JPH05112469A - Porous carrier, preparation produced therefrom and their production - Google Patents
Porous carrier, preparation produced therefrom and their productionInfo
- Publication number
- JPH05112469A JPH05112469A JP3299548A JP29954891A JPH05112469A JP H05112469 A JPH05112469 A JP H05112469A JP 3299548 A JP3299548 A JP 3299548A JP 29954891 A JP29954891 A JP 29954891A JP H05112469 A JPH05112469 A JP H05112469A
- Authority
- JP
- Japan
- Prior art keywords
- starch
- porous
- porous carrier
- preparation
- enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Description
【０００１】[0001]
【０００２】本発明は、多孔性担体及びこれを用いた製
剤、並びにそれらの製造方法に関し、詳細には、医薬、
農薬、肥料などの分野で使用される目的物質を担持可能
な多孔性担体及びこれを用いた製剤、並びにそれらの製
造方法に関する。[0002] The present invention relates to a porous carrier, a preparation using the same, and a method for producing them, and more specifically, a pharmaceutical,
The present invention relates to a porous carrier capable of supporting a target substance used in fields such as agricultural chemicals and fertilizers, a preparation using the same, and a method for producing them.
【０００３】[0003]
【０００４】従来より、医薬、農薬及び肥料等の目的物
質の効力を持続させたり、必要な条件下で該目的物質を
放出させる手段として、次のような技術が存在してい
る。Conventionally, the following techniques have been known as means for sustaining the efficacy of target substances such as pharmaceuticals, agricultural chemicals and fertilizers, and for releasing the target substances under necessary conditions.
【０００５】ａ）目的物質をイオン交換樹脂に結合させ
溶出を制限する技術。 ｂ）ワックスをマトリックスとして、その中に目的物質
を分散させる技術。 ｃ）コーティングした顆粒剤をカプセルに充填する技
術。A) A technique for binding a target substance to an ion exchange resin to limit elution. b) A technique in which wax is used as a matrix and the target substance is dispersed therein. c) A technique of filling the coated granules into capsules.
【０００６】[0006]
【０００７】しかしながら、上記した従来の技術は、目
的物質の効力の持続時間や放出条件を、主に粒の表面の
コーティング剤の選択に依ってコントロールしていたの
で、コーティング剤が溶解した後の効力等をコントロー
ルできなかった。However, in the above-mentioned conventional techniques, the duration of the potency of the target substance and the release conditions are controlled mainly by the selection of the coating agent on the surface of the particles. The efficacy etc. could not be controlled.
【０００８】即ち、上記したａ）〜ｃ）のいずれの技術
も、コーティング剤の溶解後は、例えば、目的物質を徐
々に放出するようにコントロールできなかった。That is, none of the above-mentioned techniques a) to c) could be controlled so as to gradually release the target substance after the coating agent was dissolved.
【０００９】また、従来の技術は、場合によって、人体
にとって有害であったり、加工が困難なこともあった。Further, in some cases, the conventional technique may be harmful to the human body or difficult to process.
【００１０】従って、目的物質の効力の持続時間や放出
条件を自由にコントロールすることができ、しかも、安
全で加工の容易な手段が望まれていた。Therefore, there has been a demand for a means capable of freely controlling the duration of effect of the target substance and the release conditions, and which is safe and easy to process.
【００１１】[0011]
【課題を解決するための手段】[Means for Solving the Problems]
【００１２】本発明者らは上記課題を解決するための手
段として、澱粉に生澱粉分解酵素を作用させたときに生
ずる多孔状の孔に着目し、これを担体として利用するこ
とを考えた。[0012] As a means for solving the above problems, the present inventors have focused on the porous pores produced when a raw starch degrading enzyme is made to act on starch, and have considered using this as a carrier.
【００１３】すなわち、本発明の課題を解決するための
手段は、下記のとおりである。That is, the means for solving the problems of the present invention are as follows.
【００１４】第１に、澱粉に生澱粉分解能を有する酵素
を作用させた多孔性澱粉粒よりなる、多孔性担体であ
る。First, there is a porous carrier composed of porous starch granules obtained by reacting starch with an enzyme capable of degrading raw starch.
