たスラリーを塗布し、乾燥
させた後、これを熱処理してガラスを軟化融着させてガ
ラス層を形成し、或はさらにこれを結晶化させて結晶化
ガラス層を形成する。Further, a pair of titanium or titanium alloy substrates formed into a substantially plate shape is prepared. Next, on one surface of each substrate, a slurry obtained by kneading a solution containing a glass powder having bioactivity and an organic binder was applied, dried, and then heat-treated to soften and fuse the glass. A glass layer is formed, or this is further crystallized to form a crystallized glass layer.
【００１７】次いでこのようにして作製した一対の基板
を、ガラス層又は結晶化ガラス層が形成された面を外側
にして、上記弾性部材の上面及び下面に熱圧着、或は接
着剤を用いて接着することにより、本発明の人工椎間板
を得ることができる。Next, the pair of substrates thus manufactured are thermocompression bonded to the upper and lower surfaces of the elastic member or with an adhesive with the surface on which the glass layer or the crystallized glass layer is formed being outside. By bonding, the artificial intervertebral disc of the present invention can be obtained.
【００１８】[0018]
【実施例】以下、本発明の人工椎間板を実施例に基づい
て説明する。EXAMPLES The artificial intervertebral disc of the present invention will be described below based on examples.
【００１９】表１は本発明の実施例（試料Ｎｏ．１〜
３）及び比較例（試料Ｎｏ．４〜６）を示している。Table 1 shows examples of the present invention (Sample Nos. 1 to 1).
3) and comparative examples (Sample Nos. 4 to 6) are shown.
【００２０】[0020]
【表１】 [Table 1]
【００２１】試料Ｎｏ．１〜３は次のようにして作製し
た。Sample No. 1-3 were produced as follows.
【００２２】まず基板として４５φ×１ｍｍの大きさの
チタン又はチタン合金をそれぞれ２枚づつ用意した。ま
た重量％でＣａＯ ３６．０％、Ｐ2 Ｏ5 ９．２％、Ｍ
ｇＯ１１．２％、ＳｉＯ2 ４３．６％の組成を有するガ
ラス粉末を、ターピネオールにポリイソブチルアクリレ
ートを５重量％混合した溶液に分散させてスラリーとし
た。次いでこれを各基板の片側の表面に塗布し、乾燥
後、真空中で熱処理した。なお試料Ｎｏ．１に用いる基
板については８００℃で１時間熱処理することによって
ガラス粉末を軟化融着させてガラス層を形成し、また試
料Ｎｏ．２及び３に用いる基板については９５０℃で１
時間熱処理することによってガラス粉末を軟化融着させ
るとともに結晶化させて結晶化ガラス層を形成した。First, two titanium or titanium alloys each having a size of 45φ × 1 mm were prepared as substrates. Also, CaO 36.0%, P 2 O 5 9.2%, M by weight%
A glass powder having a composition of gO 11.2% and SiO 2 43.6% was dispersed in a solution in which 5% by weight of polyisobutyl acrylate was mixed with terpineol to obtain a slurry. Then, this was applied to the surface on one side of each substrate, dried, and then heat-treated in vacuum. Sample No. The substrate used for No. 1 was heat-treated at 800 ° C. for 1 hour to soften and fuse the glass powder to form a glass layer. The substrate used for 2 and 3 is 1 at 950 ° C.
The glass powder was softened and fused by heat treatment for a time and crystallized to form a crystallized glass layer.
【００２３】さらに弾性部材として４５φ×１０ｍｍの
大きさのシリコーンゴム（Ｑ７４７２０、ダウコーニン
グ社製）を用意し、この上面及び下面に、基板をガラス
層又は結晶化ガラス層が形成された面を外側にして接着
し、試料を得た。なお接着には接着剤（プライマーＡ、
信越化学工業株式会社製）を用いた。Further, a silicone rubber (Q74720, manufactured by Dow Corning) having a size of 45φ × 10 mm is prepared as an elastic member, and the upper surface and the lower surface of the substrate are the surfaces on which the glass layer or the crystallized glass layer is formed are the outside. And adhered to obtain a sample. For the adhesion, an adhesive (primer A,
Shin-Etsu Chemical Co., Ltd.) was used.
【００２４】試料Ｎｏ．４は、次のようにして作製し
た。まず試料Ｎｏ．２と同様のチタン合金からなる基板
を２枚用意し、各基板の片側の表面にプラズマ溶射によ
りアパタイト層を形成した。次いで試料Ｎｏ．１〜３で
使用したのと同様のシリコーンゴム製の弾性部材の上面
及び下面に、接着剤を用いてアパタイト層が外側になる
ように基板を接着した。Sample No. 4 was manufactured as follows. First, sample No. Two substrates made of the same titanium alloy as in No. 2 were prepared, and an apatite layer was formed on one surface of each substrate by plasma spraying. Then sample No. Substrates were bonded to the upper and lower surfaces of the same elastic member made of silicone rubber as used in 1 to 3 with an adhesive so that the apatite layer was on the outside.
