JPH05307042A - Automatic blood analyzing device - Google Patents
Automatic blood analyzing deviceInfo
- Publication number
- JPH05307042A JPH05307042A JP11172492A JP11172492A JPH05307042A JP H05307042 A JPH05307042 A JP H05307042A JP 11172492 A JP11172492 A JP 11172492A JP 11172492 A JP11172492 A JP 11172492A JP H05307042 A JPH05307042 A JP H05307042A
- Authority
- JP
- Japan
- Prior art keywords
- sample
- specimen
- dispensing
- blood
- container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
Landscapes
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
Description
【0001】[0001]
【産業上の利用分野】本発明は、臨床検査等に使用され
る抗原抗体反応を利用した自動血液分析装置に関するも
のである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an automatic hematology analyzer utilizing an antigen-antibody reaction used in clinical tests and the like.
【0002】[0002]
【従来の技術】血液検査では、患者から血液を採取しそ
の血液を遠心分離して血球と血清とを一つの試料容器内
で分離して検査装置に使用する。この血液検査装置で
は、試料として血球のみを使用する場合と、血清のみを
使用する場合とがあり、そのために図4に示すように遠
心分離した血球1と血清2とを収容する試料容器3内に
試料分注用ノズル4を侵入させ、侵入の度合いを調整し
ながら別個に採取していた。2. Description of the Related Art In a blood test, blood is collected from a patient, the blood is centrifuged, and blood cells and serum are separated in a single sample container for use in a testing device. In this blood test apparatus, there are a case where only blood cells are used as a sample and a case where only serum is used. For this reason, as shown in FIG. 4, the inside of the sample container 3 containing the blood cells 1 and the serum 2 that have been centrifuged. The sample-dispensing nozzle 4 was made to invade, and the sample was separately collected while adjusting the degree of intrusion.
【0003】採取された試料は必要数の希釈容器に分注
された後、所要の希釈倍率に希釈される。次に、反応容
器に希釈された試料を分注し、さらに試薬を規定量分注
して抗原抗体結合反応による凝集反応を起こさせる。次
に、反応容器内の凝集パターンを光学的に測光し、検査
の判定を行うのである。こうした検査方法は周知のもの
であり、特公平2−16875号公報等を始めとして多
くの文献に開示されている。The collected sample is dispensed into a required number of dilution containers and then diluted to a required dilution ratio. Next, the diluted sample is dispensed into a reaction container, and a prescribed amount of a reagent is further dispensed to cause an agglutination reaction by an antigen-antibody binding reaction. Next, the aggregation pattern in the reaction vessel is optically measured to determine the inspection. Such an inspection method is well known, and is disclosed in many documents including Japanese Patent Publication No. 2-16875.
【0004】試料として血球を使用する検査としては、
例えば赤血球の型(ABO式)等の検査があり、この場
合の試薬としては抗血清が用いられる。また、血清を使
用する検査としては、各種抗体、ビールス等があり、こ
の場合の試薬としては各種抗原が用いられる。さらに血
清を用いる感染症検査としては従来、免疫沈降法、RP
HA、RIA、EIA等が知られているが、簡便性、コ
スト、判定精度等の面からRPHA(逆受身血球凝集
法)が多用されている。また、血液型の検査においても
RPHAが多用されている。As an inspection using blood cells as a sample,
For example, there is a test for erythrocyte type (ABO type), and in this case, antiserum is used as a reagent. Further, tests using serum include various antibodies, viruses, etc., and various antigens are used as reagents in this case. In addition, immunoprecipitation and RP have been conventionally used as infectious disease tests using serum.
Although HA, RIA, EIA and the like are known, RPHA (reverse passive hemagglutination method) is frequently used in terms of simplicity, cost, determination accuracy and the like. Also, RPHA is frequently used in blood type tests.
