JPH05214364A - Detergent composition - Google Patents

Abstract

PURPOSE:To obtain the subject composition useful for patients of atopic dermatosis, etc., having weak de-fatting power, no drying, no stretching feeling, low irritation, excellent foaming properties and cleaning properties, comprising a specific surfactant, a specific anionic surfactant, etc., a specific antiseptic. CONSTITUTION:The objective composition comprising (A) one or more surfactants selected from a group consisting of an anionic surfactant of formula I (R<1> is 1-40C hydrocarbon; R<2> is lower alkyl; A is lower alkylene) or its salt and an amphoteric surfactant of formula II (R<3> is R<1>; R<4> and R<5> are lower alkyl; B is A) (the ratio of the anionic surfactant of formula I and the amphoteric surfactant is preferably 4/1-2/3 by weight), (B) an anionic surfactant of formula III (R<6> is R<1>; n is l-10;) or its salt and (C) preferably 0.001-1.0wt.% hinokitiol or its salt. The total amounts of the components A and B used is preferably 5-30wt.%.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to a detergent composition having low irritation and low degreasing power.

[0002]

2. Description of the Related Art Since the conventional detergent compositions (for example, shampoo) which have been used conventionally have strong irritancy, they promote the occurrence of itch or cause allergies. It could not be used for patients with skin diseases such as dermatitis and contact dermatitis, especially for patients who are vulnerable to irritation. Furthermore, the conventional detergent composition generally has a large problem in the amount of oil retained due to excessively high degreasing power, which causes dryness and a feeling of tightness of the skin, which is a factor that hinders normal skin activity. Sometimes it was. On the other hand, the detergent composition having weak degreasing power was not satisfactory in terms of usability such as poor foaming.

The object of the present invention is that it has good essential properties as a cleaning agent such as foamability and detergency, and is used for patients with atopic dermatitis or other skin diseases, especially for patients who are vulnerable to irritation. (EN) A low-irritant detergent composition which can be used, and further provides a detergent composition having a weak degreasing power.

[0004]

The inventor of the present invention has conducted extensive studies to achieve the above object. As a result, hinokitiol or a salt thereof has extremely low irritation to the skin and has an excellent antiseptic effect, and is very useful as an antiseptic for a composition that comes into contact with the skin such as cosmetics and detergents. I found that there is. Then, hinokitiol or its salt is used as a preservative, and at least one of a specific anionic surfactant and an amphoteric surfactant is used as a surfactant in combination with a specific weakly acidic anionic surfactant. In this case, it has been found that, while sufficiently maintaining essential properties such as detergency as a cleaning agent, irritation to the skin is significantly reduced, and a degreasing agent having a weak degreasing power can be obtained. The present invention has been completed.

That is, the present invention includes: i) the general formula

[0006]

[Chemical 3]

(Wherein R ¹ represents a saturated or unsaturated hydrocarbon group having 40 or less carbon atoms, R ² represents a lower alkyl group, and A represents a lower alkylene group). Activator or salt thereof, and general formula

[0008]

[Chemical 4]

(In the formula, R ³ represents a saturated or unsaturated hydrocarbon group having 40 or less carbon atoms, R ⁴ and R ⁵ each represent a lower alkyl group, and B represents a lower alkylene group.)
At least one surfactant selected from the group consisting of zwitterionic surfactants represented by: ii) a general formula R ⁶ O (CH ₂ CH ₂ O) _n CH ₂ COOH (III) (wherein R ⁶ represents a saturated or unsaturated hydrocarbon group having 40 or less carbon atoms, and 1≤n≤10), and an anionic surfactant represented by the formula (1) or a salt thereof, and iii) a preservative composed of hinokitiol or a salt thereof The present invention provides a detergent composition containing an agent.

In the present specification, the lower alkyl group is a linear or branched alkyl group having 1 to 6 carbon atoms such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl and hexyl. Particularly preferably, a methyl group can be exemplified.