【００２５】試料Ｎｏ．５及び６は次のようにして作製
した。Sample No. 5 and 6 were produced as follows.
【００２６】まずＳｉＯ2 ３４．２％、Ｐ2 Ｏ5 １６．
３％、ＣａＯ ４４．９％、ＭｇＯ４．６％、ＣａＦ2
０．７５％の組成を有し、４５φ×１ｍｍ及び４５φ×
５ｍｍの大きさのアパタイトやウオラストナイトを含有
する結晶化ガラス（Ａ−Ｗ結晶化ガラス）からなる基板
をそれぞれ２枚づつ用意した。次いで試料Ｎｏ．１〜３
で使用したのと同様のシリコーンゴム製の弾性部材の上
面及び下面に、接着剤を用いて基板を接着し、試料を得
た。なお試料Ｎｏ．６に使用した弾性部材は、試料の厚
さが他と同じ（１２ｍｍ）になるように４５φ×２ｍｍ
の大きさのものを用いた。First, SiO 2 34.2%, P 2 O 5 16.
3%, CaO 44.9%, MgO 4.6%, CaF 2
With a composition of 0.75%, 45φ × 1 mm and 45φ ×
Two substrates each made of crystallized glass (AW crystallized glass) containing apatite or wollastonite with a size of 5 mm were prepared. Then sample No. 1-3
Substrates were adhered to the upper and lower surfaces of an elastic member made of silicone rubber similar to that used in 1. to obtain a sample. Sample No. The elastic member used in No. 6 was 45φ x 2 mm so that the sample thickness was the same as the others (12 mm).
The size of was used.
【００２７】このようにして得られた各試料について可
動性の確認や生体内での安定性の評価を行うために、試
料を直径４０ｍｍの円柱の上に置き、その上に鋼球を置
いて万能試験機で圧縮試験（クロスヘッドスピード０．
５ｍｍ／ｍｉｎ、最大荷重２００ｋｇ）を行い、変形や
破壊の有無を調べた。In order to confirm the mobility and evaluate the in vivo stability of each sample thus obtained, the sample was placed on a cylinder having a diameter of 40 mm, and a steel ball was placed on it. Compression test with a universal testing machine (crosshead speed
5 mm / min, maximum load 200 kg) was applied to examine the presence or absence of deformation or breakage.
【００２８】表１から明らかなように、試料Ｎｏ．１〜
３の各試料は可動性が良好であり、また基板の破壊も生
じなかった。これに対して試料Ｎｏ．４は可動性が良好
であったものの、アパタイト層が剥離した。また試料Ｎ
ｏ．５は可動性が良好であったものの、基板が結晶化ガ
ラス製であるために６．５ｋｇの荷重で破壊が生じた。
一方基板の厚みを大きくした試料Ｎｏ．６は可動性が悪
く、しかも１３２ｋｇの荷重で破壊が生じた。As is clear from Table 1, the sample No. 1 to
Each sample of 3 had good movability and did not break the substrate. On the other hand, the sample No. No. 4 had good mobility, but the apatite layer peeled off. Sample N
o. Sample No. 5 had good movability, but since the substrate was made of crystallized glass, breakage occurred at a load of 6.5 kg.
On the other hand, sample No. The sample No. 6 had poor movability, and was broken at a load of 132 kg.
【００２９】これらの事実は本発明の人工椎間板が、可
動性や生体内安定性に優れていることを示している。These facts show that the artificial intervertebral disc of the present invention is excellent in mobility and in vivo stability.
【００３０】[0030]
【発明の効果】本発明の人工椎間板は、生体活性を有す
るガラス層又は結晶化ガラス層が形成されているために
骨との接着性がよい。EFFECTS OF THE INVENTION The artificial intervertebral disc of the present invention has good adhesion to bone because it has a glass layer or a crystallized glass layer having bioactivity.
【００３１】またガラス層や結晶化ガラス層が基板と強
固に結合しており、基板から剥離し難い。しかも基板と
弾性部材とが接着剤等によって接着しているために、荷
重がかかっても応力が一点に集中することがなく、弾性
部材が損傷することがない。それゆえ生体内で長期に亙
り安定である。Further, since the glass layer and the crystallized glass layer are firmly bonded to the substrate, they are difficult to peel off from the substrate. Moreover, since the substrate and the elastic member are adhered by an adhesive or the like, stress is not concentrated at one point even when a load is applied, and the elastic member is not damaged. Therefore, it is stable in vivo for a long time.
