JPH05112469A - Porous carrier, preparation produced therefrom and their production - Google Patents

Abstract

PURPOSE:To obtain the subject preparation having freely controllable active time and releasing condition, high safety, easy processability and excellent occlusion effect and useful for pharmaceuticals, etc., by using porous starch grains as a porous carrier and supporting the objective substance in the pores. CONSTITUTION:Starch 1 such as rice starch is treated with an enzyme having raw starch degradation activity (e.g. amylase) to obtain a porous starch grain 2. The obtained porous starch 2 is used as a porous carrier and the objective substance (e.g. acetylsalicylic acid) is supported in the pore 3 of the porous carrier to obtain the objective preparation.

Description

Detailed Description of the Invention

[0001]

[Industrial applications]

[0002] The present invention relates to a porous carrier, a preparation using the same, and a method for producing them, and more specifically, a pharmaceutical,
The present invention relates to a porous carrier capable of supporting a target substance used in fields such as agricultural chemicals and fertilizers, a preparation using the same, and a method for producing them.

[0003]

[Prior Art]

Conventionally, the following techniques have been known as means for sustaining the efficacy of target substances such as pharmaceuticals, agricultural chemicals and fertilizers, and for releasing the target substances under necessary conditions.

A) A technique for binding a target substance to an ion exchange resin to limit elution. b) A technique in which wax is used as a matrix and the target substance is dispersed therein. c) A technique of filling the coated granules into capsules.

[0006]

[Problems to be Solved by the Invention]

However, in the above-mentioned conventional techniques, the duration of the potency of the target substance and the release conditions are controlled mainly by the selection of the coating agent on the surface of the particles. The efficacy etc. could not be controlled.

That is, none of the above-mentioned techniques a) to c) could be controlled so as to gradually release the target substance after the coating agent was dissolved.

Further, in some cases, the conventional technique may be harmful to the human body or difficult to process.

Therefore, there has been a demand for a means capable of freely controlling the duration of effect of the target substance and the release conditions, and which is safe and easy to process.

[0011]

[Means for Solving the Problems]

[0012] As a means for solving the above problems, the present inventors have focused on the porous pores produced when a raw starch degrading enzyme is made to act on starch, and have considered using this as a carrier.

That is, the means for solving the problems of the present invention are as follows.

First, there is a porous carrier composed of porous starch granules obtained by reacting starch with an enzyme capable of degrading raw starch.

Secondly, there is provided a preparation in which a target substance is carried in the pores of a porous carrier made of porous starch granules obtained by reacting starch with an enzyme capable of degrading raw starch.

Thirdly, there is a method for producing a porous carrier, which is produced by reacting starch with an enzyme capable of degrading raw starch to form the starch into porous starch granules.

Fourthly, an enzyme having a ability to decompose raw starch is allowed to act on the starch to make the starch into porous starch granules, and the porous starch granules are used as a porous carrier to transform the target substance into a porous carrier. It is a method for producing a preparation, which is produced by supporting the preparation in the pores.

Usually, the size and shape of starch differ depending on the origin of the plant, but when the particle size is small, it ranges from 5 μ of rice starch to 100 μ of potato starch.

Further, the inside of the starch granules is filled with the microcrystalline structure of the starch molecules, which is layered and stacked from the center of the granules.

When an enzyme (composed of a plurality of amylases) capable of degrading raw starch is applied to the starch granules, a large number of holes are opened in the surface by the erosion of the starch granules due to the enzymatic action, and the inside of the starch granules is dissolved to form a sea surface shape. At this time, however, the state of the hole or the like for supporting the target substance can be freely set by selecting the type of starch or enzyme, the action conditions and the like.

[0021] The sea surface starch granules have a large volume in the hollow portion, and the target substance is supported thereon, and a coating agent is selected or a microencapsulation method is selected according to the purpose of the surface to obtain a target preparation.

Since the sea surface starch granules have a large volume in the hollow portion, they can be used as a porous carrier for tissue culture of animal cells and plant cells.

Since the target substance is supported on the porous carrier even after the coating agent is thawed, the preparation according to the present invention can be controlled, for example, to gradually release the target substance.

[0024]

【Example】

An embodiment of the present invention will be described below.