Examples of the saturated or unsaturated hydrocarbon group having 40 or less carbon atoms include methyl, ethyl, propyl, isopropyl, butyl, tert-butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, 11-methyldodecyl, 10-methylundecyl, tridecyl, tetradecyl, pentadecyl,
Heptadecyl, octadecyl, nonadecyl, icosyl,
Henicosyl, docosyl, tetracosyl, triacontyl, pentatriacontyl, tetracontyl, vinyl,
Allyl, isopropenyl, ethynyl, 2-pentynyl,
3-butenyl, 9-decenyl, cis-8-heptadecenyl, trans-8-heptadecenyl, 2-decynyl, 2
-Octynyl, coconut oil alkyl and the like,
Among them, a saturated or unsaturated hydrocarbon group having 5 to 19 carbon atoms is preferable, and a saturated or unsaturated hydrocarbon group having 7 to 13 carbon atoms is more preferable. Particularly, as the group defined by R ¹ in the formula (I), a saturated hydrocarbon group having 9 to 13 carbon atoms such as undecyl and tridecyl is preferable, and R 1 in the formula (II) is preferable.
^{As the} group defined by ³ , a coconut oil alkyl group, undecyl, a saturated hydrocarbon group having 9 to 13 carbon atoms such as tridecyl is preferable, and as the group defined by R ⁶ in the formula (III), A coconut oil alkyl group and a saturated hydrocarbon group having 9 to 13 carbon atoms such as undecyl and tridecyl are preferable.

As the lower alkylene group, methylene, ethylene, trimethylene, 2-methyltrimethylene, 2,2
Examples thereof include linear or branched alkylene groups having 1 to 6 carbon atoms such as dimethyltrimethylene, 1-methyltrimethylene, methylmethylene, ethylmethylene, tetramethylene, pentamethylene and hexamethylene groups. Among these, as the group defined by A in the above formula (I),
Preferred are methylene and ethylene groups, more preferred are ethylene groups, and preferred examples of the group defined by B in the formula (II) are ethylene and trimethylene groups, more preferred is trimethylene group. ..

The surfactants represented by the general formula (I), (II) or (III) are not only those having the same substituents but also those having different kinds of substituents, which are mixed and used. Good.

The salt of the compound represented by the general formula (I) or (III) includes alkali metal salts such as sodium and potassium salts, alkaline earth metal salts such as magnesium salt and Cu.
Salts, inorganic salts such as metal salts such as Zn salts, diethanolamine salts, alkanolamine salts such as 2-amino-2-ethyl-1,3-propanediol salts and triethanolamine salts, morpholine salts, piperazine salts, piperidine salts etc,
Examples thereof include organic salts such as basic amino acid salts such as ammonium salt, arginine salt, lysine salt and histidine salt. As the basic amino acid, any of a D-form, an L-form or a mixture thereof can be used.

As the salt of hinokitiol, the same salts as the above-mentioned compounds of the formula (I) or (III) can be mentioned.

In the detergent composition of the present invention, as the surfactant, at least one surfactant selected from the anionic surfactants of the general formula (I) and the amphoteric surfactants of the general formula (II) is used. The agent and the surfactant of the general formula (III) are used. These surfactants have excellent detergency as well as extremely low irritation to the skin, and when they are used in combination, the degreasing power becomes weak and the skin feels dry and taut. Can be reduced. The ratio of the surfactant used is the anionic surfactant of the general formula (I) and the general formula (I).
The ratio of the total amount of the zwitterionic surfactant (II) to the surfactant of the general formula (III) is the former: the latter (weight ratio) = 1: 2.
The range may be 0 to 20: 1, preferably 4: 1 to 1: 4, and more preferably 4: 1 to 1: 2.

In the present invention, it is particularly preferable to use the anionic surfactant of the general formula (I) and the amphoteric surfactant of the general formula (II) in combination. The properties are extremely good, and the degreasing power is moderate. When used in combination, the ratio of the surfactant of general formula (I) to the surfactant of general formula (II) is usually in the range of former: latter (weight ratio) = 1: 20 to 20: 1, preferably Is in the range of 4: 1 to 1: 3, more preferably 4: 1 to 2: 3.
Can be in the range of.