【0005】上記の各種検査法のうち凝集法は、血清試
料に含まれる測定対象物質に対し、特異的な反応を行う
成分を動物血球等に固定した血球試薬を投入し、抗原抗
体反応により生じた凝集の有無で検査対象物質の有無を
判定する方法である。図5は、抗原抗体反応の結果の凝
集パターンを示したもので、Aは非凝集像、Bは凝集
像、Cは血球が混入した場合の凝集像、Dは血球が混入
した場合の非凝集像である。したがって血清とともに血
球を分注してしまった場合、その血球は試薬との反応に
は寄与しないため図5Cに示すように中心部に集積して
しまい、抗原抗体反応が起こらない結果と判定されてし
まうおそれがある。このため血液型および感染症の検査
における誤判定を引起してしまうことがある。The agglutination method among the above-mentioned various inspection methods is caused by an antigen-antibody reaction by introducing a blood cell reagent in which a component that specifically reacts with a substance to be measured contained in a serum sample is fixed to animal blood cells and the like. It is a method of determining the presence or absence of the substance to be inspected based on the presence or absence of aggregation. FIG. 5 shows the aggregation pattern as a result of the antigen-antibody reaction. A is a non-aggregation image, B is an aggregation image, C is an aggregation image when blood cells are mixed, and D is non-aggregation when blood cells are mixed. It is a statue. Therefore, when blood cells were dispensed together with serum, the blood cells did not contribute to the reaction with the reagent and thus accumulated in the central portion as shown in FIG. 5C, and it was determined that the antigen-antibody reaction did not occur. There is a risk that This may cause erroneous determination in blood type and infectious disease tests.
【0006】そこで、反応の終了した反応容器を目視観
察して、血球を試料として使用した検査の場合は血球の
分注量が大きく異なっていないか、血清を試料として使
用した場合は血球が混入されていないかどうかを一つ一
つ確認していた。このように目視観察をしないと、血清
を試料として使用した場合に、血清試料が少なくてノズ
ルで吸引する際のノズル先端付近の引圧で血球も吸い上
げてしまった時や、血球を試料とした場合に、血球の分
注量が設定量に対して著しく異なる場合に、凝集パター
ンが異常になり検査結果を誤ってしまうおそれがあるか
らである。[0006] Therefore, visually observing the reaction container after the reaction, the amount of dispensed blood cells is not significantly different in the case of an inspection using blood cells as a sample, or blood cells are mixed when serum is used as a sample. I checked one by one to see if it was done. Without such visual observation, when serum was used as a sample, when blood cells were sucked up by suction pressure near the nozzle tip when aspirating with the nozzle due to the small amount of serum sample, or blood cells were used as a sample. In this case, if the dispensed amount of blood cells is significantly different from the set amount, the aggregation pattern may become abnormal and the test result may be erroneous.
【0007】[0007]
【発明が解決しようとする課題】上記のような従来方法
は、例えば血清を試料とした検査を行う場合、病院など
ではリアルタイムで検査結果を出し患者に処置を施さな
ければならないので、反応が終了するまで血球が混入し
てしまったかどうかの判別がつかない。さらに、病院な
どでは試料が次から次へとくるので、再検査を行うべき
試料はまとめて最後に行う。そのため検査結果が出るの
が遅れ、患者の待ち時間が長くなってしまい、ついには
その日に検査結果を知ることができず、再度の通院を余
儀無くされるということがあった。なお、抗原抗体反応
を利用した血液分析は、通常でも反応時間に1時間程度
を要する。In the conventional method as described above, for example, in the case of performing a test using serum as a sample, in a hospital or the like, the test result must be obtained in real time and the patient must be treated. It is impossible to determine whether blood cells have been mixed until after. Furthermore, in hospitals, etc., the samples come one after another, so the samples that should be retested should be collected at the end. As a result, the test results were delayed and the patient's waiting time became long, and eventually the test results could not be known on that day, and the patient was forced to visit the hospital again. A blood analysis using the antigen-antibody reaction usually requires about 1 hour for the reaction time.
【0008】さらに、最終判断が人の目視観察によって
いるので、観察する人によって判断基準が異なったり、
判断の間違いが生じることがある。検査をする試料が1
日当たり1000件というような施設もあるので、目視
観察をするには自ずと限界がある。また、目視観察の結
果により再検査をする場合、使用する試薬も高価なもの
であるため費用上も問題であった。Furthermore, since the final judgment is based on the visual observation of a person, the judgment criteria may be different depending on the person who observes it.
Misjudgment may occur. 1 sample to inspect
There are facilities such as 1000 per day, so there is a limit to the visual observation. Further, when the re-inspection is performed based on the result of visual observation, the reagent used is also expensive, which is a cost problem.
【0009】さらに、血清を試料とした検査の場合、通
常は凝集パターンが図5A、Bのようになるはずである
が、血球が混入してしまうと凝集パターンが図5C、D
のようになってしまい、判定を誤ってしまうおそれがあ
る。また、血球を試料とした検査の場合、一般的に血球
の粘度が高いために極端に精度が悪い場合がある。つま
り、分注血球量が設定より多い場合は、凝集パターンの
中心部の濃い部分が大きくなり、少ない場合は小さくな
ってしまう。しかしながら、こうした結果も反応が全て
終了した後に目視により判断しているため上記のような
問題がある。Further, in the case of a test using serum as a sample, the agglutination pattern should normally be as shown in FIGS. 5A and 5B, but when blood cells are mixed, the agglutination pattern is shown in FIGS. 5C and D.
