JPH05277118A - Standard device for origin of light absorbance of optical measuring instrument - Google Patents

Standard device for origin of light absorbance of optical measuring instrument

Info

Publication number
JPH05277118A
JPH05277118A JP4105491A JP10549192A JPH05277118A JP H05277118 A JPH05277118 A JP H05277118A JP 4105491 A JP4105491 A JP 4105491A JP 10549192 A JP10549192 A JP 10549192A JP H05277118 A JPH05277118 A JP H05277118A
Authority
JP
Japan
Prior art keywords
light
absorbance
origin
measuring instrument
optical measuring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4105491A
Other languages
Japanese (ja)
Other versions
JP2586278B2 (en
Inventor
Shoichi Tsuneishi
召一 常石
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shimadzu Corp
Original Assignee
Shimadzu Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shimadzu Corp filed Critical Shimadzu Corp
Priority to JP4105491A priority Critical patent/JP2586278B2/en
Publication of JPH05277118A publication Critical patent/JPH05277118A/en
Application granted granted Critical
Publication of JP2586278B2 publication Critical patent/JP2586278B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Abstract

PURPOSE:To simplify the construction of the standard device for the origin of light absorbance used for an optical measuring instrument which measures the optical characteristics of a light scatterable sample by constituting the standard device for the origin of the light absorbance of a milk white light scattering plate and pressing the light transmission terminal and light receiving terminal of the optical measuring instrument to the surface of the light scatterable plate. CONSTITUTION:The standard device 1 for the origin of the light absorbance is constituted by sticking a neoprene rubber plate 4 colored black on the rear surface of a polyacetal resin plate 2 which is the light scattering plate. In such a case, the thickness L of the polyacetal resin plate 2 is set by the desired absorbance. The light transmission part 8 provided at the front end of a light guide 6 for light transmission from the optical measuring instrument body and the light receiving part 12 at the front end of a light guide 10 for light reception for introducing the received light to the optical measuring instrument body are pressed to the surface of the polyacetal resin plate 2. As a result, the presence or absence of the abnormality of the fiber part or light source part, etc., of the optical measuring instrument is easily checked.

Description

【発明の詳細な説明】Detailed Description of the Invention

【0001】[0001]

【産業上の利用分野】本発明は光を用いて生体内の代謝
を測定する装置のように光散乱性試料の光学的特性を測
定する光測定装置において、吸光度の原点を定めるのに
用いる装置に関するものである。
BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an optical measuring device for measuring optical characteristics of a light-scattering sample, such as a device for measuring metabolism in a living body by using light, which is used for determining the origin of absorbance. It is about.

【0002】[0002]

【従来の技術】700〜1000nmの光は他の波長の
光に比べて生体内を比較的通りやすいので、この波長域
に吸収帯をもつヘモグロビン、酸化ヘモグロビン、チト
クロームaa3を無侵襲で測定することが試みられてい
る(例えば、特公昭61−11614号公報、「Pediat
rics」75,217〜225(1985)、「人工臓
器」19,535〜538(1990)参照)。
2. Description of the Related Art Since light having a wavelength of 700 to 1000 nm passes through a living body more easily than light having other wavelengths, hemoglobin, oxyhemoglobin, and cytochrome aa 3 having absorption bands in this wavelength range can be measured non-invasively. Has been attempted (for example, Japanese Patent Publication No. 61-11614, "Pediat
rics ” 75 , 217-225 (1985),“ artificial organ ” 19 , 535-538 (1990)).