【００１５】第２に、澱粉に生澱粉分解能を有する酵素
を作用させた多孔性澱粉粒よりなる多孔性担体の孔部
に、目的物質が担持された、製剤である。Secondly, there is provided a preparation in which a target substance is carried in the pores of a porous carrier made of porous starch granules obtained by reacting starch with an enzyme capable of degrading raw starch.
【００１６】第３に、澱粉に生澱粉分解能を有する酵素
を作用させ、該澱粉を多孔性澱粉粒とすることで製造す
る、多孔性担体の製造方法である。Thirdly, there is a method for producing a porous carrier, which is produced by reacting starch with an enzyme capable of degrading raw starch to form the starch into porous starch granules.
【００１７】第４に、澱粉に生澱粉分解能を有する酵素
を作用させ、該澱粉を多孔性澱粉粒とし、該多孔性澱粉
粒を多孔性担体として利用して、目的物質を該多孔性担
体の孔部に担持させることで製造する、製剤の製造方法
である。Fourthly, an enzyme having a ability to decompose raw starch is allowed to act on the starch to make the starch into porous starch granules, and the porous starch granules are used as a porous carrier to transform the target substance into a porous carrier. It is a method for producing a preparation, which is produced by supporting the preparation in the pores.
【００１８】通常澱粉は植物の起源により大きさや形は
異なるが、その粒径は小さいものでは米澱粉の５μから
大きいもので馬鈴薯澱粉の１００μまで存在する。Usually, the size and shape of starch differ depending on the origin of the plant, but when the particle size is small, it ranges from 5 μ of rice starch to 100 μ of potato starch.
【００１９】又、澱粉粒の内部は澱粉分子の微結晶構造
が粒の中心より層状に重なり詰まっている。Further, the inside of the starch granules is filled with the microcrystalline structure of the starch molecules, which is layered and stacked from the center of the granules.
【００２０】この澱粉粒に生澱粉分解能のある酵素（複
数のアミラーゼにより構成）を作用させると、澱粉粒の
酵素作用による侵食により表面に多数の穴を開け澱粉粒
内部を溶解し、海面状となるが、この際、澱粉や酵素の
種類、作用条件等を選択することで、目的物質を担持す
る穴等の状態を自由に設定することもできる。When an enzyme (composed of a plurality of amylases) capable of degrading raw starch is applied to the starch granules, a large number of holes are opened in the surface by the erosion of the starch granules due to the enzymatic action, and the inside of the starch granules is dissolved to form a sea surface shape. At this time, however, the state of the hole or the like for supporting the target substance can be freely set by selecting the type of starch or enzyme, the action conditions and the like.
【００２１】この海面状澱粉粒は空洞部分の体積も大き
く、ここへ目的物質を担持させ表面を目的にしたがっ
て、コーティング剤を選択、あるいはマイクロカプセル
化の方法を選択し目的の製剤を得る。[0021] The sea surface starch granules have a large volume in the hollow portion, and the target substance is supported thereon, and a coating agent is selected or a microencapsulation method is selected according to the purpose of the surface to obtain a target preparation.
【００２２】この海面状澱粉粒は空洞部分の体積が大き
く、動物細胞及び植物細胞の組織培養に用いる多孔性担
体としても利用できる。Since the sea surface starch granules have a large volume in the hollow portion, they can be used as a porous carrier for tissue culture of animal cells and plant cells.
【００２３】本発明による製剤は、コーティング剤が解
けた後でも、目的物質が多孔性担体に担持されているの
で、例えば、目的物質を徐々に放出するようにコントロ
ールできる。Since the target substance is supported on the porous carrier even after the coating agent is thawed, the preparation according to the present invention can be controlled, for example, to gradually release the target substance.
【００２４】[0024]
【００２５】以下、本発明の一実施例を説明する。An embodiment of the present invention will be described below.
【００２６】図１は多孔性担体の製造工程の説明図で、
１は原料として用いられる澱粉粒、２は多孔性澱粉粒よ
りなる多孔性担体、２ａは多孔性担体２に形成された目
的物質担持用の孔部を示す。FIG. 1 is an explanatory view of the manufacturing process of the porous carrier.