FIG. 1 is an explanatory view of the manufacturing process of the porous carrier.
Reference numeral 1 is a starch granule used as a raw material, 2 is a porous carrier composed of porous starch granules, and 2a is a hole formed in the porous carrier 2 for supporting a target substance.

[0027]

Example 1

To 1000 ml of 0.25 mM (pH 5.0) acetate buffer, 100 g of corn starch and 1.0 g of Daviase K-27 (trade name: raw starch degrading enzyme manufactured by Daikin Industries, Ltd.) were added and stirred. The mixture was allowed to stand at 40 ° C for one day, washed with water and dried to obtain a porous carrier composed of porous corn starch particles.

[0029]

Example 2

A fine powder of acetylsalicylic acid was used as the drug to be loaded on the porous carrier obtained in Example 1, and impact treatment in a high-speed air stream was carried out by Hybridizer NHS-0 type (trade name: Nara Machinery Co., Ltd.). 16000rpm, 10min),
It was packed (embedded) in the pores of the porous carrier.

Using sodium alginate as a modifying powder for this product, MechanoMill MM-10 type (trade name: Okada Seiko)
(Manufactured by Nara Machinery Co., Ltd.) and mixed treatment (1000 rpm, 10 min) by a hybridizer (manufactured by Nara Machinery Co., Ltd.).

After 4 to 5 minutes in the course of impact treatment in a high-speed air stream, a small amount of 1% calcium chloride solution was added to the hybridizer to promote gelation and film formation of the modifying powder, and calcium alginate gel was added. A formulation of acetylsalicylic acid coated with was obtained.

The preparation thus obtained was gradually released in the stomach, but when the pH increased in the intestine, the gel swelled and disintegrated, and an enteric effect was obtained.

[0034]

Example 3

A fine powder of acetylsalicylic acid was used as the drug to be loaded on the porous carrier obtained in Example 1, and impact treatment in a high-speed air stream was carried out by Hybridizer NHS-0 type (trade name: manufactured by Nara Machinery Co., Ltd.) ( 16000rpm, 10min),
It was packed (embedded) in the pores of the porous carrier.

A mixture of sodium alginate and water-soluble corn dietary fiber as a modifying powder (1
Mixing treatment (1000rp) with MechanoMill MM-10 type (trade name: Okada Seiko Co., Ltd.) using 0: 1 to 1: 1 weight ratio.
m, 10 min) and a hybridizer (manufactured by Nara Kikai Seisakusho Co., Ltd.) were subjected to shock treatment in a high-speed air stream (16000 rpm, 10 min).

After 4 to 5 minutes had passed during the impact treatment in a high-speed air stream, a small amount of 1% calcium chloride solution was added to the hybridizer to promote gelation and film formation of the modifying powder, and the mixture was dissolved A formulation of acetylsalicylic acid coated with a calcium alginate gel in which corn dietary fiber fine particles were uniformly dispersed was obtained.

The thus-obtained preparation had a slightly faster gastric release than the preparation of Example 2, but also in the intestine, the gel swelled and disintegrated as the pH increased, and an enteric effect was obtained. .

[0039]

【The invention's effect】

According to the present invention, a porous carrier having a large storage capacity can be obtained by making a hole in a food-safe starch with an enzyme. By supporting the target substance on this porous carrier, the efficacy of the target substance can be improved. The duration and release conditions can be freely controlled, and it is safe and easy to process.

[Brief description of drawings]

FIG. 1 is an explanatory view of a manufacturing process of a porous carrier.

[Explanation of symbols]

 1 Starch Granule 2 Porous Carrier 2a Pore

Continuation of the front page (51) Int.Cl. ⁵ Identification number Office reference number FI technical display area C08B 30/12 8615-4C

Claims (4)

[Claims] 1. A porous carrier comprising porous starch granules obtained by reacting starch with an enzyme capable of degrading raw starch. 2. A preparation in which a target substance is supported in the pores of a porous carrier composed of porous starch granules obtained by reacting starch with an enzyme capable of degrading raw starch. 3. A method for producing a porous carrier, which comprises producing starch by causing an enzyme having a ability to decompose raw starch to act on the starch to form the starch into porous starch granules. 4. An enzyme having a ability to decompose raw starch is allowed to act on starch to make the starch into porous starch granules, and the porous starch granules are used as a porous carrier to target the target substance to the pores of the porous carrier. A method for producing a preparation, which is produced by supporting the preparation on a substrate.