【００３２】さらに基板に高強度材料であるチタン又は
チタン合金を用いているため、基板を薄くすることがで
きる。このため可動性がよく、人体の運動に追従可能で
あり、人工椎間板として好適である。Further, since titanium or titanium alloy which is a high strength material is used for the substrate, the substrate can be thinned. Therefore, it has good mobility, can follow the movement of the human body, and is suitable as an artificial intervertebral disc.
【図１】本発明の人工椎間板の一例を示す斜視図であ
る。FIG. 1 is a perspective view showing an example of an artificial intervertebral disc of the present invention.
１ａ、１ｂ 基板 ２ 弾性部材 ３ａ、３ｂ ガラス層又は結晶化ガラス層 1a, 1b Substrate 2 Elastic member 3a, 3b Glass layer or crystallized glass layer
Claims (1)
なる略板状の弾性部材の上面及び下面にそれぞれ接着さ
れてなる人工椎間板であって、該基板がチタン又はチタ
ン合金からなるとともに、該基板の外側表面に生体活性
を有するガラス層又は結晶化ガラス層が融着されてなる
ことを特徴とする人工椎間板。1. An artificial intervertebral disc in which a pair of substantially plate-shaped substrates are respectively bonded to the upper surface and the lower surface of a substantially plate-shaped elastic member made of a medical polymer, and the substrates are made of titanium or a titanium alloy. At the same time, an artificial intervertebral disc characterized in that a glass layer or a crystallized glass layer having bioactivity is fused to the outer surface of the substrate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4160377A JPH05317407A (en) | 1992-05-27 | 1992-05-27 | Artificial intervertebral plate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4160377A JPH05317407A (en) | 1992-05-27 | 1992-05-27 | Artificial intervertebral plate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH05317407A true JPH05317407A (en) | 1993-12-03 |
Family
ID=15713654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4160377A Pending JPH05317407A (en) | 1992-05-27 | 1992-05-27 | Artificial intervertebral plate |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH05317407A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7867276B2 (en) | 2002-03-15 | 2011-01-11 | Paradigm Spine, Llc | Dynamic intervertebral implant |
| JP2011092736A (en) * | 2009-10-30 | 2011-05-12 | Depuy Products Inc | Joint prosthesis with surfaces having different textures and method of making the joint prosthesis |
-
1992
- 1992-05-27 JP JP4160377A patent/JPH05317407A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7867276B2 (en) | 2002-03-15 | 2011-01-11 | Paradigm Spine, Llc | Dynamic intervertebral implant |
| JP2011092736A (en) * | 2009-10-30 | 2011-05-12 | Depuy Products Inc | Joint prosthesis with surfaces having different textures and method of making the joint prosthesis |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2858126B2 (en) | Biological implant material and its manufacturing method | |
| Wnek et al. | Encyclopedia of biomaterials and biomedical engineering | |
| Corkhill et al. | Synthetic hydrogels VI. Hydrogel composites as wound dressings and implant materials | |
| KR100655170B1 (en) | Artificial joint system | |
| JP3012095B2 (en) | Porous bioprosthesis member and processing method for imparting elasticity thereto | |
| JP3380563B2 (en) | Orthopedic implant and its construction method | |
| Lundborg et al. | Osseointegrated thumb prostheses: a concept for fixation of digit prosthetic devices | |
| Kokubo et al. | Spontaneous formation of bonelike apatite layer on chemically treated titanium metals | |
| JPH0363898B2 (en) | ||
| CA2307954A1 (en) | Enzyme-medicated modification of fibrin for tissue engineering | |
| JPH06339490A (en) | Artificial articular cartilage and manufacture thereof | |
| US8388881B2 (en) | Method forming a one-piece articulating spacing device for a knee joint | |
| JP2023534633A (en) | Nanofiber reinforcement of adherent hydrogels | |
| Beech | Bonding of alkyl 2-cyanoacrylates to human dentin and enamel | |
| JPH03275055A (en) | Artificial intervertebral disk | |
| CN1185118A (en) | Medical device adhering to the skin | |
| Hansen et al. | Saliva contamination vs. efficacy of dentin-bonding agents | |
| JPH04141163A (en) | Porous metal material with excellent bone affinity and preparation thereof | |
| JPH05317407A (en) | Artificial intervertebral plate | |
| De Groot | Hydroxylapatite coatings for implants in surgery | |
| Kokubo et al. | SURFACE STRUCTURE OF BIOACTIVE GLASS-CERAMIC A-W IMPLANTED INTO SHEEP AND HUMAN VERTEBRA | |
| Endres et al. | A new adhesive technique for internal fixation in midfacial surgery | |
| JPH05208029A (en) | Artificial pyramid spacer | |
| Härting et al. | Glued fixation of split-skin graft to the bony orbit following exenteration | |
| JPH04242659A (en) | Vivi-implant material and manufacture thereof |