Reference numeral 1 is a starch granule used as a raw material, 2 is a porous carrier composed of porous starch granules, and 2a is a hole formed in the porous carrier 2 for supporting a target substance.
【００２７】[0027]
【実施例１】Example 1
【００２８】０．２５ｍＭ（ｐＨ５．０）の酢酸緩衝液
１０００ｍｌに、コーンスターチ１００ｇ及びダビアー
ゼＫ−２７（商品名：ダイキン工業(株)製の生澱粉分解
酵素）１．０ｇを投入し攪拌しながら４０℃で１昼夜放
置し水洗、乾燥して多孔コーンスターチ粒よりなる多孔
性担体を得た。To 1000 ml of 0.25 mM (pH 5.0) acetate buffer, 100 g of corn starch and 1.0 g of Daviase K-27 (trade name: raw starch degrading enzyme manufactured by Daikin Industries, Ltd.) were added and stirred. The mixture was allowed to stand at 40 ° C for one day, washed with water and dried to obtain a porous carrier composed of porous corn starch particles.
【００２９】[0029]
【実施例２】Example 2
【００３０】実施例１で得た多孔性担体に担持させる薬
物としてアセチルサリチル酸の微粉化物を用い、ハイブ
リダイザーＮＨＳ−０型（商品名：(株)奈良機械製作所
製）による高速気流中衝撃処理（16000rpm,10min）で、
多孔性担体の孔部に詰込（埋設）んだ。A fine powder of acetylsalicylic acid was used as the drug to be loaded on the porous carrier obtained in Example 1, and impact treatment in a high-speed air stream was carried out by Hybridizer NHS-0 type (trade name: Nara Machinery Co., Ltd.). 16000rpm, 10min),
It was packed (embedded) in the pores of the porous carrier.
【００３１】この物に改質用粉体としてアルギン酸ソー
ダを用い、メカノミルＭＭ−１０型（商品名：岡田精工
(株)製）による混合処理（1000rpm，10min）及びハイブ
リダイザー（(株)奈良機械製作所製）による高速気流中
衝撃処理（16000rpm,10min）を行った。Using sodium alginate as a modifying powder for this product, MechanoMill MM-10 type (trade name: Okada Seiko)
(Manufactured by Nara Machinery Co., Ltd.) and mixed treatment (1000 rpm, 10 min) by a hybridizer (manufactured by Nara Machinery Co., Ltd.).
【００３２】高速気流中衝撃処理の途中、４〜５分経過
後、改質用粉体のゲル化・造膜を進めるため１％の塩化
カルシウム溶液をハイブリダイザー内に小量添加しアル
ギン酸カルシウムゲルでコーティングされたアセチルサ
リチル酸の製剤を得た。After 4 to 5 minutes in the course of impact treatment in a high-speed air stream, a small amount of 1% calcium chloride solution was added to the hybridizer to promote gelation and film formation of the modifying powder, and calcium alginate gel was added. A formulation of acetylsalicylic acid coated with was obtained.
【００３３】こうして得られた製剤は胃では徐々に放出
するが腸においてｐＨが上昇するとゲルが膨潤崩壊し腸
溶性効果が得られた。The preparation thus obtained was gradually released in the stomach, but when the pH increased in the intestine, the gel swelled and disintegrated, and an enteric effect was obtained.
【００３４】[0034]
【実施例３】Example 3
【００３５】実施例１で得た多孔性担体に担持させる薬
物としてアセチルサリチル酸の微粉化物を用い、ハイブ
リダイザーＮＨＳ−０型（商品名：(株)奈良機械製作所
製）による高速気流中衝撃処理（16000rpm,10min）で、
多孔性担体の孔部に詰込（埋設）んだ。A fine powder of acetylsalicylic acid was used as the drug to be loaded on the porous carrier obtained in Example 1, and impact treatment in a high-speed air stream was carried out by Hybridizer NHS-0 type (trade name: manufactured by Nara Machinery Co., Ltd.) ( 16000rpm, 10min),
It was packed (embedded) in the pores of the porous carrier.