【0003】これらの測定で吸光度変化のみが求められ
ており、吸光度の絶対値を求めようとすれば吸光度原点
の較正方法を定めなければならない。測定対象が生体試
料でなく化学物質の場合、その透過分光測定には測定成
分を全く含まない液体(例えば蒸留水)を吸光度0の原
点にすることや、布や印刷物の測定用に、反射率100
%の基準として硫酸バリウム粉末を用いることはよく知
られている。しかし、本発明の対象である生体試料のよ
うな光散乱性試料の一部分より光を照射し、別の部分よ
り出てくる光を検出する装置に適用するのに適当な吸光
度の原点基準としては生物体と同じように散乱性の透過
特性を有し、目的の試料と同様の光の減衰率(例えば1
/103〜1/107、吸光度で3〜7)を有し、経時変
化が少ないという条件を満たす基準が望ましい。
Only the change in absorbance is required in these measurements, and in order to obtain the absolute value of absorbance, a method of calibrating the origin of absorbance must be determined. When the measurement target is not a biological sample but a chemical substance, the transmission spectroscopic measurement uses a liquid that does not contain any measurement components (for example, distilled water) as the origin of absorbance 0, and the reflectance for measuring cloth or printed matter. 100
It is well known to use barium sulphate powder as a% basis. However, as an origin reference of the absorbance suitable for applying to a device that irradiates light from a part of a light-scattering sample such as a biological sample that is the subject of the present invention and detects light emitted from another part, It has a scattering transmission characteristic similar to that of a living organism, and has the same light attenuation rate as the target sample (for example, 1
It is desirable to have a criterion that satisfies / 10 3 to 1/10 7 and an absorbance of 3 to 7) and has little change over time.

【0004】生物体と同じような光の減衰率をもち、患
者によらない吸光度測定の原点を求めることのできる吸
光度原点標準器として、光散乱体からなる光入力部と、
光散乱体からなる光出力部と、両部を結び減光機能を有
する結合部とを備えたものが提案されている(特開平4
−84959号公報参照)。
As an absorbance origin standard instrument having a light attenuation rate similar to that of a living body and capable of obtaining an origin of absorbance measurement independent of a patient, a light input section made of a light scatterer,
There has been proposed a device including a light output part made of a light scatterer and a coupling part which connects both parts and has a dimming function (Japanese Patent Laid-Open No. Hei 4).
-84959 gazette).

【0005】[0005]

【発明が解決しようとする課題】本発明は光散乱性試料
の光学的特性を測定する光測定装置で用いられる吸光度
原点標準器を簡単な構造にすることを目的とするもので
ある。
SUMMARY OF THE INVENTION It is an object of the present invention to make an absorbance origin standard device used in an optical measuring device for measuring the optical characteristics of a light scattering sample into a simple structure.

【0006】[0006]

【課題を解決するための手段】本発明の吸光度原点標準
器は、乳白色の光散乱板にてなり、その表面に光測定装
置の送光端と受光端が当接されて使用される。好ましい
態様では、光散乱板の裏面に光吸収体が設けられる。
The standard apparatus for origin of absorbance of the present invention comprises a milky white light scattering plate, and the light transmitting end and the light receiving end of the optical measuring device are in contact with the surface thereof for use. In a preferred embodiment, a light absorber is provided on the back surface of the light scattering plate.

【0007】[0007]

【作用】光散乱板の厚さを変えることによって光の入射
点から検出点までの間の光の減衰量を変えることがで
き、被測定物である人体などの生体と同じ減衰量に設定
することができる。乳白色の光散乱板としては例えば乳
白色樹脂板を用いることができ、その具体的な例として
はポリアセタール樹脂板(商品名:ジュラコン)、ポリ
プロピレン樹脂板、ポリ四フッ化エチレン樹脂板、発泡
スチロール樹脂板などを用いることができる。光吸収体
としては黒色板を用いることができ、具体的な例として
は黒色に着色されたネオプレンゴム板、黒アルマイト加
工されたアルミニウム板、内部が黒色に塗られた箱など
を用いることができる。
[Function] By changing the thickness of the light-scattering plate, the amount of light attenuation from the light incident point to the detection point can be changed, and the same amount of attenuation as that of a living body such as a human body to be measured is set. be able to. As the milky white light scattering plate, for example, a milky white resin plate can be used, and specific examples thereof include a polyacetal resin plate (trade name: Duracon), a polypropylene resin plate, a polytetrafluoroethylene resin plate, a polystyrene foam resin plate, etc. Can be used. A black plate can be used as the light absorber, and as a specific example, a black-colored neoprene rubber plate, a black-anodized aluminum plate, a box whose inside is painted black, or the like can be used. ..

