JPH05229930A - Skin-whitening cosmetic - Google Patents

Abstract

PURPOSE:To provide a skin-whitening cosmetic which has excellent effect to suppress the red spots caused by ultraviolet rays and the melanin production, further color-lightening the melanin deposit on the skin without irritation to the skin. CONSTITUTION:The objective skin-whitening cosmetic is prepared by compounding the extract from the rhizome of rhatany (Krameria triandra ruiz Pavon).

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening cosmetic composition having excellent skin safety, having the effect of rapidly lightening dark skin and preventing skin inflammation due to ultraviolet rays.

[0002]

2. Description of the Prior Art Ultraviolet rays change the color tone of skin and turn it black. This blackening is caused by the overproduction of melanin produced in melanocytes and delivered to epidermal cells, and melanin is produced by the oxidation of tyrosine.

[0003] Conventionally, in order to prevent skin blackening, stains and freckles and maintain the original white skin, vitamin C salts and fatty acid derivatives which prevent this oxidation, hydroquinone monobenzyl ether, hydrogen peroxide, etc. have been added. Whitening cosmetics have been proposed.

However, when a vitamin C derivative is added to these whitening cosmetics, the storage stability is insufficient, or the anti-inflammatory and whitening effects due to ultraviolet rays are often not sufficiently observed. On the other hand, blending hydroquinone monobenzyl ether or the like into a whitening cosmetic has the effect of lightening dark skin, but has the drawback of causing a problem in terms of skin safety. As described above, it is extremely difficult to obtain a storage-stable whitening cosmetic which has an excellent anti-inflammatory effect and a whitening effect and high skin safety.

[0005]

In view of such a situation, the inventors of the present invention have conducted intensive studies as an improvement of the drawbacks of the prior art, and as a result, have found that the extract obtained from the rhizome of Latania was blended. It was found that the whitening cosmetic composition satisfies the conditions of excellent whitening effect and anti-inflammatory effect and high skin safety, and has completed the present invention.

[0006] That is, an object of the present invention is to provide a whitening cosmetic composition which has excellent anti-inflammatory and whitening effects and high skin safety.

In order to achieve the above object, the whitening cosmetic composition of the present invention comprises a latania (Krameria trian).
It is a whitening cosmetic characterized in that it contains an extract obtained from the rhizome of (dra et Pavon).

Latania used in the whitening cosmetic composition of the present invention is a shrub native to South America, which belongs to the family Clameria and has a scientific name of K.
It is called rameria triandra Pavon. This extract was obtained from its rhizome and had tannin, rattanin, etc. as its components, and was used as a folk medicine such as astringent, anti-inflammatory drug and the like.

To obtain the extract, 1000 g of dried Latania rhizomes were ground, 3000 ml of methanol was added, and the mixture was heated in a water bath for 1 hour.
3.5 g was obtained. The crude extract was fractionated using ethyl acetate and water, and 27.5 g of a powdery dried product was obtained from the resulting aqueous layer fraction.

The amount of the Latania extract in the whitening cosmetic composition of the present invention is preferably 0.01 based on the total amount.
˜5.0 wt% (hereinafter referred to as wt%).

If the amount of the Latania extract blended is less than 0.01 w%, the desired effect of the present invention is not sufficient. Even if the amount of the Latania extract blended exceeds 5.0 w%, the increase is commensurate. The improvement of the effect cannot be expected, the feel during use tends to deteriorate, and it becomes difficult to hold the individual dosage forms.

The whitening cosmetic composition of the present invention can be formulated into lotions, emulsions, creams, packs and the like according to a conventional method.

In the whitening cosmetic composition of the present invention, a colorant, a fragrance, a preservative, a surfactant, a pigment and the like can be appropriately added within the range where the object of the present invention is achieved.

[0014]

EXAMPLES The present invention will be described in detail below based on examples and comparative examples.

Each test method of (1) tyrosinase activity inhibition test (2) skin color lightness recovery test (3) whitening practical test (4) ultraviolet erythema suppression test (5) photopatch test described in Examples is as follows. Is.

(1) Tyrosinase activity inhibition test 0.3 ml per 1 ml of Macklebein buffer (pH 6.8)
A sample solution of each concentration is added to the tyrosine solution of g / ml concentration, and pre-incubation is performed at 37 ° C for 10 minutes. 1m to this
0.1 ml of tyrosinase (manufactured by Sigma) at a concentration of g / ml
Was added and heated at 37 ° C. for 15 minutes, and then the absorbance (A) was measured at a wavelength of 475 nm using a spectrophotometer. On the other hand, the absorbance (B) of 0.1 ml of buffer solution added in place of tyrosinase, 0.1% buffer solution in place of the sample solution.
The absorbance (C) of the solution added with ml and the absorbance (D) of the sample solution added with 0.2 ml of the buffer solution instead of tyrosinase were measured, and the inhibition rate (%) was calculated according to the following formula.