【００３６】この物に改質用粉体としてアルギン酸ソー
ダと水溶性コーンダイエタリーファイバーの混合物（１
０:１〜１:１重量比）を用い、メカノミルＭＭ−１０型
（商品名：岡田精工(株)製）による混合処理（1000rp
m，10min）及びハイブリダイザー（(株)奈良機械製作所
製）による高速気流中衝撃処理（16000rpm,10min）を行
った。A mixture of sodium alginate and water-soluble corn dietary fiber as a modifying powder (1
Mixing treatment (1000rp) with MechanoMill MM-10 type (trade name: Okada Seiko Co., Ltd.) using 0: 1 to 1: 1 weight ratio.
m, 10 min) and a hybridizer (manufactured by Nara Kikai Seisakusho Co., Ltd.) were subjected to shock treatment in a high-speed air stream (16000 rpm, 10 min).
【００３７】高速気流中衝撃処理の途中、４〜５分経過
後、改質用粉体のゲル化・造膜を進めるため１％の塩化
カルシウム溶液をハイブリダイザー内に小量添加し、水
溶性コーンダイエタリーファイバー微粒子が均質に分散
されたアルギン酸カルシウムゲルでコーティングされた
アセチルサリチル酸の製剤を得た。After 4 to 5 minutes had passed during the impact treatment in a high-speed air stream, a small amount of 1% calcium chloride solution was added to the hybridizer to promote gelation and film formation of the modifying powder, and the mixture was dissolved A formulation of acetylsalicylic acid coated with a calcium alginate gel in which corn dietary fiber fine particles were uniformly dispersed was obtained.
【００３８】こうして得られた製剤は、実施例２での製
剤に比較して胃での放出はやや速くなるが、腸において
もｐＨが上昇するにつれゲルが膨潤崩壊し腸溶性効果が
得られた。The thus-obtained preparation had a slightly faster gastric release than the preparation of Example 2, but also in the intestine, the gel swelled and disintegrated as the pH increased, and an enteric effect was obtained. .
【００３９】[0039]
【００４０】本発明によると、食品として安全な澱粉に
酵素により穴を開けることにより収蔵力が大きな多孔性
担体が得られ、この多孔性担体に目的物質を担持するこ
とにより、目的物質の効力の持続時間や放出条件を自由
にコントロールすることができ、しかも、安全で加工も
容易である。According to the present invention, a porous carrier having a large storage capacity can be obtained by making a hole in a food-safe starch with an enzyme. By supporting the target substance on this porous carrier, the efficacy of the target substance can be improved. The duration and release conditions can be freely controlled, and it is safe and easy to process.
【図１】多孔性担体の製造工程の説明図。FIG. 1 is an explanatory view of a manufacturing process of a porous carrier.
１ 澱粉粒 ２ 多孔性担体 ２ａ 孔部 1 Starch Granule 2 Porous Carrier 2a Pore
フロントページの続き (51)Int.Cl.5 識別記号 庁内整理番号 ＦＩ 技術表示箇所 Ｃ０８Ｂ 30/12 8615−4Ｃ Continuation of the front page (51) Int.Cl. 5 Identification number Office reference number FI technical display area C08B 30/12 8615-4C
Claims (4)
させた多孔性澱粉粒よりなる、多孔性担体。1. A porous carrier comprising porous starch granules obtained by reacting starch with an enzyme capable of degrading raw starch.
させた多孔性澱粉粒よりなる多孔性担体の孔部に、目的
物質が担持された、製剤。2. A preparation in which a target substance is supported in the pores of a porous carrier composed of porous starch granules obtained by reacting starch with an enzyme capable of degrading raw starch.
させ、該澱粉を多孔性澱粉粒とすることで製造する、多
孔性担体の製造方法。3. A method for producing a porous carrier, which comprises producing starch by causing an enzyme having a ability to decompose raw starch to act on the starch to form the starch into porous starch granules.
