JPH05246871A - Agent for improving and treating anemia - Google Patents
Agent for improving and treating anemiaInfo
- Publication number
- JPH05246871A JPH05246871A JP4084729A JP8472992A JPH05246871A JP H05246871 A JPH05246871 A JP H05246871A JP 4084729 A JP4084729 A JP 4084729A JP 8472992 A JP8472992 A JP 8472992A JP H05246871 A JPH05246871 A JP H05246871A
- Authority
- JP
- Japan
- Prior art keywords
- anemia
- improving
- extract
- linearis
- asparagus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
【0001】[0001]
【産業上の利用分野】本発明は、マメ科に属するアスパ
ラサス・リネアリスの含有成分を有効成分とする貧血改
善治療剤に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a therapeutic agent for improving anemia, which comprises, as an active ingredient, a component of Aspalathus linealis belonging to the legume family.
【0002】[0002]
【従来の技術】血球成分の減少による貧血は比較的女性
に多く発症するが、貧血はビタミンB12投与あるいは鉄
分を多く含む食事をすることにより改善することが知ら
れている。2. Description of the Related Art Although anemia due to a decrease in blood cell components occurs in a relatively large number of women, it is known that the anemia is improved by administration of vitamin B12 or a diet rich in iron.
【0003】[0003]
【発明が解決しようとする課題】しかし、ビタミンB12
投与とか動物のレバーあるいはホーレンソウなど鉄含量
の高い材料を使う食事による方法は、効果が薄く貧血を
改善することは難しい。[Problems to be Solved by the Invention] However, vitamin B12
It is difficult to improve anemia by administration or by using a diet using high iron content materials such as animal liver or spinach.
【0004】マタ、これまで、日常経口的に容易に摂取
する方法で、貧血を改善治療する治療薬は知られていな
い。Mata, to date, has not been known as a therapeutic drug for improving and treating anemia by a method of daily oral intake.
【0005】本発明は、前記課題を解決し、貧血の改善
治療を日常経口的に摂取することで、有効な症状の改善
治療剤を提供することを目的とする。An object of the present invention is to solve the above-mentioned problems and to provide an effective therapeutic agent for improving symptom by orally ingesting an improving treatment for anemia.
【0006】そこで、本発明者らは、前記目的を達成す
るために鋭意研究を重ねた結果、マメ科に属するアスパ
ラサス・リネアリス抽出物が、貧血の患者に対し優れた
効果を有し、かつ副作用がなく安全に改善できるとの知
見を得て本発明を完成した。[0006] Therefore, as a result of intensive studies to achieve the above-mentioned object, the present inventors have found that Asparasus linealis extract belonging to the legume family has an excellent effect on patients with anemia, and The present invention has been completed based on the knowledge that it can be safely improved without side effects.
【0007】本発明の有効成分は、アスパラサス・リネ
アリスの抽出液からなり、抽出法としては、アスパラサ
ス・リネアリスの葉または茎を水及び/または有機溶媒
で抽出し、該抽出液より抽出溶媒を留去する方法、また
はアスパラサス・リネアリスの葉または茎を粉砕するこ
とによって得ることができる。また、通常の日本茶、中
国茶、紅茶などの製法と同様に抽出してもよい。The active ingredient of the present invention comprises an extract of Aspalathus linealis. As an extraction method, leaves or stems of Aspalathus linealis are extracted with water and / or an organic solvent, and the extraction solvent is extracted from the extract. Can be obtained by distilling off or by crushing leaves or stems of Aspalathus linealis. In addition, it may be extracted in the same manner as in the production method of ordinary Japanese tea, Chinese tea, black tea and the like.
【0008】水で抽出する場合には、アスパラサス・リ
ネアリスの50〜1000倍の水を加え、沸騰後、さら
に5〜30分程度沸騰抽出するのが好ましい。また、通
常の茶と同様抽出するときは、アスパラサス・リネアリ
スの乾燥葉の50〜500倍の80〜100度の湯で3
〜30分程度放置して抽出液を得る。In the case of extraction with water, it is preferable to add 50 to 1000 times as much water as Aspalathus linealis, boil and then carry out boiling extraction for about 5 to 30 minutes. Also, when extracting in the same way as ordinary tea, use 3 to 50 times the hot water of 80 to 100 degrees, which is 50 to 500 times the dry leaves of Aspalathus linearis.
Leave for about 30 minutes to obtain an extract.
【0009】有機溶媒の具体例としては、メタノール、
エタノール、アセトン等が挙げられ、抽出にあたっては
温時抽出等慣用手段を用いることができる。また、抽出
液の分離も、デカンテーションや遠心分離等の慣用手段
を用いることができる。Specific examples of the organic solvent include methanol,
Ethanol, acetone and the like can be mentioned, and conventional means such as warm extraction can be used for extraction. Further, for the separation of the extract, conventional means such as decantation or centrifugation can be used.
【0010】抽出溶媒の留去も凍結乾燥等の慣用手段を
用いることができる。また、アスパラサス・リネアリス
そのものを粉砕し、粉末化して用いることもできる。A conventional means such as freeze-drying can be used for distilling off the extraction solvent. Also, Aspalathus linealis itself can be crushed and powdered for use.
【0011】本発明は、混合してそのまま溶液、粉末顆
粒、錠剤、乳剤、ゼリー状など任意の形態で単独投与、
または他の飲食物に混合して飲食することもできる。According to the present invention, a mixture is directly administered in any form such as a solution, powder granules, tablets, emulsions or jellies.
Alternatively, it can be mixed with other foods and drinks.
【0012】投与量は、対象となる疾患の種類、程度に
より異なるが、飲料として常用する場合には、1〜5g
乾燥葉/1溶液を100ml〜1500ml/日飲食す
るのが好ましい。The dose varies depending on the type and degree of the target disease, but in the case of regular use as a drink, 1 to 5 g
It is preferable to eat and drink 100 ml to 1500 ml / day of the dried leaf / 1 solution.
【0013】アスパラサス・リネアリスは、ラットに対
する急性毒性試験で死亡例は皆無であり、生化学血液検
査および病理組織学的検査においても異常が認められな
かった。[0013] Aspalathus linealis showed no death in an acute toxicity test in rats, and no abnormality was observed in biochemical blood tests and histopathological tests.
【0014】[0014]
【効果】本発明は、ヒトを含む哺乳動物の貧血の疾患を
副作用無く、迅速に改善治療することができる。[Effect] The present invention can rapidly improve and treat anemia diseases of mammals including humans without side effects.
【0015】[0015]
製造例 採取したアスパラサス・リネアリスの葉(茎つき)を、
5mm長に切断後、ローリング、酵素醗酵、天日乾燥の
工程を経て乾燥葉とする。乾燥葉4gを水1.5リット
ルで15分間沸騰させ抽出液を得た。Production example Collected Aspalathus linealis leaves (with stem)
After cutting to a length of 5 mm, dried leaves are subjected to the steps of rolling, enzyme fermentation, and sun drying. 4 g of dried leaves were boiled with 1.5 liters of water for 15 minutes to obtain an extract.
【0016】実施例1 製造例で得た抽出液を表1に示したパネラーに1日20
0mLから1000mL飲ませ、症状の改善を調べた。
結果を表1に示す。Example 1 The extract obtained in the production example was applied to the panel shown in Table 1 20 times a day.
The mice were given 0 mL to 1000 mL and examined for improvement in symptoms.
The results are shown in Table 1.
【表1】 [Table 1]
【0017】アスパラサス・リネアリスの化学分析結果
は下記の通りである。 鉄 23.40mg/100g カルシウム 187.00mg/100g カリウム 398.00mg/100g マグネシウム 207.00mg/100g 銅 2.25ppm 亜鉛 6.74ppm セレン 0.13ppm ビタミンE 17.00mg/100g たんぱく質 8.00% フラボノイド 41.00mg/100g 抗酸化能・SOD様力価 69,000unit/g 酸不溶性蛋白成分 150mg/100g 香気成分 100mg/100g 糖含有化合物 690mg/100g The results of chemical analysis of Aspalathus linealis are as follows. Iron 23.40 mg / 100 g Calcium 187.00 mg / 100 g Potassium 398.00 mg / 100 g Magnesium 207.00 mg / 100 g Copper 2.25 ppm Zinc 6.74 ppm Selenium 0.13 ppm Vitamin E 17.00 mg / 100 g Protein 8.00% Flavonoids 41 0.000 mg / 100 g Antioxidant / SOD-like potency 69,000 unit / g Acid-insoluble protein component 150 mg / 100 g Aroma component 100 mg / 100 g Sugar-containing compound 690 mg / 100 g
【0018】また香気成分として、カルボニル化合物
(15%)、カロチノイド分解物(17%)、炭素数2
〜12の有機酸(22%)、フェノール化合物(13
%)、芳香族含酸素化合物(7%)、芳香族炭化水素
(5.5%)、テルペノイド(4%)などを含有する。
なお、酸不溶性蛋白質とは比較的分子量の大きな蛋白成
分である。As aroma components, carbonyl compound (15%), carotenoid decomposition product (17%), carbon number 2
~ 12 organic acids (22%), phenolic compounds (13
%), Aromatic oxygen-containing compounds (7%), aromatic hydrocarbons (5.5%), terpenoids (4%) and the like.
The acid-insoluble protein is a protein component having a relatively large molecular weight.
Claims (1)
成分とする貧血改善治療剤1. An anemia improving therapeutic agent comprising an Aspalathus linealis extract as an active ingredient
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4084729A JPH05246871A (en) | 1992-03-06 | 1992-03-06 | Agent for improving and treating anemia |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4084729A JPH05246871A (en) | 1992-03-06 | 1992-03-06 | Agent for improving and treating anemia |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH05246871A true JPH05246871A (en) | 1993-09-24 |
Family
ID=13838783
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4084729A Pending JPH05246871A (en) | 1992-03-06 | 1992-03-06 | Agent for improving and treating anemia |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH05246871A (en) |
-
1992
- 1992-03-06 JP JP4084729A patent/JPH05246871A/en active Pending
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