As a result, there is a risk that the judgment will be incorrect. Further, in the case of an examination using blood cells as a sample, the accuracy of blood cells may be extremely low due to the high viscosity of the blood cells. That is, when the amount of dispensed blood cells is larger than the set value, the dark part in the central part of the aggregation pattern becomes large, and when it is small, it becomes small. However, these results also have the above problems because they are visually judged after the reaction is completed.
【0010】本発明は、上記不具合を解決すべく提案さ
れるもので、試料を反応容器内に分注する以前に試料の
適不適を判定し、血液分析の効率化を図る自動血液分析
装置を提供することを目的としたものである。The present invention is proposed to solve the above-mentioned problems, and an automatic blood analyzer for determining the suitability of a sample before dispensing the sample into a reaction container to improve the efficiency of blood analysis is provided. It is intended to be provided.
【0011】[0011]
【課題を解決するための手段】本発明は、上記目的を達
成するために、試料と希釈液を混合するための希釈容器
と、希釈容器内血球の濃度測定手段と、希釈容器内血球
濃度異常の際に試料の検査結果を告知する手段を設け、
その検査結果に基づき試料の処理を停止および/または
自動再検査を行う自動血液分析装置とした。In order to achieve the above object, the present invention provides a diluting container for mixing a sample and a diluting solution, a means for measuring the concentration of blood cells in the diluting container, and an abnormal blood cell concentration in the diluting container. In the case of, a means for notifying the test result of the sample is provided,
The automatic blood analyzer is configured to stop the processing of the sample and / or perform the automatic retest based on the test result.
【0012】[0012]
【作用】このように希釈容器内血球濃度異常が事前に情
報として得られるので、これに基づき不適当な試料であ
ることを事前に確認でき、これらを全試料の検査終了後
に再検査をするというような事態を回避できる。また、
不適当な試料に対して投入する試薬の浪費を防止するこ
とができる。[Function] Since abnormal blood cell concentration in the dilution container is obtained as information in advance in this way, it is possible to confirm in advance that it is an inappropriate sample based on this, and it is said that these will be reexamined after all samples have been examined. Such a situation can be avoided. Also,
It is possible to prevent waste of a reagent to be added to an inappropriate sample.
【0013】[0013]
【実施例】以下、図面を参照しながら本発明の1実施例
を説明していく。図1は、は免疫学的凝集反応による自
動血液分析装置の斜視図であり、装置本体5の上には複
数の反応容器15をセットしたマイクロプレート14を
載置する。このマイクロプレート14は、互いに分離さ
れマトリクス状に配列された複数個の反応容器列を有す
る。ここには、縦12個、横10個の容器が配設されて
いるので、1試料に対し最大12種類の試薬が分注で
き、また最大10試料の検査が行えることとなる。DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS An embodiment of the present invention will be described below with reference to the drawings. FIG. 1 is a perspective view of an automatic hematology analyzer based on immunological agglutination reaction, in which a microplate 14 having a plurality of reaction vessels 15 set thereon is placed on the apparatus body 5. The microplate 14 has a plurality of reaction vessel rows which are separated from each other and arranged in a matrix. Since 12 containers in the vertical direction and 10 containers in the horizontal direction are arranged here, a maximum of 12 kinds of reagents can be dispensed for one sample, and a maximum of 10 samples can be inspected.
【0014】次に、この装置の構成と装置による分析作
業について説明する。先ず、装置本体5上に試料容器6
を有するケース7を載置し、試料分注用シリンジポンプ
8に連結されている試料分注用ノズル9を介して試料を
希釈容器10に分注する。分注を終えた試料分注用ノズ
ル9は、試料用洗浄槽11a中で吸排動作を行うことに
より洗浄される。次に、希釈液容器20に連結している
希釈液用シリンジポンプ12およびこれに連結している
希釈ノズル13を介して希釈容器10に希釈液を分注
し、希釈試料を作成する。Next, the structure of this apparatus and the analysis work by the apparatus will be described. First, the sample container 6 is placed on the device body 5.