The amount of the surfactant in the detergent composition is not particularly limited as long as it is in the range where the detergent effect is sufficiently exhibited.
The total amount of the surfactant is preferably 3 to 40% by weight, and more preferably 5 to 30% by weight, based on the whole composition.

The blending amount of hinokitiol or its salt is not particularly limited as long as the antiseptic effect is exerted, but it is preferably 0.001% by weight or more in the detergent composition, and 0.001 to 1 More preferably, it is set to 0.0% by weight.

By using hinokitiol or a salt thereof as an antiseptic and blending it with the above-mentioned surfactant, irritation to the skin and degreasing power are significantly reduced, and further good cleaning performance, antiseptic performance, etc. can be obtained. A cleaning composition that works is obtained.

The detergent composition of the present invention further comprises (1)
General formula

[0022]

[Chemical 5]

[Wherein R ⁷ represents a saturated or unsaturated hydrocarbon group having 40 or less carbon atoms, R ⁸ represents an alkali metal such as sodium or potassium; an alkaline earth metal such as magnesium; a metal such as copper or zinc; Represents an ion, and m is 1 or 2. ] (2) Milanol C2M Conc, Milanol C2M Conc NP, Milanol 2MC
A Modified, Milano HMS Conc (both Rhone Poulenc Surfactants & Special
ALITIES DIY.) Manufacturing, KOEI PERFUMER
Y CO., LTD.) Sales) etc., and a usual imidazolinium betaine-based zwitterionic surfactant or the like can be added, and by adding these, for example, irritation to the ocular mucosa can be reduced. The addition amount is preferably about 10 to 200% by weight of the anionic surfactant of the general formula (I).

The detergent composition of the present invention can be used in a usual pH range in which cosmetics can be used, and the pH is generally in the range of about 6.0 to 8.0, preferably 6.4 to. It is preferably within the range of about 7.5.

In the detergent composition of the present invention, other surfactants, oil agents such as higher alcohols, hair softeners such as cationized cellulose, glycerin, Propylene glycol, sorbit,
Moisturizing agents such as maltitol, viscosity adjusting agents such as methyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, carboxyvinyl polymer, polyvinyl alcohol, film forming agents such as hydrolyzed collagen, solvents such as ethanol, pH adjusting agents such as citric acid and hydrochloric acid. , UV absorbers, antioxidants, sequestering agents, bactericides, antiseptics, inorganic salts, antidandruff agents, vitamins, antiphlogistics and other medicinal agents, animal and plant extractants, pigments, fragrances, etc. it can.
It is necessary to be careful not to increase the irritation and degreasing power of the detergent composition by adding these additives, for example, when using it as a detergent composition for patients with atopic dermatitis. Is blended so as to have a skin irritation index of about 15 or less shown in the test examples below, and when used as a cleansing composition for a healthy person, blended such that a skin irritation index of about 30 or less. Is preferred.

There are no particular restrictions on the dosage form of the detergent composition of the present invention, and various conventionally known dosage forms such as liquid shampoo, cream-like face wash, gel-like face wash,
It can be used as a body shampoo, a foamy cleaning agent (filled with an aerosol container), a detergent for utensils such as tableware, a wet tissue and the like.

The detergent composition of the present invention may be used by appropriately diluting it with water before use.

[0028]

EFFECTS OF THE INVENTION The cleaning composition of the present invention has extremely low irritation to the skin and, in addition, sufficiently satisfies essential properties as a cleaning agent such as foaming property and cleaning property. In addition, since it has a weak degreasing power, it can eliminate the feeling of dryness and tightness of the skin, help maintain the amount of oil retained in a better condition, and protect it from factors that interfere with the normal activity of the skin. .. Such a detergent composition can be used for patients with atopic dermatitis or other skin diseases, and is equally useful for healthy people.