Inhibition rate (%) = (A−B) / (C−D) × 100

(2) Skin color lightness recovery test [0018] The skin of the upper arm of 20 test subjects was irradiated with the minimum amount of erythema of UV rays in the UVA and UVB regions for 3 consecutive days. Standard lightness of skin (V0
Value, V0 'value) was measured. Subsequently, it was applied 3 times a day for 4 consecutive weeks, and the skin lightness (Vn value, Vn ′) of the sample-applied part and the base-applied part skin after 1, 2 and 4 weeks from the start of irradiation
The value) was measured and the skin color recovery was evaluated according to the following criteria.

The brightness of the skin (V value of Munsell display system)
Was calculated from the X, Y, and Z values obtained by measurement with a high-speed spectrocolorimeter. The evaluation is shown by the average value of the evaluation points of 20 test subjects after 4 weeks.

[0020]

[Table 1]

(3) Practical Whitening Test A left forearm flexion side part of the forearm flexion side skin of 20 test subjects exposed to summer sunlight for 3 hours (1.5 hours a day for 2 days) From the day of sun exposure to the skin, and to the skin of the right forearm flexor lateral side, the sample and the base were applied once daily in the morning and evening for 13 weeks from 7 days after the day of sun exposure. In the evaluation, the number of people who declared that the sample application section was more effective than the base application section was shown.

(4) UV Erythema Suppression Test U was applied to the dorsal skin of 10 Hartley guinea pigs from which hair had been removed.
Irradiation with two times the minimum erythema dose of ultraviolet rays in the VB region is performed at two locations each. The sample was applied 24 hours before and immediately after irradiation, the sample application site and the base application site were set, and 24 hours later, the erythema state was evaluated according to the following criteria.

[0023]

[Table 2]

(5) Optical patch test 25 subjects were subjected to closed patch for 24 hours using a patch plate having a diameter of 1.0 cm, which was prepared by applying 0.05 g of the sample to the skin on the flexion side of the forearm, and then exposed to sunlight in summer. 6 hours (3 a day
For 2 days).

The evaluation was carried out by subject 2 according to the following criteria.
The skin condition of 5 persons was evaluated and judged. Judgment result is irradiation 2
After 4 hours, the number of people was (±) or more.

[0026]

[Table 3]

Examples 1 and 2 and Comparative Examples 1 and 2 Two-Phase Lotions In the raw material compositions shown in Table 4, the active ingredients were blended as shown in Table 4 to prepare two-phase lotions, and the above-mentioned various tests were conducted. Was carried out.

[0028]

[Table 4]

[0029]

[Table 5]

(1) Preparation Method After uniformly dissolving the B component shown in Table 4 in the C component, A
Component C and component C are uniformly mixed, stirred and dispersed, and then filled in a container. At the time of use, the contents should be evenly dispersed by shaking.

(2) Characteristics Table 5 shows the results of various tests. As shown in Table 5, Comparative Example 1 did not show good results in various tests.

The whitening cosmetics of the present invention of Examples 1 and 2 showed clearly good results in all the tests, and no skin irritation occurred in the tests on human skin.

Examples 3 and 4, Comparative Examples 3 and 4 Skin Cream The skin cream was prepared by blending the active ingredients in the raw material composition shown in Table 6 as shown in Table 7, and the above-mentioned various tests were carried out.

[0034]

[Table 6]

[0035]

[Table 7]

(1) Preparation method Component B shown in Table 6 is mixed with component C, and component A and component C are uniformly heated and dissolved to bring the temperature to 80 ° C. Next, the C component is poured into the A component and mixed by stirring, then cooled with stirring, and the C component is charged at about 50 ° C. and cooled to 30 ° C.

The results of various tests are shown in Table 7. As shown in Table 7, Examples 3 and 4 clearly show good results in all the tests, good results in the tests on human skin, and no skin irritation in the tests on human skin. Did not happen.

[0038]

As described above, the present invention is excellent in the effect of suppressing the production of melanin pigment, the effect of rapidly lightening skin pigmentation, and the effect of suppressing the inflammation of skin by ultraviolet rays.
It is obvious to provide a useful whitening cosmetic which does not cause skin irritation.

Claims (1)

[Claims] 1. Latania (Krameria tria)
A whitening cosmetic characterized in that it contains an extract obtained from the rhizome of Ndra et Pavon).