The case 7 having the above is placed, and the sample is dispensed into the dilution container 10 through the sample dispensing nozzle 9 connected to the sample dispensing syringe pump 8. The sample dispensing nozzle 9 that has completed dispensing is cleaned by performing suction / discharge operation in the sample cleaning tank 11a. Next, the diluting liquid is dispensed into the diluting container 10 via the diluting liquid syringe pump 12 connected to the diluting liquid container 20 and the diluting nozzle 13 connected to the diluting liquid syringe 20 to prepare a diluted sample.
【0015】こうして作成された希釈試料は、試料用分
注用ノズル9によりマイクロプレート14にセットされ
ている反応容器15に分注される。希釈試料の分注を1
回終了した後は、試料分注用ノズル9を試料用洗浄槽1
1aで洗浄し、次の希釈試料をマイクロプレート14の
反応容器15に分注する。なお、試料分注用ノズル9
は、X方向、Y方向、Z方向に移動できるようになって
いる。The diluted sample thus prepared is dispensed by the sample dispensing nozzle 9 into the reaction container 15 set in the microplate 14. Dispense diluted sample 1
After the completion of the operation, the sample dispensing nozzle 9 is replaced with the sample cleaning tank 1
After washing with 1a, the next diluted sample is dispensed into the reaction container 15 of the microplate 14. The sample dispensing nozzle 9
Can move in the X, Y, and Z directions.
【0016】希釈容器10は、装置本体5に形成した開
口枠5aの下方を間欠的に列方向に移動し、希釈ノズル
13の先端の真下で停止するようになっている。また、
希釈容器10は、保持部材22に開口枠5a、希釈ノズ
ル13の先端に衝突しないような高さに保持されてい
る。また、保持部材22は、無端状のベルトコンベア2
9(図2)に固定され、図示されていないステップモー
タにより所定ピッチで移送されるようになっている。The dilution container 10 intermittently moves in the row direction below the opening frame 5a formed in the apparatus main body 5 and stops immediately below the tip of the dilution nozzle 13. Also,
The dilution container 10 is held by the holding member 22 at a height such that it does not collide with the opening frame 5 a and the tip of the dilution nozzle 13. Further, the holding member 22 is an endless belt conveyor 2
It is fixed at 9 (FIG. 2) and is transferred at a predetermined pitch by a step motor (not shown).
【0017】なお、希釈容器10から反応容器15の各
ウエルへの希釈試料を分注した後は、希釈容器10を更
に移送させ回り込んで反転した状態で保持させ、洗浄用
ノズルによる洗浄水の噴射によって洗浄し、充分な水切
りもしくは乾燥空気による乾燥処理を経て再使用する。
こうした希釈容器10の移送中に、希釈容器10は前記
のように希釈ノズル13の先端の真下に停止するが、こ
の位置は図2(斜視図)、図3(断面図)に示す血球検
知センサ21a、21bにより検知される位置でもあ
る。After the diluted sample is dispensed from the diluting container 10 to each well of the reaction container 15, the diluting container 10 is further transferred, circulated and held in an inverted state, and the washing water is washed by the washing nozzle. Wash by jetting, drain thoroughly or dry with dry air before reuse.
While the diluting container 10 is being transferred, the diluting container 10 stops just below the tip of the diluting nozzle 13 as described above, but this position is shown in FIGS. 2 (perspective view) and 3 (cross-sectional view). It is also the position detected by 21a and 21b.
【0018】つまり、希釈ノズル13の真下で停止した
希釈容器10は、希釈液の分注と試料分注用ノズル9に
よる分注動作中停止しているが、この期間中に希釈容器
10内の血球の検知を行う。なお、試料分注用ノズル9
の近傍には、液面検知のための電極9aが設けてあり、
試料容器6内に収容された分離後血液から血球または血
清のいずれかを分取して、希釈容器10へ分注するよう
になっている。分注を受けた希釈容器10は、1ステッ
プ進んで希釈ノズル13による希釈液の分注を受けるの
である。ここで希釈ノズル13から噴射された希釈液
は、希釈容器10内に渦流となって適宜攪拌される。ま
た、このとき、血球検知センサ21a、21bが作動
し、希釈容器10内の血球量が測定される。血球検知セ
ンサ21は、一方が測光手段であり、他方は受光手段で
あり、図1における希釈容器10の下方で移動する保持
部材22に希釈容器10の下部をはめ込み、図3に示す
ように希釈容器10の下部に光を照射することにより血
球の検知を行う。That is, the diluting container 10 stopped immediately below the diluting nozzle 13 is stopped during the diluting liquid dispensing operation and the dispensing operation by the sample dispensing nozzle 9, but the diluting container 10 inside the diluting container 10 is stopped during this period. Detects blood cells. The sample dispensing nozzle 9
An electrode 9a for detecting the liquid level is provided near
Either blood cells or serum is separated from the separated blood contained in the sample container 6 and dispensed into the dilution container 10. The diluted container 10 that has received the dispensing proceeds to one step and receives the diluted liquid dispensed by the dilution nozzle 13. Here, the diluting liquid injected from the diluting nozzle 13 is swirled in the diluting container 10 and appropriately stirred. At this time, the blood cell detection sensors 21a and 21b are activated to measure the blood cell volume in the dilution container 10. One of the blood cell detection sensors 21 is a photometric means and the other is a light receiving means. The lower part of the diluting container 10 is fitted into a holding member 22 that moves below the diluting container 10 in FIG. 1 to dilute as shown in FIG. The blood cells are detected by irradiating the lower portion of the container 10 with light.