[0029]

The present invention will be described in more detail below with reference to examples.

Example 1 A face wash composition having the following composition was prepared.

(W / W%) Alaninate LN-30 ^* 7.5 Suwanol AM-3130N ^** 5.5 Nikkor ECTD-3NEX ^*** 2.3 Hinokitiol 0.04 99.5% Ethanol 0.5 pH adjustment Agent, pearlizing agent 100.0 (10W / W% aqueous solution pH 6.8) with proper amount of water ^* Alaninate LN-30 Nikko Chemicals Co., Ltd., N-lauroyl-N-methyl-β-alanine sodium Surfactant with main component ^** Suwanol AM-3130N manufactured by Nikko Chemicals Co., Ltd., surfactant containing coconut oil fatty acid amide propyldimethylaminoacetic acid betaine as a main component ^*** Nikkor ECTD-3NEX manufactured by Nikko Chemicals Co., Ltd., poly Oxyethylene (3)
Surfactant Containing Sodium Alkyl Ether Acetate as Main Component The above face wash composition had good detergency and low degreasing power. The skin irritation of the composition was evaluated by the following method.

A filter paper impregnated with a 1% aqueous solution of the above composition was used in a Finn chamber, Scanpor ta.
Using pe, 12 subjects were put on a closed patch for 48 hours,
After the removal, the skin reaction was evaluated at 1 hour and 24 hours. The judgment result was evaluated according to the following criteria.

No reaction 0 Slight erythema 0.5 Clear erythema 1.0 Erythema with papules or edema 2.0 After removal of the patch, the result with the highest score was selected from the results of 1 hour and 24 hours. , Total score divided by the number of subjects,
The percentage of the quotient was used as the skin irritation index.

As a comparison, a similar skin irritation test was performed on purified water. The results are shown in Table 1 below.

[0035] From the above results, it can be seen that the face wash composition of the present invention is extremely hypoallergenic.

Example 2 A body shampoo having the following composition was prepared.

(W / W%) Amizet 5C ^* 2.5 Alanone ACE ^** 7.5 Suwanol AM-3130N 3.0 Nikkor ECTD-3NEX 3.0 Hinokitiol sodium salt 0.05 Concentrated glycerin 5.0 Metal chelating agent Proper amount pH adjuster Proper amount with water 100.0 (10W / W% aqueous solution pH 6.8) ^* Amizet 5C Kawaken Fine Chemicals Co., Ltd., posioxyethylene (5) coconut oil fatty acid monoethanolamide Surfactant as the main component ^** Alanone ACE manufactured by Kawaken Fine Chemicals Co., Ltd., N-Cocoil-N-
Surfactant mainly containing methyl-β-alanine sodium Example 3 A shampoo having the following composition was prepared.

(W / W%) Alaninate LN-30 38.0 Alanone AME ^* 1.0 Suwanol AM-3130N 6.0 Nikkor ECTD-6NEX ^** 4.0 Hinokitiol triethanolamine salt 0.1 Perfume Suitable amount Metal Chelating agent Appropriate amount pH adjusting agent Appropriate amount Water makes the total amount 100.0 (pH of 10 W / W% aqueous solution 6.5) ^* Aranone AME manufactured by Kawaken Fine Chemicals Co., Ltd., N-myristoyl-
Surfactant containing sodium N-methyl-β-alanine as a main component ^** Nikkor ECTD-6NEX manufactured by Nikko Chemicals Co., Ltd., polyoxyethylene (6)
Surfactant mainly containing sodium alkyl ether acetate Example 4 A face wash having the following composition was prepared.