【0008】[0008]

【実施例】図1は一実施例を表わす。吸光度原点標準器
1は光散乱板2としてポリアセタール樹脂であるジュラ
コン(商品名)を用い、その裏面に黒に着色されたネオ
プレンゴム板4が貼りつけられたものである。ポリアセ
タール樹脂板2の厚さLは所望の吸光度によって設定す
る。ポリアセタール樹脂板2の大きさは例えば50mm
×80mm程度が適当である。ネオプレンゴム板4の厚
さは特に限定されず、例えば3mmとする。ポリアセタ
ール樹脂板2の表面には光測定装置本体からの送光用ラ
イトガイド6の先端に設けられた送光部8と、受光した
光を光測定装置本体へ導く受光用ライトガイド10の先
端の受光部12とが当接させられる。送光部8と受光部
12との間隔は人体などの被測定物に送光部8と受光部
12を取りつけて測定を行なうときの間隔と同じ間隔に
設定され、例えばその間隔は44mmである。
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT FIG. 1 shows an embodiment. The absorbance origin standard device 1 uses DURACON (trade name) which is a polyacetal resin as the light scattering plate 2, and has a black-colored neoprene rubber plate 4 attached to the back surface thereof. The thickness L of the polyacetal resin plate 2 is set according to the desired absorbance. The size of the polyacetal resin plate 2 is, for example, 50 mm
A size of about 80 mm is suitable. The thickness of the neoprene rubber plate 4 is not particularly limited and is, for example, 3 mm. On the surface of the polyacetal resin plate 2, a light transmitting unit 8 provided at the tip of a light guide 6 for transmitting light from the light measuring device body, and a tip of a light receiving light guide 10 for guiding the received light to the light measuring device body. The light receiving portion 12 is brought into contact with the light receiving portion 12. The distance between the light transmitting unit 8 and the light receiving unit 12 is set to the same distance as when the measurement is performed by mounting the light transmitting unit 8 and the light receiving unit 12 on an object to be measured such as a human body. For example, the distance is 44 mm. ..

【0009】この吸光度原点標準器1を用い、送光部8
と受光部12の間隔を44mmにしたときのポリアセタ
ール樹脂板2の厚さLと吸光度の関係を図2に示す。L
が小さいときはネオプレンゴム板4による光の吸収が大
きいために吸光度が大きく、Lが大きくなるに従ってネ
オプレンゴム板4による光の吸収の影響が小さくなって
きて吸光度が小さくなっていき、やがてポリアセタール
樹脂板2自体で定まる吸光度になる。人体の頭部に送光
部8と受光部12を44mmの間隔で当接させたときの
吸光度が約5.0であるので、この標準器1ではポリア
セタール樹脂板2の厚さLを約8mmに設定するのが適
当である。
Using this absorbance origin standard device 1, a light transmitting unit 8
FIG. 2 shows the relationship between the thickness L of the polyacetal resin plate 2 and the absorbance when the distance between the light receiving part 12 and the light receiving part 12 is set to 44 mm. L
Is small, the absorption of light by the neoprene rubber plate 4 is large, so that the absorbance is large, and as L becomes larger, the influence of the absorption of light by the neoprene rubber plate 4 becomes smaller and the absorption becomes smaller, and eventually the polyacetal resin. The absorbance is determined by the plate 2 itself. Since the absorbance when the light transmitter 8 and the light receiver 12 are brought into contact with the head of the human body at an interval of 44 mm is about 5.0, the thickness L of the polyacetal resin plate 2 in this standard device 1 is about 8 mm. It is appropriate to set to.

【0010】この実施例の標準器を用いて生体用酸素モ
ニタの吸光度原点を定め、実測を行なう場合の例を図3
と図4により説明する。図3は較正を表わしたものであ
る。26は生体用酸素モニタ本体であり、測定対象物に
光を送るための送光用ライトガイド6と測定対象物から
の光を受光するための受光用ライトガイド10が設けら
れ、送光用ライトガイド6の先端には対象物に光照射を
行なう送光部8が設けられ、受光用ライトガイド10の
先端には対象物からの光を受ける受光部12が設けられ
ている。較正を行なうために、本実施例の吸光度原点標
準器1のポリアセタール樹脂板2上に送光部8と受光部
12を所定の距離(例えば44mm)を保って取りつけ
る。28は酸素モニタ本体26の操作キー、30は表示
用液晶パネルである。
An example in which the origin of the absorbance of the oxygen monitor for a living body is determined by using the standard device of this embodiment and actual measurement is carried out is shown in FIG.
Will be described with reference to FIG. FIG. 3 represents the calibration. Reference numeral 26 denotes a living body oxygen monitor main body, which is provided with a light sending light guide 6 for sending light to the measurement target and a light receiving light guide 10 for receiving light from the measurement target. A light transmitting unit 8 that irradiates an object with light is provided at the tip of the guide 6, and a light receiving unit 12 that receives light from the object is provided at the tip of the light receiving light guide 10. In order to perform the calibration, the light transmitting unit 8 and the light receiving unit 12 are mounted on the polyacetal resin plate 2 of the absorbance origin standard 1 of this embodiment with a predetermined distance (for example, 44 mm). 28 is an operation key of the oxygen monitor main body 26, and 30 is a display liquid crystal panel.

【0011】この状態で吸光度測定を行なう。まず、予
め設定しておいた吸光度の範囲内に入っていることの確
認を行ない、装置に異常がないことを確かめる。また、
同時に酸素モニタ内部で自動ゲイン設定を含む吸光度の
出力が0になるように較正を行なう。吸光度測定を複数
の波長で行なう場合はその複数の各波長の吸光度出力が
0になるように較正を行なう。
The absorbance is measured in this state. First, confirm that the absorbance is within the preset absorbance range, and confirm that the device is normal. Also,
At the same time, calibration is performed inside the oxygen monitor so that the absorbance output including the automatic gain setting becomes zero. When the absorbance is measured at a plurality of wavelengths, calibration is performed so that the absorbance output at each of the plurality of wavelengths becomes zero.

【0012】次に、図4に示されるように測定対象の患
者に対して送光用ライトガイドの送光部6と受光用ライ
トガイド10の受光部12とを装着し、吸光度測定を行
なう。32はレコーダである。そのときの吸光度出力に
吸光度原点標準器1の吸光度値を加算すれば、患者の絶
対吸光度が得られる。複数波長で測定すれば各波長ごと
の絶対吸光度が得られる。これによって患者ごとの差を
見るためのアプローチが可能となる。
Next, as shown in FIG. 4, the light-transmitting portion 6 of the light-transmitting light guide and the light-receiving portion 12 of the light-receiving light guide 10 are attached to the patient to be measured, and the absorbance is measured. 32 is a recorder. Absolute absorbance of the patient can be obtained by adding the absorbance value of the absorbance origin standard device 1 to the absorbance output at that time. If the measurement is performed at a plurality of wavelengths, the absolute absorbance at each wavelength can be obtained. This allows an approach to see the differences between patients.

【0013】図5は他の実施例を表わしたものである。
光散乱板2の裏面に設けられる光吸収体として黒色板の
代わりに外部から光が入らないようにした箱24を用
い、その箱24の内部を黒色にしたものである。箱24
の内部は空洞でよい。なお、2の縦と横は50mm×8
0mm程度が適当である。図6は酸素モニタ本体26に
吸光度原点標準器1を内蔵した例であり、これにより吸
光度原点を容易に較正できるようになる。
FIG. 5 shows another embodiment.
As a light absorber provided on the back surface of the light scattering plate 2, a box 24 in which light from the outside is prevented is used instead of a black plate, and the inside of the box 24 is black. Box 24
The inside of may be hollow. The length and width of 2 are 50 mm x 8
About 0 mm is suitable. FIG. 6 shows an example in which the absorbance origin standard device 1 is built in the oxygen monitor main body 26, whereby the origin of absorbance can be easily calibrated.

【0014】[0014]

【発明の効果】本発明では吸光度原点標準器として乳白
色の光散乱板を用いたので、その厚さを設定することに
より特定の吸光度を容易に得ることができるので、光測
定装置のファイバー部や光源部などの異常の有無を確認
することが容易になる。また、個々の患者にかかわらな
い基準化ができるので、患者ごとの差をみることも可能
となる。特に、本発明の標準器は構造が簡単であるの
で、安価であり、かつ容易に製作することができる。
In the present invention, since the milk-white light scattering plate is used as the standard for the origin of absorbance, it is possible to easily obtain a specific absorbance by setting the thickness thereof. It becomes easy to confirm whether or not the light source unit is abnormal. In addition, since it is possible to standardize regardless of the individual patient, it is possible to see the difference for each patient. In particular, since the standard device of the present invention has a simple structure, it is inexpensive and can be easily manufactured.

【図面の簡単な説明】[Brief description of drawings]

【図1】一実施例を示す斜視図である。FIG. 1 is a perspective view showing an embodiment.

【図2】同実施例におけるポリアセタール樹脂板の厚さ
と吸光度の関係を示す図である。
FIG. 2 is a diagram showing the relationship between the thickness of a polyacetal resin plate and the absorbance in the same example.

【図3】一実施例を用いて吸光度原点の較正を行なう状
態を示す斜視図である。
FIG. 3 is a perspective view showing a state in which the origin of absorbance is calibrated using one embodiment.

【図4】吸光度原点を較正した後、測定対象物を測定す
る状態を示す斜視図である。
FIG. 4 is a perspective view showing a state in which an object to be measured is measured after the origin of absorbance is calibrated.

【図5】他の実施例を示す一部切欠き斜視図である。FIG. 5 is a partially cutaway perspective view showing another embodiment.

【図6】吸光度原点標準器を光測定装置本体に埋め込ん
だ実施例を示す装置本体の斜視図である。
FIG. 6 is a perspective view of an apparatus main body showing an embodiment in which an absorbance origin standard device is embedded in the optical measurement apparatus main body.

【符号の説明】[Explanation of symbols]

2 ポリアセタール樹脂板 4 黒色のネオプレンゴム板 8 送光部 12 受光部 2 Polyacetal resin plate 4 Black neoprene rubber plate 8 Light transmitter 12 Light receiver

Claims (1)

【特許請求の範囲】[Claims] 【請求項1】 光散乱性試料への測定光の入射点と前記
試料からの測定光の検出点が離れている状態で前記試料
の光吸収特性を測定する光測定装置で用いる吸光度原点
標準器において、乳白色の光散乱板にてなり、その表面
に光測定装置の送光端と受光端が当接されることを特徴
とする吸光度原点標準器。
1. An absorbance origin standard device for use in an optical measuring device for measuring the light absorption characteristics of a sample in a state where an incident point of the measuring light on the light scattering sample and a detection point of the measuring light from the sample are distant from each other. The standard device for origin of absorbance, characterized by comprising a milky white light-scattering plate, the light-transmitting end and the light-receiving end of the light measuring device being in contact with the surface thereof.
JP4105491A 1992-03-30 1992-03-30 Absorbance origin standard of light measurement device Expired - Fee Related JP2586278B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4105491A JP2586278B2 (en) 1992-03-30 1992-03-30 Absorbance origin standard of light measurement device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4105491A JP2586278B2 (en) 1992-03-30 1992-03-30 Absorbance origin standard of light measurement device

Publications (2)

Publication Number Publication Date
JPH05277118A true JPH05277118A (en) 1993-10-26
JP2586278B2 JP2586278B2 (en) 1997-02-26

Family

ID=14409070

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4105491A Expired - Fee Related JP2586278B2 (en) 1992-03-30 1992-03-30 Absorbance origin standard of light measurement device

Country Status (1)

Country Link
JP (1) JP2586278B2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004019780A1 (en) * 2002-08-28 2004-03-11 Akiyasu Fukumura In-vivo oxygen saturation degree determining method and instrument using near infrared radiation, and sensor sensitivity reference calibrator used for the instrument
US7675623B2 (en) 2008-03-12 2010-03-09 Shimadzu Corporation Standard device for origin of light absorbance and method of using the same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02257930A (en) * 1988-07-26 1990-10-18 Manfred Kessler Method and apparatus for determining local density of pigment and dispersion parameter for animal and human tissue
JPH0484959A (en) * 1990-07-27 1992-03-18 Shimadzu Corp Absorbance origin standard

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02257930A (en) * 1988-07-26 1990-10-18 Manfred Kessler Method and apparatus for determining local density of pigment and dispersion parameter for animal and human tissue
JPH0484959A (en) * 1990-07-27 1992-03-18 Shimadzu Corp Absorbance origin standard

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004019780A1 (en) * 2002-08-28 2004-03-11 Akiyasu Fukumura In-vivo oxygen saturation degree determining method and instrument using near infrared radiation, and sensor sensitivity reference calibrator used for the instrument
US7675623B2 (en) 2008-03-12 2010-03-09 Shimadzu Corporation Standard device for origin of light absorbance and method of using the same

Also Published As

Publication number Publication date
JP2586278B2 (en) 1997-02-26

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