【0019】血球検知センサ21a、21bによる信号
はAHP(アンプ)23で増幅され、CPU24で記憶
される。このCPU24は、希釈試料分注系25、試薬
分注系26、データ処理系27、CRT画面28に接続
されている。そこで、血球を使用した検査の場合、設定
血球量に対して測定された血球量が著しく異なる時はそ
の後の動作を継続することを中止し、自動的に前記試料
分注の段階から同じ試料の検査をする。また、血清を試
料とした検査の場合に、血球の混入が検知された時はそ
の後の動作を継続することを中止し、上記と同様に自動
的に同じ試料の検査を行う。The signals from the blood cell detection sensors 21a and 21b are amplified by the AHP (amplifier) 23 and stored in the CPU 24. The CPU 24 is connected to a diluted sample dispensing system 25, a reagent dispensing system 26, a data processing system 27, and a CRT screen 28. Therefore, in the case of a test using blood cells, when the measured blood cell volume is significantly different from the set blood cell volume, the subsequent operation is stopped and the same sample is automatically added from the sample dispensing stage. Inspect. Further, in the case of a test using serum as a sample, when the mixture of blood cells is detected, the subsequent operation is stopped and the same sample is automatically tested as described above.
【0020】こうして適正な希釈試料であることが判定
された場合は、その後、装置本体5上に用意されている
複数項目に対応する試薬を収容する試薬容器16の1つ
からから試薬分注用シリンジポンプ18に連結されてい
る試薬分注用ノズル17を介して反応容器15に所望の
試薬を分注する。この試薬分注用ノズル17もX方向、
Y方向、Z方向に移動できるようになっている。分注動
作を終えた試薬分注用ノズル17は、試薬用洗浄槽11
bに移動して吸排動作により洗浄される。次に、反応容
器8内の粒子凝集パターンを判定するには、反応容器1
5内の検体を規定時間反応させた後に光を透過させ撮像
カメラ19で測光し、判定するのである。When it is determined that the sample is a proper diluted sample, the reagent is dispensed from one of the reagent containers 16 containing the reagents corresponding to a plurality of items prepared on the apparatus main body 5 thereafter. A desired reagent is dispensed into the reaction container 15 via the reagent dispensing nozzle 17 connected to the syringe pump 18. This reagent dispensing nozzle 17 is also in the X direction,
It can be moved in the Y and Z directions. The reagent dispensing nozzle 17 that has completed the dispensing operation is the reagent cleaning tank 11
It moves to b and is washed by suction and discharge operation. Next, in order to determine the particle aggregation pattern in the reaction container 8, the reaction container 1
After allowing the sample in 5 to react for a specified time, light is transmitted and the light is measured by the imaging camera 19 to make a determination.
【0021】なお、本発明は上述した実施例に限定され
ず、幾多の変更、変形が可能である。例えば、血球検知
センサにより検知される血球量が誤判定に至らない濃度
を予め設定して、該濃度以下であれば分析を続行するよ
う構成すれば、処理能率がアップする。また、血清を用
いる分析の場合は、混入した赤血球濃度を一旦、CPU
に記憶しておき、通常通り測定した結果に対して補正を
行った後に判定を行うようにデータ処理系を構成すれ
ば、試料が無駄なくかつ正確に分析される。The present invention is not limited to the above-mentioned embodiments, but various modifications and variations are possible. For example, if the blood cell amount detected by the blood cell detection sensor is set to a concentration that does not lead to an erroneous determination and the analysis is continued if the blood cell amount is equal to or lower than this concentration, the processing efficiency is improved. Also, in the case of analysis using serum, the concentration of red blood cells mixed in is temporarily determined by the CPU.
