JPH05246873A - Agent for improving hepatic function and for preventing hangover - Google Patents

Abstract

PURPOSE:To provide the hepatic function-improving and treating agent containing the extract of Asparagus.linearis as an active ingredient, not causing adverse actions, capable of rapidly treating the hepatic diseases, having excellent safety, and useful as a hangover and drunken sickness-preventing agent such as acute alcoholism diseases, etc. CONSTITUTION:The objective hepatic function-improving and treating agent contains as an active ingredient an Asparagus.linearis extract which is obtained e.g. by adding a 50-1000 times volume of water to the leaves or stems of the Asparagus.linearis belonging to the genus Leguminosae, boiling the mixture, further boiling and extracting the mixture for 5-30min and subsequently subjecting the treated mixture to a lyophilization, etc. The agent is preferably drunk at a dose of 100-1500ml/day as a solution of 1-5g dried leaves/liter, when commonly administered as a beverage.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liver function improving treatment and an agent for preventing hangover / sickness, which contains asparagus linealis, a member of the legume family, as an active ingredient.

[0002]

2. Description of the Related Art Heretofore, there have been known some medicines for hangover.

[0003]

However, even though the conventional drugs for hangover are focused on improving hangover, they are not sufficiently effective to improve hangover and sickness. It was

The conventional hangover / sickness remedy is
Mainly due to its strong gastrointestinal properties that relieve upset stomach, etc. 2
It was not possible to prevent sunsickness or sickness.

It is an object of the present invention to provide a composition which promotes liver function, improves liver diseases and acute alcohol poisoning, and is effective in improving and preventing hangover / sickness.

[0006] Therefore, as a result of intensive studies to solve the above-mentioned object, the present inventors have found that an Aspalathus linealis extract belonging to the legume family is effective against liver diseases, especially acute alcohol poisoning or hangover. Has an excellent effect,
The present invention has been completed based on the finding that there is no side effect and that liver disease can be safely ameliorated.

The active ingredient of the present invention comprises an extract of Aspalathus linealis. As an extraction method, leaves or stems of Aspalathus linealis are extracted with water and / or an organic solvent, and the extraction solvent is extracted from the extract. Can be obtained by distilling off or by crushing leaves or stems of Aspalathus linealis. In addition, it may be extracted in the same manner as in the production method of ordinary Japanese tea, Chinese tea, black tea and the like.

In the case of extraction with water, it is preferable to add 50 to 1000 times as much water as Aspalathus linealis, boil and then carry out boiling extraction for about 5 to 30 minutes. Also, when extracting in the same manner as ordinary tea, add 50 to 500 times the water of dried leaves of Aspalathus linearias and add 90 to 100
The extract is obtained by leaving it for about 3 to 30 minutes.

Specific examples of the organic solvent include methanol,
Ethanol, acetone and the like can be mentioned, and conventional means such as warm extraction can be used for extraction. Further, for the separation of the extract, conventional means such as decantation or centrifugation can be used.

A conventional means such as freeze-drying can be used for distilling off the extraction solvent. Also, Aspalathus linealis itself can be crushed and powdered for use.

The composition is prepared by mixing the active ingredient with physiologically acceptable carriers, excipients, binders and diluents, for example granules, powders, hard capsules, soft capsules, coatings and syrups. , Suppositories, orally or parenterally as injections, or as a mixture as it is, solutions, powder granules, tablets,
It can be administered alone in any form such as an emulsion or jelly, can be used as a concentrated solution, or can be mixed with other foods and drinks.

The dose varies depending on the type and degree of the target disease, but in the case of regular use as a drink, 1 to 5 g
It is preferable to eat and drink 100 ml to 1500 ml / day of the dried leaf / 1 solution.

[0013] Aspalathus linealis showed no death in an acute toxicity test in rats, and no abnormality was observed in biochemical blood tests and histopathological tests.

[0014]

[Effects] The present invention is effective for liver diseases of mammals including humans, particularly acute alcohol poisoning diseases by eating and drinking without side effects.
Can be quickly improved and treated.

[0015]

【Example】

Production example Collected Aspalathus linealis leaves (with stem)
After cutting to a length of 5 mm, dried leaves are subjected to the steps of rolling, enzyme fermentation, and sun drying. 4 g of dried leaves were boiled with 1.5 liters of water for 15 minutes to obtain an extract.

Example 1 Various asparagus linearias obtained in the production example were drunk by various drinkers and drunks to drink several cups, and the improvement of the sickness state within 1 hour and the presence or absence of a hangover were examined. The results are shown in Table 1.

[Table 1]

Example 2 An extract group obtained by allowing mice to freely drink the extract of Aspalathus linealis obtained in the production example for 3 months instead of water, and a control group containing ordinary water After betting, the extent of accumulation of liver glycogen content was examined microscopically. The results are shown in Table 2.

[Table 2] From Table 2, it was revealed that in the extract group in which the extract was drunk, hepatic glycogen accumulation was observed in most of the mice as compared with the control, and liver functional metabolism was promoted.

The results of chemical analysis of Aspalathus linealis are as follows. Iron 23.40 mg / 100 g Calcium 187.00 mg / 100 g Potassium 398.00 mg / 100 g Magnesium 207.00 mg / 100 g Copper 2.25 ppm Zinc 6.74 ppm Selenium 0.13 ppm Vitamin E 17.00 mg / 100 g Protein 8.00% Flavonoids 41 0.000 mg / 100 g Antioxidant / SOD-like potency 69,000 unit / g Acid-insoluble protein component 150 mg / 100 g Aroma component 100 mg / 100 g Sugar-containing compound 690 mg / 100 g

As aroma components, carbonyl compound (15%), carotenoid decomposition product (17%), carbon number 2
~ 12 organic acids (22%), phenolic compounds (13
%), Aromatic oxygen-containing compounds (7%), aromatic hydrocarbons (5.5%), terpenoids (4%) and the like.
The acid-insoluble protein is a protein component having a relatively large molecular weight.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Masatoshi Nakano 36-16 Chano, Shinbayashi-cho, Chiryu-shi, Aichi (72) Inventor Masahiro Kishikawa 16-16 Nijigaoka-cho, Nagasaki-shi, Nagasaki

Claims (1)

[Claims] 1. A therapeutic agent for improving liver function, comprising an Aspalathus linealis extract as an active ingredient.