させ、該澱粉を多孔性澱粉粒とし、該多孔性澱粉粒を多
孔性担体として利用して、目的物質を該多孔性担体の孔
部に担持させることで製造する、製剤の製造方法。4. An enzyme having a ability to decompose raw starch is allowed to act on starch to make the starch into porous starch granules, and the porous starch granules are used as a porous carrier to target the target substance to the pores of the porous carrier. A method for producing a preparation, which is produced by supporting the preparation on a substrate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3299548A JPH05112469A (en) | 1991-10-21 | 1991-10-21 | Porous carrier, preparation produced therefrom and their production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3299548A JPH05112469A (en) | 1991-10-21 | 1991-10-21 | Porous carrier, preparation produced therefrom and their production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH05112469A true JPH05112469A (en) | 1993-05-07 |
Family
ID=17874047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3299548A Pending JPH05112469A (en) | 1991-10-21 | 1991-10-21 | Porous carrier, preparation produced therefrom and their production |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH05112469A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0686399A1 (en) * | 1993-12-27 | 1995-12-13 | San-Ei Sucrochemical Co. Ltd. | Powdery pharmaceutical preparation and method of manufacturing same |
| US6946148B2 (en) | 2000-10-04 | 2005-09-20 | Grain Processing Corp. | Method for absorbing fluid |
| US9005681B2 (en) | 2009-08-18 | 2015-04-14 | Glico Nutrition Co., Ltd. | Food product containing starch gel, starch granule, production method and use thereof |
| US9963581B2 (en) | 2009-08-18 | 2018-05-08 | Glico Nutrition Co., Ltd. | Food product containing starch gel, starch granule, production method and use thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01106817A (en) * | 1987-10-21 | 1989-04-24 | Kiteii:Kk | Substance sealed in porous material and production thereof |
| JPH01159047A (en) * | 1987-12-16 | 1989-06-22 | Nichiden Kagaku Kk | Production of microcapsule |
| JPH02121933A (en) * | 1988-10-28 | 1990-05-09 | Kagaku Shiryo Kenkyusho:Kk | Oily hormonal granule for animal |
| US4985082A (en) * | 1987-11-20 | 1991-01-15 | Lafayette Applied Chemistry, Inc. | Microporous granular starch matrix compositions |
| JPH03223350A (en) * | 1989-12-26 | 1991-10-02 | Nippon Shokubai Kagaku Kogyo Co Ltd | Production of porous polymer film |
-
1991
- 1991-10-21 JP JP3299548A patent/JPH05112469A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01106817A (en) * | 1987-10-21 | 1989-04-24 | Kiteii:Kk | Substance sealed in porous material and production thereof |
| US4985082A (en) * | 1987-11-20 | 1991-01-15 | Lafayette Applied Chemistry, Inc. | Microporous granular starch matrix compositions |
| JPH01159047A (en) * | 1987-12-16 | 1989-06-22 | Nichiden Kagaku Kk | Production of microcapsule |
| JPH02121933A (en) * | 1988-10-28 | 1990-05-09 | Kagaku Shiryo Kenkyusho:Kk | Oily hormonal granule for animal |
| JPH03223350A (en) * | 1989-12-26 | 1991-10-02 | Nippon Shokubai Kagaku Kogyo Co Ltd | Production of porous polymer film |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0686399A1 (en) * | 1993-12-27 | 1995-12-13 | San-Ei Sucrochemical Co. Ltd. | Powdery pharmaceutical preparation and method of manufacturing same |
| EP0686399A4 (en) * | 1993-12-27 | 1996-05-08 | San Ei Sucrochemical Co Ltd | Powdery pharmaceutical preparation and method of manufacturing same |
| AU684329B2 (en) * | 1993-12-27 | 1997-12-11 | San-Ei Sucrochemical Co., Ltd. | Powdery pharmaceutical preparation and method of manufacturing same |
| US5919486A (en) * | 1993-12-27 | 1999-07-06 | San-Ei Sucrochemical Co., Ltd. | Powder preparation and a process for preparing the same |
| US6946148B2 (en) | 2000-10-04 | 2005-09-20 | Grain Processing Corp. | Method for absorbing fluid |
| US7226760B2 (en) | 2000-10-04 | 2007-06-05 | Grain Processing Corporation | Method for preparing a fluid absorber |
| US9005681B2 (en) | 2009-08-18 | 2015-04-14 | Glico Nutrition Co., Ltd. | Food product containing starch gel, starch granule, production method and use thereof |
| US9963581B2 (en) | 2009-08-18 | 2018-05-08 | Glico Nutrition Co., Ltd. | Food product containing starch gel, starch granule, production method and use thereof |
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