If the data processing system is configured so that the judgment is made after the measurement result is corrected as usual, the sample can be analyzed accurately without waste.
【0022】[0022]
【発明の効果】以上のごとく本発明によれば、試料を反
応容器に分注する以前に試料の適不適を判定できるた
め、引き続き同一試料から再検査が行えるため、全試料
の検査終了後に行われていた従来のような再検査に比較
して、大幅な時間短縮と検査業務の改善を実現できる。
また、血球が吸引分注されたと判断してから、直ちに試
薬分注を停止させることにより、高価な試薬の浪費を防
止できることとなる。As described above, according to the present invention, since it is possible to determine the suitability of a sample before dispensing the sample into the reaction container, it is possible to carry out retesting from the same sample. Compared with the conventional re-inspection, which has been known, it is possible to significantly reduce the time and improve inspection work.
Further, by immediately stopping the reagent dispensing after determining that the blood cells have been sucked and dispensed, it is possible to prevent the waste of the expensive reagent.
【図1】本発明に用いる分析装置の斜視図である。FIG. 1 is a perspective view of an analyzer used in the present invention.
【図2】血球検知センサの斜視図である。FIG. 2 is a perspective view of a blood cell detection sensor.
【図3】血球検知センサの断面図である。FIG. 3 is a cross-sectional view of a blood cell detection sensor.
【図4】血清、血球の分離状態を示す断面図である。FIG. 4 is a cross-sectional view showing a separated state of serum and blood cells.
【図5】検体の凝集状態を示す説明図である。FIG. 5 is an explanatory diagram showing an aggregated state of a sample.
5 装置本体 6 試料容器 7 ケース 8 試料分注用シリンジ 9 試料分注用ノズル 9a 電極 10 希釈容器 11 試料用洗浄槽 12 希釈液用シリンジポンプ 13 希釈ノズル 14 マイクロプレート 15 反応容器 16 試薬容器 17 試薬分注用ノズル 18 試薬分注用シリンジポンプ 19 撮像カメラ 20 希釈液容器 5 Device Main Body 6 Sample Container 7 Case 8 Sample Dispensing Syringe 9 Sample Dispensing Nozzle 9a Electrode 10 Dilution Container 11 Sample Washing Tank 12 Diluent Syringe Pump 13 Dilution Nozzle 14 Microplate 15 Reaction Container 16 Reagent Container 17 Reagent Dispensing nozzle 18 Reagent dispensing syringe pump 19 Imaging camera 20 Diluent container
Claims (1)
と、希釈容器内血球の濃度測定手段と、希釈容器内血球
濃度異常の際に試料の検査結果を告知する手段を設け、
この検査結果に基づき試料の処理を停止および/または
自動再検査を行うことを特徴とする自動血液分析装置。1. A dilution container for mixing a sample with a diluent, means for measuring the concentration of blood cells in the dilution container, and means for notifying the test result of the sample when the concentration of blood cells in the dilution container is abnormal,
An automatic hematology analyzer characterized by stopping the processing of a sample and / or performing an automatic retest based on the result of this test.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11172492A JP3162172B2 (en) | 1992-04-30 | 1992-04-30 | Automatic blood analyzer |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11172492A JP3162172B2 (en) | 1992-04-30 | 1992-04-30 | Automatic blood analyzer |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH05307042A true JPH05307042A (en) | 1993-11-19 |
JP3162172B2 JP3162172B2 (en) | 2001-04-25 |
Family
ID=14568564
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11172492A Expired - Fee Related JP3162172B2 (en) | 1992-04-30 | 1992-04-30 | Automatic blood analyzer |
Country Status (1)
Country | Link |
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JP (1) | JP3162172B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005106506A (en) * | 2003-09-29 | 2005-04-21 | Sysmex Corp | System and device for clinical examination |
-
1992
- 1992-04-30 JP JP11172492A patent/JP3162172B2/en not_active Expired - Fee Related
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005106506A (en) * | 2003-09-29 | 2005-04-21 | Sysmex Corp | System and device for clinical examination |
JP4490069B2 (en) * | 2003-09-29 | 2010-06-23 | シスメックス株式会社 | Clinical laboratory system |
US8062591B2 (en) | 2003-09-29 | 2011-11-22 | Sysmex Corporation | Clinical laboratory test apparatus and clinical laboratory test system |
Also Published As
Publication number | Publication date |
---|---|
JP3162172B2 (en) | 2001-04-25 |
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