JPH0437542B2 - - Google Patents
Info
- Publication number
- JPH0437542B2 JPH0437542B2 JP60104883A JP10488385A JPH0437542B2 JP H0437542 B2 JPH0437542 B2 JP H0437542B2 JP 60104883 A JP60104883 A JP 60104883A JP 10488385 A JP10488385 A JP 10488385A JP H0437542 B2 JPH0437542 B2 JP H0437542B2
- Authority
- JP
- Japan
- Prior art keywords
- sample
- matrix agent
- shaft
- ionization
- introduction chamber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000002500 ions Chemical group 0.000 claims description 39
- 239000002245 particle Substances 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 13
- 239000011159 matrix material Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 13
- 239000011164 primary particle Substances 0.000 claims description 12
- 238000004949 mass spectrometry Methods 0.000 claims description 11
- 238000006073 displacement reaction Methods 0.000 claims description 9
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 239000003463 adsorbent Substances 0.000 claims description 6
- 238000004458 analytical method Methods 0.000 claims description 6
- 238000004587 chromatography analysis Methods 0.000 claims description 5
- 150000002894 organic compounds Chemical class 0.000 claims description 5
- 239000012212 insulator Substances 0.000 claims description 4
- 238000011161 development Methods 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 claims description 3
- 238000005259 measurement Methods 0.000 description 14
- 238000001004 secondary ion mass spectrometry Methods 0.000 description 9
- 238000004809 thin layer chromatography Methods 0.000 description 8
- 108090000765 processed proteins & peptides Proteins 0.000 description 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 238000000926 separation method Methods 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- 238000001228 spectrum Methods 0.000 description 5
- 239000000758 substrate Substances 0.000 description 5
- 150000001793 charged compounds Chemical class 0.000 description 4
- 238000004891 communication Methods 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical group [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000010265 fast atom bombardment Methods 0.000 description 3
- 238000010884 ion-beam technique Methods 0.000 description 3
- 238000001819 mass spectrum Methods 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 2
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000002359 drug metabolite Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- RIWRFSMVIUAEBX-UHFFFAOYSA-N n-methyl-1-phenylmethanamine Chemical class CNCC1=CC=CC=C1 RIWRFSMVIUAEBX-UHFFFAOYSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000006884 silylation reaction Methods 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60104883A JPS61260149A (ja) | 1985-05-15 | 1985-05-15 | 試料走査形質量分析方法および試料走査装置 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60104883A JPS61260149A (ja) | 1985-05-15 | 1985-05-15 | 試料走査形質量分析方法および試料走査装置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61260149A JPS61260149A (ja) | 1986-11-18 |
| JPH0437542B2 true JPH0437542B2 (enrdf_load_stackoverflow) | 1992-06-19 |
Family
ID=14392579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60104883A Granted JPS61260149A (ja) | 1985-05-15 | 1985-05-15 | 試料走査形質量分析方法および試料走査装置 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61260149A (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11139155B2 (en) | 2017-11-28 | 2021-10-05 | Hamamatsu Photonics K.K. | Laser desorption/ionization method and mass spectrometry method |
| US11335546B2 (en) | 2017-11-28 | 2022-05-17 | Hamamatsu Photonics K.K. | Laser desorption/ionization method, mass spectrometry method, sample support body, and manufacturing method of sample support body |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5032076B2 (ja) * | 2006-09-12 | 2012-09-26 | 株式会社テクノフロント | 質量分析装置 |
| JP5947533B2 (ja) * | 2011-01-19 | 2016-07-06 | キヤノン株式会社 | 情報取得方法 |
-
1985
- 1985-05-15 JP JP60104883A patent/JPS61260149A/ja active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11139155B2 (en) | 2017-11-28 | 2021-10-05 | Hamamatsu Photonics K.K. | Laser desorption/ionization method and mass spectrometry method |
| US11335546B2 (en) | 2017-11-28 | 2022-05-17 | Hamamatsu Photonics K.K. | Laser desorption/ionization method, mass spectrometry method, sample support body, and manufacturing method of sample support body |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS61260149A (ja) | 1986-11-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6838663B2 (en) | Methods and devices for laser desorption chemical ionization | |
| Siuzdak | Mass spectrometry for biotechnology | |
| EP0964427B1 (en) | Ambient pressure matrix-assisted laser desorption ionization (maldi) apparatus and method of analysis | |
| US7977629B2 (en) | Atmospheric pressure ion source probe for a mass spectrometer | |
| US7968842B2 (en) | Apparatus and systems for processing samples for analysis via ion mobility spectrometry | |
| Wang et al. | Desorption corona beam ionization source for mass spectrometry | |
| Medhe | Ionization techniques in mass spectrometry: a review | |
| US20150357173A1 (en) | Laser ablation atmospheric pressure ionization mass spectrometry | |
| US11527397B2 (en) | Desorption ion source with dopant-gas assisted ionization | |
| DE102021105327B3 (de) | Desorptions-Ionenquelle mit Postdesorptions-Ionisierung in Transmissionsgeometrie | |
| JP3424376B2 (ja) | 液体クロマトグラフ質量分析装置 | |
| Sofer et al. | An atmospheric-pressure glow discharge ionization source | |
| Sherman et al. | Laser-induced thermal desorption utilizing FT-MS detection | |
| Kolaitis et al. | Detection of nonvolatile species by laser desorption atmospheric pressure mass spectrometry | |
| US20080296488A1 (en) | Imaging mass spectrometry for small molecules in two-dimensional samples | |
| JPH0437542B2 (enrdf_load_stackoverflow) | ||
| US5589685A (en) | Matrix enhanced SIMS | |
| Schilke et al. | A laser vaporization, laser ionization time‐of‐flight mass spectrometer for the probing of fragile biomolecules | |
| Shomo II et al. | Laser desorption/Fourier transform ion cyclotron resonance vs. field desorption/magnetic sector mass spectrometry. Erythromycin, amoxicillin, digoxin, and daunorubicin | |
| EP1193730A1 (en) | Atmospheric-pressure ionization device and method for analysis of a sample | |
| JPH0351052B2 (enrdf_load_stackoverflow) | ||
| Wang et al. | A method for background reduction in a supersonic jet/multiphoton ionization reflectron time-of-flight mass spectrometer | |
| Friesen | Application of Negative Chemical Ionization Mass Spectrometry to the Analysis of Bovine Tissue for Chlorodibenzo-Para-dioxins and Related Compounds | |
| JP2948146B2 (ja) | 質量分析装置及び質量分析方法 | |
| GB2091937A (en) | Mass analysis sample ionisation |