(W / W%) Alaninate LN-30 7.0 Softofazoline NS ^* 1.5 Suwanol AM-3130N 5.0 Nikkor ECTD-3NEX 3.0 Nikkor CDS6000P ^** 2.5 Hinokitiol L-arginine salt 0. 02 Methyl paraoxybenzoate 0.1 pH adjuster Appropriate amount 100.0 with water (pH of a 10 W / W% aqueous solution is 6.8) ^* Softofazoline NS Kawaken Fine Chemicals Co., Ltd. 2-alkyl-N-
Surfactant containing carboxyethyl-N-hydroxyethyl imidazolinium betaine as a main component ^** Nikkor CDS6000P manufactured by Nikko Chemicals Co., Ltd., a surfactant containing polyethylene glycol distearate as a main component. The ingredients were prepared.

(W / W%) Alanone ALE ^* 8.0 Suwanol AM-3130N 2.0 Nikkor ECTD-6NEX 15.0 Hinokitiol morpholine salt 0.1 pH adjuster, thickener, pigment Appropriate amount All with water 100.0 (pH 7.5 of 10 W / W% aqueous solution) ^* Alanone ALE Kawaken Fine Chemicals Co., Ltd., N-lauroyl-N
-Methyl-β-alanine sodium-based surfactant Example 6 A wiping agent having the following composition was prepared.

(W / W%) Nikkor Sarcosinate LK-30 ^* 2.0 Alaninate LN-30 2.0 Suwanol AM-3130N 0.5 Nikkor ECTD-3NEX 3.0 Hinokitiol 0.1 99.5% Ethanol 2.0 pH adjuster Appropriate amount of water is 100.0 (10 W / W% aqueous solution pH 6.5) ^* Nikkor sarcosinate LK-30 Nikko Chemicals Co., Ltd., an interface containing potassium lauroyl sarcosine as a main component. Activator Example 7 A face wash having the following composition was prepared.

(W / W%) Alaninate LN-30 7.5 Suwanol AM-3130N 5.5 Nikkor ECTD-3NEX 2.3 Hinokitiol 0.02 Butyl paraoxybenzoate 0.1 Methyl paraoxybenzoate 0.1 99. 5% ethanol 0.5 pH adjuster, pearlizing agent Appropriate amount 100.0 with water (pH of a 10 W / W% aqueous solution is 6.8) Example 8 A shampoo having the following composition was prepared.

(W / W%) Alaninate LN-30 40.0 Suwanol AM-3130N 10.0 Hinokitiol 0.04 Nikkor ECTD-3NEX 0.88 pH adjuster, sequestering agent Appropriate amount The total amount is 100 with water. 0.0 (10 W / W% aqueous solution pH 6.8) Example 9 A body shampoo having the following formulation was prepared.

(W / W%) Alanone ALE 0.5 Swanol AM-3130N 2.0 Nikkor ECTD-6NEX 17.6 Milanol C2M Conc ^* 2.0 Hinokitiol 0.01 Pearling agent, pH adjuster, moisturizing agent Suitable The total amount is 100.0 (10 W / W% aqueous solution pH 7.0) with water. ^* Milanol C2M Conc Koei Kogyo Co., Ltd., coconut oil alkyl N-carboxymethoxyethyl-N-carboxymethyl imidazolinium disodium hydroxy. Surfactant mainly composed of

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Claims (1)

[Claims] 1. i) General formula: (In the formula, R ¹ represents a saturated or unsaturated hydrocarbon group having 40 or less carbon atoms, R ² represents a lower alkyl group, and A represents a lower alkylene group.) Or The salt, and the general formula: (In the formula, R ³ represents a saturated or unsaturated hydrocarbon group having 40 or less carbon atoms, R ⁴ and R ⁵ each represent a lower alkyl group, and B represents a lower alkylene group). At least one surfactant selected from the group consisting of organic surfactants, ii) a general formula R ⁶ O (CH ₂ CH ₂ O) _n CH ₂ COOH (III) (wherein R ⁶ is a carbon number Containing a saturated or unsaturated hydrocarbon group of 40 or less and 1 ≦ n ≦ 10) and an anionic surfactant represented by the formula (3), or iii) a preservative composed of hinokitiol or a salt thereof. A cleaning composition comprising: